Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation

Hansen, Morten L.; Sørensen, Rikke; Clausen, Mette T.; Fog-Petersen, Marie Louise; Raunsø, Jakob; Gadsbøll, Niels; Gislason, Gunnar H.; Folke, Fredrik; Andersen, Søren S.; Schramm, Tina K.; Abildstrøm, Steen Z.; Poulsen, Henrik E.; Køber, Lars; Torp-Pedersen, Christian

doi:10.1001/archinternmed.2010.271

Cited by 855Atrial Fibrillation Management and OutcomesAntiplatelet Therapy and Cardiovascular DiseasesBlood Coagulation and Thrombosis Mechanisms

Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation

Hansen, Morten L., Sørensen, Rikke, Clausen, Mette T., Fog-Petersen, Marie Louise, Raunsø, Jakob, Gadsbøll, Niels, Gislason, Gunnar H., Folke, Fredrik +6 more·2010·Archives of Internal Medicine

DOI 10.1001/archinternmed.2010.271

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Abstract

BACKGROUND: Patients with atrial fibrillation (AF) often require anticoagulation and platelet inhibition, but data are limited on the bleeding risk of combination therapy. METHODS: We performed a cohort study using nationwide registries to identify all Danish patients surviving first-time hospitalization for AF between January 1, 1997, and December 31, 2006, and their posthospital therapy of warfarin, aspirin, clopidogrel, and combinations of these drugs. Cox proportional hazards models were used to estimate risks of nonfatal and fatal bleeding. RESULTS: A total of 82,854 of 118,606 patients (69.9%) surviving AF hospitalization had at least 1 prescription filled for warfarin, aspirin, or clopidogrel after discharge. During mean (SD) follow-up of 3.3 (2.6) years, 13,573 patients (11.4%) experienced a nonfatal or fatal bleeding. The crude incidence rate for bleeding was highest for dual clopidogrel and warfarin therapy (13.9% per patient-year) and triple therapy (15.7% per patient-year). Using warfarin monotherapy as a reference, the hazard ratio (95% confidence interval) for the combined end point was 0.93 (0.88-0.98) for aspirin, 1.06 (0.87-1.29) for clopidogrel, 1.66 (1.34-2.04) for aspirin-clopidogrel, 1.83 (1.72-1.96) for warfarin-aspirin, 3.08 (2.32-3.91) for warfarin-clopidogrel, and 3.70 (2.89-4.76) for warfarin-aspirin-clopidogrel. CONCLUSIONS: In patients with AF, all combinations of warfarin, aspirin, and clopidogrel are associated with increased risk of nonfatal and fatal bleeding. Dual warfarin and clopidogrel therapy and triple therapy carried a more than 3-fold higher risk than did warfarin monotherapy.

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Approximately 15% of AF patients in contemporary trials and registries have a history of myocardial infarction.
“Approximately 15% of AF patients in contemporary trials 513 and registries [514][515][516] have a history of myocardial 1498 infarction.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [514]

