Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
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We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin.
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Unc13a expression in mushroom bodies plays a fundamental role in olfactory memory encoding in Drosophila, and hippocampal expression of Lpl is necessary for synaptic vesicle recycling and acquisition of memories in mice.
“Unc13a expression in mushroom bodies plays a fundamental role in olfactory memory encoding in Drosophila [86], and hippocampal expression of lipoprotein lipase (Lpl) is necessary for synaptic vesicle recycling and acquisition of memories in mice [87].”
From Rapid changes in plasma corticosterone and medial amygdala transcriptome profiles during social status change reveal molecular pathways associated with a major life history transition in mouse dominance hierarchies (2025) · cites this paper as [87]
Citation [87] is attached to the claim about hippocampal Lpl in mice, not the preceding Drosophila claim. The Online Methods (RT-PCR and Ribosome profiling; page unavailable) mention hippocampal samples, but neither that passage nor searches for Lpl, lipoprotein lipase, synaptic vesicle recycling, and memory acquisition address the attributed role of Lpl. (LLM, conf=0.76)
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Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395 · see citing works
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356 · see citing works
Self-citationBrain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313 · see citing works
Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679 · see citing works
Self-citationLeptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons
Vong, L., Ye, C., Yang, Z., Choi, B. J., Chua, S. C., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,238 · see citing works
Unbiased stereological estimation of the number of neurons in the human hippocampus
West, M. J., & Gundersen, H. J. G. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.902960102 · Cited by 1,153 · see citing works
A translational profiling approach for the molecular characterization of CNS cell types
Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134 · see citing works
Cell-type-specific isolation of ribosome-associated mRNA from complex tissues
Sanz, E., Yang, L., Su, T., Morris, D. R., McKnight, G. S., & Amieux, P. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907143106 · Cited by 982 · see citing works
Application of a translational profiling approach for the comparative analysis of CNS cell types
Doyle, J. P., Dougherty, J. D., Heiman, M., Schmidt, E. F., Stevens, T. R., Ma, G., Bupp, S., Shrestha, P., Shah, R. D., Doughty, M. L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.029 · Cited by 912 · see citing works
Ghrelin controls hippocampal spine synapse density and memory performance
Diano, S., Farr, S. A., Benoit, S. C., McNay, E. C., da Silva, I., Horvath, B., Gaskin, F. S., Nonaka, N., Jaeger, L. B., Banks, W. A., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1656 · Cited by 828 · see citing works
Self-citationUCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals
Andrews, Z. B., Liu, Z.-W., Walllingford, N., Erion, D. M., Borok, E., Friedman, J. M., Tschöp, M. H., Shanabrough, M., Cline, G., Shulman, G. I., et al. (2008) · Nature · doi:10.1038/nature07181 · Cited by 710 · see citing works
Self-citationAstrocyte–neuron metabolic relationships: for better and for worse
Allaman, I., Bélanger, M., & Magistretti, P. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2010.12.001 · Cited by 639 · see citing works
Horváth, T. L., Sármán, B., García‐Cáceres, C., Enriori, P. J., Sótonyi, P., Shanabrough, M., Borók, E., Argente, J., Chowen, J. A., Pérez–Tilve, D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004282107 · Cited by 446 · see citing works
Self-citationHunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop
Yang, Y., Atasoy, D., Su, H. H., & Sternson, S. M. (2011) · Cell · doi:10.1016/j.cell.2011.07.039 · Cited by 431 · see citing works
Neurobiology of Feeding and Energy Expenditure
Gao, Q., & Horvath, T. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094324 · Cited by 346 · see citing works
Dougherty, J. D., Schmidt, E. F., Nakajima, M., & Heintz, N. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq130 · Cited by 344 · see citing works
Early Postnatal Astroglial Cells Produce Multilineage Precursors and Neural Stem Cells In Vivo
Ganat, Y. M., Silbereis, J. C., Cave, C., Ngu, H., Anderson, G. M., Ohkubo, Y., Ment, L. R., & Vaccarino, F. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2532-06.2006 · Cited by 264 · see citing works
