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Cited by 59Schizophrenia research and treatmentPsychopathy, Forensic Psychiatry, Sexual OffendingChild and Adolescent Psychosocial and Emotional Development

Toward earlier identification and preventative intervention in schizophrenia: evidence from the London Child Health and Development Study

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Laurens, Kristin R., Cullen, Alexis E.·2016·Social Psychiatry and Psychiatric Epidemiology
DOI 10.1007/s00127-015-1151-xPMC PMC4823320
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Abstract

PURPOSE: The London Child Health and Development Study (CHADS) is a prospective, longitudinal investigation of children, sampled from the general community aged 9-11 years and assessed biennially, who present premorbid risk markers for schizophrenia. The study aims to characterise developmental trajectories of psychological, cognitive, and biological functioning in at-risk children and identify potential targets for early preventative intervention. This review summarises CHADS findings, discusses these in the context of recent theory regarding aetiology and prevention of schizophrenia, and highlights challenges to be addressed with future research. METHODS: We review (1) epidemiological information on the prevalence and correlates of developmental antecedents of schizophrenia in the general child population, (2) evidence of psychosocial, cognitive, and biological dysfunctions in at-risk children presenting multiple antecedents of schizophrenia and at-risk children with a family history of schizophrenia, and (3) related findings from an associated sample of help-seeking children receiving intervention. RESULTS: Community-based screening of 9-11-year olds identified ~9 % with a triad of antecedents of schizophrenia [including psychotic-like experiences (PLEs)] who are putatively at-risk of psychosis; these children reported greater exposure and responsivity to stressors, impairments in general intelligence and specific cognitive functions, brain structure and function abnormalities, and neuromotor dysfunction. Preliminary evidence suggests distressing PLEs are a viable target for cognitive-behavioural intervention in at-risk children. CONCLUSIONS: Intervention in early, premorbid phases of illness might alleviate current difficulties and avert future schizophrenia using benign treatments. The CHADS programme has identified several markers that may index early pathophysiology and constitute potential targets for preventative intervention.

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  • Research is following suit, with programs moving from the early identification of states immediately preceding psychosis onset in late adolescence or early adulthood to the investigation of earlier phases of illness in vulnerable children and younger adolescents (e.g. London Child Health and Development Study).

    “Interestingly, research is following suit, with programs moving from the early identification of states immediately preceding psychosis onset in late adolescence or early adulthood to the investigation of earlier phases of illness in vulnerable children and younger adolescents (e.g. London Child Health and Development Study) [136].”

    From Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care? (2020) · cites this paper as [136]

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  1. [44]Dickson H, Cullen AE, Jones R, Reichenberg A, Roberts RE, Hodgins S, Morris RG, Laurens KR (2014) Trajectories of cognitive development during adolescence in youth at-risk for schizophrenia. In: British psychological society developmental section annual conference, Amsterdam, Netherlands
  2. [89]Reynolds CR Richmond BO Revised children’s manifest anxiety scale, second edition (RCMAS-2) manual 2008 Los Angeles Western Psychological Services
  3. [90]Beck JS, Beck AT, Jolly JB, Steer RA (2005) Beck youth inventories second edition for children and adolescents manual (depression inventory for youth). Harcourt Assessment, Inc. (PsychCorp), San Antonio

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Authors
Laurens, K. R., & Cullen, A. E.
Affiliations
King's College London (GB)
Corresponding author
Laurens, Kristin R.
ORCID
Venue
Social Psychiatry and Psychiatric Epidemiology
Publisher
Springer Science and Business Media LLC
Published
2015-12-15
Volume
51
Issue
4
Pages
475-491
ISSN
  • 0933-7954 (ISSN-L)
  • 1433-9285
DOI
10.1007/s00127-015-1151-x
PMC
PMC4823320
OpenAlex
W2196589405
Cited by
59
References
129
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 8 · 2017: 5 · 2016: 6
FWCI
0.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Social Psychiatry and Psychiatric Epidemiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, cc-by)
  • QUT ePrints (Queensland University of Technology) (submittedVersion, cc-by)
  • UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
  • Research Bank (Australian Catholic University) (submittedVersion)
  • Research Bank (Australian Catholic University) (submittedVersion, cc-by)
  • UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
Funders
  • Research Trainees Coordinating Centre (GB) (CDF/08/01/015, PAS/01/05/PDA/042)
  • National Alliance for Research on Schizophrenia and Depression (NARSAD) (Young Investigator Award (2006))
  • Fundação Bial (PT) (35/06 and 194/12)
  • British Medical Association (GB) (Margaret Temple Award for schizophrenia research (2006 and 2012))
  • Psychiatry Research Trust (Research Grant 2010 (Psychosis96))
  • Waterloo Foundation Child Development Fund (164/1719)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
schizophrenia, early detection, preventive interventions, psychotic-like experiences, family history of schizophrenia, stress exposure, cognitive impairment, neuromotor dysfunction, cognitive-behavioural intervention, child mental health screening
MeSH terms
Child, Humans, London, Prospective Studies, Schizophrenia, Early Diagnosis

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