Cited by 4,339Skin Protection and Agingmelanin and skin pigmentationPsoriasis: Treatment and Pathogenesis

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The Validity and Practicality of Sun-Reactive Skin Types I Through VI

Fitzpatrick, Thomas B.·1988·Archives of Dermatology

DOI 10.1001/archderm.1988.01670060015008

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Abstract

The concept of sun-reactive "skin typing" was created in 19751for a specific need: to be able to classify personswith white skinin order to select the correct initial doses of ultraviolet A (UVA) (in joules per cubic centimeter) in the application of the then newly developed technique for the treatment of psoriasis—oral methoxsalen photochemotherapy (PUVA).2The need arose as a result of experience with several patients who were a "dark" phenotype (brown or even black hair, and some with brown eyes) but, to our surprise, developed severe phototoxic reactions following oral ingestion of 0.6 mg/kg of methoxsalen and then, two hours later, were exposed to 4 to 6 J/cm2. These initial doses were obviously too high, and it was then understood that the estimation of the white-skinned person's tolerance level to oral PUVA could not be based solely on the phenotype (hair and eye color).

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Crossref · 10.1001/archderm.1988.01670060015008

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Authors: Fitzpatrick, T. B.
Affiliations: Harvard University (US)
Corresponding author: Fitzpatrick, Thomas B.
Venue: Archives of Dermatology
Publisher: American Medical Association (AMA)
Published: 1988-06-01
Volume: 124
Issue: 6
Pages: 869
ISSN: 0003-987X (ISSN-L)
DOI: 10.1001/archderm.1988.01670060015008
OpenAlex: W4250928742
Cited by: 4,339
References: 0
Citations by year: 2026: 206 · 2025: 206 · 2024: 250 · 2023: 255 · 2022: 289 · 2021: 276 · 2020: 228 · 2019: 219 · 2018: 212 · 2017: 187 · 2016: 214 · 2015: 162 · 2014: 126 · 2013: 136 · 2012: 132
FWCI: 10.24
Type: journal article
Language: en
Open access: closed
Locations: Archives of Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: phototoxicity, PUVA, 8-methoxypsoralen, psoriasis treatment
MeSH terms: Dose-Response Relationship, Radiation, Erythema, Humans, Methods, Psoriasis, PUVA Therapy, Skin, Skin Pigmentation, Sunburn, Sunlight, Ultraviolet Rays

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The Validity and Practicality of Sun-Reactive Skin Types I Through VI

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