Self-citationLeptin regulates glutamate and glucose transporters in hypothalamic astrocytes
Fuente-Martín, E., García‐Cáceres, C., Granado, M., CEBALLOS, M. L. D., Sanchez-Garrido, M. A., Sármán, B., Liu, Z.-W., Dietrich, M. O., Tena‐Sempere, M., Argente-Arizón, P., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64102 · Cited by 198 · see citing works
Self-citationObesity induces functional astrocytic leptin receptors in hypothalamus
Hsuchou, H., He, Y., Kastin, A. J., Tu, H., Markadakis, E. N., Rogers, R. C., Fossier, P. B., & Pan, W. (2008) · Brain · doi:10.1093/brain/awp029 · Cited by 181 · see citing works
AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors
Dietrich, M. O., Bober, J., Ferreira, J. G., Tellez, L. A., Mineur, Y. S., Souza, D. O., Gao, X.-B., Picciotto, M. R., Araújo, I., Liu, Z.-W., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3147 · Cited by 158 · see citing works
Self-citationMolecular mapping of mouse brain regions innervated by leptin receptor-expressing cells
Patterson, C. M., Leshan, R. L., Jones, J. C., & Myers, M. G. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.010 · Cited by 150 · see citing works
Distribution of leptin‐sensitive cells in the postnatal and adult mouse brain
Caron, É., Sachot, C., Prévot, V., & Bouret, S. G. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22219 · Cited by 147 · see citing works
García‐Cáceres, C., Fuente-Martín, E., Burgos‐Ramos, E., Granado, M., Frago, L. M., Barrios, V., Horváth, T. L., Argente, J., & Chowen, J. A. (2011) · Endocrinology · doi:10.1210/en.2010-1252 · Cited by 107 · see citing works
Self-citationNeuroactive steroids regulate astroglia morphology in hippocampal cultures from adult rats
del Cerro, S., Garcı́a‐Estrada, J., & García‐Segura, L. M. (1995) · Glia · doi:10.1002/glia.440140109 · Cited by 80 · see citing works
Leptin receptor mRNA in rat brain astrocytes
Hsuchou, H., Pan, W., Barnes, M. J., & Kastin, A. J. (2009) · Peptides · doi:10.1016/j.peptides.2009.08.023 · Cited by 78 · see citing works
Neuronal deletion of Lepr elicits diabesity in mice without affecting cold tolerance or fertility
McMinn, J. E., Liu, S.-M., Liu, H. S., Dragatsis, I., Dietrich, P., Ludwig, T. E., Boozer, C. N., & Chua, S. C. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00535.2004 · Cited by 75 · see citing works
A comparative study of the neuronal packing density in the cerebral cortex.
SHOLL, D. A. (1959) · PubMed · Cited by 60 · see citing works
Diano, S., Naftolin, F. N., & Horváth, T. L. (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00195.x · Cited by 39 · see citing works
Self-citationDouble Fluorescence in situ Hybridization in Fresh Brain Sections
Jeong, J. K., Chen, Z., Tremere, L. A., & Pinaud, R. (2010) · Journal of Visualized Experiments · doi:10.3791/2102 · Cited by 7 · see citing works
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Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678 · see citing works
Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
Timper, K., & Brüning, J. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.026609 · Cited by 802 · see citing works
Functional diversity of astrocytes in neural circuit regulation
Haim, L. B., & Rowitch, D. H. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.159 · Cited by 618 · see citing works
Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability
García‐Cáceres, C., Quarta, C., Varela, L., Gao, Y., Gruber, T., Legutko, B., Jastroch, M., Johansson, P., Ninkovic, J., Yi, C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.07.028 · Cited by 516 · see citing works
Self-citationEnergy metabolism in health and diseases
Liu, H., Wang, S., Wang, J., Guo, X., Song, Y., Fu, K., Gao, Z., Liu, D., He, W., & Yang, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02141-x · Cited by 438 · see citing works
Leptin and the maintenance of elevated body weight
Pan, W. W., & Myers, M. G. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.168 · Cited by 344 · see citing works
Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism
García‐Cáceres, C., Balland, É., Prévot, V., Luquet, S. H., Woods, S. C., Koch, M., Horváth, T. L., Yi, C., Chowen, J. A., Verkhratsky, A., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0286-y · Cited by 326 · see citing works
Self-citationLeptin signalling pathways in hypothalamic neurons
Kwon, O., Kim, K. W., & Kim, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2133-1 · Cited by 283 · see citing works
Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus
