Cited by 201Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchCholinesterase and Neurodegenerative Diseases

Drug repositioning and repurposing for Alzheimer disease

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Ballard, Clive, Aarsland, Dag, Cummings, Jeffrey, O’Brien, John, Mills, Roger, Molinuevo, Jose Luis, Fladby, Tormod, Williams, Gareth +3 more·2020·Nature Reviews Neurology

Abstract

Drug repositioning and repurposing can enhance traditional drug development efforts and could accelerate the identification of new treatments for individuals with Alzheimer disease (AD) dementia and mild cognitive impairment. Transcriptional profiling offers a new and highly efficient approach to the identification of novel candidates for repositioning and repurposing. In the future, novel AD transcriptional signatures from cells isolated at early stages of disease, or from human neurons or microglia that carry mutations that increase the risk of AD, might be used as probes to identify additional candidate drugs. Phase II trials assessing repurposed agents must consider the best target population for a specific candidate therapy as well as the mechanism of action of the treatment. In this Review, we highlight promising compounds to prioritize for clinical trials in individuals with AD, and discuss the value of Delphi consensus methodology and evidence-based reviews to inform this prioritization process. We also describe emerging work, focusing on the potential value of transcript signatures as a cost-effective approach to the identification of novel candidates for repositioning.

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  6. [107]Sultana J & Ballard C Disease-modifying agents for rheumatoid arthritis: methotrexate, chloroquine phosphate/proguanil hydrochloride, cyclosporine, cyclophosphamide, hydroxychloroquine sulphate, sodium aurothiomalate, and sulfasalazine as potential repurposing treatments for Alzheimer’s Disease; a comprehensive literature review. Preprint at OSF https://mfr.osf.io/render?url=https%3A%2F%2Fosf.io%2F6g57a%2Fdownload (2020).
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  9. [143]Sultana J & Ballard C ACE inhibitors: captopril, ramipril, lisinopril, perindopril as potential repurposing treatments for Alzheimer’s disease; a comprehensive literature review. Preprint at OSF https://mfr.osf.io/render?url=https%3A%2F%2Fosf.io%2Fz9uc4%2Fdownload (2020).

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Authors
Ballard, C., Aarsland, D., Cummings, J., O’Brien, J., Mills, R., Molinuevo, J. L., Fladby, T., Williams, G., Doherty, P., Corbett, A., & Sultana, J.
Affiliations
  • University of Exeter (GB)
  • King's College London (GB)
  • Cleveland Clinic (US)
  • University of Oslo (NO)
  • University of Messina (IT)
Corresponding author
Ballard, Clive
Venue
Nature Reviews Neurology
Published
2020-09-16
Volume
16
Issue
12
Pages
661-673
ISSN
  • 1759-4758 (ISSN-L)
  • 1759-4766
OpenAlex
W3046419426
Cited by
201
References
132
Citations by year
2026: 17 · 2025: 38 · 2024: 46 · 2023: 32 · 2022: 33 · 2021: 34 · 2020: 1
FWCI
3.21
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Open Research Exeter (University of Exeter) (acceptedVersion)
  • Figshare (submittedVersion)
  • Royal Devon and Exeter Research Repository (Royal Devon and Exeter) (submittedVersion)
Funders
  • Wellcome Trust
  • National Institute on Aging (R01AG053798, P20AG068053)
  • National Institute of General Medical Sciences (P20GM109025)
  • National Institute of Neurological Disorders and Stroke (U01NS093334)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords
drug repurposing, Alzheimer's disease, mild cognitive impairment, gene expression profiling, Delphi consensus, microglia, neurons
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Humans, Randomized Controlled Trials as Topic, Consensus, Drug Repositioning, Cognitive Dysfunction

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