The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Sex Differences in Brain Aging: A Quantitative Magnetic Resonance Imaging Study
Abstract
BACKGROUND: Little is known about the effect of sex on age-related changes in brain structure. METHODS: Quantitative magnetic resonance imaging of the brain was performed in 330 elderly (age range, 66-96 years) volunteers living independently in the community, all of whom were participants in the Cardiovascular Health Study. Blinded measurements of global and regional brain size were made from T1-weighted axial images by means of computer-assisted edge detection and trace methods. High measurement reliabilities were obtained. RESULTS: Age-specific changes in brain size were significantly greater in men than women for the peripheral (sulcal) cerebrospinal fluid volume, the lateral (sylvian) fissure cerebrospinal fluid volume, and the parieto-occipital region area. Main effects of age were observed for all the remaining brain regions examined (cerebral hemisphere volume, frontal region area, temporoparietal region area, lateral ventricular volume, and third ventricle volume), but these effects were similar in men and women. Asymmetries in brain structures were not affected by aging in either sex. CONCLUSIONS: Our results are generally consistent with the few published studies on sex differences in brain aging and suggest that, for at least some structures, aging effects may be more apparent in men than women. The neurobiological bases and functional correlates of these sex differences require further investigation.
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The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652
Cited by
A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N. A., Friston, K. J., & Frackowiak, R. S. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0786 · Cited by 4,561
Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers
Raz, N., Lindenberger, U., Rodrigue, K. M., Kennedy, K. M., Head, D., Williamson, A., Dahle, C., Gerstorf, D., & Acker, J. D. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi044 · Cited by 2,875
Marcus, D. S., Wang, T. H., Parker, J., Csernansky, J. G., Morris, J. C., & Buckner, R. L. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.9.1498 · Cited by 2,163
Hemispheric asymmetry reduction in older adults: the HAROLD model
Cabeza, R. (2002) · Psychology and Aging · doi:10.1037/0882-7974.17.1.85 · Cited by 2,125
Sex differences in the structural connectome of the human brain
Ingalhalikar, M., Smith, A., Parker, D., Satterthwaite, T. D., Elliott, M. A., Ruparel, K., Hakonarson, H., Gur, R. E., Gur, R. C., & Verma, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316909110 · Cited by 1,223
Metadata
- Authors
- Coffey, C. E., Lucke, J. F., Saxton, J. A., Ratcliff, G., Unitas, L. J., Billig, B., & Bryan, R. N.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1998-02-01
- Volume
- 55
- Issue
- 2
- Pages
- 169
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W1970677142
- Cited by
- 438
- References
- 1
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Coffey, C. E., Lucke, J. F., Saxton, J. A., Ratcliff, G., Unitas, L. J., Billig, B., & Bryan, R. N. (1998). Sex Differences in Brain Aging: A Quantitative Magnetic Resonance Imaging Study. Archives of Neurology. https://doi.org/10.1001/archneur.55.2.169
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