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Untitled work

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Protective Effect of Renin-Angiotensin System Inhibitors on Parkinson’s Disease: A Nationwide Cohort Study

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Multifunctional angiotensin converting enzyme 2, the SARS-CoV-2 entry receptor, and critical appraisal of its role in acute lung injury

Öz, M., & Lorke, D. E. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111193 · Cited by 55 · see citing works

Effect of renin–angiotensin system on senescence

Mogi, M. (2020) · Geriatrics & Gerontology International · doi:10.1111/ggi.13927 · Cited by 48 · see citing works

Role of brain renin–angiotensin system in depression: A new perspective

Ali, N. H., Al-Kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., Hamad, R. S., Alexiou, A. T., Papadakis, M., Saad, ‏. M., & Batiha, G. E. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14525 · Cited by 45 · see citing works

How ACE inhibitors transformed the renin–angiotensin system

Bakhle, Y. S. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15045 · Cited by 41 · see citing works

Tactile stimulation of adult rats modulates hormonal responses, depression-like behaviors, and memory impairment induced by chronic mild stress: Role of angiotensin II

Costa, R., Tamascia, M. L., Sanches, A., Moreira, R. P., Cunha, T. S., Nogueira, M. D., Casarini, D. E., & Marcondes, F. K. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112250 · Cited by 36 · see citing works

Renin-angiotensin system: The underlying mechanisms and promising therapeutical target for depression and anxiety

Gong, S., & Deng, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1053136 · Cited by 35 · see citing works

The Renin-Angiotensin System and the Cerebrovascular Diseases: Experimental and Clinical Evidence

Kangussu, L. M., Marzano, L. A. S., Souza, C. F., Dantas, C. C., de Miranda, A. S., & Silva, A. C. S. E. (2019) · Protein and Peptide Letters · doi:10.2174/0929866527666191218091823 · Cited by 29 · see citing works

Involvement of the Renin-Angiotensin System in Stress: State of the Art and Research Perspectives

Correa, B. H. M., Becari, L., Fontes, M. A. P., Silva, A. C. S. E., & Kangussu, L. M. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210719142300 · Cited by 28 · see citing works

The Renin-Angiotensin System in Hypertension, a Constantly Renewing Classic: Focus on the Angiotensin AT2-Receptor

Assersen, K. B., Sumners, C., & Steckelings, U. M. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.02.095 · Cited by 28 · see citing works

Angiotensin-(1-7) and Mas receptor in the brain

Mikusic, N. L. R., Pineda, A. M., & Gironacci, M. M. (2021) · Exploration of Medicine · doi:10.37349/emed.2021.00046 · Cited by 28 · see citing works

The potential role of brain renin‐angiotensin system in the neuropathology of Parkinson disease: Friend, foe or turncoat?

Al-Qahtani, Z., Al-Kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., Ali, N. H., Alexiou, A. T., Papadakis, M., Saad, ‏. M., & Batiha, G. E. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18495 · Cited by 27 · see citing works

Ameliorative effects of hydrogen sulfide (NaHS) on chronic kidney disease-induced brain dysfunction in rats: implication on role of nitric oxide (NO) signaling

Askari, H., Abazari, M. F., Ghoraeian, P., Torabinejad, S., Aleagha, M. N., Nassiri, R. M. F., Tahmasebi, F., Abedi, N., Rajani, S. F., Salarian, A., et al. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0301-8 · Cited by 27 · see citing works

Novel Interactions Involving the Mas Receptor Show Potential of the Renin–Angiotensin system in the Regulation of Microglia Activation: Altered Expression in Parkinsonism and Dyskinesia

Rivas‐Santisteban, R., Lillo, J., Muñoz, A., Rodriguez-Perez, A. I., Labandeira-García, J. L., Navarro, G., & Franco, R. (2021) · Neurotherapeutics · doi:10.1007/s13311-020-00986-4 · Cited by 26 · see citing works

Angiotensin blockade enhances motivational reward learning via enhancing striatal prediction error signaling and frontostriatal communication

Xu, T., Zhou, X., Kanen, J. W., Wang, L., Li, J., Chen, Z., Zhang, R., Jiao, G., Zhou, F., Zhao, W., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02001-6 · Cited by 26 · see citing works

ACE2/ANG-(1-7)/Mas receptor axis activation prevents inflammation and improves cognitive functions in streptozotocin induced rat model of Alzheimer's disease-like phenotypes

Tiwari, V., Singh, J., Tiwari, P., Chaturvedi, S., Gupta, S., Mishra, A., Singh, S., Wahajuddin, M., Hanif, K., & Shukla, S. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175623 · Cited by 24 · see citing works

Neuropsychiatric Properties of the ACE2/Ang-(1-7)/Mas Pathway: A Brief Review

de Melo, L. A., & Almeida-Santos, A. F. (2019) · Protein and Peptide Letters · doi:10.2174/0929866527666191223143230 · Cited by 24 · see citing works

Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats

Moreno-Santos, B., Marchi-Coelho, C., Ferreira, W. C., & Crestani, C. C. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112947 · Cited by 24 · see citing works

The key role of the level of ACE2 gene expression in SARS-CoV-2 infection

Lecarpentier, Y., & Vallée, A. (2021) · Aging · doi:10.18632/aging.203181 · Cited by 20 · see citing works

Targeting the Angiotensin II Type 1 Receptor in Cerebrovascular Diseases: Biased Signaling Raises New Hopes

Delaitre, C., Boisbrun, M., Lecat, S., & Dupuis, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136738 · Cited by 19 · see citing works

Modulatory action of environmental enrichment on hormonal and behavioral responses induced by chronic stress in rats: Hypothalamic renin-angiotensin system components

Costa, R., Carvalho, M. S. M., Perez, J. D., Moreira, R. P., Cunha, T. S., Casarini, D. E., & Marcondes, F. K. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112928 · Cited by 18 · see citing works

Dopamine Regulates Adult Neurogenesis in the Ventricular-Subventricular Zone via Dopamine D3 Angiotensin Type 2 Receptor Interactions

García-Garrote, M., Parga, J. A., Labandeira, P., Labandeira-García, J. L., & Rodríguez‐Pallares, J. (2021) · Stem Cells · doi:10.1002/stem.3457 · Cited by 18 · see citing works

Insights in Chloroquine Action: Perspectives and Implications in Malaria and <scp>COVID</scp>‐19

Pillat, M. M., Krüger, A., Guimarães, L. M. F., Lameu, C., de Souza, E. E., Wrenger, C., & Ulrich, H. (2020) · Cytometry Part A · doi:10.1002/cyto.a.24190 · Cited by 17 · see citing works

Renin-Angiotensin System in Huntington′s Disease: Evidence from Animal Models and Human Patients

Kangussu, L. M., Rocha, N. P., Valadão, P. A. C., Machado, T. C. G., Soares, K. B., Joviano‐Santos, J. V., Latham, L. B., Colpo, G. D., Almeida‐Santos, A. F., Furr-Stimming, E. E., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147686 · Cited by 17 · see citing works

Contemporary methods of improving cognitive dysfunction in clinical depression

Knight, M. J., Mills, N. T., & Baune, B. T. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1610395 · Cited by 17 · see citing works

Potential protective role of ACE-inhibitors and AT1 receptor blockers against levodopa-induced dyskinesias: a retrospective case-control study

Contaldi, E., Magistrelli, L., Milner, A. R., Cosentino, M., Marino, F., & Comi, C. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.313061 · Cited by 16 · see citing works

Aliskiren – A promising antioxidant agent beyond hypertension reduction

Alshahrani, S. (2020) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2020.109145 · Cited by 16 · see citing works

Chronic administration of pharmacological doses of angiotensin 1‐7 and iodoangiotensin 1‐7 has minimal effects on blood pressure, heart rate, and cognitive function of spontaneously hypertensive rats

Stoyell‐Conti, F. F., Chabbra, A., Puthentharayil, J., Rigatto, K., & Speth, R. C. (2021) · Physiological Reports · doi:10.14814/phy2.14812 · Cited by 12 · see citing works

Renin-angiotensin system blockade on angiotensin-converting enzyme 2 and TMPRSS2 in human type II pneumocytes

Silva, M. G., Falcoff, N. L., Corradi, G. R., Alfie, J., Seguel, R. F., Tabaj, G. C., Iglesias, L. I., Núñez, M., Guman, G. R., & Gironacci, M. M. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120324 · Cited by 10 · see citing works

Signaling pathways and genetics of brain Renin angiotensin system in psychiatric disorders: State of the art

Barak, R., Goshtasbi, G., Fatehi, R., & Firouzabadi, N. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173706 · Cited by 9 · see citing works

The Renin-Angiotensin System in Huntington’s Disease: Villain or Hero?

Machado, T. C. G., Guatimosim, C., & Kangussu, L. M. (2020) · Protein and Peptide Letters · doi:10.2174/0929866527666200110154523 · Cited by 9 · see citing works

Angiotensin-Ⅱ and angiotensin-(1-7) imbalance affects comorbidity of depression and coronary heart disease

Han, W., Wei, Z., Dang, R., Guo, Y., Zhang, H., Geng, C., Wang, C., Feng, Q., & Jiang, P. (2020) · Peptides · doi:10.1016/j.peptides.2020.170353 · Cited by 9 · see citing works

Shared Molecular Targets in Parkinson’s Disease and Arterial Hypertension: A Systematic Review

Tulbă, D., Avasilichioaei, M. C., Dima, N., Craciun, L. M., Balanescu, P. C., Buzea, A., Băicuş, C., & Popescu, B. O. (2022) · Biomedicines · doi:10.3390/biomedicines10030653 · Cited by 7 · see citing works

Differential Roles of Angiotensin A and Alamandine in Parkinson's Disease: A Therapeutic Perspective on Nonclassical RAS Pathways

Alshehri, G. H., Al-Kuraishy, H. M., Albuhadily, A. K., Al-Gareeb, A. I., Aboutaleb, A. S., Alexiou, A. T., Papadakis, M., & Batiha, G. E. (2025) · Brain and Behavior · doi:10.1002/brb3.70721 · Cited by 5 · see citing works

Mas receptor endocytosis and signaling in health and disease

Mikusic, N. L. R., & Gironacci, M. M. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.09.001 · Cited by 5 · see citing works

Angiotensinergic Neurotransmissions in the Medial Amygdala Nucleus Modulate Behavioral Changes in the Forced Swimming Test Evoked by Acute Restraint Stress in Rats

Marchi-Coelho, C., Ferreira, W. C., Reis‐Silva, L. L., & Crestani, C. C. (2021) · Cells · doi:10.3390/cells10051217 · Cited by 5 · see citing works

125I-Angiotensin 1–7 binds to a different site than angiotensin 1–7 in tissue membrane preparations

Stoyell‐Conti, F. F., Itty, S., Abraham, C., Rigatto, K., West, C. A., & Speth, R. C. (2021) · Endocrine · doi:10.1007/s12020-020-02572-2 · Cited by 5 · see citing works

Characteristics of Angiotensin I-converting enzyme 2, type II transmembrane serine protease 2 and 4 in tree shrew indicate it as a potential animal model for SARS-CoV-2 infection

Li, N., Gu, W., Lü, C., Sun, X., Tong, P., Han, Y., Wang, W., & Dai, J. (2021) · Bioengineered · doi:10.1080/21655979.2021.1940072 · Cited by 4 · see citing works

Neuroprotective effects of candesartan in 3-nitropropionic acid-induced Huntington’s disease: modulation of angiotensin and CREB/BDNF/PGC1-α signaling

Elgindy, A. M., Atwa, A. M., El‐Awady, E., El-Sayed, N. M., & El-Orabi, N. F. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01889-6 · Cited by 3 · see citing works

The role of the renin-angiotensin system in the pathogenesis of Parkinson’s disease

Быков, Ю. Н., Тетюшкин, Н. А., Chipizubov, V., Kalyagin, A. N., & Лаврик, С. Ю. (2021) · Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» · doi:10.25557/0031-2991.2021.01.107-115 · Cited by 3 · see citing works

Neuritogenesis and protective effects activated by Angiotensin 1–7 in astrocytes-neuron interaction

Barbosa, G. A. D. C., Rubinho, M. P., Júnior, M. K. A., Pedro, J. R., Donato, L. F., Trisciuzzi, L., Silva, A. O., Ruginsk, S. G., Ceron, C. S., Peixoto, N., et al. (2024) · Neuropeptides · doi:10.1016/j.npep.2024.102480 · Cited by 2 · see citing works

Common Pathogenetic Mechanisms of Ischemic Stroke and COVID-19: the Role of Focal and Systemic Inflammation

Сидорович, Э. К. (2022) · Неврология и нейрохирургия Восточная Европа · doi:10.34883/pi.2022.12.1.046 · Cited by 2 · see citing works

Effect of heat stress on the hypothalamic expression of water channel- and noncoding RNA biogenesis-related genes in modern broilers and their ancestor red jungle fowl

Greene, E. S., Tabler, T. W., Orlowski, S., & Dridi, S. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148810 · Cited by 1 · see citing works

Neurochemical exploration for therapeutic advancements in stroke

Barik, A., Malik, N., Dubey, A., Karmarkar, G., Kumari, A., Mukherjee, U., Ghosh, B., Datta, A., Borah, A., & Bhattacharya, P. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.05.308 · Cited by 1 · see citing works

Acute calcitriol treatment alleviates cerebral ischemia reperfusion injury via activation of MasR/PI3K/Akt/CREB axis and suppression of AT-1R/NF-κB p65 signaling cascade

Eltwab, D. A., Rabie, M. A., Mohamed, R. A., & Elyamany, M. F. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178240 · Cited by 1 · see citing works

Influence of enalapril on the functional state of the central nervous system in experimental Alzheimer’s disease

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COVID-19 PATHOPHYSIOLOGY PREDICTS THAT ISCHEMIC STROKE OCCURRENCE IS AN EXPECTATION, NOT AN EXCEPTION: A SYSTEMATIC REVIEW

Maulidia, A. A., Silitonga, A. R. R., & Kurniawati, M. Y. (2023) · Journal of Advance Research in Medical & Health Science · doi:10.53555/nnmhs.v9i7.1774 · Cited by 1 · see citing works

Renin-angiotensin System: A New Promising Therapeutic and Mechanisms for Depression and AnxietyPreprint

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ACE2/ANG-(1-7)/Mas Receptor Axis Activation Prevents Inflammation, Glial Activation And Cognitive Decline In a Rat Model of STZ Induced Impairment of Learning and MemoryPreprint

Tiwari, V., Singh, J., Tiwari, P., Chaturvedi, S., Gupta, S., Mishra, A., Singh, S., Wahajuddin, M., Hanif, K., & Shukla, S. (2021) · Research Square · doi:10.21203/rs.3.rs-1002782/v1 · Cited by 1 · see citing works

Tissue-specific Stem Cells

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USO DE ANTI-HIPERTENSIVOS NA MODULAÇÃO DA ANSIEDADE EM MODELOS ANIMAIS

ALVES, L. B. D. S. (2021) · doi:10.17771/pucrio.acad.53170

Aminopeptidase Activities Interact Asymmetrically between Brain, Plasma and Systolic Blood Pressure in Hypertensive Rats Unilaterally Depleted of Dopamine

Banegas, I., Prieto, I., Segarra, A. B., Vives, F., Martínez‐Cañamero, M., Durán, R., Luna, J. D. D., Domínguez-Vías, G., & Ramírez‐Sánchez, M. (2022) · Biomedicines · doi:10.3390/biomedicines10102457

The Contribution of the Renin-Angiotensin System to Alzheimer’s Disease

Güzel, Ö., & Kehoe, P. G. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_525

Neuroprotective and therapeutic effects of renin-angiotensin system modulating drugs in Parkinson’s disease

Bordet, S. (2025) · International review of movement disorders · doi:10.1016/bs.irmvd.2025.09.004

Sistema renina-angiotensina en la enfermedad de Alzheimer

Lauxmann, M. A., Conte, O., Bruna‐Haupt, E., & Gironacci, M. M. (2025) · Methodo Investigación Aplicada a las Ciencias Biológicas · doi:10.22529/me.2025.10(3)02

Transcriptomic Evidence of MAS1 Receptor Dysregulation and a Failed Compensatory State in Human Vascular Cognitive ImpairmentPreprint

Hoyer-Kimura, C. H., Huentelman, M. J., & Hay, M. (2026) · medRxiv · doi:10.64898/2026.05.06.26352482 · Cited by 1 · see citing works

Physiopathology of the Brain Renin-Angiotensin System

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Recent Advances in the Endogenous Brain Renin-Angiotensin System and Drugs Acting on It

Aswar, U. M., Patil, R., Nilam, G., & Bodhankar, S. L. (2021) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1155/2021/9293553 · Cited by 43 · see citing works

Neurotherapeutic roles of the protective arm of the renin–angiotensin system: from inflammation to cognitive rescue

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Protective axis of the renin–angiotensin system in the brain

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The renin angiotensin system and the brain: New developments

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