Cited by 565Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and Treatments

The DOI matches its Crossref record; 88 of the 89 references it cites were found in a registry or an index.

Increased Synaptic Dopamine Function in Associative Regions of the Striatum in Schizophrenia

Kegeles, Lawrence S., Abi-Dargham, Anissa, Frankle, W. Gordon, Gil, Roberto, Cooper, Thomas B., Slifstein, Mark, Hwang, Dah-Ren, Huang, Yiyun, Haber, Suzanne N., Laruelle, Marc·2010·Archives of General Psychiatry

DOI 10.1001/archgenpsychiatry.2010.10

Open this paper in CoChat — free account

Abstract

CONTEXT: A long-standing version of the dopamine hypothesis of schizophrenia postulates that hyperactivity of dopaminergic transmission at D(2) receptors in the limbic striatum is associated with the illness and that blockade of mesolimbic D(2) receptors is responsible for the antipsychotic action of D(2) receptor antagonists. OBJECTIVE: To localize dopaminergic hyperactivity within the striatum in schizophrenia. DESIGN: Case-control study. SETTING: Inpatient research unit. PARTICIPANTS: Eighteen untreated patients with schizophrenia and 18 healthy control subjects matched for age, sex, ethnicity, parental socioeconomic status, cigarette smoking, and weight. MAIN OUTCOME MEASURES: Percentage change in dopamine D(2) receptor availability in striatal subregions within each subject measured by positron emission tomography with carbon 11-labeled raclopride before and during pharmacologically induced dopamine depletion. RESULTS: In the associative striatum, acute dopamine depletion resulted in a larger increase in D(2) receptor availability in patients with schizophrenia (mean [SD], 15% [7%]) than in control subjects (10% [7%], P = .045), suggesting higher synaptic dopamine concentration. Within the associative striatum, this effect was most pronounced in the precommissural dorsal caudate (15% [8%] in patients vs 9% [8%] in controls, P = .03). No between-group differences were observed in the limbic and sensorimotor striatum. CONCLUSIONS: These findings suggest that schizophrenia is associated with elevated dopamine function in associative regions of the striatum. Because the precommissural dorsal caudate processes information from the dorsolateral prefrontal cortex, this observation also suggests that elevated subcortical dopamine function might adversely affect performance of the dorsolateral prefrontal cortex in schizophrenia. On the other hand, the absence of a group difference in the limbic striatum brings into question the therapeutic relevance of the mesolimbic selectivity of second-generation antipsychotic drugs.

Integrity signals

Registry

Crossref · 10.1001/archgenpsychiatry.2010.10

Cites

88 of 88 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527
Four Factor Index of Social Status
Paschou, R. (1975) · Cited by 6,989
Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
Lieberman, J. A., Stroup, T. S., McEvoy, J. P., Swartz, M. S., Rosenheck, R. A., Perkins, D. O., Keefe, R. S. E., Davis, S. M., Davis, C. E., Lebowitz, B. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051688 · Cited by 5,892
Four Factor Index of Social Status [1975]
Hollingshead, A. B. (1975) · Cited by 5,151
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1976) · Science · doi:10.1126/science.3854 · Cited by 2,220
Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop
Parent, A., & Hazrati, L.-N. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00007-c · Cited by 2,161
Dopamine in schizophrenia: a review and reconceptualization
Davis, K. L., Kahn, R. S., Ko, G., & Davidson, M. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.11.1474 · Cited by 2,051
Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Weinberger, D. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020020004 · Cited by 2,025
Negative v Positive Schizophrenia
Andreasen, N. C. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290070025006 · Cited by 2,008

