Kegeles, Lawrence S.

Increased baseline occupancy of D 2 receptors by dopamine in schizophrenia

Abi-Dargham, A., Rodenhiser, J., Printz, D., Zea-Ponce, Y., Gil, R., Kegeles, L. S., Weiss, R., Cooper, T. B., Mann, J. J., Van Heertum, R. L., et al. (2000) · Proceedings of the National Academy of Sciences

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 1,020

Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum

Martinez, D., Slifstein, M., Broft, A., Mawlawi, O., Hwang, D.-R., Huang, Y., Cooper, T., Kegeles, L., Zarahn, E., Abi-Dargham, A., et al. (2003) · Journal of Cerebral Blood Flow & Metabolism

Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

Cited by 569

Increased Synaptic Dopamine Function in Associative Regions of the Striatum in Schizophrenia

Kegeles, L. S., Abi-Dargham, A., Frankle, W. G., Gil, R., Cooper, T. B., Slifstein, M., Hwang, D.-R., Huang, Y., Haber, S. N., & Laruelle, M. (2010) · Archives of General Psychiatry

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 565

Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum

Martinez, D., Gil, R., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Kegeles, L., Talbot, P., Evans, S., Krystal, J., et al. (2005) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 445

Glutamate, Dopamine, and Schizophrenia: From Pathophysiology to Treatment

LARUELLE, M., KEGELES, L. S., & ABI‐DARGHAM, A. (2003) · Annals of the New York Academy of Sciences

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 437

Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder: Proof-of-Concept

Rodriguez, C. I., Kegeles, L. S., Levinson, A., Feng, T., Marcus, S. M., Vermes, D., Flood, P., & Simpson, H. B. (2013) · Neuropsychopharmacology

Obsessive-Compulsive Spectrum DisordersTreatment of Major Depression

Cited by 386

Decreased Regional Brain Metabolism After ECT

Nobler, M. S., Oquendo, M. A., Kegeles, L. S., Malone, K. M., Campbell, C., Sackeim, H. A., & Mann, J. J. (2001) · American Journal of Psychiatry

Electroconvulsive Therapy StudiesTreatment of Major Depression

Cited by 330

Positron Emission Tomography of Regional Brain Metabolic Responses to a Serotonergic Challenge and Lethality of Suicide Attempts in Major Depression

Oquendo, M. A., Placidi, G. P. A., Malone, K. M., Campbell, C., Keilp, J., Brodsky, B., Kegeles, L. S., Cooper, T. B., Parsey, R. V., Van Heertum, R. L., et al. (2003) · Archives of General Psychiatry

Suicide and Self-Harm StudiesTreatment of Major Depression

Cited by 313

Sex differences in striatal dopamine release in young adults after oral alcohol challenge: a positron emission tomography imaging study with [11C]raclopride

Urban, N. B. L., Kegeles, L. S., Slifstein, M., Xu, X., Martinez, D., Sakr, E., Castillo, F., Moadel, T., O'Malley, S. S., Krystal, J. H., et al. (2010) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 223

Baseline and amphetamine-stimulated dopamine activity are related in drug-naïve schizophrenic subjects

Abi-Dargham, A., van de Giessen, E., Slifstein, M., Kegeles, L. S., & Laruelle, M. (2009) · Biological Psychiatry

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 213

Imaging glutamate in schizophrenia: review of findings and implications for drug discovery

Poels, E. M. P., Kegeles, L. S., Kantrowitz, J. T., Slifstein, M., Javitt, D. C., Lieberman, J. A., Abi-Dargham, A., & Girgis, R. R. (2014) · Molecular Psychiatry

Schizophrenia research and treatmentAdvanced MRI Techniques and Applications

Cited by 205

A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder

Milak, M. S., Proper, C. J., Mulhern, S. T., Parter, A. L., Kegeles, L. S., Ogden, R. T., Mao, X., Rodriguez, C. I., Oquendo, M. A., Suckow, R. F., et al. (2016) · Molecular Psychiatry

