Cited by 466Cannabis and Cannabinoid ResearchPsychedelics and Drug StudiesMedicinal Plant Extracts Effects

The DOI matches its Crossref record; 108 of the 111 references it cites were found in a registry or an index.

Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing

Open access

Fusar-Poli, Paolo, Crippa, José A., Bhattacharyya, Sagnik, Borgwardt, Stefan J., Allen, Paul, Martin-Santos, Rocio, Seal, Marc, Surguladze, Simon A., O’Carrol, Colin, Atakan, Zerrin, Zuardi, Antonio W., McGuire, Philip K.·2009·Archives of General Psychiatry

DOI 10.1001/archgenpsychiatry.2008.519

Open this paper in CoChat — free account Open PDF

Abstract

CONTEXT: Cannabis use can both increase and reduce anxiety in humans. The neurophysiological substrates of these effects are unknown. OBJECTIVE: To investigate the effects of 2 main psychoactive constituents of Cannabis sativa (Delta9-tetrahydrocannabinol [Delta9-THC] and cannabidiol [CBD]) on regional brain function during emotional processing. DESIGN: Subjects were studied on 3 separate occasions using an event-related functional magnetic resonance imaging paradigm while viewing faces that implicitly elicited different levels of anxiety. Each scanning session was preceded by the ingestion of either 10 mg of Delta9-THC, 600 mg of CBD, or a placebo in a double-blind, randomized, placebo-controlled design. PARTICIPANTS: Fifteen healthy, English-native, right-handed men who had used cannabis 15 times or less in their life. MAIN OUTCOME MEASURES: Regional brain activation (blood oxygenation level-dependent response), electrodermal activity (skin conductance response [SCR]), and objective and subjective ratings of anxiety. RESULTS: Delta9-Tetrahydrocannabinol increased anxiety, as well as levels of intoxication, sedation, and psychotic symptoms, whereas there was a trend for a reduction in anxiety following administration of CBD. The number of SCR fluctuations during the processing of intensely fearful faces increased following administration of Delta9-THC but decreased following administration of CBD. Cannabidiol attenuated the blood oxygenation level-dependent signal in the amygdala and the anterior and posterior cingulate cortex while subjects were processing intensely fearful faces, and its suppression of the amygdalar and anterior cingulate responses was correlated with the concurrent reduction in SCR fluctuations. Delta9-Tetrahydrocannabinol mainly modulated activation in frontal and parietal areas. CONCLUSIONS: Delta9-Tetrahydrocannabinol and CBD had clearly distinct effects on the neural, electrodermal, and symptomatic response to fearful faces. The effects of CBD on activation in limbic and paralimbic regions may contribute to its ability to reduce autonomic arousal and subjective anxiety, whereas the anxiogenic effects of Delta9-THC may be related to effects in other brain regions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/archgenpsychiatry.2008.519

Cites

108 of 108 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Untitled work
(1970) · Cited by 24,983
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
An Improved Diagnostic Evaluation Instrument for Substance Abuse Patients
McLellan, A. T., Luborsky, L. B., WOODY, G. E., & Brien, C. P. O. (1980) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198001000-00006 · Cited by 3,163
Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360
A differential neural response in the human amygdala to fearful and happy facial expressions
Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/383812a0 · Cited by 2,013
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728
Response and Habituation of the Human Amygdala during Visual Processing of Facial Expression
Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., Strauss, M. M., Hyman, S. E., & Rosen, B. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80219-6 · Cited by 1,711
Conscious and unconscious emotional learning in the human amygdala
Morris, J. S., Öhman, A., & Dolan, R. J. (1998) · Nature · doi:10.1038/30976 · Cited by 1,665

Show all 111 references

Research works printed but not linked: 1

Young, 2002, Facial Expressions of Emotion: Stimuli and Tests (FEEST)

