Weisgraber, Karl H.

Identification of the disulfide-linked homodimer of apolipoprotein E3 in plasma. Impact on receptor binding activity

Weisgraber, K. H., & Shinto, L. H. (1991) · Journal of Biological Chemistry

Lipoproteins and Cardiovascular HealthAlzheimer's disease research and treatments

Cited by 104

Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3: structure and genetics of an apolipoprotein E3 variant

Rall, S. C., Newhouse, Y. M., Clarke, H. R., Weisgraber, K. H., McCarthy, B. J., Mahley, R. W., & Bersot, T. P. (1989) · Journal of Clinical Investigation

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 103

Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein.

Wilson, C., Mau, T., Weisgraber, K. H., Wardell, M. R., Mahley, R. W., & Agard, D. A. (1994) · Structure

Protein Structure and DynamicsLipoproteins and Cardiovascular Health

Cited by 100

Interaction of the N-Terminal Domain of Apolipoprotein E4 with Heparin

Dong, J., Peters-Libeu, C. A., Weisgraber, K. H., Segelke, B. W., Rupp, B., Capila, I., Hernáiz, M. J., LeBrun, L. A., & Linhardt, R. J. (2001) · Biochemistry

Alzheimer's disease research and treatmentsProteoglycans and glycosaminoglycans research

Cited by 99

The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia

Horie, Y., Fazio, S., Westerlund, J. R., Weisgraber, K. H., & Rall, S. C. (1992) · Journal of Biological Chemistry

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 94

Characterization of the Heparin Binding Sites in Human Apolipoprotein E

Saito, H., Dhanasekaran, P., Nguyen, D., Baldwin, F., Weisgraber, K. H., Wehrli, S., Phillips, M. C., & Lund-Katz, S. (2003) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 90

Effects of Polymorphism on the Lipid Interaction of Human Apolipoprotein E

Saito, H., Dhanasekaran, P., Baldwin, F., Weisgraber, K. H., Phillips, M. C., & Lund-Katz, S. (2003) · Journal of Biological Chemistry

Lipid Membrane Structure and BehaviorLipoproteins and Cardiovascular Health

Cited by 89

Human apolipoprotein E expression in Escherichia coli: structural and functional identity of the bacterially produced protein with plasma apolipoprotein E

Vogel, T., Weisgraber, K. H., Zeevi, M. I., Ben-Artzi, H., Levanon, A. Z., Rall, S. C., Innerarity, T. L., Hui, D. Y., Taylor, J. M., & Kanner, D. (1985) · Proceedings of the National Academy of Sciences

Protein purification and stabilityLipoproteins and Cardiovascular Health

Cited by 88

Apolipoprotein E: genetic variants provide insights into its structure and function

Mahley, R. W., Innerarity, T. L., Rail, S. C., Weisgraber, K. H., & Taylor, J. M. (1990) · Current Opinion in Lipidology

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 88

Modulation of Apolipoprotein E Structure by Domain Interaction

Hatters, D. M., Budamagunta, M. S., Voss, J. C., & Weisgraber, K. H. (2005) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsProtein Structure and Dynamics

Cited by 88

Effect of Domain Interaction on Apolipoprotein E Levels in Mouse Brain

Ramaswamy, G., Xu, Q., Huang, Y., & Weisgraber, K. H. (2005) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsLipoproteins and Cardiovascular Health

Cited by 87

Comparison of the stabilities and unfolding pathways of human apolipoprotein E isoforms by differential scanning calorimetry and circular dichroism.

