Cited by 362Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Research

The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.

Postprandial Glucose Regulation and Diabetic Complications

Ceriello, Antonio·2004·Archives of Internal Medicine

DOI 10.1001/archinte.164.19.2090

Open this paper in CoChat — free account

Abstract

Atherosclerotic disease accounts for much of the increased mortality and morbidity associated with type 2 diabetes. Epidemiological studies support the potential of improved glycemic control to reduce cardiovascular complications. An association between glycosylated hemoglobin (HbA(1c)) level and the risk for cardiovascular complications has frequently been reported. Most epidemiological data implicate postprandial hyperglycemia in the development of cardiovascular disease, whereas the link between fasting glycemia and diabetic complications is inconclusive. Moreover, in many studies, postprandial glycemia is a better predictor of cardiovascular risk than HbA(1c) level. Postprandial glucose may have a direct toxic effect on the vascular endothelium, mediated by oxidative stress that is independent of other cardiovascular risk factors such as hyperlipidemia. Postprandial hyperglycemia also may exert its effects through its substantial contribution to total glycemic exposure. The present review examines the hypothesis that controlling postprandial glucose level is an important strategy in the prevention of cardiovascular complications associated with diabetes.

Integrity signals

Registry

Crossref · 10.1001/archinte.164.19.2090

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
Stratton, I. M. (2000) · BMJ · doi:10.1136/bmj.321.7258.405 · Cited by 9,059
Diabetes and Cardiovascular Disease: The Framingham Study
Kannel, W. B. (1979) · JAMA · doi:10.1001/jama.1979.03290450033020 · Cited by 2,936
Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. The Third National Health and Nutrition Examination Survey, 1988–1994
Harris, M. I., Flegal, K. M., Cowie, C. C., Eberhardt, M. S., Goldstein, D. E., Little, R. R., Wiedmeyer, H.-M., & Byrd-Holt, D. D. (1998) · Diabetes Care · doi:10.2337/diacare.21.4.518 · Cited by 2,703
Acarbose Treatment and the Risk of Cardiovascular Disease and Hypertension in Patients With Impaired Glucose Tolerance: The STOP-NIDDM Trial
Chiasson, J.-L., Josse, R. G., Gomis, R., Hanefeld, M., Karasik, A., Laakso, M., & for The STOP-NIDDM Trial Research Group (2003) · JAMA · doi:10.1001/jama.290.4.486 · Cited by 1,624
Contributions of Fasting and Postprandial Plasma Glucose Increments to the Overall Diurnal Hyperglycemia of Type 2 Diabetic Patients
Monnier, L., Lapinski, H., & Colette, C. (2003) · Diabetes Care · doi:10.2337/diacare.26.3.881 · Cited by 1,461
Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria
Borch‐Johnsen, K., Neil, A., Balkau, B., Larsen, S. H., Nissinen, A. E. T., Pekkanen, J., Keinanen-Kiukaanniemi, S. M., Hiltunen, L. A., Kivelä, S., Tuomilehto, J. O., et al. (1999) · The Lancet · Cited by 1,272
Defining the Relationship Between Plasma Glucose and HbA1c
Rohlfing, C. L., Wiedmeyer, H.-M., Little, R. R., England, J. D., Tennill, A., & Goldstein, D. E. (2002) · Diabetes Care · doi:10.2337/diacare.25.2.275 · Cited by 987
Risk factors for myocardial infarction and death in newly detected NIDDM: the Diabetes Intervention Study, 11-year follow-up
Hanefeld, M., Fischer, S., Julius, U., Schulze, J., Schwanebeck, U., Schmechel, H., Ziegelasch, H. J., & Lindner, J. (1996) · Diabetologia · doi:10.1007/s001250050617 · Cited by 873
Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDM
Reaven, G. M., Hollenbeck, C., Jeng, C.-Y., Wu, M. S., & Chen, Y.-D. I. (1988) · Diabetes · doi:10.2337/diab.37.8.1020 · Cited by 753

Flagged first, then by citations

Show all 52 references

1 of the 52 references couldn’t be matched to a known paper.