Show all 89 references

Sorted by citations

Items 401–500 of 565

Dopamine dysfunction in schizophrenia
Abi-Dargham, A. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.09.069 · Cited by 10
Self-citation
Preclinical Effects of Antipsychotic Drugs
Berrío, J. P., & Ellenbroek, B. A. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_447 · Cited by 8
Polypharmacy- Purpose, Benefits and Limitations
Grover, D., Tom, M., Maguire, G., & Stahl, S. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220107153813 · Cited by 7
Prior Expectations of Volatility Following Psychotherapy for Delusions
Sheffield, J. M., Sloan, A. F., Corlett, P. R., Rogers, B. P., Vandekar, S., Liu, J., Beals, K., Hall, L. M., Gautier, T., Moussa‐Tooks, A. B., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.17132 · Cited by 7
Reduced neural connectivity in the caudate anterior head predicts hallucination severity in schizophrenia
Hinkley, L. B. N., Haas, S. S., Cheung, S. W., Nagarajan, S. S., & Subramaniam, K. (2023) · Schizophrenia Research · doi:10.1016/j.schres.2023.08.030 · Cited by 7
Striatal dopamine D2/3 receptors in medication-naïve schizophrenia: an [123I] IBZM SPECT study
Chen, K.-C., Yang, Y.-K., Howes, O., Lee, H. I., Yeh, T.-L., Chiu, N.-T., Chen, P.-S., David, A., & Bramon, E. (2021) · Psychological Medicine · doi:10.1017/s0033291720005413 · Cited by 7
Efficacy of low-dose risperidone in combination with sertraline in first-episode drug-naïve patients with schizophrenia: a randomized controlled open-label study
Lang, X., Xue, M., Zang, X., Wu, F., Xiu, M., & Zhang, X. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04272-7 · Cited by 7
Targeting the dopamine receptor in schizophrenia: investigational drugs in Phase III trials
Rao, N. P., & Remington, G. J. (2013) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.873790 · Cited by 8
Dysfunction of Magnocellular/dorsal Processing Stream in Schizophrenia
Chieffi, S. (2019) · Current Psychiatry Research and Reviews · doi:10.2174/1573400515666190119163522 · Cited by 8
Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodrome
Petty, A. E., Cui, X., Ali, A. A., Du, Z., Srivastav, S., Kesby, J. P., Kirik, D., Howes, O. D., & Eyles, D. W. (2021) · Scientific Reports · doi:10.1038/s41598-021-83681-4 · Cited by 7
Neurochemical evidence that cysteamine modulates amphetamine-induced dopaminergic neuronal activity in striatum by decreasing dopamine release: an in vivo microdialysis study in freely moving rats.
Rakovska, A., Javitt, D., Petkova-Kirova, P., Balla, A., Ang, R. L., & Kalfin, R. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.08.005 · Cited by 4
Presynaptic Dopaminergic Function: Implications for Understanding Treatment Response in Psychosis
Bonoldi, I., & Howes, O. D. (2014) · CNS Drugs · doi:10.1007/s40263-014-0177-z · Cited by 8
Tardive dyskinesia in schizophrenia
Liddle, P. F. (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.112.123679 · Cited by 7
Reduced numerical density of oligodendrocytes and oligodendrocyte clusters in the head of the caudate nucleus in schizophrenia
Kolomeets, N. S., & Uranova, N. A. (2023) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2023123011103 · Cited by 6
Robust and replicable functional brain signatures of 22q11.2 deletion syndrome and associated psychosis: a deep neural network-based multi-cohort study
Supekar, K., Angeles, C. D. L., Ryali, S., Kushan, L., Schleifer, C. H., Repetto, G. M., Crossley, N. A., Simon, T., Bearden, C. E., & Menon, V. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02495-8 · Cited by 6
The Relationships between Dopaminergic, Glutamatergic, and Cognitive Functioning in 22q11.2 Deletion Syndrome: A Cross-Sectional, Multimodal 1H-MRS and 18F-Fallypride PET Study
van Hooijdonk, C. F. M., Tse, D. H. Y., Roosenschoon, J., Ceccarini, J., Booij, J., van Amelsvoort, T., & Vingerhoets, C. (2022) · Genes · doi:10.3390/genes13091672 · Cited by 6
Neuroimaging markers of aberrant brain activity and treatment response in schizophrenia patients based on brain complexity
Liu, L., Li, Z., Kong, D., Huang, Y., Wu, D., Zhao, H., Gao, X., Zhang, X., & Yang, M. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03067-8 · Cited by 6
Self-citation
Reduced insulin sensitivity may be related to less striatal glutamate: An 1H-MRS study in healthy non-obese humans
Caravaggio, F., Iwata, Y., Plitman, E., Chavez, S., Borlido, C., Chung, J. K., Kim, J., Agarwal, S. M., Gerretsen, P., Remington, G. J., et al. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.12.002 · Cited by 6