Acharya, P., Segall, M. L., Zaiou, M., Morrow, J., Weisgraber, K. H., Phillips, M. C., Lund-Katz, S., & Snow, J. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Protein Structure and DynamicsAlzheimer's disease research and treatments

Cited by 82

Differential Binding of Apolipoprotein E Isoforms to Tau and Other Cytoskeletal Proteins

Fleming, L. M., Weisgraber, K. H., Strittmatter, W. J., Troncoso, J. C., & Johnson, G. V. W. (1996) · Experimental Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 82

Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121–127

Wardell, M. R., Weisgraber, K. H., Havekes, L. M., & Rall, S. C. (1989) · Journal of Biological Chemistry

Lipoproteins and Cardiovascular HealthLipid metabolism and disorders

Cited by 80

A Monomeric, Biologically Active, Full-Length Human Apolipoprotein E

Zhang, Y., Vasudevan, S., Sojitrawala, R., Zhao, W., Cui, C., Xu, C., Fan, D., Newhouse, Y., Balestra, R., Jerome, W. G., et al. (2007) · Biochemistry

Protein Structure and DynamicsCholesterol and Lipid Metabolism

Cited by 79

Lipoproteins of Special Significance in Atherosclerosis: Insights Provided by Studies of Type III Hyperlipoproteinemia

MAHLEY, R. W., INNERARITY, T. L., RALL, S. C., & WEISGRABER, K. H. (1985) · Annals of the New York Academy of Sciences

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 75

Detrimental Effects of Apolipoprotein E4: Potential Therapeutic Targets in Alzheimers Disease

Mahley, R., Huang, Y., & Weisgraber, K. (2007) · Current Alzheimer Research

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 51

Effects of a Frequent Apolipoprotein E Isoform, ApoE4 Freiburg (Leu28→Pro), on Lipoproteins and the Prevalence of Coronary Artery Disease in Whites

Orth, M., Weng, W., Funke, H., Steinmetz, A., Assmann, G., Nauck, M., Dierkes, J., Ambrosch, A., Weisgraber, K. H., Mahley, R. W., et al. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology

Lipoproteins and Cardiovascular HealthLipid metabolism and disorders

Cited by 42

Characterization of apolipoprotein E-containing lipoproteins

Weisgraber, K. H., & Mahley, R. W. (1986) · Methods in Enzymology

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 41

Effects of polymorphism on the microenvironment of the LDL receptor-binding region of human apoE

Lund-Katz, S., Wehrli, S., Zaiou, M., Newhouse, Y., Weisgraber, K. H., & Phillips, M. C. (2001) · Journal of Lipid Research

Alzheimer's disease research and treatmentsLipoproteins and Cardiovascular Health

Cited by 40

Genetic polymorphism of apolipoprotein E: a variant form of apolipoprotein E2 distinguished by sodium dodecyl sulfate--polyacrylamide gel electrophoresis.

Utermann, G., Weisgraber, K. H., Weber, W., & Mahley, R. W. (1984) · Journal of Lipid Research

Alzheimer's disease research and treatmentsLipoproteins and Cardiovascular Health

Cited by 39

Insight on the Molecular Envelope of Lipid-Bound Apolipoprotein E from Electron Paramagnetic Resonance Spectroscopy

Hatters, D. M., Voss, J. C., Budamagunta, M. S., Newhouse, Y. N., & Weisgraber, K. H. (2009) · Journal of Molecular Biology

Electron Spin Resonance StudiesProtein Structure and Dynamics

Cited by 28

Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3' (Arg136–>His): association with mild dyslipidemia and double pre-beta very low density lipoproteins

Minnich, A., Weisgraber, K. H., Newhouse, Y., Dong, L. M., Fortin, L. J., Tremblay, M., & Davignon, J. (1995) · Journal of Lipid Research

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 26

Cellular and Molecular Biology of Lipoprotein Metabolism: Characterization of Lipoprotein Receptor-Ligand Interactions

Mahley, R. W., Innerarity, T. L., Weisgraber, K. H., Rall, S. C., Hui, D. Y., Lalazar, A., Boyles, J. K., Taylor, J. M., & Levy-Wilson, B. (1986) · Cold Spring Harbor Symposia on Quantitative Biology

Cholesterol and Lipid MetabolismLipid metabolism and disorders

Cited by 22