Jaïs, A., & Brüning, J. C. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab025 · Cited by 282 · see citing works
The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism
Prévot, V., Dehouck, B., Sharif, A., Ciofi, P., Giacobini, P., & Clasadonte, J. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00235 · Cited by 271 · see citing works
Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation
Douglass, J. D., Dorfman, M. D., Fasnacht, R., Shaffer, L. D., & Thaler, J. P. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.01.010 · Cited by 248 · see citing works
Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors
Yang, L., Qi, Y., & Yang, Y. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.002 · Cited by 242 · see citing works
Tissue-Specific Effects of Leptin on Glucose and Lipid Metabolism
Pereira, S., Cline, D. L., Glavas, M. M., Covey, S. D., & Kieffer, T. J. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa027 · Cited by 247 · see citing works
Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control
Haddad-Tóvolli, R., Dragano, N. R. V., Ramalho, A. F. S., & Velloso, L. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00224 · Cited by 226 · see citing works
Integrative neurocircuits that control metabolism and food intake
Brüning, J. C., & Fenselau, H. (2023) · Science · doi:10.1126/science.abl7398 · Cited by 214 · see citing works
Hypothalamic Inflammation in the Control of Metabolic Function
Valdearcos, M., Xu, A. W., & Koliwad, S. K. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071656 · Cited by 201 · see citing works
Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice
Dorfman, M. D., Krull, J. E., Douglass, J. D., Fasnacht, R. D., Lara-Lince, F., Meek, T. H., Shi, X., Damian, V. M., Hồng, N. T., Matsen, M. E., et al. (2017) · Nature Communications · doi:10.1038/ncomms14556 · Cited by 169 · see citing works
The Leptin Receptor Complex: Heavier Than Expected?
Wauman, J., Zabeau, L., & Tavernier, J. H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00030 · Cited by 178 · see citing works
Timper, K., del Río-Martín, A., Cremer, A. L., Bremser, S., Alber, J., Giavalisco, P., Varela, L., Heilinger, C., Nolte, H., Trifunovic, A., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.05.001 · Cited by 170 · see citing works
The physiological control of eating: signals, neurons, and networks
Watts, A. G., Kanoski, S. E., Sanchez-Watts, G., & Langhans, W. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2020 · Cited by 168 · see citing works
POMC Neurons: From Birth to Death
Toda, C., Santoro, A. N., Kim, J. D., & Diano, S. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034110 · Cited by 165 · see citing works
Self-citationZhang, Y., Reichel, J. M., Han, C., Zuniga-Hertz, J. P., & Cai, D. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.002 · Cited by 164 · see citing works
Hypothalamic innate immune reaction in obesity
Kälin, S., Heppner, F. L., Bechmann, I., Prinz, M., Tschöp, M. H., & Yi, C.-X. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.48 · Cited by 167 · see citing works
Self-citationThe role of leptin in health and disease
Ramos-Lobo, A. M., & Donato, J. (2017) · Temperature · doi:10.1080/23328940.2017.1327003 · Cited by 166 · see citing works
GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors
Mederos, S., Sánchez‐Puelles, C., Esparza, J., Valero, M., Ponomarenko, A. A., & Perea, G. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00752-x · Cited by 163 · see citing works
Morphological plasticity of astroglia: Understanding synaptic microenvironment
Heller, J. P., & Rusakov, D. A. (2015) · Glia · doi:10.1002/glia.22821 · Cited by 150 · see citing works
Hypothalamic inflammation and gliosis in obesity
Dorfman, M. D., & Thaler, J. P. (2015) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000182 · Cited by 146 · see citing works
Astrocyte–Neuron Networks: A Multilane Highway of Signaling for Homeostatic Brain Function
Mederos, S., González-Arias, C., & Perea, G. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00045 · Cited by 146 · see citing works
An adipo-biliary-uridine axis that regulates energy homeostasis
Deng, Y., Wang, Z. V., Gordillo, R., An, Y., Zhang, C., Liang, Q., Yoshino, J., Cautivo, K. M., Brabander, J. K. D., Elmquist, J. K., et al. (2017) · Science · doi:10.1126/science.aaf5375 · Cited by 137 · see citing works
Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration
Ising, C., & Heneka, M. T. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0153-x · Cited by 136 · see citing works
The special relationship: glia–neuron interactions in the neuroendocrine hypothalamus