Sorted by citations

Items 201–300 of 466

Cannabidiol efficiently suppressed the acquisition and expression of methamphetamine-induced conditioned place preference in the rat
Anooshe, M., Nouri, K., Karimi‐Haghighi, S., Mousavi, Z., & Haghparast, A. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113158 · Cited by 40
UK Medical Cannabis Registry: an analysis of clinical outcomes of medicinal cannabis therapy for generalized anxiety disorder
Ergisi, M., Erridge, S., Harris, M., Kawka, M., Nimalan, D., Salazar, O., Loupasaki, K., Ali, R., Holvey, C., Coomber, R., et al. (2021) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2022.2020640 · Cited by 40
Cannabinoids and Vanilloids in Schizophrenia: Neurophysiological Evidence and Directions for Basic Research
Ruggiero, R. N., Rossignoli, M. T., Ross, J. B. D., Hallak, J. E. C., Leite, J. P., & Bueno-Júnior, L. S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00399 · Cited by 39
Cannabidiol did not induce teratogenicity or neurotoxicity in exposed zebrafish embryos
Brigante, T. A. V., Abe, F. R., Zuardi, A. W., Hallak, J. E. C., Crippa, J. A. S., & de Oliveira, D. P. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.06.008 · Cited by 37
Self-citation
Cannabinoids in the Older Person: A Literature Review
Beedham, W., Sbai, M., Allison, I., Coary, R., & Shipway, D. (2020) · Geriatrics · doi:10.3390/geriatrics5010002 · Cited by 38
Effects of Cannabis sativa extract on haloperidol-induced catalepsy and oxidative stress in the mice
Abdel‐Salam, O. M. E., El-Din M. Gaafar, A., El Sayed El-Shamarka, M., & Salem, N. A. (2012) · PubMed Central · doi:10.17877/de290r-4916 · Cited by 36
Cannabinoid treatments for anxiety: A systematic review and consideration of the impact of sleep disturbance
Narayan, A. J., Downey, L. A., Manning, B., & Hayley, A. C. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104941 · Cited by 36
Adduct-ion formation in trapped ion mobility spectrometry as a potential tool for studying molecular structures and conformations
Zietek, B. M., Mengerink, Y., Jordens, J., Somsen, G. W., Kool, J., & Honing, M. (2017) · International Journal for Ion Mobility Spectrometry · doi:10.1007/s12127-017-0227-6 · Cited by 36
Could Cannabidiol Be a Treatment for Coronavirus Disease-19-Related Anxiety Disorders?
O’Sullivan, S. E., Stevenson, C. W., & Laviolette, S. R. (2020) · Cannabis and Cannabinoid Research · doi:10.1089/can.2020.0102 · Cited by 37
Alterations of theory of mind network activation in chronic cannabis users
Roser, P., Lissek, S., Tegenthoff, M., Nicolas, V., Juckel, G., & Brüne, M. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.05.020 · Cited by 35
Cannabinoids, interoception, and anxiety
Andrade, A. K., Renda, B., & Murray, J. E. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.03.006 · Cited by 41
Cannabidiol as a Treatment for Mood Disorders: A Systematic Review: Le cannabidiol comme traitement des troubles de l’humeur: une revue systématique
Pinto, J. V., Saraf, G., Frysch, C., Vigo, D., Keramatian, K., Chakrabarty, T., Lam, R. W. M., Kauer‐Sant’Anna, M., & Yatham, L. N. (2019) · The Canadian Journal of Psychiatry · doi:10.1177/0706743719895195 · Cited by 38
Seeing through the smoke: Human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks
Silveira, M. M., Arnold, J. C., Laviolette, S. R., Hillard, C. J., Celorrio, M., Aymerich, M. S., & Adams, W. K. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.007 · Cited by 38
Possible therapeutic applications of cannabis in the neuropsychopharmacology field
Fernández‐Ruíz, J., Galve‐Roperh, I., Sagredo, O., & Guzmán, M. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.01.013 · Cited by 35
Cannabidiol Impairs Brain Mitochondrial Metabolism and Neuronal Integrity
Drummond‐Main, C. D., Ahn, Y., Kesler, M., Gavrilovici, C., ‍Kim, D. Y., Kiroski, I., Baglot, S. L., Chen, A., Sharkey, K. A., Hill, M. N., et al. (2022) · Cannabis and Cannabinoid Research · doi:10.1089/can.2022.0011 · Cited by 34
Dissociation between the panicolytic effect of cannabidiol microinjected into the substantia nigra, pars reticulata, and fear-induced antinociception elicited by bicuculline administration in deep layers of the superior colliculus: The role of CB1-cannabinoid receptor in the ventral mesencephalon
da Silva, J. A., Biagioni, A. F., Almada, R. C., Crippa, J. A. S., Hallak, J. E. C., Zuardi, A. W., & Coimbra, N. C. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.051 · Cited by 34
Self-citation