Sorted by citations

Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes
Monnier, L., Mas, E., Ginet, C., Michel, F., Villon, L., Cristol, J.-P., & Colette, C. (2006) · JAMA · doi:10.1001/jama.295.14.1681 · Cited by 2,444
Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary
Rydén, L., Standl, E., Bartnik, M., den Berghe, G. V., Betteridge, J. D., de Boer, M., Cosentino, F., Jönsson, B., Laakso, M., Malmberg, K., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehl260 · Cited by 1,644
Oscillating Glucose Is More Deleterious to Endothelial Function and Oxidative Stress Than Mean Glucose in Normal and Type 2 Diabetic Patients
Ceriello, A., Esposito, K., Piconi, L., Ihnat, M. A., Thorpe, J. E., Testa, R., Boemi, M., & Giugliano, D. (2008) · Diabetes · doi:10.2337/db08-0063 · Cited by 1,310
“A related issue is the evidence that postprandial glycemia is a stronger risk marker for macrovascular complications than fasting glucose (6).”
BackgroundSelf-citation
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Saxena, R., the MAGIC investigators, Hivert, M., Langenberg, C., Tanaka, T., Pankow, J. S., Vollenweider, P., Lyssenko, V., Bouatia‐Naji, N., Dupuis, J., et al. (2010) · Nature Genetics · doi:10.1038/ng.521 · Cited by 630
Postprandial Blood Glucose Is a Stronger Predictor of Cardiovascular Events Than Fasting Blood Glucose in Type 2 Diabetes Mellitus, Particularly in Women: Lessons from the San Luigi Gonzaga Diabetes Study
Cavalot, F., Petrelli, A., Traversa, M., Bonomo, K., Fiora, E., Conti, M., Anfossi, G., Costa, G., & Trovati, M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1005 · Cited by 569
“Many biochemical pathways could be responsible for the influence exerted by postprandial BG on the occurrence of cardiovascular events (13, 16, 38, 39).”
Background
Postprandial Hyperglycemia/Hyperlipidemia (Postprandial Dysmetabolism) Is a Cardiovascular Risk Factor
O’Keefe, J. H., & Bell, D. S. H. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.03.107 · Cited by 538
Benefits for Type 2 Diabetes of Interrupting Prolonged Sitting With Brief Bouts of Light Walking or Simple Resistance Activities
Dempsey, P. C., Larsen, R. N., Sethi, P., Sacre, J. W., Straznicky, N. E., Cohen, N. D., Cerin, E., Lambert, G. W., Owen, N., Kingwell, B. A., et al. (2016) · Diabetes Care · doi:10.2337/dc15-2336 · Cited by 405
Effects of Fat on Gastric Emptying of and the Glycemic, Insulin, and Incretin Responses to a Carbohydrate Meal in Type 2 Diabetes
Gentilcore, D., Chaikomin, R., Jones, K. L., Russo, A., Feinle‐Bisset, C., Wishart, J. M., Rayner, C. K., & Horowitz, M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2644 · Cited by 354
Postprandial Blood Glucose Predicts Cardiovascular Events and All-Cause Mortality in Type 2 Diabetes in a 14-Year Follow-Up
Cavalot, F., Pagliarino, A., Valle, M., Di Martino, L., Bonomo, K., Massucco, P., Anfossi, G., & Trovati, M. (2011) · Diabetes Care · doi:10.2337/dc10-2414 · Cited by 322
“Furthermore, a meta-analysis of 38 prospective studies carried out in nondiabetic subjects confirmed a strong association between 2-h postchallenge blood glucose with fatal and nonfatal cardiovascular events (3), and a linear relationship between this parameter and the risk of cardiovascular death has been observed (4…”
Background
Effect of Atorvastatin and Irbesartan, Alone and in Combination, on Postprandial Endothelial Dysfunction, Oxidative Stress, and Inflammation in Type 2 Diabetic Patients
Ceriello, A., Assaloni, R., Da Ros, R., Maier, A., Piconi, L., Quagliaro, L., Esposito, K., & Giugliano, D. (2005) · Circulation · doi:10.1161/01.cir.0000165070.46111.9f · Cited by 298
Self-citation
Glycemic Variability: The Third Component of the Dysglycemia in Diabetes. Is it Important? How to Measure it?
Monnier, L., Colette, C., & Owens, D. R. (2008) · Journal of Diabetes Science and Technology · doi:10.1177/193229680800200618 · Cited by 304
Acute high‐intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes
Gillen, J. B., Little, J. P., Punthakee, Z., Tarnopolsky, M. A., Riddell, M. C., & Gibala, M. J. (2012) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01564.x · Cited by 272
“Postprandial hyperglycaemia is a major contributor to type 2 diabetes (T2D)-related complications, including cardiovascular disease [1].”
Background
Glycemic Variability
Monnier, L., & Colette, C. (2008) · Diabetes Care · doi:10.2337/dc08-s241 · Cited by 275
Glycemic index, postprandial glycemia, and the shape of the curve in healthy subjects: analysis of a database of more than 1000 foods
Brand-Miller, J. C., Stockmann, K. S., Atkinson, F. S., Petocz, P., & Denyer, G. S. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26354 · Cited by 265
Enteral Nutritional Support and Use of Diabetes-Specific Formulas for Patients With Diabetes
Elia, M., Ceriello, A., Laube, H., Sinclair, A. J., Engfer, M., & Stratton, R. J. (2005) · Diabetes Care · doi:10.2337/diacare.28.9.2267 · Cited by 246