Clasadonte, J., & Prévot, V. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.124 · Cited by 131 · see citing works
Chao, D. H. M., Kirchner, M. K., Pham, C., Foppen, E., Denis, R., Castel, J., Morel, C., Montalban, E., Hassouna, R., Bui, L. C., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.002 · Cited by 130 · see citing works
Self-citationLeptin Dysfunction and Alzheimer’s Disease: Evidence from Cellular, Animal, and Human Studies
McGuire, M. J., & Ishii, M. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0282-7 · Cited by 125 · see citing works
Obesity-induced inflammation: connecting the periphery to the brain
Le Thuc, O., & García-Cáceres, C. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01079-8 · Cited by 125 · see citing works
From Synapses to Circuits, Astrocytes Regulate Behavior
Lyon, K. A., & Allen, N. J. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.786293 · Cited by 117 · see citing works
Resolving Astrocyte Heterogeneity in the CNS
Farmer, W. T., & Murai, K. K. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00300 · Cited by 118 · see citing works
Divergent medial amygdala projections regulate approach–avoidance conflict behavior
Miller, S. M., Marcotulli, D., Shen, A., & Zweifel, L. S. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0337-z · Cited by 112 · see citing works
GABAergic‐astrocyte signaling: A refinement of inhibitory brain networks
Mederos, S., & Perea, G. (2019) · Glia · doi:10.1002/glia.23644 · Cited by 111 · see citing works
Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding
Chen, N., 杉原, 弘., Kim, J., Fu, Z., Barak, B., Sur, M., Feng, G., & Han, W. (2016) · eLife · doi:10.7554/elife.18716 · Cited by 105 · see citing works
Self-citationGruber, T., Pan, C., Contreras, R. E., Wiedemann, T., Morgan, D. A., Skowronski, A. A., Lefort, S., Murat, C. D. B., Thuc, O. L., Legutko, B., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.04.007 · Cited by 110 · see citing works
Self-citationAstroglia-specific contributions to the regulation of synapses, cognition and behaviour
Augusto‐Oliveira, M., Arrifano, G. D. P., Takeda, P. Y., Lopes-Araújo, A., Santos-Sacramento, L., Anthony, D. C., Verkhratsky, A., & Lopez, M. E. C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.039 · Cited by 107 · see citing works
FGF1 — a new weapon to control type 2 diabetes mellitus
Gasser, E., Moutos, C. P., Downes, M., & Evans, R. M. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.78 · Cited by 106 · see citing works
The hypothalamus for whole-body physiology: from metabolism to aging
Liu, T., Xu, Y., Yi, C., Tong, Q., & Cai, D. (2021) · Protein & Cell · doi:10.1007/s13238-021-00834-x · Cited by 103 · see citing works
Self-citationNew insights in leptin resistance mechanisms in mice
Balland, É., & Cowley, M. A. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.09.004 · Cited by 101 · see citing works
A conceptual framework for astrocyte function
Murphy‐Royal, C., Ching, S., & Papouin, T. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01448-8 · Cited by 107 · see citing works
Glia: silent partners in energy homeostasis and obesity pathogenesis
Douglass, J. D., Dorfman, M. D., & Thaler, J. P. (2016) · Diabetologia · doi:10.1007/s00125-016-4181-3 · Cited by 94 · see citing works
Endoplasmic Reticulum Stress, the Hypothalamus, and Energy Balance
Çakır, I., & Nillni, E. A. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.01.002 · Cited by 93 · see citing works
Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes
Fuente-Martín, E., García-Cáceres, C., Argente-Arizón, P., Díaz, F., Granado, M., Freire-Regatillo, A., Castro-González, D., Ceballos, M. L., Frago, L. M., Dickson, S. L., et al. (2016) · Scientific Reports · doi:10.1038/srep23673 · Cited by 91 · see citing works
Self-citationQuarta, C., Clemmensen, C., Zhu, Z., Yang, B. S., Joseph, S. S., Lutter, D., Yi, C., Graf, E., García‐Cáceres, C., Legutko, B., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.023 · Cited by 88 · see citing works
Self-citationThe involvement of astrocytes in early‐life adversity induced programming of the brain
Abbink, M. R., van Deijk, A. F., Heine, V. M., Verheijen, M. H. G., & Kőrösi, A. (2019) · Glia · doi:10.1002/glia.23625 · Cited by 92 · see citing works
Glial Contributions to Neural Function and Disease
Rasband, M. N. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r115.053744 · Cited by 88 · see citing works
Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis
Jin, S., Kim, J. G., Park, J. W., Koch, M., Horváth, T. L., & Lee, B. J. (2016) · Scientific Reports · doi:10.1038/srep29424 · Cited by 86 · see citing works
