The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Effect of a Purpose in Life on Risk of Incident Alzheimer Disease and Mild Cognitive Impairment in Community-Dwelling Older Persons
Open accessAbstract
CONTEXT: Emerging data suggest that psychological and experiential factors are associated with risk of Alzheimer disease (AD), but the association of purpose in life with incident AD is unknown. OBJECTIVE: To test the hypothesis that greater purpose in life is associated with a reduced risk of AD. DESIGN: Prospective, longitudinal epidemiologic study of aging. SETTING: Senior housing facilities and residences across the greater Chicago metropolitan area. PARTICIPANTS: More than 900 community-dwelling older persons without dementia from the Rush Memory and Aging Project. MAIN OUTCOME MEASURES: Participants underwent baseline evaluations of purpose in life and up to 7 years of detailed annual follow-up clinical evaluations to document incident AD. In subsequent analyses, we examined the association of purpose in life with the precursor to AD, mild cognitive impairment (MCI), and the rate of change in cognitive function. RESULTS: During up to 7 years of follow-up (mean, 4.0 years), 155 of 951 persons (16.3%) developed AD. In a proportional hazards model adjusted for age, sex, and education, greater purpose in life was associated with a substantially reduced risk of AD (hazard ratio, 0.48; 95% confidence interval, 0.33-0.69; P < .001). Thus, a person with a high score on the purpose in life measure (score = 4.2, 90th percentile) was approximately 2.4 times more likely to remain free of AD than was a person with a low score (score = 3.0, 10th percentile). This association did not vary along demographic lines and persisted after the addition of terms for depressive symptoms, neuroticism, social network size, and number of chronic medical conditions. In subsequent models, purpose in life also was associated with a reduced risk of MCI (hazard ratio, 0.71; 95% confidence interval, 0.53-0.95; P = .02) and a slower rate of cognitive decline (mean [SE] global cognition estimate, 0.03 [0.01], P < .01). CONCLUSION: Greater purpose in life is associated with a reduced risk of AD and MCI in community-dwelling older persons.
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“Existing meta-analyses are limited by the use of aggregated data from studies that adjust differently for potential confounders (eg, one study did not adjust for confounders9 and another study adjusted for only demographic variables and baseline cognition10).”
From Associations between social connections and cognition: a global collaborative individual participant data meta-analysis (2022) · cites this paper as [9]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A growing body of findings from longitudinal epidemiological studies show that purpose predicts reduced morbidity (e.g., reduced risk of Alzheimer ' s disease and mild cognitive impairment, as well as reduced risk of stroke and myocardial infarction) and extended longevity (10, 16 -21).”
From Purpose in life and use of preventive health care services (2014) · cites this paper as [16]
Experimental — accuracy not yet measuredIn the citing paper
“In numerous prospective research studies, higher PIL has been associated with better self-rated health,22 fewer chronic diseases (eg, stroke,8,19 myocardial infarctions9), reduced pain,11 less disability,7,10,11 less dementia and Alzheimer's disease,23 and reduced mortality.6,10,11”
From Purpose in Life and Positive Health Outcomes Among Older Adults (2018) · cites this paper as [23]
In the citing paper
“As in other studies, there were minimal demographic differences with the exception of those 80 years of age and older having lower PIL.”
From Purpose in Life and Positive Health Outcomes Among Older Adults (2018) · cites this paper as [23]
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Metadata
- Authors
- Boyle, P. A., Buchman, A. S., Barnes, L. L., & Bennett, D. A.
- Affiliations
- Rush University Medical Center (US)
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2010-03-01
- Volume
- 67
- Issue
- 3
- Pages
- 304
- ISSN
- 0003-990X (ISSN-L)
- PMC
- PMC2897172
- OpenAlex
- W2129597363
- Cited by
- 580
- References
- 33
- Citations by year
- 2026: 29 · 2025: 35 · 2024: 38 · 2023: 89 · 2022: 56 · 2021: 47 · 2020: 45 · 2019: 29 · 2018: 41 · 2017: 39 · 2016: 32 · 2015: 28 · 2014: 23 · 2013: 20 · 2012: 15
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG017917, R01-AG-24480, R01‐AG17917, K23 AG 23040, K23AG023040, R01AG024480, R01AG034374)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- meaning of life, Alzheimer's disease, mild cognitive impairment, cognitive decline, community-dwelling older adults, dementia risk, psychological factors
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Chicago, Cognition Disorders, Data Collection, Female, Goals, Humans, Life Style, Longitudinal Studies, Male, Prospective Studies, Psychometrics, Quality of Life, Risk Factors, Severity of Illness Index, Urban Population, Proportional Hazards Models, Housing for the Elderly, Intention
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