Khanna, Chand

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

Khanna, C., Wan, X., Bose, S., Cassaday, R., Olomu, O., Mendoza, A., Yeung, C., Gorlick, R., Hewitt, S. M., & Helman, L. J. (2004) · Nature Medicine

Sarcoma Diagnosis and TreatmentCancer Cells and Metastasis

Cited by 705

Translation of new cancer treatments from pet dogs to humans

Paoloni, M., & Khanna, C. (2008) · Nature Reviews Cancer

Veterinary Oncology ResearchHuman-Animal Interaction Studies

Cited by 668

Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression

Paoloni, M., Davis, S., Lana, S., Withrow, S., Sangiorgi, L., Picci, P., Hewitt, S., Triche, T., Meltzer, P., & Khanna, C. (2009) · BMC Genomics

Veterinary Oncology ResearchSarcoma Diagnosis and Treatment

Cited by 291

The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation

Tsai, Y. C., Mendoza, A., Mariano, J. M., Zhou, M., Kostova, Z., Chen, B., Veenstra, T., Hewitt, S. M., Helman, L. J., Khanna, C., et al. (2007) · Nature Medicine

Mechanisms of cancer metastasisUbiquitin and proteasome pathways

Cited by 186

Toward a Drug Development Path That Targets Metastatic Progression in Osteosarcoma

Khanna, C., Fan, T. M., Gorlick, R., Helman, L. J., Kleinerman, E. S., Adamson, P. C., Houghton, P. J., Tap, W. D., Welch, D. R., Steeg, P. S., et al. (2014) · Clinical Cancer Research

Sarcoma Diagnosis and TreatmentCancer Cells and Metastasis

Cited by 178

Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression

Heinecke, J. L., Ridnour, L. A., Cheng, R. Y. S., Switzer, C. H., Lizardo, M. M., Khanna, C., Glynn, S. A., Hussain, S. P., Young, H. A., Ambs, S., et al. (2014) · Proceedings of the National Academy of Sciences

Nitric Oxide and Endothelin EffectsImmune cells in cancer

Cited by 177

Positively selected enhancer elements endow osteosarcoma cells with metastatic competence

Morrow, J. J., Bayles, I., Funnell, A. P. W., Miller, T. E., Saiakhova, A., Lizardo, M. M., Bartels, C. F., Kapteijn, M. Y., Hung, S., Mendoza, A., et al. (2018) · Nature Medicine

Genomics and Chromatin DynamicsCancer Cells and Metastasis

Cited by 161

Osteosarcoma.

Gorlick, R., & Khanna, C. (2010) · Journal of Bone and Mineral Research

Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and Treatments

Cited by 157

Germline TP53 Variants and Susceptibility to Osteosarcoma

Mirabello, L., Yeager, M., Mai, P. L., Gastier-Foster, J. M., Gorlick, R., Khanna, C., Patiño-Garcia, A., Sierrasesúmaga, L., Lecanda, F., Andrulis, I. L., et al. (2015) · JNCI Journal of the National Cancer Institute

Sarcoma Diagnosis and TreatmentCancer-related Molecular Pathways

Cited by 155

Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology

LeBlanc, A. K., Breen, M., Choyke, P., Dewhirst, M., Fan, T. M., Gustafson, D. L., Helman, L. J., Kastan, M. B., Knapp, D. W., Levin, W. J., et al. (2016) · Science Translational Medicine

Veterinary Oncology ResearchScience, Research, and Medicine

Cited by 147

Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group

Roberts, R. D., Lizardo, M. M., Reed, D. R., Hingorani, P., Glover, J., Allen‐Rhoades, W., Fan, T., Khanna, C., Sweet‐Cordero, E. A., Cash, T., et al. (2019) · Cancer

Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and Treatments

Cited by 127

Modeling metastasis biology and therapy in real time in the mouse lung

Mendoza, A., Hong, S.-H., Osborne, T., Khan, M. A., Campbell, K., Briggs, J., Eleswarapu, A., Buquo, L., Ren, L., Hewitt, S. M., et al. (2010) · Journal of Clinical Investigation

Cancer Cells and MetastasisMechanisms of cancer metastasis

Cited by 92

Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation

Ridnour, L. A., Barasch, K. M., Windhausen, A. N., Dorsey, T. H., Lizardo, M. M., Yfantis, H. G., Lee, D. H., Switzer, C. H., Cheng, R. Y. S., Heinecke, J. L., et al. (2012) · PLoS ONE

Protease and Inhibitor MechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 71

Dysregulation of Ezrin Phosphorylation Prevents Metastasis and Alters Cellular Metabolism in Osteosarcoma

Ren, L., Hong, S.-H., Chen, Q.-R., Briggs, J., Cassavaugh, J., Srinivasan, S., Lizardo, M. M., Mendoza, A., Xia, A. Y., Avadhani, N., et al. (2012) · Cancer Research

Cancer Cells and MetastasisCellular Mechanics and Interactions

Cited by 50

Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression

Lizardo, M. M., Morrow, J. J., Miller, T. E., Hong, E. S., Ren, L., Mendoza, A., Halsey, C. H., Scacheri, P. C., Helman, L. J., & Khanna, C. (2016) · Neoplasia

Endoplasmic Reticulum Stress and DiseaseHeat shock proteins research

Cited by 50

mTOR Inhibition Mitigates Enhanced mRNA Translation Associated with the Metastatic Phenotype of Osteosarcoma Cells In Vivo

Morrow, J. J., Mendoza, A., Koyen, A., Lizardo, M. M., Ren, L., Waybright, T. J., Hansen, R. J., Gustafson, D. L., Zhou, M., Fan, T. M., et al. (2016) · Clinical Cancer Research

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 27