Cited by 362Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Research

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Postprandial Glucose Regulation and Diabetic Complications

Ceriello, Antonio·2004·Archives of Internal Medicine

DOI 10.1001/archinte.164.19.2090

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Abstract

Atherosclerotic disease accounts for much of the increased mortality and morbidity associated with type 2 diabetes. Epidemiological studies support the potential of improved glycemic control to reduce cardiovascular complications. An association between glycosylated hemoglobin (HbA(1c)) level and the risk for cardiovascular complications has frequently been reported. Most epidemiological data implicate postprandial hyperglycemia in the development of cardiovascular disease, whereas the link between fasting glycemia and diabetic complications is inconclusive. Moreover, in many studies, postprandial glycemia is a better predictor of cardiovascular risk than HbA(1c) level. Postprandial glucose may have a direct toxic effect on the vascular endothelium, mediated by oxidative stress that is independent of other cardiovascular risk factors such as hyperlipidemia. Postprandial hyperglycemia also may exert its effects through its substantial contribution to total glycemic exposure. The present review examines the hypothesis that controlling postprandial glucose level is an important strategy in the prevention of cardiovascular complications associated with diabetes.

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“Many biochemical pathways could be responsible for the influence exerted by postprandial BG on the occurrence of cardiovascular events (13, 16, 38, 39).”
Background

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Authors: Ceriello, A.
Affiliations: University of Udine (IT)
Corresponding author: Ceriello, Antonio
ORCID: Ceriello, Antonio
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 2004-10-25
Volume: 164
Issue: 19
Pages: 2090
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.164.19.2090
OpenAlex: W2037632798
Cited by: 362
References: 52
Citations by year: 2026: 7 · 2025: 16 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 15 · 2020: 12 · 2019: 19 · 2018: 15 · 2017: 12 · 2016: 22 · 2015: 15 · 2014: 11 · 2013: 19 · 2012: 23
FWCI: 12.81
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System (University of Udine) (submittedVersion)
STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: postprandial blood glucose, postprandial hyperglycemia, type 2 diabetes, cardiovascular complications, atherosclerosis, glycemic control, HbA1c, oxidative stress, endothelial cell cytotoxicity, glycemic exposure, cardiovascular risk prediction
MeSH terms: Blood Glucose, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Postprandial Period, Diabetes Complications

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Postprandial Glucose Regulation and Diabetic Complications

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