Overlapping Conditions Among Patients With Chronic Fatigue Syndrome, Fibromyalgia, and Temporomandibular Disorder
Abstract
Background Patients with chronic fatigue syndrome (CFS), fibromyalgia (FM), and temporomandibular disorder (TMD) share many clinical illness features such as myalgia, fatigue, sleep disturbances, and impairment in ability to perform activities of daily living as a consequence of these symptoms. A growing literature suggests that a variety of comorbid illnesses also may commonly coexist in these patients, including irritable bowel syndrome, chronic tension-type headache, and interstitial cystitis. Objective To describe the frequency of 10 clinical conditions among patients with CFS, FM, and TMD compared with healthy controls with respect to past diagnoses, degree to which they manifested symptoms for each condition as determined by expert-based criteria, and published diagnostic criteria. Methods Patients diagnosed as having CFS, FM, and TMD by their physicians were recruited from hospital-based clinics. Healthy control subjects from a dermatology clinic were enrolled as a comparison group. All subjects completed a 138-item symptom checklist and underwent a brief physical examination performed by the project physicians. Results With little exception, patients reported few past diagnoses of the 10 clinical conditions beyond their referring diagnosis of CFS, FM, or TMD. In contrast, patients were more likely than controls to meet lifetime symptom and diagnostic criteria for many of the conditions, including CFS, FM, irritable bowel syndrome, multiple chemical sensitivities, and…
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Studies of IBS among patients with chronic fatigue syndrome have reported a prevalence ranging from 35-92%.
“Studies of IBS among patients with chronic fatigue syndrome have reported a prevalence ranging from 35-92%.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [37]
Studies of IBS among CFS patients have reported a prevalence ranging from 35-92% with a median of 51%.
“Studies of IBS among CFS patients have reported a prevalence ranging from 35-92%34-38 with a median of 51%.4”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [37]
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Background
- Authors
- Aaron, L. A., Burke, M. M., & Buchwald, D.
- Affiliations
- University of Washington (US)
- ORCID
- Buchwald, Dedra
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2000-01-24
- Volume
- 160
- Issue
- 2
- Pages
- 221
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2136831026
- Cited by
- 607
- References
- 5
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 16 · 2023: 23 · 2022: 25 · 2021: 16 · 2020: 24 · 2019: 19 · 2018: 25 · 2017: 21 · 2016: 42 · 2015: 34 · 2014: 23 · 2013: 22 · 2012: 34
- FWCI
- 14.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (U19 AI 38429, U19AI038429)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- chronic fatigue syndrome, fibromyalgia, temporomandibular disorders, comorbidities, irritable bowel syndrome, multiple chemical sensitivity, headache, chronic tension-type headache, interstitial cystitis, myalgia, sleep disorders, symptom overlap
- MeSH terms
- Adult, Diagnosis, Differential, Female, Fibromyalgia, Humans, Male, Middle Aged, Physical Examination, Temporomandibular Joint Disorders, United States, Fatigue Syndrome, Chronic, Comorbidity
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