Cannabinoid Modulation of Frontolimbic Activation and Connectivity During Volitional Regulation of Negative Affect
Gorka, S. M., Phan, K. L., Lyons, M., Mori, S., Angstadt, M., & Rabinak, C. A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.359 · Cited by 35
Neuroimaging studies towards understanding the central effects of pharmacological cannabis products on patients with epilepsy
Allendorfer, J. B., & Szaflarski, J. P. (2017) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2016.11.020 · Cited by 32
Interactions between recreational cannabis use and cognitive function: lessons from functional magnetic resonance imaging
Sagar, K. A., & Gruber, S. A. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13990 · Cited by 36
Endocannabinoid Receptors in the CNS: Potential Drug Targets for the Prevention and Treatment of Neurologic and Psychiatric Disorders
Estrada, J. A., & Contreras, I. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200217140255 · Cited by 33
Cannabinoids
Howard, P. D., Twycross, R., Shuster, J. L., Mihalyo, M., & Wilcock, A. (2013) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2013.05.002 · Cited by 32
Marijuana Compounds: A Nonconventional Approach to Parkinson’s Disease Therapy
Babayeva, M., Assefa, H., Basu, P., Chumki, S. R., & Loewy, Z. G. (2016) · Parkinson s Disease · doi:10.1155/2016/1279042 · Cited by 38
Cannabis Use, Anxiety, and Perceptions of Risk among Canadian Undergraduates: The Moderating Role of Gender
Hellemans, K. G. C., Wilcox, J., Nino, J. N., Young, M. M., & McQuaid, R. J. (2019) · The Canadian Journal of Addiction · doi:10.1097/cxa.0000000000000059 · Cited by 31
Brain Mapping Biomarkers of Socio-Emotional Processing in Schizophrenia
Taylor, S. F., & MacDonald, A. W. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr105 · Cited by 31
Drug effects on responses to emotional facial expressions
Miller, M. A., Bershad, A. K., & de Wit, H. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000164 · Cited by 31
Endocannabinoid and dopaminergic system: the pas de deux underlying human motivation and behaviors
Laksmidewi, A. A. A. P., & Soejitno, A. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-021-02326-y · Cited by 35
Cannabidiol normalizes resting-state functional connectivity in treatment-resistant epilepsy
Nenert, R. E., Allendorfer, J. B., Bebin, E. M., Gaston, T. E., Grayson, L. E., Houston, J. T., & Szaflarski, J. P. (2020) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2020.107297 · Cited by 31
Cortico-cerebellar abnormalities in adolescents with heavy marijuana use
Lopez-Larson, M. P., Rogowska, J., Bogorodzki, P., Bueler, C. E., McGlade, E., & Yurgelun-Todd, D. A. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2011.11.005 · Cited by 31
Reduction in Cerebral Perfusion after Heroin Administration: A Resting State Arterial Spin Labeling Study
Denier, N., Gerber, H., Vogel, M., Klarhöfer, M., Riecher‐Rössler, A., Wiesbeck, G. A., Lang, U. E., Borgwardt, S., & Walter, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071461 · Cited by 30
Self-citation
Genetic variation in the endocannabinoid system and response to Cognitive Behavior Therapy for child anxiety disorders
Lester, K. J., Coleman, J. R. I., Roberts, S., Keers, R., Breen, G. D., Bögels, S. M., Creswell, C., Hudson, J. L., McKinnon, A., Nauta, M. H., et al. (2016) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32467 · Cited by 31
Reduced Response to Reward in Smokers and Cannabis Users
Martin-Söelch, C., Kobel, M., Stoecklin, M., Michael, T., Weber, S., Krebs, B., & Opwis, K. (2009) · Neuropsychobiology · doi:10.1159/000239685 · Cited by 30
Cannabis use and symptoms of anxiety in adolescence and the moderating effect of the serotonin transporter gene
Otten, R., Huizink, A. C., Monshouwer, K., Creemers, H. E., & Onrust, S. A. (2016) · Addiction Biology · doi:10.1111/adb.12372 · Cited by 29
Targeting the Endocannabinoid System in Psychiatric Illness
Katzman, M. A., Furtado, M., & Anand, L. (2016) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000581 · Cited by 30
Δ-Tetrahydrocannabinol Increases Dopamine D1-D2 Receptor Heteromer and Elicits Phenotypic Reprogramming in Adult Primate Striatal Neurons
Hasbi, A., Madras, B. K., Bergman, J., Kohut, S. J., Lin, Z., Withey, S. L., & George, S. R. (2019) · iScience · doi:10.1016/j.isci.2019.100794 · Cited by 29
Normalizing effect of heroin maintenance treatment on stress-induced brain connectivity