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
(1996) · The Lancet · doi:10.1016/s0140-6736(96)09457-3 · Cited by 6,503 · see citing works
A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee
Dennis, M. S. (1996) · The Lancet · Cited by 2,724 · see citing works
Effect of clopidogrel added to aspirin in patients with atrial fibrillation
The ACTIVE Investigators (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901301 · Cited by 2,102 · see citing works
Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial
(2006) · The Lancet · doi:10.1016/s0140-6736(06)68845-4 · Cited by 1,952 · see citing works
PLACEBO-CONTROLLED, RANDOMISED TRIAL OF WARFARIN AND ASPIRIN FOR PREVENTION OF THROMBOEMBOLIC COMPLICATIONS IN CHRONIC ATRIAL FIBRILLATION
Petersen, P., GODTFREDSEN, J., Boysen, G., Andersen, E. D., & Andersen, B. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91200-2 · Cited by 1,814 · see citing works
Stroke Prevention in Atrial Fibrillation Study. Final results.
Prevention, S., & Atrial Fibrillation Investigators (1991) · Circulation · doi:10.1161/01.cir.84.2.527 · Cited by 1,696 · see citing works
Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial
Mant, J., Hobbs, F. R., Fletcher, K., Roalfe, A., Fitzmaurice, D., Lip, G. Y., & Murray, E. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61233-1 · Cited by 1,556 · see citing works
The Effect of Low-Dose Warfarin on the Risk of Stroke in Patients with Nonrheumatic Atrial Fibrillation
The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators* (1990) · New England Journal of Medicine · doi:10.1056/nejm199011293232201 · Cited by 1,525 · see citing works
ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation—Executive Summary
Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.009 · Cited by 1,157 · see citing works
Canadian atrial fibrillation anticoaguiation (CAFA) study
Connolly, S. J., Laupacis, A., Gent, M., Roberts, R. S., Cairns, J. A., & Joyner, C. D. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90585-w · Cited by 1,109 · see citing works
Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation: Stroke Prevention in Atrial Fibrillation III randomised clinical trial
(1996) · The Lancet · doi:10.1016/s0140-6736(96)03487-3 · Cited by 1,092 · see citing works
Warfarin in the Prevention of Stroke Associated with Nonrheumatic Atrial Fibrillation
Barnes, D. J. (1993) · New England Journal of Medicine · doi:10.1056/nejm199301143280227 · Cited by 1,068 · see citing works
Major Hemorrhage and Tolerability of Warfarin in the First Year of Therapy Among Elderly Patients With Atrial Fibrillation
Hylek, E. M., Evans‐Molina, C., Shea, C., Henault, L. E., & Regan, S. (2007) · Circulation · doi:10.1161/circulationaha.106.653048 · Cited by 1,062 · see citing works
Risk Factors for Intracranial Hemorrhage in Outpatients Taking Warfarin
Hylek, E. M., & Singer, D. E. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-120-11-199406010-00001 · Cited by 921 · see citing works
Antithrombotic Therapy in Atrial Fibrillation
Singer, D. E., Albers, G. W., Dalen, J. E., Fang, M. C., Go, A. S., Halperin, J. L., Lip, G. Y. H., & Manning, W. J. (2008) · CHEST Journal · doi:10.1378/chest.08-0678 · Cited by 755 · see citing works
Oral Anticoagulants vs Aspirin in Nonvalvular Atrial Fibrillation
van Walraven, C., Hart, R. G., Singer, D. E., Laupacis, A., Connolly, S. J., Petersen, P., Koudstaal, P. J., Chang, Y., & Hellemons, B. S. P. (2002) · JAMA · doi:10.1001/jama.288.19.2441 · Cited by 715 · see citing works
Risk Factors for Complications of Chronic Anticoagulation: A Multicenter Study
Fihn, S. D., McDonell, M., Martin, D., Henikoff, J. G., Vermes, D., Kent, D., White, R. H., & for the Warfarin Optimized Outpatient Follow-up Study Group* (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-118-7-199304010-00005 · Cited by 670 · see citing works
ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation–executive summary
Authors Task Force Members, Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl176 · Cited by 645 · see citing works
Risk of bleeding in patients with acute myocardial infarction treated with different combinations of aspirin, clopidogrel, and vitamin K antagonists in Denmark: a retrospective analysis of nationwide registry data
Sørensen, R., Hansen, M. L., Abildstrom, S. Z., Hvelplund, A., Andersson, C., Jørgensen, C. H., Madsen, J. K., Hansen, P. R., Køber, L., Torp-Pedersen, C. T., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61751-7 · Cited by 575 · see citing works
The Danish prescription registries.
Gaist, D., Sørensen, H. T., & Hallas, J. (1997) · PubMed · Cited by 570 · see citing works
Meta-analysis: Anticoagulant Prophylaxis to Prevent Symptomatic Venous Thromboembolism in Hospitalized Medical Patients
Dentali, F., Douketis, J. D., Gianni, M., Lim, W., & Crowther, M. A. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-4-200702200-00007 · Cited by 542 · see citing works
Fixed Minidose Warfarin and Aspirin Alone and in Combination vs Adjusted-Dose Warfarin for Stroke Prevention in Atrial Fibrillation
Gulløv, A. L., Koefoed, B. G., Petersen, P., Pedersen, T. S., Andersen, E. D., GODTFREDSEN, J., & Boysen, G. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.14.1513 · Cited by 301 · see citing works
Long-term compliance with beta-blockers, angiotensin-converting enzyme inhibitors, and statins after acute myocardial infarction
Gislason, G., Rasmussen, J. N., Abildstrom, S. Z., Gadsbøll, N., Buch, P., Friberg, J., Rasmussen, S., Køber, L., Stender, S., Madsen, M., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi705 · Cited by 301 · see citing works
Safety and efficacy of combined antiplatelet-warfarin therapy after coronary stenting
Karjalainen, P. P., Porela, P., Ylitalo, A., Vikman, S., Nyman, K., Vaittinen, M.-A., Airaksinen, T. J., Niemelä, M., Vahlberg, T. J., & Airaksinen, J. K. E. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehl488 · Cited by 286 · see citing works
Anticoagulant and Antiplatelet Therapy Use in 426 Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention and Stent Implantation
Ruiz-Nodar, J. M., Marín, F., Hurtado, J. A., Valencia, J., Pinar, E., Pineda, J., Gimeno, J. R., Sogorb, F., Valdés, M., & Lip, G. Y. H. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.11.035 · Cited by 269 · see citing works
Alcohol Consumption and Risk of Atrial Fibrillation in Men and Women
Mukamal, K. J., Tolstrup, J. S., Friberg, J., Jensen, G. B., & Grønbæk, M. (2005) · Circulation · doi:10.1161/circulationaha.105.547844 · Cited by 269 · see citing works
For the Veterans Affairs Stroke Prevention in Nonrheumatic Atrial Fibrillation Investigators : Warfarin in the prevention of stroke associated with nonrheumatic atrial fibrillation
Ezekowitz (1992) · New England Journal of Medicine · Cited by 266 · see citing works
Combined Anticoagulant–Antiplatelet Use and Major Bleeding Events in Elderly Atrial Fibrillation Patients
Shireman, T. I., Howard, P. A., Kresowik, T. F., & Ellerbeck, E. F. (2004) · Stroke · doi:10.1161/01.str.0000141933.75462.c2 · Cited by 229 · see citing works
Combination therapy with aspirin, clopidogrel and warfarin following coronary stenting is associated with a significant risk of bleeding.
Khurram, Z., Chou, E. T., Minutello, R. M., Bergman, G. W., Parikh, M., Naidu, S. S., Wong, S. C., & Hong, M. K. (2006) · PubMed · Cited by 186 · see citing works
Risks and benefits of combining aspirin with anticoagulant therapy in patients with atrial fibrillation: An exploratory analysis of stroke prevention using an oral thrombin inhibitor in atrial fibrillation (SPORTIF) trials
Flaker, G. C., Gruber, M. J., Connolly, S. J., Goldman, S. M., Chaparro, S. V., Vahanian, A. S., Halinen, M., Horrow, J. C., & Halperin, J. L. (2006) · American Heart Journal · doi:10.1016/j.ahj.2006.06.024 · Cited by 181 · see citing works
Optimal INR for prevention of stroke and death in atrial fibrillation: a critical appraisal
Odén, A., Fahlén, M., & Hart, R. G. (2004) · Thrombosis Research · doi:10.1016/j.thromres.2004.11.025 · Cited by 162 · see citing works
The pattern of use of non‐steroidal anti‐inflammatory drugs (NSAIDs) from 1997 to 2005: a nationwide study on 4.6 million people
Fosbøl, E. L., Gislason, G., Jacobsen, S., Abildstrom, S. Z., Hansen, M. L., Schramm, T. K., Folke, F., Sørensen, R., Rasmussen, J. N., Køber, L., et al. (2008) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1592 · Cited by 144 · see citing works
Antithrombotic therapy in patients treated with oral anticoagulation undergoing coronary artery stenting. An expert consensus document with focus on atrial fibrillation
Rubboli, A., Halperin, J. L., Airaksinen, J. K. E., Buerke, M., Eeckhout, É., Freedman, S. B., Gershlick, A., Schlitt, A., Tse, H., Verheugt, F. W. A., et al. (2008) · Annals of Medicine · doi:10.1080/07853890802089786 · Cited by 127 · see citing works
Combining warfarin and antiplatelet therapy after coronary stenting in the Global Registry of Acute Coronary Events: is it safe and effective to use just one antiplatelet agent?
Nguyen, M. C., Lim, Y. L., Walton, A., Lefkovits, J., Agnelli, G., Goodman, S. G., Budaj, A., Gulba, D. C., Allegrone, J., Brieger, D. B., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm186 · Cited by 121 · see citing works
Increased Major Bleeding Complications Related to Triple Antithrombotic Therapy Usage in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Artery Stenting
Manzano‐Fernández, S., Pastor, F. J., Marín, F. R., Cambronero, F., Martínez, C. C., Pascual-Figal, D. A., Garrido, I. P., Pinar, E., Valdés, M., & Lip, G. Y. H. (2008) · CHEST Journal · doi:10.1378/chest.08-0350 · Cited by 120 · see citing works
Major haemorrhagic complications during oral anticoagulant therapy in a Danish Population‐based cohort
Steffensen, F. H., Kristensen, K., Ejlersen, E., Dahlerup, J. F., & Sørensen, H. T. (1997) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1997.tb00023.x · Cited by 104 · see citing works
Dual Antiplatelet Therapy After Percutaneous Coronary Intervention With Stent Implantation in Patients Taking Chronic Oral Anticoagulation
Rogacka, R., Chieffo, A., Michev, I., Airoldi, F., Latib, A., Cosgrave, J., Montorfano, M., Carlino, M., Sangiorgi, G., Castelli, A., et al. (2008) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2007.11.004 · Cited by 97 · see citing works
Risk of Major Bleeding with Concomitant Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients Receiving Long‐Term Warfarin Therapy
DeEugenio, D. L., Kolman, L. R., DeCaro, M. V., Andrel, J. A., Chervoneva, I., Duong, P. V., Lam, L., McGowan, C., Lee, G., DeCaro, M. J., et al. (2007) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.27.5.691 · Cited by 91 · see citing works
Aspirin and clopidogrel with or without phenprocoumon after drug eluting coronary stent placement in patients on chronic oral anticoagulation
Sarafoff, N., Ndrepepa, G., Mehilli, J., Dörrler, K., Schulz, S., Iijima, R., Byrne, R. A., Schömig, A., & Kastrati, A. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.01989.x · Cited by 84 · see citing works
Outcomes Associated With Combined Antiplatelet and Anticoagulant Therapy
Johnson, S. G., Rogers, K. R., Delate, T., & Witt, D. M. (2008) · CHEST Journal · doi:10.1378/chest.07-2627 · Cited by 80 · see citing works
Use of sumatriptan in Denmark in 1994–5: an epidemiological analysisof nationwide prescription data
Gaist, D., Andersen, M. T., Aarup, A., Hallas, J., & Gram, L. F. (1997) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1997.00582.x · Cited by 53 · see citing works
Hospital Variation in Mortality After First Acute Myocardial Infarction in Denmark From 1995 to 2002
Rasmussen, S., Zwisler, A., Abildstrom, S. Z., Madsen, J. K., & Madsen, M. (2005) · Medical Care · doi:10.1097/01.mlr.0000178195.07110.d3 · Cited by 50 · see citing works
Trends in Risk of Stroke in Patients with a Hospital Diagnosis of Nonvalvular Atrial Fibrillation: National Cohort Study in Denmark, 1980–2002
Frost, L., Andersen, L. V., Vestergaard, P., Husted, S., & Mortensen, L. S. (2006) · Neuroepidemiology · doi:10.1159/000092795 · Cited by 37 · see citing works
Gastroduodenal mucosal damage with salsalate versus aspirin: Results of experimental models and endoscopic studies in humans
Scheiman, J. M., & Elta, G. H. (1990) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(90)90025-b · Cited by 32 · see citing works
Atrial fibrillation pharmacotherapy after hospital discharge between 1995 and 2004: a shift towards beta-blockers
Hansen, M. L., Gadsbøll, N., Gislason, G., Abildstrom, S. Z., Schramm, T. K., Folke, F., Friberg, J., Sørensen, R., Rasmussen, S., Poulsen, H. E., et al. (2008) · EP Europace · doi:10.1093/europace/eun011 · Cited by 24 · see citing works

