Rowland, Malcolm

Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

Pang, K. S., & Rowland, M. (1977) · Journal of Pharmacokinetics and Biopharmaceutics

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 797

Physiologically Based Pharmacokinetic Modeling 1: Predicting the Tissue Distribution of Moderate-to-Strong Bases

Rodgers, T., Leahy, D., & Rowland, M. (2005) · Journal of Pharmaceutical Sciences

Computational Drug Discovery MethodsDrug Transport and Resistance Mechanisms

Cited by 776

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

Rowland, M., Peck, C., & Tucker, G. (2011) · Annual Review of Pharmacology and Toxicology

Pharmaceutical studies and practicesPharmacogenetics and Drug Metabolism

Cited by 662

Mechanistic Approaches to Volume of Distribution Predictions: Understanding the Processes

Rodgers, T., & Rowland, M. (2007) · Pharmaceutical Research

Computational Drug Discovery MethodsProtein Interaction Studies and Fluorescence Analysis

Cited by 420

Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective

Shebley, M., Sandhu, P., Emami Riedmaier, A., Jamei, M., Narayanan, R., Patel, A., Peters, S. A., Reddy, V. P., Zheng, M., de Zwart, L., et al. (2018) · Clinical Pharmacology & Therapeutics

Pharmaceutical studies and practicesStatistical Methods in Clinical Trials

Cited by 395

Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

Pang, K. S., & Rowland, M. (1977) · Journal of Pharmacokinetics and Biopharmaceutics

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 217

PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: Comparative assessement of prediction methods of human clearance

Ring, B. J., Chien, J. Y., Adkison, K. K., Jones, H. M., Rowland, M., Jones, R. D., Yates, J. W. T., Ku, M. S., Gibson, C. R., He, H., et al. (2011) · Journal of Pharmaceutical Sciences

Pharmaceutical studies and practicesAnimal testing and alternatives

Cited by 206

PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

Poulin, P., Jones, R. D. O., Jones, H. M., Gibson, C. R., Rowland, M., Chien, J. Y., Ring, B. J., Adkison, K. K., Ku, M. S., He, H., et al. (2011) · Journal of Pharmaceutical Sciences

Pharmaceutical studies and practicesPharmacogenetics and Drug Metabolism

Cited by 174

The Role of Physiologically Based Pharmacokinetic Modeling in Regulatory Review

Huang, S.-M., & Rowland, M. (2012) · Clinical Pharmacology & Therapeutics

Pharmaceutical studies and practicesStatistical Methods in Clinical Trials

Cited by 150

Hepatic clearance of drugs. III. Additional experimental evidence supporting the “wellstirred” model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liverin situ preparation

Pang, K. S., & Rowland, M. (1977) · Journal of Pharmacokinetics and Biopharmaceutics

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 77

Tissue lipids and drug distribution: Dog versus rat

Rodgers, T., Jones, H. M., & Rowland, M. (2012) · Journal of Pharmaceutical Sciences

Pharmacogenetics and Drug MetabolismComputational Drug Discovery Methods

Cited by 31

Uncertainty Analysis in Pharmacokinetics and Pharmacodynamics: Application to Naratriptan

Gueorguieva, I., Nestorov, I. A., Aarons, L., & Rowland, M. (2005) · Pharmaceutical Research

Migraine and Headache StudiesStatistical Methods in Clinical Trials

Cited by 18