Apolipoprotein E Protects against Neuropathology Induced by a High-Fat Diet and Maintains the Integrity of the Blood-Brain Barrier during Aging

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

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Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

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Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

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Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

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Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma.

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Apolipoprotein E ϵ4 and cerebral hemorrhage associated with amyloid angiopathy

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Apolipoprotein E ε4 allele is associated with deposition of amyloid β-protein following head injury

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Neurodegeneration in the Central Nervous System of apoE-Deficient Mice

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Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease.

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Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation

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Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia

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Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury

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Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice

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Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia

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Altered immune responses in apolipoprotein E-deficient mice

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Severe learning deficits in apolipoprotein E-knockout mice in a water maze task

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Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse

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Inflammatory pathogenesis in Alzheimer's disease: biological mechanisms and cognitive sequeli

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Reduction of Isoprostanes and Regression of Advanced Atherosclerosis by Apolipoprotein E

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Progression and regression of atherosclerosis in APOE3-Leiden transgenic mice: an immunohistochemical study

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Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice

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Altered synaptic plasticity in hippocampal CA1 area of apolipoprotein E deficient mice

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The effect of apoE on dementia is not through atherosclerosis: The Rotterdam Study

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Advances in cell biology of blood-brain barrier transport.

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Slow tonic muscle fibers in the thyroarytenoid muscles of human vocal folds; a possible specialization for speech

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A one-step immunohistochemical method for detection of blood—brain barrier disturbances for immunoglobulins in lesioned rat brain with special reference to false-positive labelling in immunohistochemistry

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Brains of Aged Apolipoprotein E‐Deficient Mice Have Increased Levels of F2‐Isoprostanes, In Vivo Markers of Lipid Peroxidation

Praticò, D., Rokach, J., & Tangirala, R. K. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730736.x · Cited by 53 · see citing works

Atypical xanthomatosis in apolipoprotein E-deficient mice after cholesterol feeding

VANREE, J., Gijbels, M. J., VANDENBROEK, W., Hofker, M. H., & Havekes, L. M. (1995) · Atherosclerosis · doi:10.1016/0021-9150(94)05419-j · Cited by 43 · see citing works

Possible Link between Lipid Metabolism and Cerebral Amyloid Angiopathy in Alzheimer’s Disease: A Role for High-Density Lipoproteins?

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Increased Cerebral Cortical Lipid Peroxidation and Abnormal Phospholipids in Aged Homozygous apoE-Deficient C57BL/6J Mice

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The effect of APOE on dementia is not through atherosclerosis: The Rotterdam Study

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Cerebral lipid deposition in aged apolipoprotein-E-deficient mice.

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Synaptic alterations in apolipoprotein E knockout mice

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Increased blood–brain barrier permeability in LP-BM5 infected mice is mediated by neuroexcitatory mechanisms

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Apolipoprotein E deficiency effects on learning in mice are dependent upon the background strain

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Blood-Brain Barrier: From Physiology to Disease and Back

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Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

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Microvascular injury and blood–brain barrier leakage in Alzheimer's disease

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Age-associated Physiological and Pathological Changes at the Blood-Brain Barrier: A Review

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Effects of high-fat diet exposure on learning & memory

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Biological markers in CSF and blood for axonal degeneration in multiple sclerosis

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Apolipoprotein E: Diversity of Cellular Origins, Structural and Biophysical Properties, and Effects in Alzheimer's Disease

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The Role of Drug Transporters at the Blood-Brain Barrier

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Blood-brain barrier alterations in ageing and dementia

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Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease

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Elevated levels of homocysteine compromise blood-brain barrier integrity in mice.

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Crystal Structure of Human Carboxylesterase 1 Complexed with the Alzheimer's Drug Tacrine

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Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease

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Biochemical markers related to Alzheimer’s dementia in serum and cerebrospinal fluid

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ApoE Deficiency Compromises the Blood Brain Barrier Especially After Injury

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ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage

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Effects of Subchronic Exposures to Concentrated Ambient Particles: VII. Degeneration of Dopaminergic Neurons in Apo E−/−Mice

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Apolipoproteins and aging: emerging mechanisms

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The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects

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Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice

Lane-Donovan, C., Wong, W. M., Durakoglugil, M. S., Wasser, C. R., Jiang, S., Xian, X., & Herz, J. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1054-16.2016 · Cited by 115 · see citing works

Dietary plant sterols accumulate in the brain

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The role of the low-density lipoprotein receptor–related protein 1 (LRP-1) in regulating blood-brain barrier integrity

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Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus

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Mouse Models to Study the Effect of Cardiovascular Risk Factors on Brain Structure and Cognition

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Blueberry Supplementation Improves Memory in Middle-Aged Mice Fed a High-Fat Diet

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The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice

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Resveratrol Attenuates High-Fat Diet-Induced Disruption of the Blood–Brain Barrier and Protects Brain Neurons from Apoptotic Insults

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ApoE-Dependent Protective Effects of Sesamol on High-Fat Diet-Induced Behavioral Disorders: Regulation of the Microbiome-Gut–Brain Axis

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Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism

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Translational aspects of blood–brain barrier transport and central nervous system effects of drugs: From discovery to patients

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Regulation of Tight-Junction Integrity by Insulin in an In Vitro Model of Human Blood–Brain Barrier

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Age-Related Changes in the Behavior of Apolipoprotein E Knockout Mice

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The Role of Steroid Hormones in the Modulation of Neuroinflammation by Dietary Interventions

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Cerebral Accumulation of Dietary Derivable Plant Sterols does not Interfere with Memory and Anxiety Related Behavior in Abcg5−/− Mice

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Absence of ApoE Upregulates Murine Brain ApoD and ABCA1 Levels, But Does Not Affect Brain Sterol Levels, While Human ApoE3 and Human ApoE4 Upregulate Brain Cholesterol Precursor Levels

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Cerebral Oxidative Stress and Microvasculature Defects in TNF-α Expressing Transgenic and Porphyromonas gingivalis -Infected ApoE –/– Mice

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Peripheral cholesterol metabolic disorders and Alzheimer s disease

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Cerebrospinal Fluid and Blood Biomarkers of Neuroaxonal Damage in Multiple Sclerosis

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White matter injury, cholesterol dysmetabolism, and APP/Abeta dysmetabolism interact to produce Alzheimer’s disease (AD) neuropathology: A hypothesis and review

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Peripheral cholesterol, metabolic disorders and Alzheimer's disease.

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Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity

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Rosuvastatin reduces gliosis and the accelerated weight gain observed in WT and ApoE−/− mice exposed to a high cholesterol diet

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The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis

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Utility of Animal Models to Understand Human Alzheimer’s Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals

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Apolipoprotein CI Knock-Out Mice Display Impaired Memory Functions

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Modulation of plasma lipid levels affects benzo[a]pyrene‐induced DNA damage in tissues of two hyperlipidemic mouse models

Curfs, D. M. J., Beckers, L., Godschalk, R., Gijbels, M. J., & van Schooten, F. (2003) · Environmental and Molecular Mutagenesis · doi:10.1002/em.10200 · Cited by 20 · see citing works

Effects of Sex, Age, and Apolipoprotein E Genotype on Brain Ceramides and Sphingosine-1-Phosphate in Alzheimer’s Disease and Control Mice

den Hoedt, S., Crivelli, S. M., Leijten, F. P. J., Losen, M. H., Stevens, J., Mané-Damas, M., de Vries, H. E., Walter, J., Mirzaian, M., Sijbrands, E. J. G., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.765252 · Cited by 18 · see citing works

Liuwei Dihuang Decoction Alleviates Cognitive Dysfunction in Mice With D-Galactose-Induced Aging by Regulating Lipid Metabolism and Oxidative Stress via the Microbiota-Gut-Brain Axis