Low-Dose Ziprasidone in Combination with Sertraline for First-Episode Drug-Naïve Patients with Schizophrenia: a Randomized Controlled Trial
Zhu, C., Guan, X., Wang, Y., Liu, J., Kosten, T. R., Xiu, M., Wu, F., & Zhang, X. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01242-7 · Cited by 6
Balance between direct and indirect pathways of the nucleus accumbens controls social behavior in micePreprint
Merrer, J. L., Detraux, B., Gandía, J., Groote, A. D., Fonteneau, M., d’Exaerde, A. D. K., & Becker, J. A. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.28.518147 · Cited by 6
Whole-genome sequencing shows modulation of neurodegenerative genes by Withania somnifera in human SK-N-SH cells
Sharma, E., Mehta, D. S., Jadhav, N., Gujrati, G., Dhananya, S., Moorthy, M., Ramaswamy, G., Zhou, Y., & Nair, S. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1512727 · Cited by 5
Deficit of satellite oligodendrocytes of neurons in the rostral part of the head of the caudate nucleus in schizophrenia
Kolomeets, N. S., & Uranova, N. A. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01869-x · Cited by 5
In vivo absolute quantification of striatal and extrastriatal D2/3 receptors with [123I]epidepride SPECT
Tsartsalis, S., Tournier, B. B., & Millet, P. (2020) · EJNMMI Research · doi:10.1186/s13550-020-00650-0 · Cited by 5
Eye Movements and Schizophrenia: A Review on Smooth Pursuit, Saccadic Movements, and Exploratory Eye Movements
ÇORUM, E. N. (2024) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.18863/pgy.1535133 · Cited by 4
Hypermethylation and increased expression of the DRD2 gene in schizophrenia
Qing, L., Zou, T., Yin, W., Wu, R., Cheng, T., Yuan, H., Zhou, C., Chen, X., Wang, J., Yang, T., et al. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07154-y · Cited by 4
Protective Effects of N-Acetylcysteine Against Schizophrenia-Related Behavioral and Parvalbumin Interneuron Deficits Induced by Adolescent Stress
Freitas, I. D. S., Guimarães, F. S., & Gomes, F. V. (2025) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgaf029 · Cited by 4
THPP-1 PDE10A inhibitor reverses the cognitive deficits and hyperdopaminergic state in a neurodevelopment model of schizophrenia
Uliana, D., Martinez, A., & Grace, A. A. (2024) · Schizophrenia Research · doi:10.1016/j.schres.2024.10.003 · Cited by 3
Relationship between regional gray matter volumes and dopamine D2 receptor and transporter in living human brains
Kurose, S., Kubota, M., Takahata, K., Yamamoto, Y., Fujiwara, H., Kimura, Y., Ito, H., Takeuchi, H., Mimura, M., Suhara, T., et al. (2021) · Human Brain Mapping · doi:10.1002/hbm.25538 · Cited by 3
Decreased serum levels of α‐synuclein in patients with schizophrenia and their unaffected siblings
Göverti, D., Büyüklüoğlu, N., Yüksel, R. N., Kaya, H., Yücel, Ç., & Göka, E. (2023) · Early Intervention in Psychiatry · doi:10.1111/eip.13398 · Cited by 4
Can the season of birth risk factor for schizophrenia be prevented by bright light treatment for the second trimester mother around the winter solstice?
Schwartz, P. J. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.10.014 · Cited by 4
Imaging the Dopamine D3 Receptor In Vivo
Slifstein, M., Rabiner, E. A., & Gunn, R. N. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418677-4.00011-7 · Cited by 4
Self-citation
Goal-Directed Deficits in Schizophrenia
Morris, R. W. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812098-9.00017-6 · Cited by 4
Modeling Psychiatric Disorders in Experimental Animals
Moore, H. M., & Robbins, T. W. (2015) · Wiley eBooks · doi:10.1002/9781118753378.ch17 · Cited by 4
Neuromelanin MRI: Dark Substance Shines a Light on Dopamine Dysfunction and Cocaine Use
Bradberry, C. W. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20091305 · Cited by 6
Age- and sex-dependent effects of stressors on activity of the nucleus reuniens of the thalamus
Uliana, D. L., & Grace, A. A. (2025) · Schizophrenia Research · doi:10.1016/j.schres.2025.09.018 · Cited by 3
From dopamine to muscarine: xanomeline-trospium (KarXT) as a novel direction in the psychopharmacotherapy of schizophrenia
Żełabowski, K., Pichowicz, W., Dembowska, J., Szwajkowski, M., Mykhailova, D., Wurm, G., Biedka, K., Błaszczyk, K., & Piotrowski, P. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1774437 · Cited by 3
Apical integration theory provides a neural basis for understanding disorganization and consciousness in the schizophrenias
Silverstein, S. M., Zolnik, T. A., Larkum, M. E., & Thompson, J. L. (2026) · Current Research in Neurobiology · doi:10.1016/j.crneur.2026.100165 · Cited by 4
Fine-scale striatal parcellation using diffusion MRI tractography and graph neural networks
