Effect of Antihypertensive Therapy on Cognitive Function in Early Executive Cognitive Impairment: A Double-blind Randomized Clinical Trial
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Do Angiotensin Receptor Blockers Really Hold Promise for the Improvement of Cognitive Functioning?—Reply
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ACEIs and ARBs may preserve cognitive function in hypertensive populations.
“Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may improve cerebral hemodynamics185 and endothelial function186, and preserve cognitive function in hypertensive populations187.”
From Mechanisms and treatment of late-life depression (2019) · cites this paper as [187]
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In situ monitoring of health in older adults: technologies and issues
Kang, H. G., Mahoney, D. F., Hoenig, H., Hirth, V. A., Bonato, P., Hajjar, I., Lipsitz, L. A., & for the Center for Integration of Medicine and Innovative Technology Working Group on Advanced Approaches to Physiologic Monitoring for the Aged (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02959.x · Cited by 227 · see citing works
Self-citationRompe, F., Artuc, M., Hallberg, A., Alterman, M., Ströder, K., Thöne‐Reineke, C., Reichenbach, A., Schacherl, J., Dahlöf, B., Bäder, M., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.147843 · Cited by 208 · see citing works
Ghiadoni, L., Virdis, A., Magagna, A., Taddei, S., & Salvetti, A. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.501 · Cited by 171 · see citing works
Hypertension, Executive Dysfunction, and Progression to Dementia
Oveisgharan, S., & Hachinski, V. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.312 · Cited by 84 · see citing works
Ciobica, A. S., Bild, W., Hriţcu, L., & Haulica, I. D. (2009) · PubMed · Cited by 66 · see citing works
Grigsby, J., Kaye, K., Shetterly, S. M., Baxter, J., Morgenstern, N. E., & Hamman, R. F. (2002) · Neuroepidemiology · doi:10.1159/000065638 · Cited by 47 · see citing works
The angiotensin II type 2 receptor in the brain
Horiuchi, M., Mogi, M., & Iwai, M. (2009) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320309347793 · Cited by 44 · see citing works
Hajjar, I. M., Hart, M., Milberg, W., Novak, V., & Lipsitz, L. A. (2009) · BMC Geriatrics · doi:10.1186/1471-2318-9-48 · Cited by 35 · see citing works
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The vascular depression hypothesis: mechanisms linking vascular disease with depression
Taylor, W. D., Aizenstein, H. J., & Alexopoulos, G. S. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.20 · Cited by 923 · see citing works
Mechanisms and treatment of late-life depression
Alexopoulos, G. S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0514-6 · Cited by 592 · see citing works
Andrieu, S., Coley, N., Lovestone, S., Aisen, P. S., & Vellas, B. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00153-2 · Cited by 293 · see citing works
The depressor axis of the renin–angiotensin system and brain disorders: a translational approach
Gironacci, M. M., Vicario, A., Cerezo, G., & Silva, M. G. (2018) · Clinical Science · doi:10.1042/cs20180189 · Cited by 60 · see citing works
Impact of COVID-19 on Alzheimer’s Disease Risk: Viewpoint for Research Action
Abate, G., Memo, M., & Uberti, D. (2020) · Healthcare · doi:10.3390/healthcare8030286 · Cited by 56 · see citing works
First-line diuretics versus other classes of antihypertensive drugs for hypertension
Reinhart, M., Puil, L., Salzwedel, D. M., & Wright, J. M. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008161.pub3 · Cited by 38 · see citing works
Mechanisms and treatment of late-life depression
Alexopoulos, G. S. (2021) · Focus · doi:10.1176/appi.focus.19304 · Cited by 22 · see citing works
Healthy heart, healthy brain: hypertension affects cognitive functioning in older age
Scullin, M. K., Le, D. T., & Shelton, J. T. (2017) · Translational Issues in Psychological Science · doi:10.1037/tps0000131 · Cited by 11 · see citing works
- Authors
- Hajjar, I., Hart, M., Chen, Y.-L., Mack, W., Milberg, W., Chui, H., & Lipsitz, L.
- Affiliations
- University of Southern California (US)
- Hebrew SeniorLife (US)
- Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles
- Harvard University (US)
- Beth Israel Deaconess Medical Center (US)
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2012-03-12
- Volume
- 172
- Issue
- 5
- Pages
- 442
- ISSN
- 0003-9926 (ISSN-L)
- PMC
- PMC3536822
- OpenAlex
- W2141176548
- Cited by
- 84
- References
- 8
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 10 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 8 · 2015: 7 · 2014: 8 · 2013: 13 · 2012: 4
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5ul1rr031986-02, UL1TR000130)
- National Institute on Aging (R37AG025037, P01AG004390, K23AG030057)
- National Center for Research Resources (UL1-RR031986)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- antihypertensive therapy, cognitive function, executive function, cognitive impairment, angiotensin receptor blockers, hypertension, drug effects on cognition
- MeSH terms
- Age Factors, Aged, Benzimidazoles, Biphenyl Compounds, Blood Pressure Determination, Cognition, Cognition Disorders, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Hydrochlorothiazide, Hypertension, Male, Middle Aged, Sex Factors, Tetrazoles, Treatment Outcome, Lisinopril
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