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Cited by 7Diabetes, Cardiovascular Risks, and LipoproteinsAcute Ischemic Stroke ManagementDementia and Cognitive Impairment Research

Metabolic Syndrome Compared With Type 2 Diabetes Mellitus as a Risk Factor for Stroke: The Framingham Offspring Study

Najarian, Robert M.·2006·Archives of Internal Medicine
DOI 10.1001/archinte.166.1.106
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Abstract

Background Metabolic syndrome (MetS) has been recognized as a prediabetic constellation of symptoms and an independent risk factor for cardiovascular disease.Methods To evaluate the age-adjusted risk of stroke and population-attributable risk associated with MetS and compare with those of overt type 2 diabetes mellitus (hereinafter, "diabetes"), we determined the prevalence of MetS alone, diabetes alone, and both in 2097 subjects in the Framingham Offspring Study, aged 50 to 81 years and free of stroke. Age-adjusted risk ratios, 10-year incidence, and population-attributable risks of stroke were estimated for men and women with MetS alone, diabetes alone, and both.Results Criteria for MetS were met in 30.3% of men and 24.7% of women. Twenty-four percent of men had MetS alone; 7% had diabetes alone; and 6% had both. Twenty percent of women had MetS alone; 3% had diabetes alone; and 5% had both. Over 14 years of follow-up, 75 men and 55 women developed a first stroke; all but 4 events were ischemic. Relative risk (RR) of stroke in persons with both diabetes and MetS (RR, 3.28; confidence interval [CI], 1.82-5.92) was higher than that for either condition alone (MetS alone: RR, 2.10; CI, 1.37-3.22; diabetes alone: RR, 2.47; CI, 1.31-4.65). The population-attributable risk, owing to its greater prevalence, was greater for MetS alone than for diabetes alone (19% vs 7%), particularly in women (27% vs 5%).Conclusions Metabolic syndrome is more prevalent than diabetes and a significant independent risk factor for stroke in people without diabetes. Prevention and control of MetS and its components are likely to reduce stroke incidence.

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  • In the Framingham Offspring Study, both MetS and T2D increased the risk of stroke by approximately 2-fold, and those patients with both had an even higher risk.

    “In the Framingham Offspring Study, both MetS and T2D increased the risk of stroke by approximately 2-fold, and those patients with both had an even higher risk (12).”

    From The CardioMetabolic Health Alliance (2015) · cites this paper as [12]

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Authors
Najarian, R. M.
Affiliations
Boston University (US)
Corresponding author
Najarian, Robert M.
ORCID
Najarian, Robert M.
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2006-01-09
Volume
166
Issue
1
Pages
106
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.166.1.106
OpenAlex
W1572014162
Cited by
0
References
26
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
Archives of Internal Medicine (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (N01‐HC25195)
  • National Institute of Neurological Disorders and Stroke (5-R01-NS-17950)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
metabolic syndrome, type 2 diabetes, stroke, stroke risk factors, cardiovascular risk

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