Cited by 137Adipose Tissue and MetabolismRegulation of Appetite and ObesityLipid metabolism and biosynthesis

Sympathetic nervous system control of triglyceride metabolism: novel concepts derived from recent studies

Open access
Geerling, Janine J., Boon, Mariëtte R., Kooijman, Sander, Parlevliet, Edwin T., Havekes, Louis M., Romijn, Johannes A., Meurs, Illiana M., Rensen, Patrick C.N.·2014·Journal of Lipid Research

Abstract

Important players in triglyceride (TG) metabolism include the liver (production), white adipose tissue (WAT) (storage), heart and skeletal muscle (combustion to generate ATP), and brown adipose tissue (BAT) (combustion toward heat), the collective action of which determine plasma TG levels. Interestingly, recent evidence points to a prominent role of the hypothalamus in TG metabolism through innervating the liver, WAT, and BAT mainly via sympathetic branches of the autonomic nervous system. Here, we review the recent findings in the area of sympathetic control of TG metabolism. Various neuronal populations, such as neuropeptide Y (NPY)-expressing neurons and melanocortin-expressing neurons, as well as peripherally produced hormones (i.e., GLP-1, leptin, and insulin), modulate sympathetic outflow from the hypothalamus toward target organs and thereby influence peripheral TG metabolism. We conclude that sympathetic stimulation in general increases lipolysis in WAT, enhances VLDL-TG production by the liver, and increases the activity of BAT with respect to lipolysis of TG, followed by combustion of fatty acids toward heat. Moreover, the increased knowledge about the involvement of the neuroendocrine system in TG metabolism presented in this review offers new therapeutic options to fight hypertriglyceridemia by specifically modulating sympathetic nervous system outflow toward liver, BAT, or WAT.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1194/jlr.r045013

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Increased SNS tone in WAT could be directly triggered by hypoglycemia sensing in the brain.

    “This increased SNS tone in WAT could be directly triggered by hypoglycemia sensing in the brain 67, 68.”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

3 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Geerling, J. J., Boon, M. R., Kooijman, S., Parlevliet, E. T., Havekes, L. M., Romijn, J. A., Meurs, I. M., & Rensen, P. C. N.
Affiliations
  • Leiden University Medical Center (NL)
  • Netherlands Organisation for Applied Scientific Research (NL)
  • Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author
Boon, Mariëtte R.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2014-02
Volume
55
Issue
2
Pages
180-189
ISSN
0022-2275 (ISSN-L)
OpenAlex
W2155317536
Cited by
137
References
99
Citations by year
2026: 7 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 15 · 2021: 16 · 2020: 11 · 2019: 8 · 2018: 10 · 2017: 24 · 2016: 10 · 2015: 8 · 2014: 6
FWCI
0.88
Type
journal article
Language
en
Open access
Locations
  • Journal of Lipid Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • TNO Repository (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Pure Amsterdam UMC (submittedVersion)
  • Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders
  • Diabetes Fonds
  • Leids Universitair Medisch Centrum
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
sympathetic nervous system, triglyceride metabolism, hypothalamus, neuropeptide Y neurons, glucagon-like peptide-1, leptin, insulin, lipolysis, white adipose tissue, brown adipose tissue, hypertriglyceridemia, neuroendocrine regulation, thermogenesis
MeSH terms
Animals, Adipose Tissue, Brown, Humans, Lipoproteins, Liver, Sympathetic Nervous System, Triglycerides, Adipose Tissue, White

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review