Liu, B., Chen, B., Yi, J., Long, H., Wen, H., Tian, F., Liu, Y., Xiao, L., & Li, L. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.949298 · Cited by 17 · see citing works

LRP-1 Pathway Targeted Inhibition of Vascular Abnormalities in the Retina of Diabetic Mice

Hossain, A., Tauhid, L., Davenport, I. R., Huckaba, T. M., Graves, R. A., Mandal, T. K., Muniruzzaman, S., Ahmed, S. A., & Bhattacharjee, P. S. (2016) · Current Eye Research · doi:10.1080/02713683.2016.1203441 · Cited by 13 · see citing works

Coronal ApoE Protein Combines with LRP1 to Inactivate GSK3β That Mitigates Silica Nanoparticle-Induced Brain Lesion

Wei, W., Sun, H., Yang, B. V., Song, E., & Song, Y. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00728 · Cited by 10 · see citing works

PBPK Modeling Approach for Predictions of Human CNS Drug Brain Distribution

de Lange, E. C. M. (2015) · Wiley eBooks · doi:10.1002/9781118788523.ch14 · Cited by 10 · see citing works

Red wine consumption mitigates the cognitive impairments in low-density lipoprotein receptor knockout (LDLr−/−) mice

de Paula, G. C., de Oliveira, J., Engel, D. F., Lopes, S. C., Moreira, E. L. G., Figueiredo, C. P., Prediger, R. D., & de Bem, A. F. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1704472 · Cited by 9 · see citing works

Apolipoprotein E knockout may affect cognitive function in D-galactose-induced aging mice through the gut microbiota–brain axis

Chen, B., Yi, J., Xu, Y., Wen, H., Tian, F., Liu, Y., Xiao, L., Li, L., & Liu, B. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.939915 · Cited by 9 · see citing works

Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels

den Hoedt, S., Janssen, C. I. F., Astarita, G., Piomelli, D., Leijten, F. P. J., Crivelli, S. M., Verhoeven, A. J. M., de Vries, H. E., Walter, J., Martínez‐Martínez, P., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160739 · Cited by 8 · see citing works

Chlamydia pneumoniae infection enhances microglial activation in atherosclerotic mice

Voorend, M., van der Ven, A. J. A. M., Mulder, M. T., Lodder, J., Steinbusch, H. W. M., & Bruggeman, C. A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.09.022 · Cited by 6 · see citing works

Animal models and lysosomal pathogenesis of atherosclerosis

Wang, Z., Li, X., Moura, A. K., Hu, J. Z., Wang, Y., & Zhang, Y. (2025) · Animal Advances · doi:10.48130/animadv-0025-0003 · Cited by 5 · see citing works

Varying Dietary Component Ratios and Lingonberry Supplementation May Affect the Hippocampal Structure of ApoE–/– Mice

Shepilov, D., Kovalenko, T., Osadchenko, I., Smozhanyk, K., Marungruang, N., Ушакова, Г. А., Муравйова, Д. В., Hållenius, F. F., Prykhodko, O., & Skibo, G. G. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.565051 · Cited by 4 · see citing works

Disease Influence on BBB Transport in Neurodegenerative Disorders

de Lange, E. C. M. (2013) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4614-9105-7_22 · Cited by 3 · see citing works

PKPD Aspects of Brain Drug Delivery in a Translational Perspective

de Lange, E. (2014) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4614-9105-7_9 · Cited by 1 · see citing works

Evaluation of the Disaster Preparedness School Program at Sekolah Dasar Negeri Baluwarti and Sekolah Dasar Negeri Bangunrejo 1 in Yogyakarta

Afisa, A., & Sakir, S. (2020) · JPPUMA Jurnal Ilmu Pemerintahan dan Sosial Politik Universitas Medan Area · doi:10.31289/jppuma.v8i2.3557 · Cited by 2 · see citing works

Cholesterol Trafficking in the Brain

Lütjohann, D., Vanmierlo, T., & Mulder, M. (2009) · Springer eBooks · doi:10.1007/978-3-642-00300-4_5 · Cited by 4 · see citing works

