Tschöp, Matthias H.

Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism

Andrews, Z. B., Erion, D., Beiler, R., Liu, Z.-W., Abizaid, A., Zigman, J., Elsworth, J. D., Savitt, J. M., DiMarchi, R., Tschöp, M., et al. (2009) · The Journal of Neuroscience

Parkinson's Disease Mechanisms and TreatmentsRegulation of Appetite and Obesity

Cited by 289

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

Habegger, K. M., Stemmer, K., Cheng, C., Müller, T. D., Heppner, K. M., Ottaway, N., Holland, J., Hembree, J. L., Smiley, D., Gelfanov, V., et al. (2013) · Diabetes

Fibroblast Growth Factor ResearchPancreatic function and diabetes

Cited by 245

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

Mroz, P. A., Finan, B., Gelfanov, V., Yang, B., Tschöp, M. H., DiMarchi, R. D., & Perez-Tilve, D. (2019) · Molecular Metabolism

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 229

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

Finan, B., Clemmensen, C., Zhu, Z., Stemmer, K., Gauthier, K., Müller, L., De Angelis, M., Moreth, K., Neff, F., Perez-Tilve, D., et al. (2016) · Cell

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 191

Ghrelin regulation of glucose metabolism

Poher, A.-L., Tschöp, M. H., & Müller, T. D. (2018) · Peptides

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 186

Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity

Nogueiras, R., Pérez-Tilve, D., Veyrat-Durebex, C., Morgan, D. A., Varela, L., Haynes, W. G., Patterson, J. T., Disse, E., Pfluger, P. T., López, M., et al. (2009) · The Journal of Neuroscience

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 182

Reappraisal of GIP Pharmacology for Metabolic Diseases

Finan, B., Müller, T. D., Clemmensen, C., Perez-Tilve, D., DiMarchi, R. D., & Tschöp, M. H. (2016) · Trends in Molecular Medicine

Diabetes Treatment and ManagementRegulation of Appetite and Obesity

Cited by 180

GLP-1/glucagon receptor co-agonism for treatment of obesity

Sánchez-Garrido, M. A., Brandt, S. J., Clemmensen, C., Müller, T. D., DiMarchi, R. D., & Tschöp, M. H. (2017) · Diabetologia

Pharmacology and Obesity TreatmentDiabetes Treatment and Management

Cited by 175

Hypothalamic innate immune reaction in obesity

Kälin, S., Heppner, F. L., Bechmann, I., Prinz, M., Tschöp, M. H., & Yi, C.-X. (2015) · Nature Reviews Endocrinology

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 167

Restoration of leptin responsiveness in diet‐induced obese mice using an optimized leptin analog in combination with exendin‐4 or FGF21

Müller, T. D., Sullivan, L. M., Habegger, K., Yi, C., Kabra, D., Grant, E., Ottaway, N., Krishna, R., Holland, J., Hembree, J., et al. (2012) · Journal of Peptide Science

Regulation of Appetite and ObesityPharmacology and Obesity Treatment

Cited by 156

Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes

Capozzi, M. E., DiMarchi, R. D., Tschöp, M. H., Finan, B., & Campbell, J. E. (2018) · Endocrine Reviews

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 153

GIPR/GLP-1R dual agonist therapies for diabetes and weight loss—chemistry, physiology, and clinical applications

Campbell, J. E., Müller, T. D., Finan, B., DiMarchi, R. D., Tschöp, M. H., & D’Alessio, D. A. (2023) · Cell Metabolism

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 149

Targeted pharmacological therapy restores β-cell function for diabetes remission

Sachs, S., Bastidas-Ponce, A., Tritschler, S., Bakhti, M., Böttcher, A., Sánchez-Garrido, M. A., Tarquis-Medina, M., Kleinert, M., Fischer, K., Jall, S., et al. (2020) · Nature Metabolism

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 147

Synaptic plasticity in neuronal circuits regulating energy balance

Zeltser, L. M., Seeley, R. J., & Tschöp, M. H. (2012) · Nature Neuroscience

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 147

Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function

Balsevich, G., Häusl, A. S., Meyer, C. W., Karamihalev, S., Feng, X., Pöhlmann, M. L., Dournes, C., Uribe-Marino, A., Santarelli, S., Labermaier, C., et al. (2017) · Nature Communications

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 134

Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents

Day, J. W., Gelfanov, V., Smiley, D., Carrington, P. E., Eiermann, G., Chicchi, G., Erion, M. D., Gidda, J., Thornberry, N. A., Tschöp, M. H., et al. (2012) · Peptide Science

Diabetes Treatment and ManagementRegulation of Appetite and Obesity

Cited by 133

Dietary sugars, not lipids, drive hypothalamic inflammation

Gao, Y., Bielohuby, M., Fleming, T., Grabner, G. F., Foppen, E., Bernhard, W., Guzmán-Ruiz, M., Layritz, C., Legutko, B., Zinser, E., et al. (2017) · Molecular Metabolism

Neuroinflammation and Neurodegeneration MechanismsRegulation of Appetite and Obesity

Cited by 131

Transforming obesity: The advancement of multi-receptor drugs

Kusminski, C. M., Perez-Tilve, D., Müller, T. D., DiMarchi, R. D., Tschöp, M. H., & Scherer, P. E. (2024) · Cell

Pharmacology and Obesity TreatmentDiabetes Treatment and Management

Cited by 126

Current Understanding of the Hypothalamic Ghrelin Pathways Inducing Appetite and Adiposity

Al Massadi, O., López, M., Tschöp, M., Diéguez, C., & Nogueiras, R. (2017) · Trends in Neurosciences

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 124

GLP-1 receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits

Nauck, M. A., Tuttle, K. R., Tschöp, M. H., & Blüher, M. (2026) · The Lancet

Diabetes Treatment and ManagementPharmacology and Obesity Treatment

Cited by 123

Long-Term Cold Adaptation Does Not Require FGF21 or UCP1

Keipert, S., Kutschke, M., Ost, M., Schwarzmayr, T., van Schothorst, E. M., Lamp, D., Brachthäuser, L., Hamp, I., Mazibuko, S. E., Hartwig, S., et al. (2017) · Cell Metabolism

Adipose Tissue and MetabolismFibroblast Growth Factor Research

Cited by 122

Testosterone Replacement Therapy Restores Normal Ghrelin in Hypogonadal Men

Pagotto, U., Gambineri, A., Pelusi, C., Genghini, S., Cacciari, M., Otto, B., Castañeda, T., Tschöp, M., & Pasquali, R. (2003) · The Journal of Clinical Endocrinology & Metabolism

Hormonal and reproductive studiesRegulation of Appetite and Obesity

Cited by 120

Central Nervous System Regulation of Energy Metabolism: Ghrelin versus Leptin

Nogueiras, R., Tschöp, M. H., & Zigman, J. M. (2008) · Annals of the New York Academy of Sciences

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 115

Ghrelin, obesity and diabetes

Wiedmer, P., Nogueiras, R., Broglio, F., D'Alessio, D., & Tschöp, M. H. (2007) · Nature Clinical Practice Endocrinology & Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 111