“In three of these (61,73,74), the difference was reported to be statistically significant, while the remaining three studies (14,56,59) did not report any statistical analysis.”
ResultSelf-citation
The “Metabolic Memory” Theory and the Early Treatment of Hyperglycemia in Prevention of Diabetic Complications
Testa, R., Bonfigli, A. R., Prattichizzo, F., Sala, L. L., Nigris, V. D., & Ceriello, A. (2017) · Nutrients · doi:10.3390/nu9050437 · Cited by 239
“This tight control should also include “postprandial” hyperglycemia [47,48] as it is accompanied by the formation of specific reactive species [49] and AGEs, not only in plasma [50] but also intracellularly [51].”
BackgroundSelf-citation
Assessment of a personalized approach to predicting postprandial glycemic responses to food among individuals without diabetes
Mendes-Soares, H., Raveh-Sadka, T., Azulay, S., Edens, K., Ben-Shlomo, Y., Cohen, Y., Ofek, T., Bachrach, D., Stevens, J., Colibaseanu, D., et al. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2018.8102 · Cited by 212
Glucose Variability
Service, F. J. (2013) · Diabetes · doi:10.2337/db12-1396 · Cited by 228
“Otherwise the effect of improved mean glycemia is amenable to study with techniques less arduous than the task of controlling postprandial hyperglycemia (37).”
Background
Relationships Between Daily Acute Glucose Fluctuations and Cognitive Performance Among Aged Type 2 Diabetic Patients
Rizzo, M. R., Marfella, R., Barbieri, M., Boccardi, V., Vestini, F., Lettieri, B., Canonico, S., & Paolisso, G. (2010) · Diabetes Care · doi:10.2337/dc10-0389 · Cited by 213
“From a more practical point of view, exposure to glycemic disorders can be described as a function of two components: 1) the duration and magnitude of chronic sustained hyperglycemia and 2) the acute fluctuations of glucose over a daily period (6,7).”
Background
Guideline for management of postmeal glucose in diabetes
1 (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.08.002 · Cited by 185
Hemodialyzed type I and type II diabetic patients in the US: Characteristics, glycemic control, and survival
Williams, M. E., Lacson, E., Teng, M. F., Ofsthun, N. J., & Lazarus, J. M. (2006) · Kidney International · doi:10.1038/sj.ki.5001789 · Cited by 181
Postprandial hyperglycemia as an etiological factor in vascular failure
Node, K., & Inoue, T. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-23 · Cited by 183
The emerging challenge in diabetes: The “metabolic memory”
Ceriello, A. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.05.005 · Cited by 177
“Damaged mitochondria are thought to release more ROS and set in motion a vicious cycle of increasing DNA damage leading to increased ROS production that in turn leads to more DNA damage (Ceriello et al., 2004a).”
Self-citation
Hypothesis: the ‘metabolic memory’, the new challenge of diabetes
Ihnat, M. A., Thorpe, J. E., & Ceriello, A. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02138.x · Cited by 169
Self-citation
Postprandial glucose regulation: New data andnew implications
Leiter, L. A., Ceriello, A., Davidson, J. A., Hanefeld, M., Monnier, L., Owens, D. R., Tajima, N., & Tuomilehto, J. O. (2005) · Clinical Therapeutics · doi:10.1016/j.clinthera.2005.11.020 · Cited by 160
Self-citation
Effects of protein on glycemic and incretin responses and gastric emptying after oral glucose in healthy subjects
Karamanlis, A., Chaikomin, R., Doran, S., Bellon, M., Bartholomeusz, F. D. L., Wishart, J. M., Jones, K. L., Horowitz, M., & Rayner, C. K. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1364 · Cited by 149
“Glycemic control is a major determinant of the development and progression of the complications associated with diabetes (1–3), and recent studies have highlighted the particular importance of postprandial hyperglycemia (4, 5).”
Background
Postprandial hyperglycaemia and cardiovascular complications of diabetes: An update
Ceriello, A., Davidson, J., Hanefeld, M., Leiter, L. A., Monnier, L., Owens, D. R., Tajima, N., & Tuomilehto, J. O. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.05.006 · Cited by 155
Self-citation
Management of Type 1 Diabetes With a Very Low–Carbohydrate Diet
Lennerz, B. S., Barton, A. B., Bernstein, R. K., Dikeman, R. D., Diulus, C. A., Hallberg, S. J., Rhodes, E. T., Ebbeling, C. B., Westman, E. C., Yancy, W. S., et al. (2018) · PEDIATRICS · doi:10.1542/peds.2017-3349 · Cited by 149
Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control
Lang Lehrskov, L., Lyngbaek, M. P., Soederlund, L., Legaard, G. E., Ehses, J. A., Heywood, S. E., Wewer Albrechtsen, N. J., Holst, J. J., Karstoft, K., Pedersen, B. K., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.008 · Cited by 135
ROSES: role of self‐monitoring of blood glucose and intensive education in patients with Type 2 diabetes not receiving insulin. A pilot randomized clinical trial
Franciosi, M., Lucisano, G., Pellegrini, F., Cantarello, A., Consoli, A., Cucco, L., Ghidelli, R., Sartore, G., Sciangula, L., Nicolucci, A., et al. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03268.x · Cited by 137
Early Progression of Diabetic Nephropathy Correlates With Methylglyoxal-Derived Advanced Glycation End Products
Beisswenger, P. J., Howell, S. K., Russell, G. B., Miller, M. E., Rich, S. S., & Mauer, M. S. (2013) · Diabetes Care · doi:10.2337/dc12-2689 · Cited by 135
Plant-Derived Bioactive Peptides: A Treatment to Cure Diabetes
Patil, S. P., Goswami, A., Kalia, K., & Kate, A. S. (2019) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-019-09899-z · Cited by 131
Role of NFAT5 in Inflammatory Disorders Associated with Osmotic Stress
Neuhofer, W. (2010) · Current Genomics · doi:10.2174/138920210793360961 · Cited by 136
“In addition, oscillatory hyperglycemia as routinely found in most patients, causes more acute increases in plasma concentrations of pro-inflammatory cytokines including IL-6, IL-18, and TNF- , as compared to chronic hyperglycemia [60].”
Background
Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials
Bergouignan, A., Latouche, C., Heywood, S., Grace, M. S., Reddy-Luthmoodoo, M., Natoli, A. K., Owen, N., Dunstan, D. W., & Kingwell, B. A. (2016) · Scientific Reports · doi:10.1038/srep32044 · Cited by 121
Hypothesis: the “metabolic memory”, the new challenge of diabetes
Ceriello, A. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(09)70002-6 · Cited by 120
Self-citation
Self-Monitoring of Blood Glucose (SMBG) in Insulin- and Non–Insulin-Using Adults with Diabetes: Consensus Recommendations for Improving SMBG Accuracy, Utilization, and Research
Hirsch, I. B., Bode, B. W., Childs, B. P., Close, K. L., Fisher, W. A., Gavin, J. R., Ginsberg, B. H., Raine, C. H., & Verderese, C. A. (2008) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2008.0104 · Cited by 121
When basal insulin therapy in type 2 diabetes mellitus is not enough—what next?
Raccah, D., Bretzel, R. G., Owens, D. R., & Riddle, M. C. (2007) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.733 · Cited by 112
“However, physiological evidence suggests that rapid increments of glucose can have harmful effects on the vascular endothelium, perhaps mediated by an oxidative stress [27,28].”
Background
Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
Watanabe, H., Inaba, Y., Kimura, K., Matsumoto, M., Kaneko, S., Kasuga, M., & Inoue, H. (2017) · Nature Communications · doi:10.1038/s41467-017-02537-6 · Cited by 107
Whole-Grain Processing and Glycemic Control in Type 2 Diabetes: A Randomized Crossover Trial
Åberg, S., Mann, J. I., Neumann, S., Ross, A. B., & Reynolds, A. N. (2020) · Diabetes Care · doi:10.2337/dc20-0263 · Cited by 107
The challenges of achieving postprandial glucose control using closed‐loop systems in patients with type 1 diabetes
Gingras, V., Taleb, N., Roy‐Fleming, A., Legault, L., & Rabasa‐Lhoret, R. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13052 · Cited by 113
“Controlling postprandial glucose excursions is identified as a key component of achieving a recommended HbA1c.2,18 The 2-hours post-meal glucose target in individuals with T1D is between 5 and 10 mmol/L in most patients.2,19 CHO content of meals is the main determinant of postprandial glucose excursion.20,21 Consequen…”
Dietary glycemic index and the risk of age-related macular degeneration
Kaushik, S., Wang, J. J., Flood, V. M., Tan, J. S. L., Barclay, A. W., Wong, T. Y., Brand-Miller, J. C., & Mitchell, P. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.1104 · Cited by 101
“Normal levels of glycemia tend to depress plasma antioxidant capacity (32) and hyperglycemia has been shown to generate oxidative stress (33–36).”
Background
Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability
Sala, L. L., Mrakic‐Sposta, S., Micheloni, S., Prattichizzo, F., & Ceriello, A. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0748-2 · Cited by 98
“Since GV is considered a strong predictor of the elevated risk of developing vascular complications [4, 5], even in non-diabetic subjects [6], it has attracted a great deal attention in clinical practice.”
BackgroundSelf-citation
Glycemic index, postprandial glycemia and cardiovascular disease
Dickinson, S. P., & Brand-Miller, J. C. (2005) · Current Opinion in Lipidology · doi:10.1097/00041433-200502000-00012 · Cited by 98
Postprandial glucose spikes, an important contributor to cardiovascular disease in diabetes?
Hanssen, N. M. J., Kraakman, M. J., Flynn, M. C., Nagareddy, P. R., Schalkwijk, C. G., & Murphy, A. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.570553 · Cited by 90
Acarbose: oral antidiabetes drug with additional cardiovascular benefits
Hanefeld, M., & Schaper, F. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.2.153 · Cited by 87
Eight-Point Glucose Testing Versus the Continuous Glucose Monitoring System in Evaluation of Glycemic Control in Type 1 Diabetes
The Diabetes Research in Children Network (DirecNet) Study Group (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2510 · Cited by 88
Effects of the brown rice diet on visceral obesity and endothelial function: the BRAVO study
Shimabukuro, M., Higa, M., Kinjo, R., Yamakawa, K., Tanaka, H., Kozuka, C., Yabiku, K., Taira, S.-I., Sata, M., & Masuzaki, H. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513002432 · Cited by 86
“glucose levels with macrovascular complications((11,14)).”
Background
The effect of continuous subcutaneous glucose monitoring (CGMS) versus intermittent whole blood finger-stick glucose monitoring (SBGM) on hemoglobin A1c (HBA1c) levels in Type I diabetic patients: A systematic review
Chetty, V. T., Almulla, A., Odueyungbo, A., & Thabane, L. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.02.014 · Cited by 85
GUIDELINES ON DIABETES, PRE-DIABETES, AND CARDIOVASCULAR DISEASES
Rydén, L., Standl, E., Bartnik, M., den Berghe, G. V., Betteridge, J. D., de Boer, M. J., Cosentino, F., Jönsson, B., Laakso, M., Malmberg, K., et al. (2007) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2007-3-4-71-99 · Cited by 81
“The metabolic determinants and physiological bases of FPG and 2-hPG differ to some extent.(1,16,17) This means the categorization of an individual on a FPG value may differ from that based on a 2-hPG.”
Background
Acute Glucose Fluctuations and Chronic Sustained Hyperglycemia as Risk Factors for Cardiovascular Diseases in Patients with Type 2 Diabetes
Colette, C., & Monnier, L. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-985157 · Cited by 81
Hyperglycemia during Induction Therapy is Associated with Poorer Survival in Children with Acute Lymphocytic Leukemia
Sonabend, R., McKay, S. V., Okcu, M. F., Yan, J., Haymond, M. W., & Margolin, J. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.01.072 · Cited by 81
Cutaneous Complications With Continuous or Flash Glucose Monitoring Use: Systematic Review of Trials and Observational Studies
Asarani, N. A. M., Reynolds, A. N., Styles, S. E., de Bock, M. I., & Wheeler, B. J. (2019) · Journal of Diabetes Science and Technology · doi:10.1177/1932296819870849 · Cited by 81
“Achieving healthy glycemic control is a critical goal for those with diabetes given the increased risk of both micro- and macrovascular complications.(1,2) Crucial to achieving this is frequent self-monitoring of glucose.”
Background
Impact of postprandial glucose control on diabetes-related complications: How is the evidence evolving?
Madsbad, S. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.09.019 · Cited by 78
“PPG is a key contributor to overall glycaemic control, and represents a primary target to improve HbA1c levels and, in turn, to reduce the vascular complications of diabetes [5-9].”
Background
The glycemic index and cardiovascular disease risk
Brand-Miller, J. C., Dickinson, S. P., Barclay, A. W., & Celermajer, D. S. (2007) · Current Atherosclerosis Reports · doi:10.1007/s11883-007-0064-x · Cited by 77
Optimizing Display, Analysis, Interpretation and Utility of Self-Monitoring of Blood Glucose (SMBG) Data for Management of Patients with Diabetes
Rodbard, D. (2007) · Journal of Diabetes Science and Technology · doi:10.1177/193229680700100111 · Cited by 74
Glycemic Index, Retinal Vascular Caliber, and Stroke Mortality
Kaushik, S., Wang, J. J., Wong, T. Y., Flood, V. M., Barclay, A. W., Brand-Miller, J. C., & Mitchell, P. (2008) · Stroke · doi:10.1161/strokeaha.108.513812 · Cited by 74
Acute hyperglycaemia rapidly increases arterial stiffness in young patients with type 1 diabetes
Gordin, D., Rönnback, M., Forsblom, C. M., Heikkilä, O., Saraheimo, M., & Groop, P. (2007) · Diabetologia · doi:10.1007/s00125-007-0730-0 · Cited by 76
“This, together with the observation of the effect of postprandial hyperglycaemia on HbA1c in patients with type 1 diabetes in the Diabetes Control and Complications Trial (DCCT) [41, 42], is an additional reason to strictly control daily blood glucose levels.”
Background
Sustained IL-1α, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus
Duque, J. S. R., Flores, R. L., Oliver, S. R., Pontello, A. M., Zaldivar, F. P., & Galassetti, P. R. (2008) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2007.00243.x · Cited by 72
Cardiovascular Disease in Diabetes Mellitus
Szuszkiewicz-Garcia, M., & Davidson, J. A. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.09.001 · Cited by 76
“tolerance test, as well as after a meal challenge, has proved to be a good predictor of cardiovascular events and mortality.(13) This relationship is linear.”
A Novel Analytical Method for Assessing Glucose Variability: Using CGMS in Type 1 Diabetes Mellitus
McCall, A. L., Cox, D. J., Crean, J., Gloster, M., & Kovatchev, B. P. (2006) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2006.8.644 · Cited by 72
Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: full text: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)
Authors Task Force Members, Rydén, L., Standl, E., Bartnik, M., den Berghe, G. V., Betteridge, J. D., de Boer, M., Cosentino, F., Jönsson, B., Laakso, M., et al. (2007) · European Heart Journal Supplements · doi:10.1093/eurheartj/ehl261 · Cited by 76
Atherogenicity of postprandial hyperglycemia and lipotoxicity
Ceriello, A., & Genovese, S. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9341-8 · Cited by 78
“and those in the general population [2].”
Self-citation
Synthesis of novel α-glucans with potential health benefits through controlled glucose release in the human gastrointestinal tract
Gangoiti, J., Corwin, S., Lamothe, L. M., Vafiadi, C., Hamaker, B. R., & Dijkhuizen, L. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1516621 · Cited by 73
Pramlintide in the Treatment of Diabetes Mellitus
Edelman, S. V., Maier, H., & Wilhelm, K. (2008) · BioDrugs · doi:10.2165/0063030-200822060-00004 · Cited by 68
DPP-4 inhibitors: pharmacological differences and their clinical implications
Ceriello, A., Sportiello, L., Rafaniello, C., & Rossi, F. (2014) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2014.944862 · Cited by 69
“Acute fluctuations of glucose more than chronic high glucose in the T2D individual have a harmful effect [82] through activation of oxidative stress at mitochondrial level [83].”
BackgroundSelf-citation
The Effect of Chromium Picolinate and Biotin Supplementation on Glycemic Control in Poorly Controlled Patients with Type 2 Diabetes Mellitus: A Placebo-Controlled, Double-Blinded, Randomized Trial
Singer, G. M., & Geohas, J. (2006) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2006.8.636 · Cited by 67
“18 Adverse effects of post-prandial hyperglycemia have been demonstrated.”
Carbohydrate restriction for diabetes: rediscovering centuries-old wisdom
Lennerz, B. S., Koutnik, A. P., Azova, S., Wolfsdorf, J. I., & Ludwig, D. S. (2021) · Journal of Clinical Investigation · doi:10.1172/jci142246 · Cited by 78
Exercise and 24-h Glycemic Control
van Dijk, J., MANDERS, R. J. F., Canfora, E. E., van Mechelen, W., Hartgens, F., Stehouwer, C. D. A., & van Loon, L. J. C. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31827ad8b4 · Cited by 67
Inhibitory effect of roasted/ unroasted Argania spinosa seeds oil on α- glucosidase, α-amylase and intestinal glucose absorption activities
Daoudi, N. E., Bouhrim, M., Ouassou, H., Legssyer, A., Mekhfi, H., Ziyyat, A., Aziz, M., & Bnouham, M. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2020.09.020 · Cited by 64
Continuous glucose monitoring in patients with type 2 diabetes: Why? When? Whom?
Monnier, L., Colette, C., Boegner, C., Pham, T. C., Lapinski, H., & Boniface, H. (2007) · Diabetes & Metabolism · doi:10.1016/j.diabet.2006.11.007 · Cited by 63
Glycemic Variability: Assessing Glycemia Differently and the Implications for Dietary Management of Diabetes
Tay, J., Thompson, C. H., & Brinkworth, G. D. (2015) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-121214-104422 · Cited by 63
“Recent evidence suggests that elevated PPG contributes to suboptimal glycemic control (4), has detrimental effects on CVD risk (51), and plays a significant role in the etiology of diabetes complications (238).”
Background
Safety and magnitude of changes in blood glucose levels following exercise performed in the fasted and the postprandial state in men with type 2 diabetes
Gaudet-Savard, T., Ferland, A., Broderick, T. L., Garneau, C., Tremblay, A., Nadeau, A., & Poirier, P. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3282efaf38 · Cited by 61
Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia
Li, H., Wei, J., Lin, M., Smith, D. J., Vainio, J., Lin, C.-H., Chiang, F., Shih, S., Huang, C.-H., Wu, M.-Y., et al. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.03.041 · Cited by 57
Effects of S21403 (mitiglinide) on postprandial generation of oxidative stress and inflammation in type 2 diabetic patients
Assaloni, R., ROS, R. D., Quagliaro, L., Piconi, L., Maier, A., Zuodar, G., Motz, E., & Ceriello, A. (2005) · Diabetologia · doi:10.1007/s00125-005-1849-5 · Cited by 56
“Therefore, emerging evidence suggesting that the modulation of postprandial hyperglycaemia makes it possible to reduce these factors, which are very probably involved in the pathogenesis of CVD, seems to be of clinical interest and relevance.”
InfluentialSelf-citation
Hyperglycemia during induction therapy is associated with increased infectious complications in childhood acute lymphocytic leukemia
Sonabend, R., McKay, S. V., Okcu, M. F., Yan, J., Haymond, M. W., & Margolin, J. (2008) · Pediatric Blood & Cancer · doi:10.1002/pbc.21624 · Cited by 56
“Additionally, postprandial hyperglycemia has been shown to be a more powerful predictor of diabetic complications than glycosylated hemoglobin (HbA1c) and fasting hyperglycemia alone [24].”
Background
Importance of Postprandial Glucose in Relation to A1C and Cardiovascular Disease
Hershon, K. S., Hirsch, B. R., & Odugbesan, O. (2019) · Clinical Diabetes · doi:10.2337/cd18-0040 · Cited by 62
“Studies have shown that, in addition to its contribution to overall A1C, PPG is an independent risk factor for CVD, with a demonstrated linear relationship of PPG and risk of cardiovascular (CV) death (13).”
Background
Basal insulin or premix analogue therapy in type 2 diabetes patients
Raskin, P., Hollander, P. A., Lewin, A. J., Gabbay, R. A., Bode, B. W., & Garber, A. J. (2007) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2006.09.006 · Cited by 55
“Although not yet confirmed by prospective intervention trials, as recently reviewed by several authors, numerous observational studies have demonstrated that improved control of postprandial glucose is statistically associated with a significantly decreased risk of macrovascular [7–10] and microvascular [11] complicat…”
BackgroundResult
Relationships between glucose excursion and the activation of oxidative stress in patients with newly diagnosed type 2 diabetes or impaired glucose regulation
Zheng, F., Lu, W., Jia, C., Li, H., Wang, Z., & Jia, W. (2010) · Endocrine · doi:10.1007/s12020-009-9296-6 · Cited by 55
“The condition of chronic hyperglycemia can present in two different forms: sustained hyperglycemia and fluctuating hyperglycemia [ 4 , 5]. Glycated hemoglobin (HbA1c), an indicator of chronic sustained hyperglycemia, is the standard by which glycemic control is measured.”
Background
Inhibition of α‐Glucosidase, Intestinal Glucose Absorption, and Antidiabetic Properties by Caralluma europaea
Ouassou, H., Zahidi, T., Bouknana, S., Bouhrim, M., Mekhfi, H., Ziyyat, A., Legssyer, A., Aziz, M., & Bnouham, M. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/9589472 · Cited by 54
“Most epidemiological data implicate postprandial hyperglycemia in the development of chronic complications [8].”
Background
Evaluation of a simple policy for pre- and post-prandial blood glucose self-monitoring in people with type 2 diabetes not on insulin
Bonomo, K., De Salve, A., Fiora, E., Mularoni, E., Massucco, P., Poy, P., Pomero, A., Cavalot, F., Anfossi, G., & Trovati, M. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.10.021 · Cited by 53
Impact of Nutrient Type and Sequence on Glucose Tolerance: Physiological Insights and Therapeutic Implications
Nesti, L., Mengozzi, A., & Tricò, D. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00144 · Cited by 53
Haemoglobin A1c levels and subsequent cardiovascular disease in persons without diabetes: a meta-analysis of prospective cohorts
Santos‐Oliveira, R., Purdy, C., da Silva, M. P., Carneiro-Leão, A. M. D. A., Machado, M., & Einarson, T. R. (2011) · Diabetologia · doi:10.1007/s00125-011-2078-8 · Cited by 51
“However, despite the increasing number of studies of glycaemic control and CVEs, few have examined that relationship in persons without diabetes [1–8].”
Background
Phytochemical Analysis, α-Glucosidase and α-Amylase Inhibitory Activities and Acute Toxicity Studies of Extracts from Pomegranate (Punica granatum) Bark, a Valuable Agro-Industrial By-Product
Laaraj, N., Bouhrim, M., Kharchoufa, L., Tiji, S., Bendaha, H., Addi, M., Drouet, S., Hano, C., Lorenzo, J. M., Bnouham, M., et al. (2022) · Foods · doi:10.3390/foods11091353 · Cited by 56
“One of the treatments for decreasing postprandial hyperglycemia is related to the inhibition of digestive enzymes and the reduction in glucose intestinal absorption [5].”
Background
Exploring the Variability in Acute Glycemic Responses to Exercise in Type 2 Diabetes
Terada, T., Friesen, A., Chahal, B. S., Bell, G. J., McCargar, L. J., & Boulé, N. G. (2013) · Journal of Diabetes Research · doi:10.1155/2013/591574 · Cited by 53
“Given the possible pathogenic role postprandial hyperglycemia plays on the risk of diabetic complications [24, 25], performing exercise within 2 hours ofmeal intakemay be a good strategy to attenuate meal-induced hyperglycemia.”
Background
Dietary Glycemic Load Is a Predictor of Age-Related Hearing Loss in Older Adults ,
Gopinath, B., Flood, V. M., McMahon, C. M., Burlutsky, G., Brand-Miller, J. C., & Mitchell, P. L. R. (2010) · Journal of Nutrition · doi:10.3945/jn.110.128462 · Cited by 50
Relationship Between Diurnal Blood Pressure Variation and Diurnal Blood Glucose Levels in Type 2 Diabetic Patients
Pistrosch, F., Reissmann, E., Wildbrett, J., Koehler, C., & Hanefeld, M. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2006.10.010 · Cited by 49
What Do We Need beyond Hemoglobin A1c to Get the Complete Picture of Glycemia in People with Diabetes?
Hinzmann, R., Schlaeger, C., & Tran, C. T. (2012) · International Journal of Medical Sciences · doi:10.7150/ijms.4520 · Cited by 51
“The exposure to elevated blood glucose levels in people with diabetes involves two components: the duration and magnitude of chronically sustained hyperglycemia, reflected in HbA1c, and the acute fluctuations of glucose around a mean value from peaks to nadirs over a daily period [69-73], reflecting intermittent acute…”
Background
Peak-time determination of post-meal glucose excursions in insulin-treated diabetic patients
Daenen, S., Sola‐Gazagnes, A., M’Bemba, J., Dorange-Breillard, C., Defer, F., Elgrably, F., Larger, É., & Slama, G. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2009.12.002 · Cited by 49
Point: Postprandial Glucose Levels Are a Clinically Important Treatment Target
Ceriello, A. (2010) · Diabetes Care · doi:10.2337/dc10-0634 · Cited by 51
“pothesis (11), including the recent data of”
BackgroundSelf-citation
CGMS and Glycemic Variability, Relevance in Clinical Research to Evaluate Interventions in T2D, a Literature Review
Breyton, A.-E., Lambert-Porcheron, S., Laville, M., Vinoy, S., & Nazare, J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.666008 · Cited by 48
Insulin Aspart in the Management of Diabetes Mellitus: 15 Years of Clinical Experience
Hermansen, K., Bohl, M., & Schioldan, A. G. (2015) · Drugs · doi:10.1007/s40265-015-0500-0 · Cited by 47
“Some studies have indicated that postprandial glucose is a predictor of CVD or mortality independent of fasting glucose levels [19–24]; however, the current evidence for this is still highly controversial [25].”
Background
Antiinflammatory and ROS Suppressive Effects of the Addition of Fiber to a High-Fat High-Calorie Meal
Ghanim, H., Batra, M., Abuaysheh, S., Green, K., Makdissi, A., Kuhadiya, N. D., Chaudhuri, A., & Dandona, P. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2669 · Cited by 46
The Role of Molecular and Inflammatory Indicators in the Assessment of Cognitive Dysfunction in a Mouse Model of Diabetes
Piątkowska‐Chmiel, I., Herbet, M., Gawrońska‐Grzywacz, M., Ostrowska-Leśko, M., & Dudka, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083878 · Cited by 46
“High fasting glucose and insulin levels and high HOMA-IR index didn’t only confirm effective induction of experimental type 2 diabetes but also made it possible to observe CNS dysfunction widely described in the literature [6,7,11,13,49].”
Background
Control of plasma glucose with alpha-glucosidase inhibitor attenuates oxidative stress and slows the progression of heart failure in mice
Liao, Y., Takashima, S., ZHAO, H., ASANO, Y., Shintani, Y., Minamino, T., KIM, J., Fujita, M., HORI, M., & Kitakaze, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.01.021 · Cited by 45
Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load
Walsh, L. K., Restaino, R. M., Neuringer, M., Manrique, C. M., & Padilla, J. (2016) · Clinical Science · doi:10.1042/cs20160501 · Cited by 43
“It is well established that hyperglycemia is a major underlying contributor to cardiovascular disease (3, 12, 13, 14, 41, 51, 60, 63).”
Background
Cardiac cell death in early diabetes and its modulation by dietary fatty acids
Ghosh, S., & Rodrigues, B. B. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.08.010 · Cited by 43
Exercise-nutrient interactions for improved postprandial glycemic control and insulin sensitivity
Gillen, J. B., Estafanos, S., & Govette, A. (2021) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2021-0168 · Cited by 52
Diabetic Gastroparesis and Its Impact on Glycemia
Chang, J., Rayner, C. K., Jones, K. L., & Horowitz, M. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2010.08.007 · Cited by 43
Glycation and biomarkers of vascular complications of diabetes
Beisswenger, P. J. (2010) · Amino Acids · doi:10.1007/s00726-010-0784-z · Cited by 42
A study on the glycemic, lipid and blood pressure control among the type 2 diabetes patients of north Kerala, India
Kumar, S., & Sandhya, A. S. (2017) · Indian Heart Journal · doi:10.1016/j.ihj.2017.10.007 · Cited by 43

Authors: Ceriello, A.
Affiliations: University of Udine (IT)
Corresponding author: Ceriello, Antonio
ORCID: Ceriello, Antonio
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 2004-10-25
Volume: 164
Issue: 19
Pages: 2090
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.164.19.2090
OpenAlex: W2037632798
Cited by: 362
References: 52
Citations by year: 2026: 7 · 2025: 16 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 15 · 2020: 12 · 2019: 19 · 2018: 15 · 2017: 12 · 2016: 22 · 2015: 15 · 2014: 11 · 2013: 19 · 2012: 23
FWCI: 12.81
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System (University of Udine) (submittedVersion)
STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: postprandial blood glucose, postprandial hyperglycemia, type 2 diabetes, cardiovascular complications, atherosclerosis, glycemic control, HbA1c, oxidative stress, endothelial cell cytotoxicity, glycemic exposure, cardiovascular risk prediction
MeSH terms: Blood Glucose, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Postprandial Period, Diabetes Complications

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Postprandial Glucose Regulation and Diabetic Complications

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks