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Cited by 300

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Ulcer Prevention in Long-term Users of Nonsteroidal Anti-inflammatory Drugs: Results of a Double-blind, Randomized, Multicenter, Active- and Placebo-Controlled Study of Misoprostol vs Lansoprazole

Graham, David Y., Agrawal, Naurang M., Campbell, Donald R., Haber, Marian M., Collis, Cyndy, Lukasik, Nancy L., Huang, Bidan·2002·Archives of Internal Medicine
DOI 10.1001/archinte.162.2.169
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Abstract

BACKGROUND: Studies that report prevention of ulcer recurrence among long-term users of nonsteroidal anti-inflammatory drugs (NSAIDs) that do not stratify for Helicobacter pylori status may not be generalizable to the large population of individuals without H pylori. METHODS: This was a prospective, double-blind, multicenter, active- and placebo-controlled study among 537 patients without H pylori who were long-term users of NSAIDs and who had a history of endoscopically documented gastric ulcer. Patients were randomized to receive placebo, 200 microg of misoprostol 4 times a day, or 15 or 30 mg of lansoprazole once daily for 12 weeks. Ulcer status was determined by endoscopy at 4, 8, and 12 weeks. RESULTS: Patients receiving lansoprazole (15 or 30 mg) remained free from gastric ulcer longer than those who received placebo (P<.001) but for a shorter time than those who received misoprostol. By week 12, the percentages of gastric ulcer-free patients were as follows: placebo, 51% (95% confidence interval [CI], 41.1%-61.3%); misoprostol, 93% (95% CI, 87.2%-97.9%); 15-mg lansoprazole, 80% (95% CI, 72.5%-87.3%); and 30-mg lansoprazole, 82% (95% CI, 75.0%-89.6%). A significantly higher proportion of patients in the misoprostol group reported treatment-related adverse events and early withdrawal from the study. When the impact of withdrawals on ulcer development was considered (as failures), therapy was successful for 69% for each of the active treatment groups and 35% for the placebo group. CONCLUSIONS: Proton pump inhibitors such as lansoprazole are superior to placebo for the prevention of NSAID-induced gastric ulcers but not superior to misoprostol, 800 microg/d. When the poor compliance and potential adverse effects associated with misoprostol are considered, proton pump inhibitors and full-dose misoprostol are clinically equivalent.

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Metadata

Authors
Graham, D. Y., Agrawal, N. M., Campbell, D. R., Haber, M. M., Collis, C., Lukasik, N. L., & Huang, B.
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2002-01-28
Volume
162
Issue
2
Pages
169
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.162.2.169
OpenAlex
W2110739516
Cited by
300
References
15
FWCI
14.73
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Ulcer Prevention in Long-term Users of Nonsteroidal Anti-inflammatory Drugs: Results of a Double-blind, Randomized, Multicenter, Active- and Placebo-Controlled Study of Misoprostol vs Lansoprazole. https://app.cochat.ai/papers/10.1001/archinte.162.2.169
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Graham, D. Y., Agrawal, N. M., Campbell, D. R., Haber, M. M., Collis, C., Lukasik, N. L., & Huang, B. (2002). Ulcer Prevention in Long-term Users of Nonsteroidal Anti-inflammatory Drugs: Results of a Double-blind, Randomized, Multicenter, Active- and Placebo-Controlled Study of Misoprostol vs Lansoprazole. Archives of Internal Medicine. https://doi.org/10.1001/archinte.162.2.169

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.