Self-citationTRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons
Allison, M. B., Patterson, C. M., Krashes, M. J., Lowell, B. B., Myers, M. G., & Olson, D. P. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.01.012 · Cited by 85 · see citing works
The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system
Bouyakdan, K., Martin, H., Liénard, F., Budry, L., Taïb, B., Rodaros, D., Chrétien, C., Biron, É., Husson, Z., Cota, D., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123454 · Cited by 82 · see citing works
Neurogenetic basis for circadian regulation of metabolism by the hypothalamusPreprint
Cedernaes, J., Waldeck, N. J., & Bass, J. T. (2019) · Genes & Development · doi:10.1101/gad.328633.119 · Cited by 84 · see citing works
Zhang, K., Förster, R., He, W., Liao, X., Li, J., Yang, C., Qin, H., Wang, M., Ding, R., Li, R., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00949-8 · Cited by 325 · see citing works
Relationship Between Obesity, Alzheimer’s Disease, and Parkinson’s Disease: an Astrocentric View
Martín-Jiménez, C., Gaitán-Vaca, D. M., Echeverrı́a, V., González, J., & Barreto, G. E. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0193-8 · Cited by 77 · see citing works
Regulation of food intake by astrocytes in the brainstem dorsal vagal complex
MacDonald, A. J., Holmes, F. E., Beall, C., Pickering, A. E., & Ellacott, K. L. J. (2019) · Glia · doi:10.1002/glia.23774 · Cited by 77 · see citing works
Nucleus accumbens cytoarchitecture predicts weight gain in children
Rapuano, K. M., Laurent, J. S., Hagler, D. J., Hatton, S. N., Thompson, W. K., Jernigan, T. L., Dale, A. M., Casey, B. J., & Watts, R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007918117 · Cited by 79 · see citing works
Hunger-promoting AgRP neurons trigger an astrocyte-mediated feed-forward autoactivation loop in mice
Varela, L., Stutz, B., Song, J. E., Kim, J. G., Liu, Z.-W., Gao, X., & Horváth, T. L. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144239 · Cited by 75 · see citing works
Self-citationInteraction of astrocytes and T cells in physiological and pathological conditions
Xie, L., & Yang, S. (2015) · Brain Research · doi:10.1016/j.brainres.2015.03.026 · Cited by 77 · see citing works
Cannabinoid Receptor Signaling in Central Regulation of Feeding Behavior: A Mini-Review
Koch, M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00293 · Cited by 77 · see citing works
Self-citationGlial cells as integrators of peripheral and central signals in the regulation of energy homeostasis
Nampoothiri, S. S., Nogueiras, R., Schwaninger, M., & Prévot, V. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00610-z · Cited by 75 · see citing works
Cui, Q. N., Stein, L. M., Fortin, S. M., & Hayes, M. R. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15683 · Cited by 71 · see citing works
Hypothalamic ER stress: A bridge between leptin resistance and obesity
Ramírez, S., & Claret, M. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.04.025 · Cited by 72 · see citing works
Endozepines and their receptors: Structure, functions and pathophysiological significance
Tonon, M., Vaudry, H., Chuquet, J., Guillebaud, F., Fan, J., Masmoudi‐Kouki, O., Vaudry, D., Lanfray, D., Morin, F., Prévot, V., et al. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.06.008 · Cited by 70 · see citing works
New Pharmacological Perspectives for the Leptin Receptor in the Treatment of Obesity
Roujeau, C., Jockers, R., & Dam, J. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00167 · Cited by 70 · see citing works
Estradiol effects on hypothalamic AMPK and BAT thermogenesis: A gateway for obesity treatment?
López, M., & Tena-Sempere, M. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.03.014 · Cited by 70 · see citing works
Role of Non-Neuronal Cells in Body Weight and Appetite Control
Argente-Arizón, P., Freire‐Regatillo, A., Argente, J., & Chowen, J. A. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00042 · Cited by 68 · see citing works
Self-citationRegionally encoded functional heterogeneity of astrocytes in health and disease: A perspective
Clarke, B. E., Taha, D. M., Tyzack, G. E., & Patani, R. (2020) · Glia · doi:10.1002/glia.23877 · Cited by 67 · see citing works
Wang, X., & Li, L. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.722028 · Cited by 67 · see citing works
Glial cells and energy balance
Argente-Arizón, P., Guerra-Cantera, S., García‐Segura, L. M., Argente, J., & Chowen, J. A. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0182 · Cited by 69 · see citing works
Self-citationNeuroendocrine integration of nutritional signals on reproduction.