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2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation
Ibanez, B., James, S., Agewall, S., Antunes, M. J., Bucciarelli-Ducci, C., Bueno, H., Caforio, A. L. P., Crea, F., Goudevenos, J. A., Halvorsen, S., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehx393 · Cited by 9,728 · see citing works
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H. G., Cigarroa, J. E., Cleveland, J. C., CONTI, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000041 · Cited by 7,119 · see citing works
ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation
Authors Task Force Members, Steg, P. G., James, S. K., Atar, D., Badano, L. P., Lundqvist, C. B., Borger, M. A., Mario, C. D., Dickstein, K., Ducrocq, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs215 · Cited by 6,837 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
2021 ESC/EACTS Guidelines for the management of valvular heart disease
Vahanian, A., Beyersdorf, F., Praz, F., Milojevic, M., Baldus, S., Bauersachs, J., Capodanno, D., Conradi, L., De Bonis, M., De Paulis, R., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehab395 · Cited by 5,685 · see citing works
Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
Kernan, W. N., Ovbiagele, B., Black, H. R., Bravata, D. M., Chimowitz, M. I., Ezekowitz, M. D., Fang, M. C., Fisher, M., Furie, K. L., Heck, D. V., et al. (2014) · Stroke · doi:10.1161/str.0000000000000024 · Cited by 5,170 · see citing works
2014 ESC/EACTS Guidelines on myocardial revascularization
Authors Task Force Members, Windecker, S., Kolh, P., Alfonso, F., Collet, J., Cremer, J., Falk, V., Filippatos, G., Hamm, C. W., Head, S. J., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu278 · Cited by 4,340 · see citing works
2014 ESC/EACTS Guidelines on myocardial revascularization
Kolh, P. H., Windecker, S., Alfonso, F., Collet, J., Cremer, J., Falk, V., Filippatos, G. S., Hamm, C. W., Head, S. J., Jüni, P., et al. (2014) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezu366 · Cited by 4,211 · see citing works
2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes
Amsterdam, E. A., Wenger, N. K., Brindis, R. G., Casey, D. E., Ganiats, T. G., Holmes, D. R., Jaffe, A. S., Jneid, H., Kelly, R. F., Kontos, M. C., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.09.017 · Cited by 3,595 · see citing works
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H., Cigarroa, J. E., Cleveland, J. C., Conti, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.022 · Cited by 2,955 · see citing works
2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS
Valgimigli, M., Bueno, H., Byrne, R. A., Collet, J., Costa, F., Jeppsson, A., Jüni, P., Kastrati, A., Kolh, P. H., Mauri, L., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx419 · Cited by 2,999 · see citing works
Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial
Dewilde, W. J., Oirbans, T., Verheugt, F. W., Kelder, J. C., De Smet, B. J., Herrman, J.-P., Adriaenssens, T., Vrolix, M., Heestermans, A. A., Vis, M. M., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62177-1 · Cited by 1,719 · see citing works
2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease
Levine, G. N., Bates, E., Bittl, J. A., Brindis, R. G., Fihn, S. D., Fleisher, L. A., Granger, C. B., Lange, R. A., Mack, M. J., Mauri, L., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.03.513 · Cited by 1,648 · see citing works
Oral Anticoagulant Therapy
Ageno, W., Gallus, A. S., Wittkowsky, A. K., Crowther, M. A., Hylek, E. M., & Palareti, G. (2012) · CHEST Journal · doi:10.1378/chest.11-2292 · Cited by 1,505 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
Evidence-Based Management of Anticoagulant Therapy
Holbrook, A. M., Schulman, S., Witt, D. M., Vandvik, P. O., Fish, J., Kovacs, M. J., Svensson, P. J., Veenstra, D. L., Crowther, M. A., & Guyatt, G. H. (2012) · CHEST Journal · doi:10.1378/chest.11-2295 · Cited by 1,273 · see citing works
2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines: an update of the 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention, 2011 ACCF/AHA guideline for coronary artery bypass graft surgery, 2012 ACC/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease, 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction, 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes, and 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery
Levine, G. N., Bates, E. R., Bittl, J. A., Brindis, R. G., Fihn, S. D., Fleisher, L. A., Granger, C. B., Lange, R. A., Mack, M. J., Mauri, L., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000404 · Cited by 1,355 · see citing works
Antithrombotic therapy after acute coronary syndrome or PCI in atrial fibrillation
Lopes, R. D., Heizer, G., Aronson, R., Vora, A. N., Massaro, T., Mehran, R., Goodman, S. G., Windecker, S., Darius, H., Li, J., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1817083 · Cited by 1,228 · see citing works
Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study
Friberg, L., Rosenqvist, M., & Lip, G. Y. H. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr488 · Cited by 1,192 · see citing works
2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Amsterdam, E. A., Wenger, N. K., Brindis, R. G., Casey, D. E., Ganiats, T. G., Holmes, D. R., Jaffe, A. S., Jneid, H., Kelly, R. F., Kontos, M. C., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000134 · Cited by 1,059 · see citing works
Apixaban with Antiplatelet Therapy after Acute Coronary Syndrome
Alexander, J. H., Lópes, R. D., James, S. K., Kilaru, R., He, Y., Mohan, P., Bhatt, D. L., Goodman, S. G., Verheugt, F. W. A., Flather, M. D., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1105819 · Cited by 1,002 · see citing works
Antithrombotic Therapy for Atrial Fibrillation
Lip, G. Y. H., Banerjee, A., Boriani, G., Chiang, C. E., Fargo, R. A., Freedman, B., Lane, D. A., Ruff, C. T., Turakhia, M. P., Werring, D. J., et al. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.07.040 · Cited by 952 · see citing works
Stroke and bleeding in atrial fibrillation with chronic kidney disease
Olesen, J. B., Lip, G. Y. H., Kamper, A.-L., Hommel, K., Køber, L., Lane, D. A., Lindhardsen, J., Gislason, G. H., & Torp-Pedersen, C. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1105594 · Cited by 930 · see citing works
Antithrombotic Therapy for Atrial Fibrillation
You, J. J., Singer, D. E., Howard, P. A., Lane, D. A., Eckman, M. H., Fang, M. C., Hylek, E. M., Schulman, S., Go, A. S., Hughes, M., et al. (2012) · CHEST Journal · doi:10.1378/chest.11-2304 · Cited by 924 · see citing works
Edoxaban-based versus vitamin K antagonist-based antithrombotic regimen after successful coronary stenting in patients with atrial fibrillation (ENTRUST-AF PCI): a randomised, open-label, phase 3b trial
Vranckx, P., Valgimigli, M., Eckardt, L., Tijssen, J. G. P., Lewalter, T., Gargiulo, G., Batushkin, V., Campo, G. C., Lysak, Z., Ip, V., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31872-0 · Cited by 698 · see citing works
Direct Oral Anticoagulant Use: A Practical Guide to Common Clinical Challenges
Chen, A., Stecker, E. C., & Warden, B. A. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.017559 · Cited by 679 · see citing works
2021 ESC/EACTS Guidelines for the management of valvular heart disease
Beyersdorf, F., Vahanian, A. S., Milojevic, M., Praz, F., Baldus, S. E., Bauersachs, J. K., Capodanno, D., Conradi, L., Bonis, M. D., Paulis, R. D., et al. (2021) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezab389 · Cited by 635 · see citing works
Guidelines on oral anticoagulation with warfarin – fourth edition
Keeling, D. M., Baglin, T. P., Tait, R. C., Watson, H. G., Perry, D. J., Baglin, C., Kitchen, S., & Makris, M. (2011) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.08753.x · Cited by 584 · see citing works
