Sleep, sleep deprivation and infectious disease: Studies in animals
Abstract
Common perceptions that the desire for sleep is increased during mild infectious diseases like colds and 'the flu' have fostered beliefs that sleep promotes recovery from infectious disease and that lack of sleep increases susceptibility to infections. However, until recently, the relationship between infectious disease and vigilance received relatively little systematic study. At present, several model systems provide evidence that infectious disease is accompanied by alterations in sleep. Indeed, increased sleepiness, like fever and anorexia, may be viewed as a facet of the acute phase response to infectious challenge. Recent studies also suggest that sleep, sleep deprivation and infectious disease may be related via mechanisms of the immune system (Fig. 1). Data are now accumulating to address questions such as whether immune processes alter sleep, whether sleep or sleep deprivation influences immune competence, and whether sleep facilitates recovery from infectious disease.
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Corresponding findings were obtained in rabbits, where the amount of SWS predicted the survival rate after a pathogen challenge.
“Corresponding findings were obtained in rabbits, where the amount of SWS predicted the survival rate after a pathogen challenge (1205).”
From About Sleep's Role in Memory (2013) · cites this paper as [1205]
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- Authors
- Toth, L. A.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Toth, Linda A.
- Venue
- Advances in Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 1995
- Volume
- 5
- Issue
- 1
- Pages
- 79-92
- ISSN
- 0960-5428 (ISSN-L)
- OpenAlex
- W2038848909
- Cited by
- 93
- References
- 4
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 2
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advances in Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns026429-10)
- National Cancer Institute (CA21765, P30CA021765)
- National Institute of Neurological Disorders and Stroke (NS-26429)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep, sleep deprivation, infectious diseases, immune system, sleep-immune interaction, fever, anorexia, acute phase response, sleepiness, recovery from infection, sustained attention
- MeSH terms
- Acetylmuramyl-Alanyl-Isoglutamine, Animals, Arousal, Fever, Hormones, Humans, Infections, Neuropeptides, Rabbits, Sleep, Sleep Deprivation, Species Specificity, Neuroimmunomodulation, Cytokines, Mice, Rats
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