Evans, M. C., & Anderson, G. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0212 · Cited by 54 · see citing works
Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis
Ameroso, D., Meng, A., Chen, S., Felsted, J., Dulla, C. G., & Rios, M. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00566-0 · Cited by 67 · see citing works
Calì, C., Cantando, I., Veloz Castillo, M. F., Gonzalez, L., & Bezzi, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168922 · Cited by 66 · see citing works
Large-scale recording of astrocyte activity
Nimmerjahn, A., & Bergles, D. E. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.01.015 · Cited by 67 · see citing works
Organizing principles of astrocytic nanoarchitecture in the mouse cerebral cortex
Salmon, C. K., Syed, T. A., Kacerovsky, J. B., Alivodej, N., Schober, A. L., Sloan, T. F. W., Pratte, M. T., Rosen, M. P., Green, M., Chirgwin-Dasgupta, A., et al. (2023) · Current Biology · doi:10.1016/j.cub.2023.01.043 · Cited by 67 · see citing works
The role of astrocytes in the hypothalamic response and adaptation to metabolic signals
Chowen, J. A., Argente-Arizón, P., Freire‐Regatillo, A., Frago, L. M., Horváth, T. L., & Argente, J. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.03.001 · Cited by 63 · see citing works
Self-citationGao, Y., Vidal-Itriago, A., Milanova, I. V., Korpel, N. L., Kalsbeek, M. J. T., Tom, R. Z., Kalsbeek, A., Hofmann, S. M., & Yi, C. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.11.003 · Cited by 64 · see citing works
Self-citationA GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism
Ou, Z., Ma, Y., Sun, Y., Zheng, G., Wang, S., Xing, R., Chen, X. '., Han, Y., Wang, J., Lu, Q. R., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.060 · Cited by 64 · see citing works
Hagemann, T. L., Powers, B. E., Lin, N., Mohamed, A. F., Dague, K. L., Hannah, S. C., Bachmann, G., Mazur, C., Rigo, F., Olsen, A. L., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abg4711 · Cited by 62 · see citing works
Hebebrand, J., Hildebrandt, T., Schlögl, H., Seitz, J., Denecke, S., Vieira, D. B., Gradl-Dietsch, G., Peters, T., Antel, J., Lau, D., et al. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104807 · Cited by 61 · see citing works
Glucose and hypothalamic astrocytes: More than a fueling role?
Leloup, C., Allard, C., Carneiro, L., Fioramonti, X., Collins, S. C., & Pénicaud, L. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.06.007 · Cited by 62 · see citing works
Deletion of astrocytic BMAL1 results in metabolic imbalance and shorter lifespan in mice
Barca‐Mayo, O., Boender, A. J., Armirotti, A., & Tonelli, D. D. P. (2019) · Glia · doi:10.1002/glia.23764 · Cited by 63 · see citing works
Rahman, M. H., Bhusal, A., Lee, W., Lee, I., & Suk, K. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.024 · Cited by 57 · see citing works
Hypothalamic obesity: from basic mechanisms to clinical perspectives
Argente, J., Farooqi, I. S., Chowen, J. A., Kühnen, P., López, M., Morselli, E., Gan, H.-W., Spoudeas, H. A., Wabitsch, M., & Tena-Sempere, M. (2025) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(24)00283-3 · Cited by 57 · see citing works
Self-citationShi, Z., Pelletier, N. E., Wong, J., Li, B., Sdrulla, A. D., Madden, C. J., Marks, D. L., & Brooks, V. L. (2020) · eLife · doi:10.7554/elife.55357 · Cited by 60 · see citing works
Profiling changes in cortical astroglial cells following chronic stress
Simard, S., Coppola, G., Rudyk, C., Hayley, S. P., McQuaid, R. J., & Salmaso, N. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0105-x · Cited by 58 · see citing works
Self-citationBáez-Jurado, E., Rincon‐Benavides, M. A., Hidalgo‐Lanussa, O., Guio-Vega, G. P., Ashraf, G. M., Sahebkar, A., Echeverrı́a, V., García‐Segura, L. M., & Barreto, G. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.09.001 · Cited by 62 · see citing works
Iridoids and other monoterpenes in the Alzheimer’s brain: Recent development and future prospects
Habtemariam, S. (2018) · Molecules · doi:10.3390/molecules23010117 · Cited by 55 · see citing works
Sex differences in the neuroendocrine control of metabolism and the implication of astrocytes
Chowen, J. A., Argente-Arizón, P., Freire‐Regatillo, A., & Argente, J. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.05.003 · Cited by 54 · see citing works
Self-citationCrosby, K. M., Murphy‐Royal, C., Wilson, S. A., Gordon, G. R., Bains, J. S., & Pittman, Q. J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0569-18.2018 · Cited by 54 · see citing works
The Effects of Leptin on Glial Cells in Neurological Diseases
Fujita, Y., & Yamashita, T. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00828 · Cited by 54 · see citing works
Metabolic pressure and the breach of immunological self-tolerance
Rosa, V. D., Cava, A. L., & Matarese, G. (2017) · Nature Immunology · doi:10.1038/ni.3851 · Cited by 53 · see citing works
Hypothalamic microglia as potential regulators of metabolic physiology.
Valdearcos, M., Myers, M. G., & Koliwad, S. K. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0040-0 · Cited by 52 · see citing works
Kim, D. W., Glendining, K. A., Grattan, D. R., & Jasoni, C. L. (2016) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2016.06.005 · Cited by 50 · see citing works
Butiaeva, L. I., Slutzki, T., Swick, H. E., Bourguignon, C., Robins, S. C., Liu, X., Storch, K.-F., & Kokoeva, M. V. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.05.017 · Cited by 50 · see citing works
Adlanmérini, M., Nguyen, H. C. B., Krusen, B. M., Teng, C. W., Geisler, C. E., Peed, L. C., Carpenter, B. J., Hayes, M. R., & Lazar, M. A. (2020) · Journal of Clinical Investigation · doi:10.1172/jci140424 · Cited by 51 · see citing works
Activation of hypothalamic astrocytes suppresses feeding without altering emotional states
Sweeney, P. R., Qi, Y., Xu, Z., & Yang, Y. (2016) · Glia · doi:10.1002/glia.23073 · Cited by 49 · see citing works
Physiological and Epigenetic Features of Yoyo Dieting and Weight Control
Contreras, R. E., Schriever, S. C., & Pfluger, P. T. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01015 · Cited by 52 · see citing works
- Authors
- Kim, J. G., Suyama, S., Koch, M., Jin, S., Argente-Arizon, P., Argente, J., Liu, Z.-W., Zimmer, M. R., Jeong, J. K., Szigeti-Buck, K., Gao, Y., Garcia-Caceres, C., Yi, C.-X., Salmaso, N., Vaccarino, F. M., Chowen, J., Diano, S., Dietrich, M. O., Tschöp, M. H., & Horvath, T. L.
- Affiliations
- Yale University (US)
- Instituto de Salud Carlos III (ES)
- Helmholtz Munich (DE)
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2014-06-01
- Volume
- 17
- Issue
- 7
- Pages
- 908-910
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4113214
- OpenAlex
- W2018870528
- Cited by
- 336
- References
- 29
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 32 · 2023: 18 · 2022: 28 · 2021: 29 · 2020: 29 · 2019: 27 · 2018: 36 · 2017: 48 · 2016: 25 · 2015: 33 · 2014: 5
- FWCI
- 18.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Funders
- National Institutes of Health (DP1OD006850)
- National Institute on Aging (R01AG040236)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP1DK098058, R01DK097566)
- National Institute of Neurological Disorders and Stroke (P01NS062686)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- leptin signaling, astrocytes, leptin receptor, hypothalamus, arcuate nucleus, POMC neurons, AgRP neurons, synaptic remodeling, food intake regulation, ghrelin, glial morphology, conditional gene deletion, fasting
- MeSH terms
- Animals, Astrocytes, Cell Count, Eating, Glial Fibrillary Acidic Protein, Hypothalamus, Immunohistochemistry, Male, Microscopy, Electron, Nerve Net, Neurons, Pro-Opiomelanocortin, Pulmonary Gas Exchange, RNA, Messenger, Signal Transduction, In Situ Hybridization, Mice, Knockout, Excitatory Postsynaptic Potentials, Leptin, Mice, Melanocortins, Real-Time Polymerase Chain Reaction, Primary Cell Culture
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