Cited by 321Amyotrophic Lateral Sclerosis ResearchMultiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

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Lymphocytic Infiltrates in the Spinal Cord in Amyotrophic Lateral Sclerosis

Engelhardt, J. I., Tajti, J., Appel, S. H.·1993·Archives of Neurology

DOI 10.1001/archneur.1993.00540010026013

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Abstract

Objective Immunohistochemical examination was undertaken to assess the presence of lymphocytes and lymphocyte subsets in the spinal cord in amyotrophic lateral sclerosis (ALS). Design Twenty-seven consecutive ALS autopsy cases and 11 consecutive disease--control autopsy cases were examined. Tissue sections were reacted with mouse monoclonal antibody to human leukocyte common antigen, or monoclonal antibody to human B-cell L26 antigen, and detected with immunoperoxidase techniques. Unfixed sections were reacted with antihuman Leu-3a and Leu-3b/CD4 or antihuman Leu-2a/CD8 mouse monoclonal antibody and then detected with peroxidase techniques. Setting Tertiary care hospital. Cases Amyotrophic lateral sclerosis and non-ALS control autopsy specimens. Main outcome measure Detection of lymphocytes by histological and immunohistochemical reactivity. Results Perivascular and intraparenchymal lymphocytic infiltrates were found in the spinal cord of 18 of 27 consecutive ALS autopsy cases. The lymphocytes possessed only T-cell markers; no B-cell markers could be demonstrated. T-helper cells were found in proximity to degenerating corticospinal tracts, while T-helper and T-suppressor/cytotoxic cells were demonstrated in ventral horns. Lymphocytes were present in the spinal cord of only one control specimen (multiple sclerosis) and in none of the remaining 10 control specimens. In ALS tissue, the lymphocytic infiltrates did not correlate with the rate of progression or stage of the disease…

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A note on the use of picric acid-paraformaldehyde-glutaraldehyde fixative for correlated light and electron microscopic immunocytochemistry
Somogyi, P., & Takagi, H. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90035-5 · Cited by 572
Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.
Kawamata, T., Akiyama, H., Yamada, T., & McGeer, P. L. (1992) · PubMed Central · Cited by 546
Expression of the histocompatibility glycoprotein HLA-DR in neurological disease
McGeer, P. L., Itagaki, S., & McGeer, E. G. (1988) · Acta Neuropathologica · doi:10.1007/bf00689592 · Cited by 420
Diagnosis of Human Lymphoma with Monoclonal Antileukocyte Antibodies
Warnke, R. A., Gatter, K. C., Falini, B., Hildreth, P. D. K., Woolston, R.-E., Pulford, K. A. F., Cordell, J., Cohen, B., Wolf‐Peeters, C. D., & Mason, D. Y. (1983) · New England Journal of Medicine · doi:10.1056/nejm198311243092102 · Cited by 366
Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in man.
Engleman, E. G., Benike, C. J., Glickman, E., & Evans, R. L. (1981) · The Journal of Experimental Medicine · doi:10.1084/jem.154.1.193 · Cited by 301
IgG Reactivity in the Spinal Cord and Motor Cortex in Amyotrophic Lateral Sclerosis
Engelhardt, J. I., & Appel, S. H. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530110068019 · Cited by 221
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Serum antibodies to GM 1 ganglioside in amyotrophic lateral sclerosis
Pestronk, A., Adams, R. N., Clawson, L., Cornblath, D. R., Kuncl, R. W., Griffin, D. E., & Drachman, D. B. (1988) · Neurology · doi:10.1212/wnl.38.9.1457 · Cited by 152
Utilization of monoclonal antibody L26 in the identification and confirmation of B-cell lymphomas. A sensitive and specific marker applicable to formalin-and B5-fixed, paraffin-embedded tissues.
Cartun, R. W., Coles, F. B., & Pastuszak, W. (1987) · PubMed · Cited by 139
Major histocompatibility complex antigen expression in the affected tissues in amyotrophic lateral sclerosis
Lampson, L. A., Kushner, P. D., & Sobel, R. A. (1990) · Annals of Neurology · doi:10.1002/ana.410280311 · Cited by 128
Amyotrophic Lateral Sclerosis
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Authors: Engelhardt, J. I., Tajti, J., & Appel, S. H.
Affiliations: Baylor College of Medicine (US)
ORCID: Tajti, J.
Appel, S. H.
Venue: Archives of Neurology
Publisher: American Medical Association (AMA)
Published: 1993-01-01
Volume: 50
Issue: 1
Pages: 30-36
ISSN: 0003-9942 (ISSN-L)
DOI: 10.1001/archneur.1993.00540010026013
OpenAlex: W2069781018
Cited by: 318
References: 25
Citations by year: 2026: 8 · 2025: 9 · 2024: 14 · 2023: 19 · 2022: 20 · 2021: 10 · 2020: 16 · 2019: 14 · 2018: 15 · 2017: 11 · 2016: 12 · 2015: 14 · 2014: 10 · 2013: 14 · 2012: 19
FWCI: 5.43
Type: journal article
Language: en
Open access: closed
Locations: Archives of Neurology (publishedVersion)
PubMed (publishedVersion)
SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: amyotrophic lateral sclerosis, spinal cord, lymphocyte infiltration, T cells, T helper cells, suppressor/cytotoxic T cells, corticospinal tract degeneration, ventral horn, B cells, CD45, CD4, CD8, neuroinflammation
MeSH terms: Adult, Aged, Amyotrophic Lateral Sclerosis, B-Lymphocytes, Female, Humans, Male, Middle Aged, Spinal Cord, CD4-Positive T-Lymphocytes, CD4 Antigens, CD8 Antigens, Leukocyte Common Antigens, T-Lymphocytes, Regulatory

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Lymphocytic Infiltrates in the Spinal Cord in Amyotrophic Lateral Sclerosis

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