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Cited by 537

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Exposure to Particulate Air Pollution and Cognitive Decline in Older Women

Open access
Weuve, Jennifer·2012·Archives of Internal Medicine

Abstract

BACKGROUND: Chronic exposure to particulate air pollution may accelerate cognitive decline in older adults, although data on this association are limited. Our objective was to examine long-term exposure to particulate matter (PM) air pollution, both coarse ([PM 2.5-10 μm in diameter [PM(2.5-10)]) and fine (PM <2.5 μm in diameter [PM(2.5)]), in relation to cognitive decline. METHODS: The study population comprised the Nurses' Health Study Cognitive Cohort, which included 19,409 US women aged 70 to 81 years. We used geographic information system-based spatiotemporal smoothing models to estimate recent (1 month) and long-term (7-14 years) exposures to PM(2.5-10), and PM(2.5) preceding baseline cognitive testing (1995-2001) of participants residing in the contiguous United States. We used generalized estimating equation regression to estimate differences in the rate of cognitive decline across levels of PM(2.5-10) and PM(2.5) exposures. The main outcome measure was cognition, via validated telephone assessments, administered 3 times at approximately 2-year intervals, including tests of general cognition, verbal memory, category fluency, working memory, and attention. RESULTS: Higher levels of long-term exposure to both PM(2.5-10) and PM(2.5) were associated with significantly faster cognitive decline. Two-year decline on a global score was 0.020 (95% CI, -0.032 to -0.008) standard units worse per 10 μg/m(3) increment in PM(2.5-10) exposure and 0.018 (95% CI, -0.035 to -0.002) units worse per 10 μg/m(3) increment in PM(2.5) exposure. These differences in cognitive trajectory were similar to those between women in our cohort who were approximately 2 years apart in age, indicating that the effect of a 10-μg/m(3) increment in long-term PM exposure is cognitively equivalent to aging by approximately 2 years. CONCLUSION: Long-term exposure to PM(2.5-10) and PM(2.5) at levels typically experienced by many individuals in the United States is associated with significantly worse cognitive decline in older women.

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Metadata

Authors
Weuve, J.
Venue
Archives of Internal Medicine
Published
2012-02-13
Volume
172
Issue
3
Pages
219
ISSN
0003-9926 (ISSN-L)
OpenAlex
W2139902758
Cited by
537
References
7
FWCI
15.94
Type
journal article
Language
en
Open access
bronze

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Weuve, J. (2012). Exposure to Particulate Air Pollution and Cognitive Decline in Older Women. Archives of Internal Medicine. https://doi.org/10.1001/archinternmed.2011.683

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