Anal Sphincter Dysfunction in Parkinson's Disease
Abstract
Striated anal sphincter function was studied electrophysiologically and radiologically in six patients with Parkinson's disease and chronic constipation. In five cases, there was paradoxic anal sphincter muscle contraction during simulated defecation straining resembling anismus-type pelvic outlet obstruction. Radiologic studies showed functional improvement of the defecatory mechanism following the administration of the dopamine receptor agonist apomorphine in four patients. Dysfunction of the striated anal sphincter musculature may be a significant cause of constipation in some parkinsonian patients, occurring as part of the generalized extrapyramidal motor disorder.
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Patients with Parkinson's disease may experience difficulties in rectal evacuation because of rectal sphincter dysfunction.
“Patients may also experience difficulties in rectal evacuation because of rectal sphincter dysfunction (Mathers et al. 1989).”
From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Mathers et al. 1989
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- Authors
- Mathers, S. E., Kempster, P. A., Law, P. J., Frankel, J. P., Bartram, C. I., Lees, A. J., Stern, G. M., & Swash, M.
- Affiliations
- St Mark's Hospital (GB)
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1989-10-01
- Volume
- 46
- Issue
- 10
- Pages
- 1061-1064
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W2024245396
- Cited by
- 158
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 11 · 2015: 3 · 2014: 8 · 2013: 5 · 2012: 8
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Keywords
- anal sphincter dysfunction, Parkinson's disease, chronic constipation, anismus, apomorphine, dopamine agonists, extrapyramidal disorders, defecation
- MeSH terms
- Anal Canal, Constipation, Defecation, Electromyography, Female, Fluoroscopy, Humans, Male, Middle Aged, Parkinson Disease
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