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Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing
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CONTEXT: Cannabis use can both increase and reduce anxiety in humans. The neurophysiological substrates of these effects are unknown. OBJECTIVE: To investigate the effects of 2 main psychoactive constituents of Cannabis sativa (Delta9-tetrahydrocannabinol [Delta9-THC] and cannabidiol [CBD]) on regional brain function during emotional processing. DESIGN: Subjects were studied on 3 separate occasions using an event-related functional magnetic resonance imaging paradigm while viewing faces that implicitly elicited different levels of anxiety. Each scanning session was preceded by the ingestion of either 10 mg of Delta9-THC, 600 mg of CBD, or a placebo in a double-blind, randomized, placebo-controlled design. PARTICIPANTS: Fifteen healthy, English-native, right-handed men who had used cannabis 15 times or less in their life. MAIN OUTCOME MEASURES: Regional brain activation (blood oxygenation level-dependent response), electrodermal activity (skin conductance response [SCR]), and objective and subjective ratings of anxiety. RESULTS: Delta9-Tetrahydrocannabinol increased anxiety, as well as levels of intoxication, sedation, and psychotic symptoms, whereas there was a trend for a reduction in anxiety following administration of CBD. The number of SCR fluctuations during the processing of intensely fearful faces increased following administration of Delta9-THC but decreased following administration of CBD. Cannabidiol attenuated the blood oxygenation level-dependent signal in the amygdala and the anterior and posterior cingulate cortex while subjects were processing intensely fearful faces, and its suppression of the amygdalar and anterior cingulate responses was correlated with the concurrent reduction in SCR fluctuations. Delta9-Tetrahydrocannabinol mainly modulated activation in frontal and parietal areas. CONCLUSIONS: Delta9-Tetrahydrocannabinol and CBD had clearly distinct effects on the neural, electrodermal, and symptomatic response to fearful faces. The effects of CBD on activation in limbic and paralimbic regions may contribute to its ability to reduce autonomic arousal and subjective anxiety, whereas the anxiogenic effects of Delta9-THC may be related to effects in other brain regions.
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“Moreover, CBD has shown to disrupt forward intrinsic connectivity between the amygdala and the anterior cingulate during the neural response to fearful faces (Fusar-Poli et al, 2009b).”
From Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients (2011) · cites this paper as Fusar-Poli et al, 2009b
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“CBD (600 mg) modulated the patterns of brain activity while subjects processed stimuli depicting intensely fearful faces, attenuating responses in the anterior and posterior cingulate and amygdala.”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [60]
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Cites
(1970) · Cited by 24,983
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
An Improved Diagnostic Evaluation Instrument for Substance Abuse Patients
McLellan, A. T., Luborsky, L. B., WOODY, G. E., & Brien, C. P. O. (1980) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198001000-00006 · Cited by 3,163
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360
A differential neural response in the human amygdala to fearful and happy facial expressions
Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/383812a0 · Cited by 2,013
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728
Response and Habituation of the Human Amygdala during Visual Processing of Facial Expression
Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., Strauss, M. M., Hyman, S. E., & Rosen, B. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80219-6 · Cited by 1,711
Conscious and unconscious emotional learning in the human amygdala
Morris, J. S., Öhman, A., & Dolan, R. J. (1998) · Nature · doi:10.1038/30976 · Cited by 1,665
Research works printed but not linked: 1
- Young, 2002, Facial Expressions of Emotion: Stimuli and Tests (FEEST)
Cited by
Sorted by citations
Items 101–200 of 466