Schmidt, A., Walter, M., Gerber, H., Seifritz, E., Brenneisen, R., Wiesbeck, G. A., Riecher‐Rössler, A., Lang, U. E., & Borgwardt, S. (2014) · Brain · doi:10.1093/brain/awu326 · Cited by 29
Self-citation
The Yin and Yang of Cannabis: A Systematic Review of Human Neuroimaging Evidence of the Differential Effects of Δ9-Tetrahydrocannabinol and Cannabidiol
Gunasekera, B., Davies, C., Martín‐Santos, R., & Bhattacharyya, S. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.10.007 · Cited by 27
Self-citation
Cannabinoids in the management of behavioral, psychological, and motor symptoms of neurocognitive disorders: a mixed studies systematic review
Bahji, A., Breward, N. J., DUFF, W. R. D., Absher, N., Patten, S. B., Alcorn, J., & Mousseau, D. D. (2022) · Journal of Cannabis Research · doi:10.1186/s42238-022-00119-y · Cited by 29
Natural product-derived therapies for treating drug-resistant epilepsies: From ethnopharmacology to evidence-based medicine
Challal, S., Skiba, A., Langlois, M., Esguerra, C. V., Wolfender, J., Crawford, A. D., & Skalicka‐Woźniak, K. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116740 · Cited by 29
Δ9-Tetrahydrocannabinol decreases willingness to exert cognitive effort in male rats
Silveira, M. M., Adams, W. K., Morena, M., Hill, M. N., & Winstanley, C. A. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150363 · Cited by 27
The Anxiolytic Effects of Cannabidiol (CBD)
Zuardi, A. W., Crippa, J. A. S., Hallak, J. E. C., Campos, A. C., & Guimarães, F. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-800756-3.00097-1 · Cited by 29
Self-citation
Acute effects of different types of cannabis on young adult and adolescent resting-state brain networks
Ertl, N., Freeman, T. P., Mokrysz, C., Ofori, S., Borissova, A., Petrilli, K., Curran, H. V., Lawn, W., & Wall, M. B. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01891-6 · Cited by 26
Cannabinoids and endocannabinoids as therapeutics for nervous system disorders: preclinical models and clinical studies
Duncan, R. S., Riordan, S. M., Gernon, M. C., & Koulen, P. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382220 · Cited by 30
Acute Effects of Methylphenidate, Modafinil, and MDMA on Negative Emotion Processing
Schmidt, A., Müller, F., Dolder, P. C., Schmid, Y., Zanchi, D., Egloff, L., Liechti, M. E., & Borgwardt, S. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx112 · Cited by 24
Self-citation
The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data
Gouvêa, E. S., Filho, A. F. D. S., Ota, V., Mrad, V. C., Gadelha, A., Bressan, R. A., Cordeiro, Q., & Belangero, S. I. (2017) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2016-1969 · Cited by 25
Recommendation to reconsider examining cannabis subtypes together due to opposing effects on brain, cognition and behavior.
Rømer Thomsen, K., Callesen, M. B., & Feldstein Ewing, S. W. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.025 · Cited by 24
Urinary cannabinoid levels during nabiximols (Sativex®)-medicated inpatient cannabis withdrawal.
Kevin, R. C., Allsop, D. J., Lintzeris, N., Dunlop, A. J., Booth, J., & McGregor, I. S. (2017) · Forensic Toxicology · doi:10.1007/s11419-016-0330-0 · Cited by 24
Brain endocannabinoid signaling exhibits remarkable complexity
Gorzkiewicz, A., & Szemraj, J. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.06.012 · Cited by 26
The acute effects of cannabidiol on emotional processing and anxiety: a neurocognitive imaging study
Bloomfield, M., Yamamori, Y., Hindocha, C., Jones, A., Yim, J. L., Walker, H. R., Statton, B. K., Wall, M. B., Lees, R., Howes, O. D., et al. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06070-3 · Cited by 30
Cannabidiol in clinical and preclinical anxiety research. A systematic review into concentration–effect relations using the IB-de-risk tool
Kwee, C., van Gerven, J., Bongaerts, F. L. P., Cath, D. C., Jacobs, G. E., Baas, J. M. P., & Groenink, L. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811221124792 · Cited by 27
Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect
Rabinak, C. A., Sripada, C., Angstadt, M., de Wit, H., & Phan, K. L. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0747-x · Cited by 26
Cannabidiol has a unique effect on global brain activity: a pharmacological, functional MRI study in awake mice
Sadaka, A. H., Ozuna, A. G., Ortiz, R. J., Kulkarni, P., Johnson, C. T., Bradshaw, H. B., Cushing, B. S., Li, A.-L., Hohmann, A. G., & Ferris, C. F. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02891-6 · Cited by 24
