Long‐acting injectable antipsychotics in early psychosis: a literature review
Abstract
Aim: There are sound reasons for considering the use of long‐acting injectable antipsychotics early in the course of schizophrenia. We reviewed available literature on the subject. Method: We conducted an electronic database search and critically reviewed all studies in which a long‐acting injectable antipsychotic was evaluated in early psychosis patients. Results: There is a need for well‐designed studies as most of those reported were open‐label and non‐comparative, and samples were frequently small. Conclusions: The available evidence does suggest that long‐acting injectable antipsychotics can be used safely and effectively in early stages of the illness, and that they may be associated with better outcomes than with oral medications. However, this is largely supported by evidence from naturalistic cohort studies and a small number of controlled trials of risperidone long‐acting injection. Evidence for olanzapine and paliperidone long‐acting injectables in particular is limited.
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Heterogeneity of international guidelines hampers the underutilization of LAIs.
“the heterogeneity of international guidelines”
From The role of shared decision-making in improving adherence to pharmacological treatments in patients with schizophrenia: A clinical review (2020) · cites this paper as [65]
The prejudice that the therapeutic relationship would be weakened by the adoption of LAIs, particularly in the early stages of the disease, hampers the underutilization of LAIs.
“and the prejudice that therapeutic relationship would be weakened by the adoption of LAIs, particularly in the early stages of the disease [65]”
From The role of shared decision-making in improving adherence to pharmacological treatments in patients with schizophrenia: A clinical review (2020) · cites this paper as [65]
Overestimation of patient's adherence hampers the underutilization of LAIs in clinical routine care.
“Other factors hampering the underutilization of LAIs in clinical routine care include the overestimation of patient’s adherence”
From The role of shared decision-making in improving adherence to pharmacological treatments in patients with schizophrenia: A clinical review (2020) · cites this paper as [65]
The time-consuming process of using SDM style for proposing LAIs treatment hampers the underutilization of LAIs.
“the time-consuming process of using SDM style for proposing the LAIs treatment”
From The role of shared decision-making in improving adherence to pharmacological treatments in patients with schizophrenia: A clinical review (2020) · cites this paper as [65]
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- Authors
- Emsley, R., Chiliza, B., Asmal, L., Mashile, M., & Fusar‐Poli, P.
- Affiliations
- Stellenbosch University (ZA)
- King's College London (GB)
- Corresponding author
- Emsley, Robin
- Venue
- Early Intervention in Psychiatry
- Publisher
- Wiley
- Published
- 2013-01-24
- Volume
- 7
- Issue
- 3
- Pages
- 247-254
- ISSN
- 1751-7885 (ISSN-L)
- 1751-7893
- OpenAlex
- W2108805155
- Cited by
- 61
- References
- 44
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 6 · 2016: 3 · 2015: 8 · 2014: 8 · 2013: 1
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Early Intervention in Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- AstraZeneca
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- long-acting injectable antipsychotics, early psychosis, schizophrenia, long-acting injectable risperidone, medication adherence, open-label study
- MeSH terms
- Delayed-Action Preparations, Humans, Injections, Intramuscular, Schizophrenia, Antipsychotic Agents, Early Medical Intervention
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