Anormalidades cognitivas no uso da cannabis
Solowij, N., & Pesa, N. (2010) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462010000500006 · Cited by 91
A marijuana-drug interaction primer: Precipitants, pharmacology, and pharmacokinetics
Cox, E. J., Maharao, N. V., Patilea-Vrana, G., Unadkat, J. D., Rettie, A. E., McCune, J. S., & Paine, M. F. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.001 · Cited by 91
Cannabidiol does not display drug abuse potential in mice behavior
Viudez‐Martínez, A., García‐Gutiérrez, M. S., Medrano-Relinque, J., Navarrón, C. M., Navarrete, F., & Manzanares, J. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0032-8 · Cited by 92
Gobira, P. H., Vilela, L. R., Gonçalves, B. D. C., Santos, R. P. M., de Oliveira, A. C., Vieira, L. B., Aguiar, D. C., Crippa, J. A., & Moreira, F. A. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.08.007 · Cited by 89
Self-citationTambaro, S., & Bortolato, M. (2011) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488912798842269 · Cited by 93
Bossong, M. G., van Hell, H. H., Jager, G., Kahn, R. S., Ramsey, N. F., & Jansma, J. M. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.06.009 · Cited by 99
Réus, G. Z., Stringari, R. B., Ribeiro, K. F., Luft, T., Abelaira, H. M., Fries, G. R., Aguiar, B. W., Kapczinski, F., Hallak, J. E., Zuardi, A. W., et al. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00579.x · Cited by 86
Self-citationEvidence for Use of Cannabinoids in Mood Disorders, Anxiety Disorders, and PTSD: A Systematic Review
Stanciu, C. N., Brunette, M. F., Teja, N., & Budney, A. J. (2021) · Psychiatric Services · doi:10.1176/appi.ps.202000189 · Cited by 94
Endocannabinoids, cannabinoids and the regulation of anxiety
Petrie, G. N., Nastase, A. S., Aukema, R. J., & Hill, M. N. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108626 · Cited by 91
Uso terapêutico dos canabinoides em psiquiatria
Crippa, J. A. S., Zuardi, A. W., & Hallak, J. E. C. (2010) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462010000500009 · Cited by 93
Self-citationCannabis use and cognition in schizophrenia
Løberg, E. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.053.2009 · Cited by 85
Zuardi, A. W., Hallak, J. E. C., & Crippa, J. A. S. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2495-x · Cited by 84
Self-citationWright, M., Ciano, P. D., & Brands, B. (2020) · Cannabis and Cannabinoid Research · doi:10.1089/can.2019.0052 · Cited by 87
Neuropharmacological Effects of the Main Phytocannabinoids: A Narrative Review
SANTOS, R. G. D., Hallak, J. E. C., & Crippa, J. A. S. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-57369-0_3 · Cited by 82
Self-citationHeterogeneity in the composition of marijuana seized in California
Burgdorf, J. R., Kilmer, B., & Pacula, R. L. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.11.031 · Cited by 81
Acute effects of cannabinoids on symptoms of obsessive‐compulsive disorder: A human laboratory study
Kayser, R. R., Haney, M., Raskin, M., Arout, C. A., & Simpson, H. B. (2020) · Depression and Anxiety · doi:10.1002/da.23032 · Cited by 87
Valvassori, S. S., Elias, G., de Souza, B., Petronilho, F., Dal-Pizzol, F., Kapczinski, F., Trzesniak, C., Tumas, V., Dursun, S., Nisihara Chagas, M. H., et al. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881109106925 · Cited by 80
Self-citationInvolvement of the endocannabinoid system in reward processing in the human brain
van Hell, H. H., Jager, G., Bossong, M. G., Brouwer, A., Jansma, J. M., Zuurman, L., van Gerven, J., Kahn, R. S., & Ramsey, N. F. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2428-8 · Cited by 77
Bourque, J., & Potvin, S. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.596601 · Cited by 96
Steenkamp, M. M., Blessing, E., Galatzer‐Levy, I. R., Hollahan, L., & Anderson, W. T. (2017) · Depression and Anxiety · doi:10.1002/da.22596 · Cited by 80
Withdrawal from THC during adolescence: Sex differences in locomotor activity and anxiety
Harte‐Hargrove, L. C., & Dow-Edwards, D. L. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.02.048 · Cited by 73
Bhattacharyya, S., Egerton, A., Kim, E., Rosso, L., Barros, D. A. R., Hammers, A., Brammer, M. J., Turkheimer, F., Howes, O. D., & McGuire, P. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-14203-4 · Cited by 73