Anxiolytic effects of endocannabinoid enhancing compounds: A systematic review and meta-analysis
Kwee, C., Leen, N. A., der Kamp, R. C. V., Lissa, C. J. V., Cath, D. C., Groenink, L., & Baas, J. M. P. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.04.001 · Cited by 24
CBD enhances the cognitive score of adolescent rats prenatally exposed to THC and fine-tunes relevant effectors of hippocampal plasticity
Castelli, V., Lavanco, G., D’Amico, C., Feo, S., Tringali, G., Kuchař, M., Cannizzaro, C., & Brancato, A. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1237485 · Cited by 23
Acute effects of delta-9-tetrahydrocannabinol on performance monitoring in healthy volunteers
Spronk, D. B. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00059 · Cited by 24
Marijuana use in adults admitted to a Canadian epilepsy monitoring unit
Massot‐Tarrús, A., & McLachlan, R. S. (2016) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2016.08.002 · Cited by 23
Cannabidiol in Foods and Food Supplements: Evaluation of Health Risks and Health Claims
Engeli, B. E., Lachenmeier, D. W., Diel, P. R., Guth, S., Villar-Fernandez, M., Roth, A., Lampen, A., Cartus, A. T., Wätjen, W., Hengstler, J. G., et al. (2025) · Nutrients · doi:10.3390/nu17030489 · Cited by 23
Intrinsic Frontolimbic Connectivity and Mood Symptoms in Young Adult Cannabis Users
Shollenbarger, S. G., Thomas, A. M., Wade, N. E., Gruber, S. A., Tapert, S. F., Filbey, F. M., & Lisdahl, K. M. (2019) · Frontiers in Public Health · doi:10.3389/fpubh.2019.00311 · Cited by 24
Cannabis sativa L. (var. indica) Exhibits Hepatoprotective Effects by Modulating Hepatic Lipid Profile and Mitigating Gluconeogenesis and Cholinergic Dysfunction in Oxidative Hepatic Injury
Erukainure, O. L., Matsabisa, M. G., Salau, V. F., Oyedemi, S. O., Oyenihi, O. R., Ibeji, C. U., & Islam, M. S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.705402 · Cited by 22
The Mood Boost from Tobacco Cigarettes is More Erratic with the Additions of Cannabis and Alcohol
Kendall, A. D., Hedeker, D., Diviak, K. R., & Mermelstein, R. J. (2022) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntac001 · Cited by 22
The Impact of Cannabis Use on Cognition in People with HIV: Evidence of Function-Dependent Effects and Mechanisms from Clinical and Preclinical Studies
Ayoub, S. M., Holloway, B. M., Miranda, A. H., Roberts, B. Z., Young, J. W., Minassian, A., & Ellis, R. J. (2024) · Current HIV/AIDS Reports · doi:10.1007/s11904-024-00698-w · Cited by 22
Neuroanatomical substrates involved in cannabinoid modulation of defensive responses
Moreira, F. A., Aguiar, D., Resstel, L. B. M., Lisboa, S. F. D. S., Campos, A. C., Gomes, F. V., & Guimarães, F. S. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111400651 · Cited by 24
Made from concentrate? A national web survey assessing dab use in the United States
Sagar, K. A., Lambros, A. M., Dahlgren, M. K., Smith, R. T., & Gruber, S. A. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.05.022 · Cited by 22
Temporal Changes in the Cross-Sectional Associations between Cannabis Use, Suicidal Ideation, and Depression in a Nationally Representative Sample of Canadian Adults in 2012 Compared to 2002
Halladay, J. E., Munn, C., Boyle, M., Jack, S. M., & Georgiades, K. (2019) · The Canadian Journal of Psychiatry · doi:10.1177/0706743719854071 · Cited by 22
Cannabis: The never-ending, nefarious nepenthe of the 21st century: What should the clinician know?
Greydanus, D. E., Kaplan, G., Baxter, L. E., Patel, D. R., & Feucht, C. L. (2015) · Disease-a-Month · doi:10.1016/j.disamonth.2015.01.004 · Cited by 22
Medicinal herbal remedies in neurodegenerative diseases: an update on antioxidant potential
Sarkar, B., Rana, N., Singh, C., & Singh, A. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03027-5 · Cited by 26
The effect of cannabidiol on simulated car driving performance: A randomised, double‐blind, placebo‐controlled, crossover, dose‐ranging clinical trial protocol
McCartney, D., Benson, M. J., Suraev, A. S., Irwin, C. G., Arkell, T. R., Grunstein, R. R., Hoyos, C. M., & McGregor, I. S. (2020) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2749 · Cited by 21
A systematic review of neuroimaging and acute cannabis exposure in age-of-risk for psychosis
Cupo, L., Plitman, E., Guma, E., & Chakravarty, M. M. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01295-w · Cited by 21
A Double-Blind, Randomized, Placebo-Controlled Test of the Effects of Cannabidiol on Experiences of Test Anxiety Among College Students