Gao, J., Liu, M., Qian, M., Tang, H., Wang, J., Ma, L., Li, Y., Dai, X., Wang, Z., Lu, F., et al. (2025) · Medical Image Analysis · doi:10.1016/j.media.2025.103482 · Cited by 3
Dopamine Receptors and Dopamine Release
KESSLER, R. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418677-4.00012-9 · Cited by 3
Probabilistic association learning in schizophrenia
Weickert, T. W. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.08.015 · Cited by 4
Neurochemical models of psychosis risk and onset
Oliver, D., Modinos, G., & McGuire, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-813201-2.00012-0 · Cited by 2
Mathematical Models of Neuromodulation and Implications for Neurology and Psychiatry
Best, J. A., Nijhout, H. F., & Reed, M. C. (2017) · Springer series in bio-/neuroinformatics · doi:10.1007/978-3-319-49959-8_8 · Cited by 3
Dopamine Receptor Imaging in Schizophrenia
Hirvonen, J., & Hietala, J. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418677-4.00013-0 · Cited by 3
Haloperidol ameliorates androgen-induced behavioral deficits in developing male rats
Qi, C., Ji, X., Zhang, G., Kang, Y., Huang, Y., Cui, R., Li, S., Cui, H., & Shi, G. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0642 · Cited by 3
Self-citation
Dopamine
Mehta, T., Murala, S., & Siddiqui, J. (2022) · Springer eBooks · doi:10.1007/978-3-031-07897-2_1 · Cited by 3
Circadian rhythms in auditory hallucinations and psychosis
Ngo, H.-V. V., Oster, H., Andreou, C., & Obleser, J. (2023) · Acta Physiologica · doi:10.1111/apha.13944 · Cited by 3
A corticostriatal learning mechanism linking excess striatal dopamine and auditory hallucinationsPreprint
Lakshminarasimhan, K. J., Buck, J., Kellendonk, C., & Horga, G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.18.643990 · Cited by 3
Neural fingerprints of data driven cognitive subtypes across the psychosis spectrum: a B-SNIP study
Meda, S. A., Dykins, M. M., Hill, S. K., Clementz, B. A., Keedy, S., McDowell, J. E., Ivleva, E. I., Gershon, E. S., Keshavan, M. S., Tamminga, C. A., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03422-3 · Cited by 2
Altered cortical-striatal circuits connectivity is associated with psychotic symptoms in patients with first-episode, drug-naïve early-onset schizophrenia
Wang, L., Liu, R., Liao, J., Fan, L., Zhuo, L., & Li, H. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1695904 · Cited by 1
TAAR1-mediated pathways regulating nigrostriatal function and the discovery and pharmacological characterization of a novel TAAR1 agonist, Selutaront
Zhang, J., Deng, X., Lv, J., Lu, J., Wang, L., Wang, W., Lei, H., Wang, Y., & Tian, J. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1759454 · Cited by 2
Magnetic resonance texture alterations in the caudate nucleus following 18 weeks of clozapine treatment in patients with treatment-resistant schizophrenia
Jo, W., Moon, S., Sim, H., Park, I., Kwon, M. J., Kim, S., Jung, W. H., Kim, K. W., & Kim, E. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03967-x · Cited by 2
The impact of subcaudate tractotomy on delusions and hallucinations in psychotic patients
Vilela-Filho, O., Ragazzo, P. C., Canêdo, D., Barreto, U. S., de Oliveira, P. M., Goulart, L. C., Reis, M. D., & Campos, T. M. (2021) · Surgical Neurology International · doi:10.25259/sni_599_2021 · Cited by 2
Brain structural abnormalities of the associative striatum in adolescents and young adults at genetic high-risk of schizophrenia: Implications for illness endophenotypes
Nestor, P. G., Levin, L. K., Stone, W. S., Giuliano, A. J., Seidman, L. J., & Levitt, J. J. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.08.027 · Cited by 2
Using Nonhuman Primate Models to Reverse-Engineer Prefrontal Circuit Failure Underlying Cognitive Deficits in Schizophrenia
Chafee, M. V. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_407 · Cited by 2
Connectivity alterations of mesostriatal pathways in first episode psychosis
Hayward, N., Triana, A. M., Panula, J. M., Kieseppä, T., Suvisaari, J., & Raij, T. T. (2023) · Schizophrenia · doi:10.1038/s41537-023-00339-y · Cited by 2
Hippocampal perineuronal net degradation identifies prefrontal and striatal circuits involved in schizophrenia-like changes in marmosets
Gwilt, M., Hodgson, A. R., Axelsson, S. F. A., Cockcroft, G. J., McIver, L. B., Hird, M., Stasiak, A., McKenzie, C., Ip, S., Cardinal, R. N., et al. (2025) · Science Advances · doi:10.1126/sciadv.adu0975 · Cited by 2
An ace in the hole? Opportunities and limits of using mice to understand schizophrenia neurobiology