Self-citationMcCartney, D., Benson, M. J., Desbrow, B., Irwin, C. G., Suraev, A. S., & McGregor, I. S. (2020) · Sports Medicine - Open · doi:10.1186/s40798-020-00251-0 · Cited by 79
The effects of cannabidiol on persecutory ideation and anxiety in a high trait paranoid group
Hundal, H., Lister, R., Evans, N., Antley, A., Englund, A., Murray, R. M., Freeman, D. H., & Morrison, P. D. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117737400 · Cited by 70
Neuronal populations mediating the effects of endocannabinoids on stress and emotionality
Häring, M., Guggenhuber, S., & Lutz, B. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.035 · Cited by 72
Turna, J., Simpson, W. S., Patterson, B. A., Lucas, P., & Ameringen, M. V. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.01.024 · Cited by 69
Dellazizzo, L., Potvin, S., Athanassiou, M., & Dumais, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.567887 · Cited by 72
The Impact of Cannabidiol on Human Brain Function: A Systematic Review
Batalla, A., Bos, J., Postma, A., & Bossong, M. G. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.618184 · Cited by 75
Platt, B., Kamboj, S. K., Morgan, C. J. A., & Curran, H. V. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.05.004 · Cited by 76
van Leeuwen, A. P., Creemers, H. E., Greaves‐Lord, K., Verhulst, F. C., Ormel, J., & Huizink, A. C. (2011) · Addiction · doi:10.1111/j.1360-0443.2011.03448.x · Cited by 66
Mason, N. L., Theunissen, E. L., Hutten, N. R. P. W., Tse, D. H. Y., Toennes, S. W., Stiers, P. L. J., & Ramaekers, J. G. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.12.003 · Cited by 64
Campos, A. C., de Paula Soares, V., Carvalho, M. C., Ferreira, F. R., Vicente, M. A., Brandão, M. L., Zuardi, A. W., Zangrossi, H., & Guimarães, F. S. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2878-7 · Cited by 65
Self-citationEffects of cannabidiol plus naltrexone on motivation and ethanol consumption
Viudez‐Martínez, A., García‐Gutiérrez, M. S., Fraguas‐Sánchez, A. I., Torres‐Suárez, A. I., & Manzanares, J. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14380 · Cited by 68
Cannabidiol: Swinging the Marijuana Pendulum From ‘Weed’ to Medication to Treat the Opioid Epidemic
Hurd, Y. L. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2016.12.006 · Cited by 64
Impact of Cannabis Use on Male Sexual Health
Shamloul, R. M., & Bella, A. J. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.02198.x · Cited by 64
Haney, M., & Evins, A. E. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.251 · Cited by 67
Adverse Structural and Functional Effects of Marijuana on the Brain: Evidence Reviewed
Mandelbaum, D. E., & de la Monte, S. M. (2016) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2016.09.004 · Cited by 66
Acute Effects of Marijuana Smoking on Negative and Positive Affect
Metrik, J., Kahler, C. W., McGeary, J. E., Monti, P. M., & Rohsenow, D. J. (2011) · Journal of Cognitive Psychotherapy · doi:10.1891/0889-8391.25.1.31 · Cited by 67
Elsebai, M. F., Rempel, V., Schnakenburg, G., Kehraus, S., Müller, C. E., & König, G. M. (2011) · ACS Medicinal Chemistry Letters · doi:10.1021/ml200183z · Cited by 61
van Hell, H. H., Bossong, M. G., Jager, G., Kristo, G., van Osch, M. J. P., Zelaya, F. O., Kahn, R. S., & Ramsey, N. F. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000526 · Cited by 63
The neuropharmacology of cannabinoid receptor ligands in central signaling pathways
Brunt, T. M., & Bossong, M. G. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14982 · Cited by 67
Mastinu, A., Premoli, M., Ferrari‐Toninelli, G., Tambaro, S., Maccarinelli, G., Memo, M., & Bonini, S. A. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0013 · Cited by 62
Psychobiological responses to unpleasant emotions in cannabis users
Somaini, L., Manfredini, M., Amore, M., Zaimovic, A., Raggi, M. A., Leonardi, C., Gerra, M. L., Donnini, C., & Gerra, G. (2011) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-011-0223-5 · Cited by 64
Vlachou, S., & Panagis, G. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990433 · Cited by 62
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Stone, J. M. (2011) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125311400779 · Cited by 60
Grimm, O., Löffler, M., Kamping, S., Hartmann, A., Rohleder, C., Leweke, F. M., & Flor, H. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.04.004 · Cited by 62
Bossong, M. G., Jansma, J. M., Bhattacharyya, S., & Ramsey, N. F. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.11.017 · Cited by 62
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Jurkus, R., Day, H. L. L., Guimarães, F. S., Lee, J. L. C., Bertoglio, L. J., & Stevenson, C. W. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00454 · Cited by 60
Cahill, S. P., Lunn, S. E., Diaz, P. L., & Page, J. E. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.626853 · Cited by 56
Rabinak, C. A., Blanchette, A., Zabik, N. L., Peters, C., Marusak, H. A., Iadipaolo, A. S., & Elrahal, F. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05499-8 · Cited by 57
The therapeutic potential of purified cannabidiol
O’Sullivan, S. E., Jensen, S. S., Nikolajsen, G. N., Bruun, H. Z., Bhuller, R., & Hoeng, J. (2023) · Journal of Cannabis Research · doi:10.1186/s42238-023-00186-9 · Cited by 61
Saha, S., Scott, J. G., Varghese, D., Degenhardt, L. J., Slade, T. N., & McGrath, J. J. (2011) · BMC Psychiatry · doi:10.1186/1471-244x-11-202 · Cited by 58
Atakan, Z., Bhattacharyya, S., Allen, P., Martín‐Santos, R., Crippa, J. A. S., Borgwardt, S., Fusar‐Poli, P., Seal, M. L., Sallis, H., Stahl, D. R., et al. (2012) · Psychological Medicine · doi:10.1017/s0033291712001924 · Cited by 56
Self-citationTwardowschy, A., Castiblanco-Urbina, M. A., Uribe-Mariño, A., Biagioni, A. F., Salgado-Rohner, C. J., Crippa, J. A. S., & Coimbra, N. C. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113493363 · Cited by 56
Self-citationAudu, B. S., Ofojekwu, P. C., Ujah, A., & Ajima, M. N. O. (2014) · The Journal of Phytopharmacology · doi:10.31254/phyto.2014.3106 · Cited by 53
Rapp, C., Bugra, H., Riecher‐Rössler, A., Tamagni, C., & Borgwardt, S. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802884861 · Cited by 56
Self-citationThe Endocannabinoid System and Anxiety
Lisboa, S. F. D. S., Gomes, F. V., Terzian, A. L. B., de Aguiar, D. C., Moreira, F. A., Resstel, L. B. M., & Guimarães, F. S. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2016.09.006 · Cited by 56
Kamal, B., Kamal, F., & Lantela, D. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00730 · Cited by 59
Fonzo, G. A. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.10.002 · Cited by 58
Babson, K. A., & Bonn‐Miller, M. O. (2014) · Current Addiction Reports · doi:10.1007/s40429-014-0016-9 · Cited by 54
van Winkel, R., & Kuepper, R. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153631 · Cited by 56
Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults
Arndt, D. L., & de Wit, H. (2017) · Cannabis and Cannabinoid Research · doi:10.1089/can.2017.0014 · Cited by 55
Genaro, K., Fabris, D., Arantes, A. L. F., Zuardi, A. W., Crippa, J. A. S., & Prado, W. A. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00391 · Cited by 55
Self-citationEffects of delta-9-tetrahydrocannabinol on evaluation of emotional images
Ballard, M. E., Bedi, G., & de Wit, H. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112446530 · Cited by 60
The Impact of Cannabidiol on Psychiatric and Medical Conditions
Oberbarnscheidt, T., & Miller, N. S. (2020) · Journal of Clinical Medicine Research · doi:10.14740/jocmr4159 · Cited by 55
Dey, A., & De, J. N. (2015) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2015.01.002 · Cited by 52
Gene-Environment Interactions Underlying the Effect of Cannabis in First Episode Psychosis
Pelayo‐Terán, J. M., Suárez‐Pinilla, P., Chadi, N., & Crespo‐Facorro, B. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802884609 · Cited by 51
Patrician, A., Bratinčević, M. V., Mijačika, T., Banić, I., Marendić, M., Sutlović, D., Dujić, Ž., & Ainslie, P. N. (2019) · Advances in Therapy · doi:10.1007/s12325-019-01074-6 · Cited by 51
Terminology and assessment tools of psychosis: A systematic narrative review
Seiler, N., Nguyen, T., Yung, A. R., & O'Donoghue, B. N. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12966 · Cited by 53
Kwee, C., Baas, J. M. P., van der Flier, F. E., Groenink, L., Duits, P., Eikelenboom, M., van der Veen, D. C., Moerbeek, M., Batelaan, N. M., van Balkom, A. J. L. M., et al. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.04.003 · Cited by 50
Heitzeg, M. M., Cope, L. M., Martz, M. E., Hardee, J. E., & Zucker, R. A. (2015) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.09.003 · Cited by 54
Evidences for the Anti-panic Actions of Cannabidiol
Soares-Rachetti, V. D. P., & Campos, A. C. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160509123955 · Cited by 52
Therapeutic potential and safety considerations for the clinical use of synthetic cannabinoids
Sholler, D. J., Huestis, M. A., Amendolara, B., Vandrey, R. G., & Cooper, Z. D. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.173059 · Cited by 50
Cannabis and cognition: short- and long-term effects
Solowij, N., & Pesa, N. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511706080.009 · Cited by 47
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Hahn, B. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx105 · Cited by 52
Leweke, F. M., Mueller, J. K., Lange, B., Fritze, S., Topor, C. E., Koethe, D., & Rohleder, C. (2018) · CNS Drugs · doi:10.1007/s40263-018-0539-z · Cited by 48
The endocannabinoid system as a target for modelling psychosis
Koethe, D., Hoyer, C., & Leweke, F. M. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1591-7 · Cited by 47
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Pintori, N., Caria, F., Luca, M. A. D., & Miliano, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065251 · Cited by 50
Rabinak, C. A., & Phan, K. L. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990437 · Cited by 49
Abnormalities in neuroendocrine stress response in psychosis: the role of endocannabinoids
Appiah‐Kusi, E., Leyden, E., Parmar, S. R., Mondelli, V., McGuire, P. K., & Bhattacharyya, S. (2015) · Psychological Medicine · doi:10.1017/s0033291715001786 · Cited by 46
Self-citationBidirectional Effects of Cannabidiol on Contextual Fear Memory Extinction
Song, C., Stevenson, C. W., Guimarães, F. S., & Lee, J. L. C. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00493 · Cited by 48
Is there a role for cannabidiol in psychiatry?
Khoury, J. M., das Neves, M. D. C. L., Roque, M. A. V., Queiroz, D. A. D. B., de Freitas, A. A. C., de Fátima, Â., Moreira, F. A., & Garcia, F. D. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1285049 · Cited by 45
Gender differences in the effects of cannabidiol on ethanol binge drinking in mice
Viudez‐Martínez, A., García‐Gutiérrez, M. S., & Manzanares, J. (2019) · Addiction Biology · doi:10.1111/adb.12765 · Cited by 44
Arnold, J. C., Boucher, A. A., & Karl, T. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802884726 · Cited by 45
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Self-citation
Metadata
- Authors
- Fusar-Poli, P., Crippa, J. A., Bhattacharyya, S., Borgwardt, S. J., Allen, P., Martin-Santos, R., Seal, M., Surguladze, S. A., O’Carrol, C., Atakan, Z., Zuardi, A. W., & McGuire, P. K.
- Affiliations
- The University of Melbourne (AU)
- King's College London (GB)
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2009-01-01
- Volume
- 66
- Issue
- 1
- Pages
- 95
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W1967735252
- Cited by
- 465
- References
- 111
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 24 · 2023: 31 · 2022: 22 · 2021: 43 · 2020: 43 · 2019: 27 · 2018: 30 · 2017: 35 · 2016: 23 · 2015: 28 · 2014: 21 · 2013: 19 · 2012: 37
- FWCI
- 22.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Funders
- Psychiatry Research Trust
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Medical Research Council
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- delta-9-tetrahydrocannabinol, cannabidiol, cannabis, anxiety, emotional processing, fearful faces, amygdala, anterior cingulate cortex, posterior cingulate cortex, skin conductance response, autonomic arousal, brain activation, anxiogenic effects, anxiolytic effects
- MeSH terms
- Adult, Amygdala, Anxiety, Arousal, Brain, Cannabidiol, Double-Blind Method, Emotions, Facial Expression, Fear, Frontal Lobe, Galvanic Skin Response, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Parietal Lobe, Pattern Recognition, Visual, Psychiatric Status Rating Scales, Psychoses, Substance-Induced, Psychotropic Drugs, Dronabinol, Parahippocampal Gyrus, Young Adult
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