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 144

Investigation of Cortical Glutamate–Glutamine and γ-Aminobutyric Acid in Obsessive–Compulsive Disorder by Proton Magnetic Resonance Spectroscopy

Simpson, H. B., Shungu, D. C., Bender, J., Mao, X., Xu, X., Slifstein, M., & Kegeles, L. S. (2012) · Neuropsychopharmacology

Obsessive-Compulsive Spectrum DisordersAdvanced MRI Techniques and Applications

Cited by 138

Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression

Parsey, R. V., Oquendo, M. A., Zea-Ponce, Y., Rodenhiser, J., Kegeles, L. S., Pratap, M., Cooper, T. B., Van Heertum, R., Mann, J. J., & Laruelle, M. (2001) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Cited by 133

Striatal amphetamine-induced dopamine release in patients with schizotypal personality disorder studied with single photon emission computed tomography and [123I]iodobenzamide

Abi-Dargham, A., Kegeles, L. S., Zea-Ponce, Y., Mawlawi, O., Martinez, D., Mitropoulou, V., O'Flynn, K., Koenigsberg, H. W., Van Heertum, R., Cooper, T., et al. (2004) · Biological Psychiatry

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 128

Striatal and extrastriatal dopamine release measured with PET and [18F] fallypride

Slifstein, M., Kegeles, L. S., Xu, X., Thompson, J. L., Urban, N., Castrillon, J., Hackett, E., Bae, S. ‐., Laruelle, M., & Abi‐Dargham, A. (2010) · Synapse

Neurotransmitter Receptor Influence on BehaviorMedical Imaging Techniques and Applications

Cited by 115

Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial

Javitt, D. C., Carter, C. S., Krystal, J. H., Kantrowitz, J. T., Girgis, R. R., Kegeles, L. S., Ragland, J. D., Maddock, R. J., Lesh, T. A., Tanase, C., et al. (2018) · JAMA Psychiatry

Schizophrenia research and treatmentTreatment of Major Depression

Cited by 100

Ventromedial prefrontal cortex/anterior cingulate cortex Glx, glutamate, and GABA levels in medication-free major depressive disorder

Kantrowitz, J. T., Dong, Z., Milak, M. S., Rashid, R., Kegeles, L. S., Javitt, D. C., Lieberman, J. A., & John Mann, J. (2021) · Translational Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 100

Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression: A Randomized Clinical Trial

Milak, M. S., Rashid, R., Dong, Z., Kegeles, L. S., Grunebaum, M. F., Ogden, R. T., Lin, X., Mulhern, S. T., Suckow, R. F., Cooper, T. B., et al. (2020) · JAMA Network Open

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 63

Rapid Resolution of Obsessions After an Infusion of Intravenous Ketamine in a Patient With Treatment-Resistant Obsessive-Compulsive Disorder

Rodriguez, C. I., Kegeles, L. S., Flood, P., & Simpson, H. B. (2011) · The Journal of Clinical Psychiatry

Obsessive-Compulsive Spectrum DisordersTreatment of Major Depression

Cited by 59

Modulation of amphetamine-induced dopamine release by group II metabotropic glutamate receptor agonist LY354740 in non-human primates studied with positron emission tomography

van Berckel, B. N. M., Kegeles, L. S., Waterhouse, R., Guo, N., Hwang, D.-R., Huang, Y., Narendran, R., Van Heertum, R., & Laruelle, M. (2006) · Neuropsychopharmacology

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 43

Pharmacokinetics and brain distribution in non human primate of R(-)[123I]DOI, A 5HT2A/2C serotonin agonist

Zea-Ponce, Y., Kegeles, L. S., Guo, N., Raskin, L., Bakthavachalam, V., & Laruelle, M. (2002) · Nuclear Medicine and Biology

Radiopharmaceutical Chemistry and ApplicationsNeurotransmitter Receptor Influence on Behavior

Cited by 14