The DOI matches its OpenAlex record; 20 of the 20 references it cites were found in a registry or an index.
Racial Pigmentation and the Cutaneous Synthesis of Vitamin D
Abstract
The varying epidermal melanin content that produces racial pigmentation determines the number of photons that reach the lower (malpighian) cellular layers, where vitamin D3 synthesis takes place. We investigated the effect of racial pigmentation on vitamin D3 formation, stimulating the process with a fixed dose of UVB radiation (wavelengths, 290 to 320 nm). Vitamin D nutritional status was further assessed measuring serum 25-hydroxyvitamin D and the most active serum metabolite, 1,25-dihydroxyvitamin D. Experimental subjects were young (third decade of life) and healthy, representing the white, Oriental (East Asian), Indian (South Asian), and black races. Basal serum vitamin D3 levels were similar among groups, ranging from 2.3 +/- 0.6 nmol/L (mean +/- SEM) for blacks to 3.4 +/- 1.0 nmol/L for Indians. Following whole-body exposure to 27 mJ/cm2 of UVB, there was a significant racial group effect on serum vitamin D3 levels. Post-UVB levels were significantly higher in whites (31.4 +/- 4.4 nmol/L) than in Indians or blacks (12.8 +/- 2.9 and 9.1 +/- 2.1 nmol/L, respectively), while the levels in Orientals (27.8 +/- 4.4 nmol/L) differed significantly from those in blacks and Indians but not in whites. Race had only a marginal effect on serum 25-hydroxyvitamin D, with higher levels in whites than in blacks (69.9 +/- 12.7 vs 29.7 +/- 6.2 nmol/L). Serum 1,25-dihydroxyvitamin D and vitamin D binding protein levels were similar in all groups. We conclude that while racial pigmentation has a photoprotective effect, it does not prevent the generation of normal levels of active vitamin D metabolites.
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Citations
Cites
Anderson, R. R., & Parrish, J. A. (1981) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12479191 · Cited by 2,456
INCREASED SKIN PIGMENT REDUCES THE CAPACITY OF SKIN TO SYNTHESISE VITAMIN D3
Clemens, T. L., Henderson, S. L., Adams, J. S., & Holick, M. F. (1982) · The Lancet · doi:10.1016/s0140-6736(82)90214-8 · Cited by 1,164
REINHARDT, T. A., HORST, R. L., ORF, J. W., & HOLLIS, B. W. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-58-1-91 · Cited by 801
Photosynthesis of Previtamin D 3 in Human Skin and the Physiologic Consequences
Holick, M. F., MacLaughlin, J. A., Clark, M. B., Holick, S. A., Potts, J. T., Anderson, R. R., Blank, I. H., Parrish, J. A., & Elias, P. (1980) · Science · doi:10.1126/science.6251551 · Cited by 776
Sunscreens Suppress Cutaneous Vitamin D3Synthesis*
MATSUOKA, L. Y., IDE, L., WORTSMAN, J., MACLAUGHLIN, J. A., & HOLICK, M. F. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-6-1165 · Cited by 602
Self-citationHolick, M. F., MacLaughlin, J. A., & Doppelt, S. H. (1981) · Science · doi:10.1126/science.6256855 · Cited by 558
Evidence for alteration of the vitamin D-endocrine system in blacks.
Bell, N. H., Greene, A., Epstein, S., Oexmann, M. J., Shaw, S., & Shary, J. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111995 · Cited by 454
Vitamin D Binding Protein (Gc-Globulin)*
COOKE, N. E., & HADDAD, J. G. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-3-294 · Cited by 266
Cell Layer and Density of Negro and Caucasian Stratum Corneum
Weigand, D. A., Haygood, C., & Gaylor, J. R. (1974) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12679412 · Cited by 258
Metabolism of Vitamin D3-3H in Human Subjects: Distribution in Blood, Bile, Feces, and Urine*
Avioli, L. V., Lee, S. W., McDonald, J. E., Lund, J., & DeLuca, H. F. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105605 · Cited by 178
Cited by
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., et al. (2006) · Science · doi:10.1126/science.1123933 · Cited by 3,924
Decreased bioavailability of vitamin D in obesity
Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.690 · Cited by 3,204
Self-citationMelanin pigmentation in mammalian skin and its hormonal regulation
Slominski, A., Tobin, D. J., Shibahara, S., & Wortsman, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00044.2003 · Cited by 2,015
The Protective Role of Melanin Against UV Damage in Human Skin †
Brenner, M., & Hearing, V. J. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00226.x · Cited by 1,741
Prevention of Rickets and Vitamin D Deficiency in Infants, Children, and Adolescents
Wagner, C. L., Greer, F. R., & and the Section on Breastfeeding and Committee on Nutrition (2008) · Pediatrics · doi:10.1542/peds.2008-1862 · Cited by 1,613
Metadata
- Authors
- Matsuoka, L. Y.
- Venue
- Archives of Dermatology
- Publisher
- American Medical Association
- Published
- 1991-04-01
- Volume
- 127
- Issue
- 4
- Pages
- 536-536
- ISSN
- 0003-987X (ISSN-L)
- OpenAlex
- W2005988779
- Cited by
- 302
- References
- 20
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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