Management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous coronary or valve interventions: a joint consensus document of the European Society of Cardiology Working Group on Thrombosis, European Heart Rhythm Association (EHRA), European Association of Percutaneous Cardiovascular Interventions (EAPCI) and European Association of Acute Cardiac Care (ACCA) endorsed by the Heart Rhythm Society (HRS) and Asia-Pacific Heart Rhythm Society (APHRS)
Task Force Members, Lip, G. Y. H., Windecker, S., Huber, K., Kirchhof, P. F., Marín, F. R., ten Berg, J. M., Hæusler, K. G., Boriani, G., Capodanno, D., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu298 · Cited by 567 · see citing works
2021 ESC/EACTS Guidelines for the management of valvular heart disease: Developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)
Vahanian, A. S., Beyersdorf, F., Praz, F., Milojevic, M., Baldus, S. E., Bauersachs, J. K., Capodanno, D., Conradi, L., Bonis, M. D., Paulis, R. D., et al. (2022) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2022.05.006 · Cited by 544 · see citing works
Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task Force at the 13th International Congress on antiphospholipid antibodies
Ruiz-Irastorza, G., Cuadrado, M., Ruiz-Arruza, I., Brey, R., Crowther, M., Derksen, R., Erkan, D., Krilis, S., Machin, S., Pengo, V, et al. (2011) · Lupus · doi:10.1177/0961203310395803 · Cited by 506 · see citing works
The value of the CHA2DS2-VASc score for refining stroke risk stratification in patients with atrial fibrillation with a CHADS2 score 0–1: A nationwide cohort study
Olesen, J. B., Torp-Pedersen, C. T., Hansen, M. L., & Lip, G. Y. H. (2012) · Thrombosis and Haemostasis · doi:10.1160/th12-03-0175 · Cited by 484 · see citing works
2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation
Ibáñez, B., James, S. K., Agewall, S., Antunes, M. J., Bucciarelli‐Ducci, C., Bueno, H., Caforio, A. L. P., Crea, F., Goudevenos, J. A., Halvorsen, S., et al. (2017) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2017.11.010 · Cited by 469 · see citing works
2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
Roffi, M., Patrono, C., Collet, J., Mueller, C. E., Valgimigli, M., Andreotti, F., Bax, J. J., Borger, M. A., Brotons, C., Chew, D. P., et al. (2015) · Kardiologia Polska · doi:10.5603/kp.2015.0243 · Cited by 459 · see citing works
Risks of thromboembolism and bleeding with thromboprophylaxis in patients with atrial fibrillation: A net clinical benefit analysis using a ‘real world’ nationwide cohort study
Lip, G., Lindhardsen, J., Lane, D., Ahlehoff, O., Hansen, M., Raunsø, J., Tolstrup, J., Hansen, P., Gislason, G., Torp-Pedersen, C., et al. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-05-0364 · Cited by 428 · see citing works
2014 ESC/EACTS Guidelines on myocardial revascularization
Windecker, S., Kolh, P. H., Alfonso, F., Collet, J., Cremer, J., Falk, V., Filippatos, G. S., Hamm, C. W., Head, S. J., Jüni, P., et al. (2014) · Kardiologia Polska · doi:10.5603/kp.2014.0224 · Cited by 416 · see citing works
2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS
Valgimigli, M., Bueno, H., Byrne, R. A., Collet, J., Costa, F., Jeppsson, A., Jüni, P., Kastrati, A., Kolh, P. H., Mauri, L., et al. (2017) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezx334 · Cited by 416 · see citing works
Intracranial Hemorrhage in Atrial Fibrillation Patients During Anticoagulation With Warfarin or Dabigatran
Hart, R. G., Diener, H., Yang, S., Connolly, S. J., Wallentin, L. C., Reilly, P. A., Ezekowitz, M. D., & Yusuf, S. (2012) · Stroke · doi:10.1161/strokeaha.112.650614 · Cited by 405 · see citing works
2017 EACTS Guidelines on perioperative medication in adult cardiac surgery
Sousa‐Uva, M., Head, S. J., Milojevic, M., Collet, J., Landoni, G., Castellà, M., Dunning, J., Guðbjartsson, T., Linker, N., Sandoval, E., et al. (2017) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezx314 · Cited by 402 · see citing works
2021 ESC/EACTS Guidelines for the management of valvular heart disease
Vahanian, A. S., Beyersdorf, F., Praz, F., Milojevic, M., Baldus, S. E., Bauersachs, J. K., Capodanno, D., Conradi, L., Bonis, M. D., Paulis, R. D., et al. (2022) · EuroIntervention · doi:10.4244/eij-e-21-00009 · Cited by 387 · see citing works
Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation
Nijenhuis, V. J., Brouwer, J., Delewi, R., Hermanides, R. S., Holvoet, W., Dubois, C., Frambach, P., Bruyne, B. D., van Houwelingen, G. K., der Heyden, J. A. S. V., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1915152 · Cited by 357 · see citing works
Management of Patients at Risk for and With Left Ventricular Thrombus: A Scientific Statement From the American Heart Association
Levine, G. N., McEvoy, J. W., Fang, J. C.-T., Ibeh, C., McCarthy, C. P., Misra, A., Shah, Z. I., Shenoy, C., Spinler, S. A., Vallurupalli, S., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001092 · Cited by 350 · see citing works
Oral anticoagulation and antiplatelets in atrial fibrillation patients after myocardial infarction and coronary intervention.
Lamberts, M., Gislason, G., Olesen, J., Kristensen, S., Olsen, A. S., Mikkelsen, A., Christensen, C. B., Lip, G., Køber, L., Torp-Pedersen, C., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.029 · Cited by 350 · see citing works
2014 ESC/EACTS Guidelines on myocardial revascularization
Windecker, S., Kolh, P. H., Alfonso, F., Collet, J., Cremer, J., Falk, V., Filippatos, G. S., Hamm, C. W., Head, S. J., Jüni, P., et al. (2015) · EuroIntervention · doi:10.4244/eijy14m09_01 · Cited by 332 · see citing works
National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand: Australian Clinical Guidelines for the Diagnosis and Management of Atrial Fibrillation 2018
Brieger, D. B., Amerena, J. V., Attia, J., Bajorek, B. V., Chan, K. H., Connell, C., Freedman, B., Ferguson, C., Hall, T. L., Haqqani, H. M., et al. (2018) · Heart Lung and Circulation · doi:10.1016/j.hlc.2018.06.1043 · Cited by 328 · see citing works
2020 ACC Expert Consensus Decision Pathway for Anticoagulant and Antiplatelet Therapy in Patients With Atrial Fibrillation or Venous Thromboembolism Undergoing Percutaneous Coronary Intervention or With Atherosclerotic Cardiovascular Disease
Kumbhani, D. J., Cannon, C. P., Beavers, C. J., Bhatt, D. L., Cuker, A. C., Gluckman, T. J., Marine, J. E., Mehran, R., Messe, S. R., Patel, N. S., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.09.011 · Cited by 314 · see citing works
2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease
Levine, G. N., Bates, E. R., Bittl, J. A., Brindis, R. G., Fihn, S. D., Fleisher, L. A., Granger, C. B., Lange, R. A., Mack, M. J., Mauri, L., et al. (2016) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2016.07.044 · Cited by 304 · see citing works
Oral Anticoagulant Therapy Prescription in Patients With Atrial Fibrillation Across the Spectrum of Stroke Risk
Hsu, J. C., Maddox, T. M., Kennedy, K. F., Katz, D. F., Marzec, L., Lubitz, S. A., Gehi, A. K., Turakhia, M. P., & Marcus, G. M. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2015.0374 · Cited by 302 · see citing works
Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
Guyatt, G. H., Akl, E. A., Crowther, M. A., Gutterman, D. D., & nemann, H. J. S. (2013) · Cited by 289 · see citing works
Antiplatelet Therapy for Stable Coronary Artery Disease in Atrial Fibrillation Patients Taking an Oral Anticoagulant: A Nationwide Cohort Study
Lamberts, M., Gislason, G., Lip, G., Lassen, J., Olesen, J., Mikkelsen, A., Sørensen, R., Køber, L., Torp-Pedersen, C., & Hansen, M. L. (2014) · Circulation · doi:10.1161/circulationaha.113.004834 · Cited by 280 · see citing works