Villarin, J. M., & Kellendonk, C. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03060-7 · Cited by 2
Forging a Role for Iron in the Dopamine Dysfunction of Schizophrenia
Cassidy, C., Wang, Y., & Abi‐Dargham, A. (2025) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20250639 · Cited by 2
Self-citation
Glutamate and Schizophrenia: From Theory to Treatment Implications
Javitt, D. C. (2014) · Cited by 2
The developmental relationship between central dopaminergic level and response inhibition from late childhood to young adulthood
Zhang, T., Zhang, Q., Wang, C., & Chen, A. (2017) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2017.02.009 · Cited by 2
Striatal and Thalamic Auditory Response During Deep Brain Stimulation for Essential Tremor: Implications for Psychosis
Gault, J., Thompson, J. A., Maharajh, K., Hosokawa, P. W., Stevens, K. E., D, A. O. M., Liedtke, E. I., Ojemann, A., Ojemann, S. G., & Abosch, A. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13101 · Cited by 2
Dopamine and Response to Antipsychotic Medication
Ntephe, C., & Demjaha, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-57231-0_14 · Cited by 2
Four-modality imaging of unmedicated subjects with schizophrenia: 18F-fluorodeoxyglucose and 18F-fallypride PET, diffusion tensor imaging, and MRI
Buchsbaum, M. S., Mitelman, S. A., Christian, B. T., Merrill, B., Buchsbaum, B. R., Mitelman, D., Mukherjee, J., & Lehrer, D. S. (2021) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2021.111428 · Cited by 2
The neuromediator mechanisms of the cognitive deficit in schizophrenia
Storozheva, Z. I., Kirenskaya, A. V., & Proshin, A. T. (2015) · Neurochemical Journal · doi:10.1134/s1819712415030095 · Cited by 2
The role of agonistic/antagonistic activity in the development of psychotropic effects of antipsychotics
Kozlovskiy, V. I., Kosterin, D. N., & Popov, M. Y. (2019) · V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY · doi:10.31363/2313-7053-2019-1-3-7 · Cited by 2
Personality Dimensions in Psychopathy: Potential Explanatory Models for Primary and Secondary TraitsPreprint
Murphy, B. A., & Giurgiutiu, D. (2012) · SSRN Electronic Journal · doi:10.2139/ssrn.1978268 · Cited by 1
Pharmacological Treatment
Sherin, J. E., & Marder, S. R. (2011) · doi:10.1002/9780470978672.ch6 · Cited by 2
Neurobiology of psychosis and schizophrenia 2022: Nottingham meeting
Sami, M. B., & Liddle, P. F. (2023) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2023.152415 · Cited by 1
Pilot study of the DRD3, GHRL, FTO, LEPR, INSIG2, GSTP1, ABCB1 genes expression in peripheral blood leukocytes in schizophrenic patients with metabolic syndrome
Boiko, A. S., Paderina, D. Z., Викторовна, М. Е., Kornetova, E. G., Bokhan, N. A., & Ivanova, S. А. (2024) · Нейрохимия · doi:10.31857/s1027813324010052 · Cited by 1
The Role of Fatty Acid Amide Hydrolase, a Key Regulatory Endocannabinoid Enzyme, in Domain-Specific Cognitive Performance in Psychosis
Weidenauer, A., Ramesh, R. G., Lalang, N., Watts, J. J., Lepage, M., Rusjan, P., & Mizrahi, R. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae212 · Cited by 1
Free Imagination
Tse, P. U. (2024) · doi:10.1093/oso/9780198901181.001.0001 · Cited by 2
Halved Dose of Antipsychotics Versus High-Dose Antipsychotic Therapy for Relapse in Patients with Schizophrenia Receiving High-Dose Antipsychotic Therapy: A Randomized Single-Blind Trial
Ataniya, R., Koike, T., & Inamoto, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094003 · Cited by 1
Differential trajectories of corticostriatal structural connectivity in individuals at clinical high risk for psychosis according to functional outcome
Choe, E., Park, H., Jang, J., Kim, M., & Kwon, J. S. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03567-1 · Cited by 1
Low-dose paliperidone combined with sertraline for first-episode and medication-naïve patients with schizophrenia: an open-label, randomized trial
Lin, Z., Guan, X., Lang, X., Xiu, M., & Wu, F. (2025) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-025-02160-3 · Cited by 1
Cognitive Deficits in Schizophrenia: Brain Deorganization and Neurorehabilitation
Gialama, V., Dimitriou, N., Σκώκου, Μ., & Nasios, G. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-03398-7_3 · Cited by 1
Optimising therapy for schizophrenia and depression: old and new solutions
Titmarsh, S. (2012) · Progress in Neurology and Psychiatry · doi:10.1002/pnp.259
Schizophrenia
Ellenbroek, B. A., & Youn, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801657-2.00009-4 · Cited by 1
Aripiprazole, Aripiprazole Monohydrate, and Aripiprazole Lauroxil
