Cited by 692Schizophrenia research and treatmentDementia and Cognitive Impairment ResearchPsychopathy, Forensic Psychiatry, Sexual Offending

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Cognitive Functioning in Prodromal Psychosis: A Meta-analysis

Fusar-Poli, Paolo, Deste, Giacomo, Smieskova, Renata, Barlati, Stefano, Yung, Alison R., Howes, Oliver, Stieglitz, Rolf-Dieter, Vita, Antonio, McGuire, Philip, Borgwardt, Stefan·2012·Archives of General Psychiatry

DOI 10.1001/archgenpsychiatry.2011.1592

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Abstract

CONTEXT: A substantial proportion of people at clinical high risk (HR) of psychosis will develop a psychotic disorder over time. Cognitive deficits may predate the onset of psychosis and may be useful as markers of increased vulnerability to illness. OBJECTIVE: To quantitatively examine the cognitive functioning in subjects at HR in the literature to date. DATA SOURCES: Electronic databases were searched until January 2011. All studies reporting cognitive performance in HR subjects were retrieved. STUDY SELECTION: Nineteen studies met the inclusion criteria, comprising a total of 1188 HR subjects and 1029 controls. DATA EXTRACTION: Neurocognitive functioning and social cognition as well as demographic, clinical, and methodological variables were extracted from each publication or obtained directly from its authors. DATA SYNTHESIS: Subjects at HR were impaired relative to controls on tests of general intelligence, executive function, verbal and visual memory, verbal fluency, attention and working memory, and social cognition. Processing speed domain was also affected, although the difference was not statistically significant. Later transition to psychosis was associated with even more marked deficits in the verbal fluency and memory domains. The studies included reported relatively homogeneous findings. There was no publication bias and a sensitivity analysis confirmed the robustness of the core results. CONCLUSIONS: The HR state for psychosis is associated with significant and widespread impairments in neurocognitive functioning and social cognition. Subsequent transition to psychosis is particularly associated with deficits in verbal fluency and memory functioning.

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Authors: Fusar-Poli, P., Deste, G., Smieskova, R., Barlati, S., Yung, A. R., Howes, O., Stieglitz, R.-D., Vita, A., McGuire, P., & Borgwardt, S.
Affiliations: University of Brescia (IT)
University of Basel (CH)
University of Manchester (GB)
ORCID: Deste, Giacomo
Yung, Alison R.
Howes, Oliver
Stieglitz, Rolf-Dieter
Vita, Antonio
McGuire, Philip
Borgwardt, Stefan
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2012-06-01
Volume: 69
Issue: 6
Pages: 562-71
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archgenpsychiatry.2011.1592
OpenAlex: W2149592078
Cited by: 691
References: 81
Citations by year: 2026: 23 · 2025: 28 · 2024: 43 · 2023: 36 · 2022: 53 · 2021: 48 · 2020: 47 · 2019: 44 · 2018: 56 · 2017: 45 · 2016: 74 · 2015: 48 · 2014: 68 · 2013: 51 · 2012: 27
FWCI: 44.32
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords: prodromal psychosis, clinical high risk for psychosis, cognitive impairment, neurocognitive function, social cognition, executive function, verbal fluency, memory, processing speed, transition to psychosis, vulnerability indicators
MeSH terms: Cognition Disorders, Humans, Psychotic Disorders, Risk

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Cognitive Functioning in Prodromal Psychosis: A Meta-analysis

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