Cognitive interventions targeting brain plasticity in the prodromal and early phases of schizophrenia
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Several important paradigm shifts have occurred in the field of schizophrenia treatment, including an increased focus on early detection, the development of preemptive interventions, and the view of schizophrenia as a neurodevelopmental disease characterized by decreased efficiency and abnormal connectivity in cortical and subcortical neural networks. In this review, we briefly describe some of the neural impairments that contribute to the development of schizophrenia, with an emphasis on the impact of stress and trauma on cognitively vulnerable neural systems. We then present current data on two behavioral interventions that target these critical risk factors and that aim to preempt the onset of schizophrenia in vulnerable individuals or improve the clinical course in recent-onset schizophrenia: cognitive therapy and computerized cognitive training.
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Prolonged developmental plasticity may provide a diagnostic opportunity for cognitive interventions targeting brain plasticity in the prodromal stage.
“Prolonged developmental plasticity may then provide a diagnostic opportunity for cognitive interventions targeting brain plasticity in the prodromal stage (62–64).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [64]
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Stress and HPA-axis functioning in young people at ultra high risk for psychosis
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Blunted cortisol response to a psychosocial stressor in schizophrenia
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Statistics and Related Topics in Single-Molecule Biophysics
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Specific Cognitive Training Normalizes Auditory Sensory Gating in Schizophrenia: A Randomized Trial
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Pubertal neurodevelopment and the emergence of psychotic symptoms
Walker, E. F., & Bollini, A. M. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00347-4 · Cited by 112 · see citing works
Conrad, C. D., MacMillan, D. D., Tsekhanov, S., Wright, R. L., Baran, S. E., & Fuchs, R. A. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.01.002 · Cited by 104 · see citing works
A Functional Magnetic Resonance Imaging Study of Auditory Mismatch in Schizophrenia
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The lifetime trajectory of schizophrenia and the concept of neurodevelopment
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French, P., & Morrison, A. P. (2004) · Thammasat University Digital Collections · doi:10.1002/9780470713259 · Cited by 97 · see citing works
More harm than good: The case against using antipsychotic drugs to prevent severe mental illness
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Becker, H. E., Nieman, D. H., Wiltink, S., Dingemans, P. M. A. J., van de Fliert, J. R., Velthorst, E., de Haan, L., van Amelsvoort, T., & Linszen, D. H. (2010) · Psychological Medicine · doi:10.1017/s0033291710000048 · Cited by 96 · see citing works
Computer-aided neurocognitive remediation as an enhancing strategy for schizophrenia rehabilitation
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Cognitive remediation for adolescents with early onset psychosis: a 1‐year follow‐up study
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White matter and cognitive function in schizophrenia
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HPA axis function and symptoms in adolescents at clinical high risk for schizophrenia
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Platelet serotonin, plasma cortisol, and dexamethasone suppression test in schizophrenic patients
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Neural changes following cognitive behaviour therapy for psychosis: a longitudinal study
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Self-citationDo Child Abuse and Maltreatment Increase Risk of Schizophrenia?
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Ueland, T., & Rund, B. R. (2003) · Acta Psychiatrica Scandinavica · doi:10.1046/j.0001-690x.2003.00239.x · Cited by 70 · see citing works
The MCPP challenge test in schizophrenia: Hormonal and behavioral responses
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Psychological interventions in early psychosis. A treatment handbook
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Cognitive decline following psychosis onset
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Diurnal cortisol in schizophrenia patients with childhood trauma
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Functional integration in schizophrenia: too little or too much? Preliminary results on fMRI data
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Neurodevelopment During Adolescence
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Young people at ultra high risk for psychosis: a research update
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Pituitary volume increase during emerging psychosis
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Gene-Environment Interactions Underlying the Effect of Cannabis in First Episode Psychosis
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Self-citationStress and the Prodromal Phase of Psychosis
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HPA axis functioning associated with transition to psychosis: Combined DEX/CRH test
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Genetic correlate of cognitive training response in schizophrenia
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Research works printed but not linked: 1
- Brown E under review Increases in cortical gamma oscillatory activity corelate with improved behavior after computerized cognitive training in schizophrenia
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Do “brain-training” programs work?
Simons, D. J., Boot, W. R., Charness, N., Gathercole, S. E., Chabris, C. F., Hambrick, D. Z., & Stine-Morrow, E. A. L. (2016) · Psychological Science in the Public Interest · doi:10.1177/1529100616661983 · Cited by 1,183 · see citing works
Deficits in social cognition in first episode psychosis: A review of the literature
Healey, K. M., Bartholomeusz, C. F., & Penn, D. L. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.10.001 · Cited by 154 · see citing works
Early interventions in risk groups for schizophrenia: what are we waiting for?
Sommer, I. E., Bearden, C. E., van Dellen, E., Breetvelt, E. J., Duijff, S. N., Maijer, K., van Amelsvoort, T., de Haan, L., Gur, R. E., Arango, C., et al. (2016) · npj Schizophrenia · doi:10.1038/npjschz.2016.3 · Cited by 140 · see citing works
Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons
Morishita, H., Cabungcal, J.-H., Chen, Y., Do, K. Q., & Hensch, T. K. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.026 · Cited by 92 · see citing works
McClure, M. M., Graff, F., Triebwasser, J., Perez-Rodriguez, M., Rosell, D. R., Koenigsberg, H., Hazlett, E. A., Siever, L. J., Harvey, P. D., & New, A. S. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.18030349 · Cited by 38 · see citing works
- Authors
- Fisher, M., Loewy, R., Hardy, K., Schlosser, D., & Vinogradov, S.
- Affiliations
- San Francisco VA Medical Center (US)
- University of California, San Francisco (US)
- Venue
- Annual Review of Clinical Psychology
- Publisher
- Annual Reviews
- Published
- 2013-03-28
- Volume
- 9
- Issue
- 1
- Pages
- 435-463
- ISSN
- 1548-5943 (ISSN-L)
- 1548-5951
- PMC
- PMC4745413
- OpenAlex
- W2165398545
- Cited by
- 71
- References
- 152
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 12 · 2015: 6 · 2014: 8 · 2013: 6
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of Mental Health (R01MH081051, T32MH089920)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- schizophrenia, prodromal symptoms, early-onset schizophrenia, cognitive intervention, neuroplasticity, cognitive therapy, computerized cognitive training, stress, trauma, neurodevelopmental model, neural network connectivity, early detection
- MeSH terms
- Humans, Neuronal Plasticity, Schizophrenia, Schizophrenic Psychology, Cognitive Behavioral Therapy, Prodromal Symptoms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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