Meyer, J. M., & Stahl, S. M. (2021) · Cambridge University Press eBooks · doi:10.1017/9781009002103.019 · Cited by 1
The MAM Model to Study the Role of Dopamine in Schizophrenia
Zhu, X., Uliana, D. L., & Grace, A. A. (2022) · Neuromethods · doi:10.1007/978-1-0716-2799-0_10 · Cited by 1
Reduced Number Density of Oligodendrocytes and Oligodendrocyte Clusters in the Head of the Caudate Nucleus in Schizophrenia
Kolomeets, N. S., & Uranova, N. A. (2023) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-023-01509-2 · Cited by 1
Action of Antipsychotics
Gangadhar, B. N., & Rao, N. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00115-9 · Cited by 1
Extending Corticostriatal Systems
Deutch, A. Y. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0242 · Cited by 1
Cannabis use in delusional infestation with folie à deux
Lee, J. S., Dean, E. A., & Jimenez, X. F. (2020) · Journal of Substance Use · doi:10.1080/14659891.2020.1833094 · Cited by 1
Molecular Imaging
Červenka, S., & Farde, L. (2020) · Springer eBooks · doi:10.1007/978-3-030-35206-6_8 · Cited by 1
Examining associations between social anhedonia and convergent thinking using the Remote Associates Test
Spann, D. J., Straub, K. T., Hua, J. P. Y., Pellegrini, A. M., & Kerns, J. G. (2022) · Cognitive Neuropsychiatry · doi:10.1080/13546805.2022.2126302
Evidence for upregulation of excitatory synaptic transmission in the substantia nigra in Schizophrenia: a postmortem ultrastructural study
Brown, N. K., Roche, J. K., Farmer, C. B., & Roberts, R. C. (2023) · Journal of Neural Transmission · doi:10.1007/s00702-023-02593-x · Cited by 1
Studying biomarkers in populations at genetic and clinical high risk for psychosis
de Koning, M. B. (2013) · doi:10.26481/dis.20131129mk · Cited by 1
The role of dopamine D2 and neuregulin-1 receptors in schizophrenia relevant phenotypes of cognition, attention and memory
Mathur, N. (2012) · Nottingham ePrints (University of Nottingham) · Cited by 1
Neurobiological and genetic markers in schizophrenia: a theoretical replication using the Allen Institute for Brain Sciences online database
Gallander, K. (2012) · CSUN ScholarWorks (California State University, Northridge) · Cited by 1
A new cortical parcellation based on systematic review of primate anatomical tracing studies on corticostriatal projectionsPreprint
Dinh, T., Nerland, S., Maximov, I. I., Barth, C., Vernon, A. C., Agartz, I., & Jørgensen, K. N. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.20.496804 · Cited by 1
Fronto-striato-thalamic circuit connectivity and neuromelanin in schizophrenia: an fMRI and neuromelanin-MRI studyPreprint
Kwon, J. S., Choi, S., Kim, M., Kim, T., Choi, E., Lee, J., Moon, S. Y., Cho, S. S., & Lee, J. (2023) · Research Square · doi:10.21203/rs.3.rs-2725867/v1 · Cited by 1
Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodentsPreprint
Li, Z., Mukherjee, D., Duric, B., Austin-Zimmerman, I., Trotta, G., Spinazzola, E., Quattrone, D., Murray, R. M., & Forti, M. D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.15.571463 · Cited by 1
The Impact of Genetic Polymorphisms on Neuroreceptor Imaging
Willeit, M., Kasper, S. F., & Praschak-Rieder, N. (2014) · Springer eBooks · doi:10.1007/978-3-642-42014-6_6
Sexual Dimorphism in Monoamine Metabolism in BrdU-Treated Rats Showing Behavioral Dopamine Hypersensitivity: An Animal Model of Schizophrenia
Muneoka, K. T., & Kuwagat, M. (2013) · InTech eBooks · doi:10.5772/55348
Epidemiological and biological mechanisms of cannabis as cause of psychosis
Kuepper, R. (2012) · Research Publications (Maastricht University) · doi:10.26481/dis.20120504rk
Evaluation of novel dual-hit models of 'schizophrenia-like' symptoms in the rat
Gaskin, P. L. R. (2014) · UPT. Syiah Kuala University Library (Syiah Kuala University)
Das soziale Gehirn und schizophrene Erkrankungen
Löffler, N., Berkefeld, A., Kaaden, S., Reiff, J., & Braus, D. F. (2011) · Nervenheilkunde · doi:10.1055/s-0038-1627796
The neural basis of aberrant salience attribution in unmedicated patients with schizophrenia spectrum disorders
Delfin, C. (2014) · Högskolan Kristianstad Publikationer
Reply to: Hippocampal Glutamate Levels and Striatal Dopamine D2/3 Receptor Occupancy in Subjects at Ultra High Risk of Psychosis
Stone, J. M., Howes, O. D., Egerton, A., Kambeitz, J. P., Allen, P., Lythgoe, D. J., Tuura, R., McLean, M. A., Barker, G. J., & McGuire, P. K. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.039
Behaviour and biomarkers in frontotemporal dementia: Implications for general psychiatry
Wijeratne, C. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412439054