Management and Outcomes of Major Bleeding During Treatment With Dabigatran or Warfarin
Majeed, A., Hwang, H.-G., Connolly, S. J., Eikelboom, J. W., Ezekowitz, M. D., Wallentin, L. C., Brueckmann, M., Fraessdorf, M., Yusuf, S., & Schulman, S. (2013) · Circulation · doi:10.1161/circulationaha.113.002332 · Cited by 277 · see citing works
Old and new oral anticoagulants: Food, herbal medicines and drug interactions
Minno, A. D., Frigerio, B., Spadarella, G., Ravani, A. L., Sansaro, D., Amato, M., Kitzmiller, J. P., Pepi, M., Tremoli, E., & Baldassarre, D. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.02.001 · Cited by 247 · see citing works
Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options—a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference
Kirchhof, P. F., Lip, G. Y. H., Gelder, I. C. V., Bax, J. J., Hylek, E. M., Kääb, S., Schotten, U., Wegscheider, K., Boriani, G., Brandes, A., et al. (2011) · EP Europace · doi:10.1093/europace/eur241 · Cited by 242 · see citing works
Triple therapy with aspirin, prasugrel, and vitamin K antagonists in patients with drug-eluting stent implantation and an indication for oral anticoagulation
Sarafoff, N., Martischnig, A., Wealer, J., Mayer, K., Mehilli, J., Sibbing, D., & Kastrati, A. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.036 · Cited by 236 · see citing works
Association of Warfarin Therapy Duration After Bioprosthetic Aortic Valve Replacement With Risk of Mortality, Thromboembolic Complications, and Bleeding
Mérie, C., Køber, L., Olsen, P. S., Andersson, C., Gislason, G., Jensen, J. S., & Torp-Pedersen, C. T. (2012) · JAMA · doi:10.1001/jama.2012.54506 · Cited by 230 · see citing works
Shear-Dependent Platelet Aggregation: Mechanisms and Therapeutic Opportunities
Rana, A., Westein, E., Niego, B., & Hagemeyer, C. E. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00141 · Cited by 227 · see citing works
ESC Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting With ST-Segment Elevation
Steg, P. G., James, S. K., Atar, D., Badano, L. P., Lundqvist, C. B., Borger, M. A., Mario, C. D., Dickstein, K., Ducrocq, G., Fernández‐Avilés, F., et al. (2012) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2012.10.010 · Cited by 214 · see citing works
2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy
Mehta, S. R., Bainey, K. R., Cantor, W. J., Lordkipanidzé, M., Marquis‐Gravel, G., Robinson, S. D., Sibbald, M., So, D. Y. F., Wong, G. C., Abunassar, J. G., et al. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.12.012 · Cited by 211 · see citing works
Open-Label Randomized Trial Comparing Oral Anticoagulation With and Without Single Antiplatelet Therapy in Patients With Atrial Fibrillation and Stable Coronary Artery Disease Beyond 1 Year After Coronary Stent Implantation
Matsumura‐Nakano, Y., Shizuta, S., Komasa, A., Morimoto, T., Masuda, H., Shiomi, H., Goto, K., Nakai, K., Ogawa, H., Kobori, A., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.036768 · Cited by 210 · see citing works
Major Bleeding Rates in Atrial Fibrillation Patients on Single, Dual, or Triple Antithrombotic Therapy
van Rein, N., Heide‐Jørgensen, U., Lijfering, W. M., Dekkers, O. M., Sørensen, H. T., & Cannegieter, S. C. (2019) · Circulation · doi:10.1161/circulationaha.118.036248 · Cited by 207 · see citing works
Consensus Document: Antithrombotic therapy in patients with atrial fibrillation undergoing coronary stenting
Eikelboom, J. W., Berger, P. B., Holmes, D. R., Bhatt, D. L., Becker, R. C., Angiolill, D., Faxon, D. P., & Moliterno, D. J. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-04-0262 · Cited by 204 · see citing works
Bleeding risk in ‘real world’ patients with atrial fibrillation: comparison of two established bleeding prediction schemes in a nationwide cohort
Olesen, J. B., Lip, G. Y. H., Hansen, P. R., Lindhardsen, J., Ahlehoff, O., Andersson, C., Weeke, P. E., Hansen, M. L., Gislason, G., & Torp-Pedersen, C. T. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04378.x · Cited by 201 · see citing works
Severe Renal Impairment and Stroke Prevention in Atrial Fibrillation
Marinigh, R., Lane, D. A., & Lip, G. Y. H. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.12.013 · Cited by 195 · see citing works
Empirical estimation of under-reporting in the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS)
Alatawi, Y. M., & Hansen, R. A. (2017) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2017.1323867 · Cited by 194 · see citing works
Dabigatran use in Danish atrial fibrillation patients in 2011: a nationwide study
Sørensen, R., Gislason, G., Torp-Pedersen, C. T., Olesen, J. B., Fosbøl, E. L., Hvidtfeldt, M. W., Karasoy, D., Lamberts, M., Charlot, M. G., Køber, L., et al. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-002758 · Cited by 184 · see citing works
The critical care management of spontaneous intracranial hemorrhage: a contemporary review
Manoel, A. L. D. O., Goffi, A., Zampieri, F. G., Turkel‐Parrella, D., Duggal, A., Marotta, T. R., Macdonald, R. L., & Abrahamson, S. (2016) · Critical Care · doi:10.1186/s13054-016-1432-0 · Cited by 177 · see citing works
S2k-Leitlinie Gastrointestinale Blutung
Götz, M., Anders, M., Biecker, E., Bojarski, C., Braun, G., Brechmann, T., Dechêne, A., Dollinger, M., Gawaz, M., Kiesslich, R., et al. (2017) · Zeitschrift für Gastroenterologie - German Journal of Gastroenterology · doi:10.1055/s-0043-116856 · Cited by 108 · see citing works
Management of Antithrombotic Therapy in Atrial Fibrillation Patients Undergoing PCI
Capodanno, D., Huber, K., Mehran, R., Lip, G. Y. H., Faxon, D. P., Granger, C. B., Vranckx, P., Lópes, R. D., Montalescot, G., Cannon, C. P., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.05.016 · Cited by 172 · see citing works
Safety and efficacy of dual vs. triple antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: a systematic review and meta-analysis of randomized clinical trials
Golwala, H. B., Cannon, C. P., Steg, P. G., Doros, G. D., Qamar, A., Ellis, S. G., Oldgren, J., ten Berg, J. M., Kimura, T., Hohnloser, S. H., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy162 · Cited by 167 · see citing works
Non-vitamin K antagonist oral anticoagulation agents in anticoagulant naive atrial fibrillation patients: Danish nationwide descriptive data 2011-2013
Olesen, J. B., Sørensen, R., Hansen, M. L., Lamberts, M., Weeke, P. E., Mikkelsen, A. P., Køber, L., Gislason, G., Torp-Pedersen, C. T., & Fosbøl, E. L. (2014) · EP Europace · doi:10.1093/europace/euu225 · Cited by 164 · see citing works
Cardiovascular safety of non-aspirin non-steroidal anti-inflammatory drugs: review and position paper by the Working Group for Cardiovascular Pharmacotherapy of the European Society of Cardiology
Schmidt, M., Lamberts, M., Olsen, A.-M. S., Fosbøll, E., Niessner, A., Tamargo, J., Rosano, G., Agewall, S., Kaski, J. C., Kjeldsen, K., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv505 · Cited by 164 · see citing works
The Golden Age of Minimally Invasive Cardiothoracic Surgery: Current and Future Perspectives
Iribarne, A., Easterwood, R. M., Chan, E. Y., Yang, J. A., Soni, L. K., Russo, M. J., Smith, C. R., & Argenziano, M. (2011) · Future Cardiology · doi:10.2217/fca.11.23 · Cited by 156 · see citing works
Apixaban vs. warfarin with concomitant aspirin in patients with atrial fibrillation: insights from the ARISTOTLE trial
Alexander, J. H., Lópes, R. D., Thomas, L. E., Alings, M., Atar, D., Aylward, P. E., Goto, S., Hanna, M., Huber, K., Husted, S., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht445 · Cited by 156 · see citing works
Use and Associated Risks of Concomitant Aspirin Therapy With Oral Anticoagulation in Patients With Atrial Fibrillation