Stanley, T. B., Ferretti, M. L., Bonn‐Miller, M. O., & Irons, J. G. (2022) · Cannabis and Cannabinoid Research · doi:10.1089/can.2022.0062 · Cited by 23
Cannabidiol and its Potential Evidence-Based Psychiatric Benefits – A Critical Review
Dammann, I., Rohleder, C., & Leweke, F. M. (2024) · Pharmacopsychiatry · doi:10.1055/a-2228-6118 · Cited by 24
The acute effects of cannabidiol on the neural correlates of reward anticipation and feedback in healthy volunteers
Lawn, W., Hill, J., Hindocha, C., Yim, J. L., Yamamori, Y., Jones, G., Walker, H. R., Green, S. F., Wall, M. B., Howes, O. D., et al. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120944148 · Cited by 20
How do stupendous cannabinoids modulate memory processing via affecting neurotransmitter systems?
Vaseghi, S., Nasehi, M., & Zarrindast, M. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.018 · Cited by 21
Archaeobotanical evidence of the use of medicinal cannabis in a secular context unearthed from south China
Bai, Y., Jiang, M., Xie, T., Jiang, C., Gu, M., Zhou, X., Yan, X., Yuan, Y., & Huang, L. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114114 · Cited by 20
Adjunctive Management of Opioid Withdrawal with the Nonopioid Medication Cannabidiol
Kudrich, C., Hurd, Y. L., Salsitz, E. A., & Wang, A. (2021) · Cannabis and Cannabinoid Research · doi:10.1089/can.2021.0089 · Cited by 21
Cannabidiol and cannabis-inspired terpene blends have acute prosocial effects in the BTBR mouse model of autism spectrum disorder
Staben, J., Koch, M., Reid, K., Muckerheide, J., Gilman, L., McGuinness, F., Kiesser, S., Oswald, I. W. H., Koby, K. A., Martin, T. J., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1185737 · Cited by 23
Cannabis, e-cigarettes and anesthesia
Lynn, R. R., & Galinkin, J. L. (2020) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000872 · Cited by 23
Medical Cannabis for Chronic Noncancer Pain: A Systematic Review of Health Care Recommendations
Chang, Y., Zhu, M., Vannabouathong, C., Mundi, R., Chou, R. S., & Bhandari, M. (2021) · Pain Research and Management · doi:10.1155/2021/8857948 · Cited by 20
Anterior cingulate volume reductions in abstinent adolescent and young adult cannabis users: Association with affective processing deficits
Maple, K. E., Thomas, A. M., Kangiser, M. M., & Lisdahl, K. M. (2019) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2019.04.011 · Cited by 22
Interaction of Cannabis Use and Aging: From Molecule to Mind
Yoo, H. B., DiMuzio, J. M., & Filbey, F. M. (2019) · Journal of Dual Diagnosis · doi:10.1080/15504263.2019.1665218 · Cited by 21
Harm to Others from Substance Use and Abuse: The Underused Potential in Nationwide Registers
Lund, I. O., & Bukten, A. (2015) · Substance Abuse Research and Treatment · doi:10.4137/sart.s23545 · Cited by 18
Delta-9-tetrahydrocannabinol intoxication is associated with increased prefrontal activation as assessed with functional near-infrared spectroscopy: A report of a potential biomarker of intoxication
Gilman, J. M., Yücel, M. A., Pachas, G. N., Potter, K. W., Levar, N., Broos, H. C., Manghis, E. M., Schuster, R. M., & Evins, A. E. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.05.012 · Cited by 19
Altered relationship between cortisol response to social stress and mediotemporal function during fear processing in people at clinical high risk for psychosis: a preliminary report
Davies, C., Appiah‐Kusi, E., Wilson, R. P., Blest‐Hopley, G., Bossong, M. G., Valmaggia, L., Brammer, M. J., Pérez, J., Allen, P., Murray, R. M., et al. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01318-z · Cited by 18
Self-citation
The Vulnerability to Schizophrenia Mainstream Research Paradigms and Phenomenological Directions
Stanghellini, G., & Fusar‐Poli, P. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799316109 · Cited by 18
Self-citation
The effects of Cannabidiol (CBD) and Delta-9-Tetrahydrocannabinol (THC) on the recognition of emotions in facial expressions: A systematic review of randomized controlled trials
Rossi, G. N., Osório, F. D. L., Morgan, C. J. A., Crippa, J. A. S., Bouso, J. C., Rocha, J. M., Zuardi, A. W., Hallak, J. E. C., & SANTOS, R. G. D. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.034 · Cited by 17
Self-citation
Systematic literature review of human studies assessing the efficacy of cannabidiol for social anxiety
Fliegel, D. K., & Lichenstein, S. D. (2022) · Psychiatry Research Communications · doi:10.1016/j.psycom.2022.100074 · Cited by 20
