Weisgraber, Karl H.

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,363

Plasma lipoproteins: apolipoprotein structure and function.

Mahley, R. W., Innerarity, T. L., Rall, S. C., & Weisgraber, K. H. (1984) · Journal of Lipid Research

Lipid metabolism and disordersCholesterol and Lipid Metabolism

Cited by 1,155

Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease

Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2006) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 912

Apolipoprotein E: Structure-Function Relationships

Weisgraber, K. H. (1994) · Advances in Protein Chemistry

Lipid metabolism and disordersCholesterol and Lipid Metabolism

Cited by 830

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

Nathan, B. P., Bellosta, S., Sanan, D. A., Weisgraber, K. H., Mahley, R. W., & Pitas, R. E. (1994) · Science

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 795

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.

Weisgraber, K. H., Rall, S. C., & Mahley, R. W. (1981) · Journal of Biological Chemistry

Lipoproteins and Cardiovascular HealthLipid metabolism and disorders

Cited by 777

Human apolipoprotein E. The complete amino acid sequence

Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1982) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsLipoproteins and Cardiovascular Health

Cited by 741

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

Pitas, R. E., Boyles, J. K., Lee, S. H., Hui, D., & Weisgraber, K. H. (1987) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismBarrier Structure and Function Studies

Cited by 714

Three-Dimensional Structure of the LDL Receptor-Binding Domain of Human Apolipoprotein E

Wilson, C., Wardell, M. R., Weisgraber, K. H., Mahley, R. W., & Agard, D. A. (1991) · Science

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 678

Abnormal lipoprotein receptor‐binding activity of the human E apoprotein due to cysteine‐arginine interchange at a single site

Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1982) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 673

Apolipoprotein E structure: insights into function

Hatters, D. M., Peters-Libeu, C. A., & Weisgraber, K. H. (2006) · Trends in Biochemical Sciences

Alzheimer's disease research and treatmentsLipoproteins and Cardiovascular Health

Cited by 583

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2009) · Journal of Lipid Research

Lipoproteins and Cardiovascular HealthAlzheimer's disease research and treatments

Cited by 580

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Goedert, M., Weisgraber, K. H., Dong, L. M., Jakes, R., Huang, D. Y., Pericak-Vance, M., Schmechel, D., & Roses, A. D. (1994) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 474

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

Kowal, R. C., Herz, J., Weisgraber, K. H., Mahley, R. W., Brown, M. S., & Goldstein, J. L. (1990) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 445

Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes

Zannis, V. I., Breslow, J. L., Utermann, G., Mahley, R. W., Weisgraber, K. H., Havel, R. J., Goldstein, J. L., Brown, M. S., Schonfeld, G., Hazzard, W. R., et al. (1982) · Journal of Lipid Research

Lipoproteins and Cardiovascular HealthAlzheimer's disease research and treatments

Cited by 436

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

Sanan, D. A., Weisgraber, K. H., Russell, S. J., Mahley, R. W., Huang, D., Saunders, A., Schmechel, D., Wisniewski, T., Frangione, B., & Roses, A. D. (1994) · Journal of Clinical Investigation

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 404

Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects.

Rall, S. C., Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1982) · Proceedings of the National Academy of Sciences

Lipoproteins and Cardiovascular HealthAlzheimer's disease research and treatments

Cited by 345

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

Harris, F. M., Brecht, W. J., Xu, Q., Tesseur, I., Kekonius, L., Wyss-Coray, T., Fish, J. D., Masliah, E., Hopkins, P. C., Scearce-Levie, K., et al. (2003) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 342

Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

Evans, K. C., Berger, E. P., Cho, C. G., Weisgraber, K. H., & Lansbury, P. T. (1995) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 333

Human apolipoprotein E: Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms

Dong, L. M., Wilson, C., Wardell, M. R., Simmons, T., Mahley, R. W., Weisgraber, K. H., & Agard, D. A. (1994) · Journal of Biological Chemistry

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 320

Human Apolipoprotein E4 Domain Interaction

Dong, L.-M., & Weisgraber, K. H. (1996) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 318

Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain

Morrow, J. A., Segall, M. L., Lund-Katz, S., Phillips, M. C., Knapp, M., Rupp, B., & Weisgraber, K. H. (2000) · Biochemistry

Protein Structure and DynamicsAlzheimer's disease research and treatments

Cited by 315

Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112

Weisgraber, K. H. (1990) · Journal of Lipid Research

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 304

Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains.

Wetterau, J. R., Aggerbeck, L. P., Rall, S. C., & Weisgraber, K. H. (1988) · Journal of Biological Chemistry

Protein Structure and DynamicsProtein purification and stability

Cited by 293