Cited by 330Cannabis and Cannabinoid ResearchRegulation of Appetite and ObesityNeurotransmitter Receptor Influence on Behavior

Cannabinoids, opioids and eating behavior: The molecular face of hedonism?

Cota, Daniela, Tschöp, Matthias H., Horvath, Tamas L., Levine, Allen S.·2006·Brain Research Reviews

Abstract

Obesity represents nowadays one of the most devastating health threats. Published reports even project a decline in life expectancy of US citizens due to the rapidly increasing prevalence of obesity. This alarming increase is intimately linked with recent changes of environment and lifestyle in western countries. In this context, the rewarding or even addictive properties of popular food may represent one of the most serious obstacles to overcome for an effective anti-obesity therapy. Therefore, in addition to molecular networks controlling energy homeostasis, now researchers are starting to define central nervous mechanisms governing hedonic and addictive components of food intake. A recently emerging body of data suggests that the endogenous cannabinoid and opioid systems both represent key circuits responding to the rewarding value of food. This review focuses on the role of these two systems for the homeostatic and hedonic aspects of eating behavior and includes their anatomical and functional interactions. Independent from the degree to which eating can be considered an addiction, cannabinoid and opioid receptor antagonists are promising anti-obesity drugs, since they are targeting both hedonic and homeostatic components of energy balance control.

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Crossref · 10.1016/j.brainresrev.2005.10.004

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  • Several neurotransmitters, hormones, and neuropeptides involved in homeostatic regulation of food intake have been implicated in the rewarding effects of food and drugs.

    “Several neurotransmitters, including DA, cannabinoids, opioids, gamma-aminobutyric acid (GABA) and serotonin, as well as hormones and neuropeptides involved in homeostatic regulation of food intake, such as insulin, orexin, leptin, ghrelin, PYY, glucagon-like peptide-1 (GLP-1) have been implicated in the rewarding effects of food and drugs (Tables 1 and 2) (18–21).”

    From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [19]

  • Several neurotransmitters, including DA, cannabinoids, opioids and serotonin, as well as hormones and neuropeptides involved in homeostatic regulation of food intake such as insulin, orexin, leptin and ghrelin, have been implicated in the rewarding effects of food.

    “Several neurotransmitters, including DA, cannabinoids, opioids and serotonin, as well as hormones and neuropetides involved in homeostatic regulation of food intake, such as insulin, orexin, leptin and ghrelin, have been implicated in the rewarding effects of food (Atkinson 2008;Cason et al 2010;Cota et al 2006).”

    From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Cota et al 2006

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Authors
Cota, D., Tschöp, M. H., Horvath, T. L., & Levine, A. S.
Affiliations
  • University of Cincinnati (US)
  • Veterans Health Administration (US)
Corresponding author
Cota, Daniela
Venue
Brain Research Reviews
Publisher
Elsevier BV
Published
2006-06
Volume
51
Issue
1
Pages
85-107
ISSN
0165-0173 (ISSN-L)
OpenAlex
W1981407855
Cited by
330
References
200
Citations by year
2026: 3 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 13 · 2019: 46 · 2018: 11 · 2017: 20 · 2016: 12 · 2015: 16 · 2014: 17 · 2013: 12 · 2012: 20
FWCI
2.59
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
cannabinoids, opioid system, dietary habits, food reward, food addiction, obesity, energy homeostasis, endocannabinoid system, opioid receptors, anti-obesity drugs, cannabinoid receptor antagonists, opioid antagonists, hedonic eating
MeSH terms
Animals, Cannabinoids, Energy Metabolism, Feeding Behavior, Humans, Narcotic Antagonists, Narcotics, Obesity, Receptors, Opioid, Receptor Cross-Talk, Receptors, Cannabinoid, Cannabinoid Receptor Modulators, Cannabinoid Receptor Antagonists

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