Circadian disruption and human health: A bidirectional relationship
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Circadian rhythm disorders have been classically associated with disorders of abnormal timing of the sleep–wake cycle, however circadian dysfunction can play a role in a wide range of pathology, ranging from the increased risk for cardiometabolic disease and malignancy in shift workers, prompting the need for a new field focused on the larger concept of circadian medicine. The relationship between circadian disruption and human health is bidirectional, with changes in circadian amplitude often preceding the classical symptoms of neurodegenerative disorders. As our understanding of the importance of circadian dysfunction in disease grows, we need to develop better clinical techniques for identifying circadian rhythms and also develop circadian based strategies for disease management. Overall this review highlights the need to bring the concept of time to all aspects of medicine, emphasizing circadian medicine as a prime example of both personalized and precision medicine.
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Disturbed rest-activity rhythms lead to desynchronization of internal molecular clocks, thereby disturbing circadian biochemical processes, secretion of hormones, metabolic functions, and physiological parameters.
“Existing evidence shows that disturbed rest-activity rhythms, as, for example, in shift workers, lead to desynchronization of internal molecular clocks, thereby disturbing circadian biochemical processes, secretion of hormones, metabolic functions, and physiological parameters [66-68].”
From Digital Biomarkers for Depression Screening With Wearable Devices: Cross-sectional Study With Machine Learning Modeling (2021) · cites this paper as [67]
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- Authors
- Abbott, S. M., Malkani, R. G., & Zee, P. C.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Abbott, Sabra M.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2019-01-03
- Volume
- 51
- Issue
- 1
- Pages
- 567-583
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC7261021
- OpenAlex
- W2904994316
- Cited by
- 161
- References
- 180
- Citations by year
- 2026: 21 · 2025: 25 · 2024: 29 · 2023: 23 · 2022: 19 · 2021: 19 · 2020: 15 · 2019: 10
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P01AG011412)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- circadian rhythm disruption, circadian medicine, circadian dysfunction, shift work, cardiometabolic disease, cancer risk, neurodegenerative diseases, circadian amplitude, personalized medicine, precision medicine, sleep-wake cycle
- MeSH terms
- Circadian Rhythm, Humans, Melatonin, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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