Steinberg, B. A., Kim, S., Piccini, J. P., Fonarow, G. C., Lópes, R. D., Thomas, L. E., Ezekowitz, M. D., Ansell, J., Kowey, P. R., Singer, D. E., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.002927 · Cited by 154 · see citing works
Reversal of anticoagulants: an overview of current developments
Thiele, T., Selleng, K., & Greinacher, A. (2015) · Thrombosis and Haemostasis · doi:10.1160/th14-11-0982 · Cited by 148 · see citing works
Antithrombotic drugs and risk of hemorrhagic stroke in the general population
García-Rodríguez, L., Gaist, D., Morton, J., Cookson, C., & Gonzáléz-Pérez, A. (2013) · Neurology · doi:10.1212/wnl.0b013e31829e6ffa · Cited by 114 · see citing works
Adverse Drug Events as a Cause of Hospitalization in Older Adults
Salvi, F., Marchetti, A., D’Angelo, F., Boemi, M., Lattanzio, F., & Cherubini, A. (2012) · Drug Safety · doi:10.1007/bf03319101 · Cited by 148 · see citing works
Stroke and recurrent haemorrhage associated with antithrombotic treatment after gastrointestinal bleeding in patients with atrial fibrillation: nationwide cohort study
Staerk, L., Lip, G. Y. H., Olesen, J. B., Fosbøl, E. L., Pallisgaard, J. L., Bonde, A. N., Gundlund, A., Lindhardt, T. B., Hansen, M. L., Torp-Pedersen, C., et al. (2015) · BMJ · doi:10.1136/bmj.h5876 · Cited by 146 · see citing works
Bleeding Risk of Patients With Acute Venous Thromboembolism Taking Nonsteroidal Anti-Inflammatory Drugs or Aspirin
Davidson, B. L., Verheijen, S., Lensing, A. W. A., Gebel, M., Brighton, T., Lyons, R. M., Rehm, J., & Prins, M. H. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.946 · Cited by 142 · see citing works
2015 ESC Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-segment Elevation
Roffi, M., Patrono, C., Collet, J., Mueller, C. E., Valgimigli, M., Andreotti, F., Bax, J. J., Borger, M. A., Brotons, C., Chew, D. P., et al. (2015) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2015.10.009 · Cited by 136 · see citing works
Warfarin and Antiplatelet Therapy Versus Warfarin Alone for Treating Patients With Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement
Altisent, O. A., Durand, É., Muñoz-García, A. J., y, L. N.-F., Cheema, A. N., Kefer, J., Gutiérrez, E., Benitez, L. M., Amat-Santos, I. J., Serra, V., et al. (2016) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2016.06.025 · Cited by 135 · see citing works
Risk/Benefit Tradeoff of Antithrombotic Therapy in Patients With Atrial Fibrillation Early and Late After an Acute Coronary Syndrome or Percutaneous Coronary Intervention
Alexander, J. H., WOJDYLA, D. M., Vora, A. N., Thomas, L. E., Granger, C. B., Goodman, S. G., ARONSON, R. S., Windecker, S., Mehran, R., & Lópes, R. D. (2020) · Circulation · doi:10.1161/circulationaha.120.046534 · Cited by 140 · see citing works
Oral anticoagulants for stroke prevention in atrial fibrillation: current status, special situations, and unmet needs
Verheugt, F. W. A., & Granger, C. B. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60245-8 · Cited by 134 · see citing works
Aspirin Instead of Oral Anticoagulant Prescription in Atrial Fibrillation Patients at Risk for Stroke
Hsu, J. C., Maddox, T. M., Kennedy, K. F., Katz, D. F., Marzec, L., Lubitz, S. A., Gehi, A. K., Turakhia, M. P., & Marcus, G. M. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.03.581 · Cited by 133 · see citing works
Thromboembolic risk in 16 274 atrial fibrillation patients undergoing direct current cardioversion with and without oral anticoagulant therapy
Hansen, M. L., Jepsen, R. M. H. G., Olesen, J. B., Ruwald, M. H., Karasoy, D., Gislason, G., Hansen, J., Køber, L., Husted, S., & Torp-Pedersen, C. T. (2014) · EP Europace · doi:10.1093/europace/euu189 · Cited by 132 · see citing works
The role of aspirin for stroke prevention in atrial fibrillation
Lip, G. Y. H. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2011.112 · Cited by 129 · see citing works
Management of Antithrombotic Therapy after Acute Coronary Syndromes
Rodríguez, F., & Harrington, R. A. (2021) · New England Journal of Medicine · doi:10.1056/nejmra1607714 · Cited by 130 · see citing works
Vonoprazan prevents low-dose aspirin-associated ulcer recurrence: randomised phase 3 study
Kawai, T., Oda, K., Funao, N., Nishimura, A., Matsumoto, Y., Mizokami, Y., Ashida, K., & Sugano, K. (2017) · Gut · doi:10.1136/gutjnl-2017-314852 · Cited by 124 · see citing works
Drug–drug interactions with warfarin: A systematic review and meta‐analysis
Wang, M., Zeraatkar, D., Obeda, M., Lee, M., Garcia, M. C., Nguyen, L., Agarwal, A., Al‐Shalabi, F., Benipal, H., Ahmad, A., et al. (2021) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14833 · Cited by 116 · see citing works
Assessment and Mitigation of Bleeding Risk in Atrial Fibrillation and Venous Thromboembolism: Executive Summary of a European and Asia-Pacific Expert Consensus Paper
Gorog, D. A., Gue, Y. X., Chao, T., Fauchier, L., Ferreiro, J. L., Huber, K., Konstantinides, S., Lane, D. A., Marín, F. R., Oldgren, J., et al. (2022) · Thrombosis and Haemostasis · doi:10.1055/s-0042-1750385 · Cited by 115 · see citing works
Concomitant Use of Single Antiplatelet Therapy With Edoxaban or Warfarin in Patients With Atrial Fibrillation: Analysis From the ENGAGE AF‐TIMI48 Trial
Xu, H., Ruff, C. T., Giugliano, R. P., Murphy, S. A., Nordio, F., Patel, I. J., Shi, M., Mercuri, M. F., Antman, E. M., & D, E. B. M. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002587 · Cited by 111 · see citing works
Practical Management of Anticoagulation in Patients With Atrial Fibrillation
Kovacs, R. J., Flaker, G. C., Saxonhouse, S. J., Doherty, J. U., Birtcher, K. K., Cuker, A. C., Davidson, B. L., Giugliano, R. P., Granger, C. B., Jaffer, A. K., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.01.049 · Cited by 110 · see citing works
Shared Decision Making in Atrial Fibrillation
Seaburg, L., Hess, E. P., Coylewright, M. J., Ting, H. H., McLeod, C. J., & Montori, V. M. (2014) · Circulation · doi:10.1161/circulationaha.113.004498 · Cited by 110 · see citing works
Antithrombotic Therapy in Patients With Atrial Fibrillation Undergoing Coronary Stenting
Faxon, D. P., Eikelboom, J. W., Berger, P. B., Holmes, D. R., Bhatt, D. L., Moliterno, D. J., Becker, R. C., & Angiolillo, D. J. (2011) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.111.965186 · Cited by 108 · see citing works
Non-cardiac surgery in patients with coronary artery disease: risk evaluation and periprocedural management
Cao, D., Chandiramani, R., Capodanno, D., Berger, J. S., Levin, M. A., Hawn, M. T., Angiolillo, D. J., & Mehran, R. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0410-z · Cited by 101 · see citing works
Outcomes of Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention Receiving an Oral Anticoagulant and Dual Antiplatelet Therapy
Jackson, L. R., Ju, C., Zettler, M., Messenger, J. C., Cohen, D. J., Stone, G. W., Baker, B. A., Effron, M., Peterson, E. D., & Wang, T. Y. (2015) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2015.08.018 · Cited by 97 · see citing works
Relation of nonsteroidal anti-inflammatory drugs to serious bleeding and thromboembolism risk in patients with atrial fibrillation receiving antithrombotic therapy: a nationwide cohort study.
Lamberts, M., Lip, G., Hansen, M. L., Lindhardsen, J., Olesen, J., Raunsø, J., Olsen, A., Andersen, P., Gerds, T., Fosbøl, E., et al. (2014) · Annals of Internal Medicine · doi:10.7326/m13-1581 · Cited by 93 · see citing works
Bleeding and antidotes in new oral anticoagulants
Majeed, A., & Schulman, S. (2013) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2013.07.001 · Cited by 97 · see citing works
Addressing the Challenge of Polypharmacy
Mair, A. R., Wilson, M., & Dreischulte, T. (2019) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023508 · Cited by 104 · see citing works