Effect of Diet as a Factor of Exposome on Brain Function

Fedotova, A., Tiaglik, A. B., & Semyanov, A. V. (2021) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093021030108 · Cited by 2 · see citing works

Translational Approaches for Predicting CNS Drug Effects Using Microdialysis

de Lange, E. C. M. (2012) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4614-4815-0_8 · Cited by 1 · see citing works

Apolipoproteins E and C1 in the brain: role in Alzheimer's disease

Abildayeva, K. (2006) · doi:10.26481/dis.20061220ka

Brain sterol metabolism : modulating Alzheimer’s disease

Vanmierlo, T. (2010) · doi:10.26481/dis.20100930tv

Cholesterol: nieuw therapeutisch target bij de ziekte van Alzheimer?

Mulder, M. T., & van Mierlo, T. (2007) · Neuropraxis · doi:10.1007/bf03079128

Experimental Animal Models to Evaluate Physiological Activities of Agricultural Products, Food Components, and Drugs

Yamaki, K. (2010) · NIPPON SHOKUHIN KOGYO GAKKAISHI · doi:10.3136/nskkk.57.49

Alzheimer´s disease and apolipoprotein E.A prospective, population-based molecular genetic and neuropathological study of individuals aged 85 years or more

Polvikoski, T. M. (2004) · Työväentutkimus Vuosikirja

Dietary cholesterol effects on learning, memory and amyloid beta: Learning and memory effects on brain cholesterol and sulfatide levels

Darwish, D. S. (2010) · doi:10.33915/etd.3252

Hormonal and non-hormonal factors associated with cognition in post-menopausal women

Rodrigues, M. A. (2004) · UWA Profiles and Research Repository (UWA)

Effect of resveratrol on mesenteric adipose tissue and the cerebellar cortex of a rabbit model of high-fat diet

Omar, S. M. M., & Abulsaad, K. A. (2015) · The Egyptian Journal of Histology · doi:10.1097/01.ehx.0000464784.42319.33

Anti-Aging Medicine LiteratureWatch

(2001) · Rejuvenation Research · doi:10.1089/10945450152850713

Disease Influence on BBB Transport in Neurodegeneration

de Lange, E. C. M. (2022) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-030-88773-5_22

Apoprotein E: Structural insights functionality and genetic variability

Tewari, S., & Ranade, S. D. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40563-1.00008-9

BindingDB Entry 2794: Crystal structure of human carboxylesterase 1 complexed with the Alzheimer s drug tacrine: from binding promiscuity to selective inhibition.

BindingDB (2008) · UC San Diego · doi:10.7270/q2n014t9

Impairment of the Blood–Nerve and Blood–Brain Barriers in Apolipoprotein E Knockout Mice

Fullerton, S. M., Shirman, G. A., Strittmatter, W. J., & Matthew, W. D. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7631 · Cited by 117 · see citing works

ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage

Hafezi-Moghadam, A., Thomas, K. L., & Wagner, D. D. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00563.2005 · Cited by 149 · see citing works

Aging-Related Changes in Blood-Brain Barrier Integrity and the Effect of Dietary Fat

Takechi, R., Pallebage‐Gamarallage, M. M., Lam, V., Giles, C., & Mamo, J. C. L. (2012) · Neurodegenerative Diseases · doi:10.1159/000343211 · Cited by 59 · see citing works

ApoE Deficiency Compromises the Blood Brain Barrier Especially After Injury

Methia, N., André, P., Hafezi-Moghadam, A., Economopoulos, M., Thomas, K. L., & Wagner, D. D. (2001) · Molecular Medicine · doi:10.1007/bf03401973 · Cited by 150 · see citing works

Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in an in Vitro Blood-Brain Barrier Model

Nishitsuji, K., Hosono, T., Nakamura, T., Bu, G., & Michikawa, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.225532 · Cited by 275 · see citing works