Using Functional Near-Infrared Spectroscopy to Measure Effects of Delta 9-Tetrahydrocannabinol on Prefrontal Activity and Working Memory in Cannabis Users
Keleş, H. O., Radoman, M., Pachas, G. N., Evins, A. E., & Gilman, J. M. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00488 · Cited by 19
THC and endocannabinoids differentially regulate neuronal activity in the prefrontal cortex and hippocampus in the subchronic PCP model of schizophrenia
Aguilar, D. D., Giuffrida, A., & Lodge, D. J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115612239 · Cited by 16
Modulation of the Endocannabinoid and Oxytocinergic Systems as a Potential Treatment Approach for Social Anxiety Disorder
SANTOS, R. G. D., Osório, F. D. L., Martín‐Santos, R., Zuardi, A. W., Hallak, J. E. C., & Crippa, J. A. S. (2019) · CNS Drugs · doi:10.1007/s40263-019-00669-5 · Cited by 17
Self-citation
Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters
Crippa, J. A. S., Pereira, L. C., Pereira, L. C., Zimmermann, P. M. D. R., Brum, L., Rechia, L. M., Dias, I. C. D. S., Hallak, J. E. C., Campos, A. C., Guimarães, F. S., et al. (2021) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2020-1684 · Cited by 16
Self-citation
Modulation of cognitive and emotional processing by cannabidiol: the role of the anterior cingulate cortex
Kowal, M. A., Hazekamp, A., Colzato, L. S., van Steenbergen, H., & Hommel, B. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00147 · Cited by 16
Arachidonoyl serotonin (AA-5-HT) modulates general fear-like behavior and inhibits mesolimbic dopamine release
Freels, T. G., Lester, D. B., & Cook, M. N. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.01.010 · Cited by 15
The effects of pelleted cannabidiol supplementation on heart rate and reaction scores in horses
Draeger, A. L., Thomas, E. P., Jones, K. A., Davis, A. J., & Porr, C. A. S. (2021) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2021.09.003 · Cited by 19
Diversity and variability of bioactive compounds in Cannabis sativa: Effects on therapeutic and environmental uses and orientations for future research
Oihabi, M. E., Soultana, M., Ammari, M., Allal, L. B., & Lanjri, A. F. (2024) · Case Studies in Chemical and Environmental Engineering · doi:10.1016/j.cscee.2024.100732 · Cited by 16
Exploring the safety of cannabidiol (CBD): A comprehensive in vitro evaluation of the genotoxic and mutagenic potential of a CBD isolate and extract from Cannabis sativa L
Štern, A., Novak, M., Kološa, K., Trontelj, J., Žabkar, S., Šentjurc, T., Filipič, M., & Žegura, B. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116969 · Cited by 15
Overlapping Mechanisms of Stress-Induced Relapse to Opioid Use Disorder and Chronic Pain: Clinical Implications
Ghitza, U. E. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00080 · Cited by 15
Adolescent Cannabis Use and Conduct Problems: the Mediating Influence of Callous-Unemotional Traits
Hawes, S. W., Pacheco‐Colón, I., Ross, J. M., & González, R. (2018) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-018-9958-9 · Cited by 15
Cannabidiol for at risk for psychosis youth: A randomized controlled trial
Amminger, G. P., Lin, A. P., Kerr, M., Weller, A., Spark, J., Pugh, C., O’Callaghan, S., Berger, M., Clark, S. R., Scott, J. G., et al. (2021) · Early Intervention in Psychiatry · doi:10.1111/eip.13182 · Cited by 17
Cannabinoids for the treatment of cannabis use disorder: New avenues for reaching and helping youth?
Thomsen, K. R., Thylstrup, B., Kenyon, E. A., Lees, R., Baandrup, L., Ewing, S. W. F., & Freeman, T. P. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.033 · Cited by 15
Cannabis sativa L. Mitigates Oxidative Stress and Cholinergic Dysfunction; and Modulates Carbohydrate Metabolic Perturbation in Oxidative Testicular Injury
Erukainure, O. L., Matsabisa, M. G., Salau, V. F., Erhabor, J. O., & Islam, M. S. (2021) · Comparative Clinical Pathology · doi:10.1007/s00580-021-03200-9 · Cited by 15
Neurofunctional changes in adolescent cannabis users with and without bipolar disorder
Bitter, S. M., Adler, C. M., Eliassen, J. C., Weber, W. A., Welge, J. A., Burciaga, J., Shear, P. K., Strakowski, S. M., & DelBello, M. P. (2014) · Addiction · doi:10.1111/add.12668 · Cited by 15
Computational identification of potential microRNAs and their targets from expressed sequence tags of marijuana ( Cannabis sativa )
Hasan, M. A., Hussain, M. H., Chowdhury, A. S., Dhar, S. B., Abedin, M., & Fima, I. N. (2016) · Meta Gene · doi:10.1016/j.mgene.2016.10.002 · Cited by 14