The concurrent use of antithrombotic therapies and the risk of bleeding in patients with atrial fibrillation
Azoulay, L., Dell’Aniello, S., Simon, T. A., Renoux, C., & Suissa, S. (2013) · Thrombosis and Haemostasis · doi:10.1160/th12-08-0542 · Cited by 37 · see citing works
Is combination antithrombotic therapy safe for patients with atrial fibrillation?
Myrvang, H. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2010.170 · Cited by 1 · see citing works
Risk Versus Benefit of Combined Aspirin and Warfarin Therapy in Patients With Atrial Fibrillation
Nagaraj, T. A., Snider, M. J., Davidson, E. R., Weiss, R., Li, J., & Afzal, M. R. (2020) · Journal of Pharmacy Practice · doi:10.1177/0897190020916638 · Cited by 4 · see citing works
Warfarin Versus Warfarin and Aspirin in Atrial Fibrillation
Curiale, G. G., Rivera‐Lara, L., Singla, A., & Fisher, M. (2011) · Neurological Bulletin · doi:10.7191/neurol_bull.2011.1027 · Cited by 2 · see citing works
Antithrombotic Therapy With Ticagrelor in Atrial Fibrillation Subjects After Percutaneous Coronary Intervention
Lu, W., Wang, Y., Chen, L., Li, Y., Zhang, R., Chen, Z., Yan, J., Yang, M., Han, B., Wang, Z., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.745549 · Cited by 8 · see citing works

Authors: Hansen, M. L., Sørensen, R., Clausen, M. T., Fog-Petersen, M. L., Raunsø, J., Gadsbøll, N., Gislason, G. H., Folke, F., Andersen, S. S., Schramm, T. K., Abildstrøm, S. Z., Poulsen, H. E., Køber, L., & Torp-Pedersen, C.
Affiliations: Copenhagen University Hospital (DK)
ORCID: Hansen, Morten L.
Sørensen, Rikke
Raunsø, Jakob
Gislason, Gunnar H.
Folke, Fredrik
Poulsen, Henrik E.
Køber, Lars
Torp-Pedersen, Christian
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 2010-09-13
Volume: 170
Issue: 16
Pages: 1433-41
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinternmed.2010.271
OpenAlex: W2144471064
Cited by: 855
References: 45
Citations by year: 2026: 16 · 2025: 23 · 2024: 23 · 2023: 25 · 2022: 41 · 2021: 37 · 2020: 64 · 2019: 83 · 2018: 63 · 2017: 75 · 2016: 80 · 2015: 68 · 2014: 63 · 2013: 76 · 2012: 63
FWCI: 42.19
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Keywords: atrial fibrillation, bleeding risk, warfarin, aspirin, clopidogrel, combination antithrombotic therapy, triple therapy, dual therapy, anticoagulation, platelet aggregation inhibition, fatal bleeding
MeSH terms: Clopidogrel, Aged, Anticoagulants, Aspirin, Atrial Fibrillation, Brain Ischemia, Denmark, Drug Therapy, Combination, Female, Hemorrhage, Humans, Male, Registries, Risk, Ticlopidine, Warfarin, Cohort Studies, Comorbidity, Incidence, Proportional Hazards Models, Stroke

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Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation

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