Mononucleosis and Chronic Daytime Sleepiness: A Long-term Follow-up Study
Abstract
• Twelve patients between 14 and 26 years of age, ten with infectious mononucleosis and two with Guillain-Barré syndrome, all of whom were suspected of having had Epstein-Barr viral infection, developed daytime sleepiness. The daytime somnolence was confirmed objectively by polygraphic monitoring seven weeks to 41/2 months after the onset of clinical symptoms. The patients have been followed up for three to 12 years. None has had any other neurologic sequelae, but all have disabling daytime sleepiness. Treatment brings only mild relief. A retrospective chart study of 35 patients with infectious mononucleosis did not identify, on the basis of initial clinical symptoms, those patients who developed chronic impairment. (Arch Intern Med1986;146:1333-1335)
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Nonconventional EEG sleep analysis studies found alterations in SWA, such as lower SWA in the ultra-low delta range or a blunted SWA response to a sleep onset delay, and alterations of cyclic alternating patterns indicating increased sleep instability in ME/CFS patients.
“a few studies also found alterations in SWA, such as lower SWA in the ultra-low delta range (i.e., slow oscillatory activity) (330) or a blunted SWA response to a sleep onset delay in ME/CFS patients (17), as well as alterations of cyclic alternating patterns, indicating increased sleep instability (219).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [219]
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- Authors
- Guilleminault, C.
- Corresponding author
- Guilleminault, Christian
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1986-07-01
- Volume
- 146
- Issue
- 7
- Pages
- 1333
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W4317639534
- Cited by
- 62
- References
- 0
- Citations by year
- 2025: 1 · 2024: 4 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 2 · 2013: 2 · 2012: 3
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- Funders
- National Institute on Aging (AG-02504)
- National Center for Research Resources (RR 00 070)
- Topics
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- infectious mononucleosis, Epstein-Barr virus infection, Guillain-Barré syndrome, long-term follow-up, neurological sequelae
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