Authors: Fusar-Poli, P., Crippa, J. A., Bhattacharyya, S., Borgwardt, S. J., Allen, P., Martin-Santos, R., Seal, M., Surguladze, S. A., O’Carrol, C., Atakan, Z., Zuardi, A. W., & McGuire, P. K.
Affiliations: The University of Melbourne (AU)
King's College London (GB)
ORCID: Bhattacharyya, Sagnik
Borgwardt, Stefan J.
Allen, Paul
Seal, Marc
Atakan, Zerrin
McGuire, Philip K.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2009-01-01
Volume: 66
Issue: 1
Pages: 95
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archgenpsychiatry.2008.519
OpenAlex: W1967735252
Cited by: 465
References: 111
Citations by year: 2026: 11 · 2025: 14 · 2024: 24 · 2023: 31 · 2022: 22 · 2021: 43 · 2020: 43 · 2019: 27 · 2018: 30 · 2017: 35 · 2016: 23 · 2015: 28 · 2014: 21 · 2013: 19 · 2012: 37
FWCI: 22.12
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (publishedVersion, other-oa)
Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
Funders: Psychiatry Research Trust
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Medical Research Council
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
Keywords: delta-9-tetrahydrocannabinol, cannabidiol, cannabis, anxiety, emotional processing, fearful faces, amygdala, anterior cingulate cortex, posterior cingulate cortex, skin conductance response, autonomic arousal, brain activation, anxiogenic effects, anxiolytic effects
MeSH terms: Adult, Amygdala, Anxiety, Arousal, Brain, Cannabidiol, Double-Blind Method, Emotions, Facial Expression, Fear, Frontal Lobe, Galvanic Skin Response, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Parietal Lobe, Pattern Recognition, Visual, Psychiatric Status Rating Scales, Psychoses, Substance-Induced, Psychotropic Drugs, Dronabinol, Parahippocampal Gyrus, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks