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Cited by 249Attention Deficit Hyperactivity DisorderHemispheric Asymmetry in NeuroscienceAutism Spectrum Disorder Research

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Development of Cortical Asymmetry in Typically Developing Children and Its Disruption in Attention-Deficit/Hyperactivity Disorder

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Shaw, Philip, Lalonde, Francois, Lepage, Claude, Rabin, Cara, Eckstrand, Kristen, Sharp, Wendy, Greenstein, Deanna, Evans, Alan, Giedd, J. N., Rapoport, Judith·2009·Archives of General Psychiatry
DOI 10.1001/archgenpsychiatry.2009.103PMC PMC2948210
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Abstract

CONTEXT: Just as typical development of anatomical asymmetries in the human brain has been linked with normal lateralization of motor and cognitive functions, disruption of asymmetry has been implicated in the pathogenesis of neurodevelopmental disorders such as attention-deficit/hyperactivity disorder (ADHD). No study has examined the development of cortical asymmetry using longitudinal neuroanatomical data. OBJECTIVE: To delineate the development of cortical asymmetry in children with and without ADHD. DESIGN: Longitudinal study. SETTING: Government Clinical Research Institute. PARTICIPANTS: A total of 218 children with ADHD and 358 typically developing children, from whom 1133 neuroanatomical magnetic resonance images were acquired prospectively. MAIN OUTCOME MEASURES: Cortical thickness was estimated at 40 962 homologous points in the left and right hemispheres, and the trajectory of change in asymmetry was defined using mixed-model regression. RESULTS: In right-handed typically developing individuals, a mean (SE) increase in the relative thickness of the right orbitofrontal and inferior frontal cortex with age of 0.011 (0.0018) mm per year (t(337) = 6.2, P < .001) was balanced against a relative left-hemispheric increase in the occipital cortical regions of 0.013 (0.0015) mm per year (t(337) = 8.1, P < .001). Age-related change in asymmetry in non-right-handed typically developing individuals was less extensive and was localized to different cortical regions. In ADHD, the posterior component of this evolving asymmetry was intact, but the prefrontal component was lost. CONCLUSIONS: These findings explain the way that, in typical development, the increased dimensions of the right frontal and left occipital cortical regions emerge in adulthood from the reversed pattern of childhood cortical asymmetries. Loss of the prefrontal component of this evolving asymmetry in ADHD is compatible with disruption of prefrontal function in the disorder and demonstrates the way that disruption of typical processes of asymmetry can inform our understanding of neurodevelopmental disorders.

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Metadata

Authors
Shaw, P., Lalonde, F., Lepage, C., Rabin, C., Eckstrand, K., Sharp, W., Greenstein, D., Evans, A., Giedd, J. N., & Rapoport, J.
Affiliations
National Institute of Mental Health (US)
ORCID
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
2009-08-01
Volume
66
Issue
8
Pages
888
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archgenpsychiatry.2009.103
PMC
PMC2948210
OpenAlex
W2055703423
Cited by
249
References
81
Citations by year
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FWCI
13.61
Type
journal article
Language
en
Open access
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (ZIAMH002240, ZIAMH002794)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords
cortical asymmetry, attention deficit hyperactivity disorder, hemispheric lateralization, cortical thickness, brain development, children, prefrontal cortex, orbitofrontal cortex, inferior frontal cortex, occipital cortex, handedness
MeSH terms
Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Brain, Brain Mapping, Cerebral Cortex, Child, Child Development, Child, Preschool, Frontal Lobe, Humans, Functional Laterality, Longitudinal Studies, Magnetic Resonance Imaging, Prospective Studies, Prefrontal Cortex

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