Authors: Kegeles, L. S., Abi-Dargham, A., Frankle, W. G., Gil, R., Cooper, T. B., Slifstein, M., Hwang, D.-R., Huang, Y., Haber, S. N., & Laruelle, M.
Affiliations: Columbia University Irving Medical Center (US)
ORCID: Kegeles, Lawrence S.
Frankle, W. Gordon
Cooper, Thomas B.
Slifstein, Mark
Huang, Yiyun
Haber, Suzanne N.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2010-03-01
Volume: 67
Issue: 3
Pages: 231
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archgenpsychiatry.2010.10
OpenAlex: W1999984108
Cited by: 565
References: 89
Citations by year: 2026: 17 · 2025: 26 · 2024: 33 · 2023: 25 · 2022: 42 · 2021: 23 · 2020: 32 · 2019: 42 · 2018: 32 · 2017: 38 · 2016: 45 · 2015: 41 · 2014: 47 · 2013: 32 · 2012: 47
FWCI: 25.78
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (K02MH01603-01, K02MH001603, R01MH054192)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: schizophrenia, synaptic dopamine, associative striatum, dorsal caudate, dopamine depletion, mesolimbic dopamine system, dopamine hypothesis of schizophrenia, atypical antipsychotics, dorsolateral prefrontal cortex, positron emission tomography, raclopride
MeSH terms: Adult, Brain Mapping, Carbon Radioisotopes, Caudate Nucleus, Corpus Striatum, Dopamine, Female, Humans, Image Processing, Computer-Assisted, Male, Synaptic Transmission, Putamen, Schizophrenia, Synapses, Case-Control Studies, Prefrontal Cortex, Receptors, Dopamine D2, alpha-Methyltyrosine, Raclopride, Positron-Emission Tomography

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Increased Synaptic Dopamine Function in Associative Regions of the Striatum in Schizophrenia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks