The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Caloric Intake and the Risk of Alzheimer Disease
Abstract
BACKGROUND: Diet may play a role in Alzheimer disease (AD). OBJECTIVE: To examine the association between caloric intake and AD. METHODS: Elderly individuals free of dementia at baseline (N = 980) were followed for a mean of 4 years. Daily intake of calories, carbohydrates, fats, and protein were recalled using a semiquantitative food frequency questionnaire administered between the baseline and first follow-up visits. Proportional hazards models were used to examine the associations of quartiles of intake and incident AD, adjusting for confounders. RESULTS: There were 242 incident cases of AD during 4023 years of follow-up (6 cases per 100 person-years). Compared with individuals in the lowest quartile of caloric intake, those in the highest quartile had an increased risk of AD (hazard ratio, 1.5; 95% confidence interval [CI], 1.0-2.2). Among individuals with the apolipoprotein E epsilon4 allele, the hazard ratios of AD for the highest quartiles of calorie and fat intake were 2.3 (95% CI, 1.1-4.7) and 2.3 (95% CI, 1.1-4.9), respectively, compared with the lowest quartiles. The hazard ratios of AD for the highest quartiles of calorie and fat intake compared with the lowest quartiles in individuals without the apolipoprotein E epsilon4 allele were close to 1 and were not statistically significant (P =.83 and P =.61, respectively). CONCLUSION: Higher intake of calories and fats may be associated with higher risk of AD in individuals carrying the apolipoprotein E epsilon4 allele.
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Reproducibility and validity of a semiquantitative food frequency questionnaire
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Dietary fat intake and the risk of incident dementia in the Rotterdam study
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Self-citationDietary Intake, Dietary Patterns, and Changes With Age: An Epidemiological Perspective
Wakimoto, P., & Block, G. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.suppl_2.65 · Cited by 391
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Dietary Restriction Benefits Learning and Motor Performance of Aged Mice
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Cited by
Mediterranean diet and risk for Alzheimer's disease
Scarmeas, N., Stern, Y., Tang, M., Mayeux, R., & Luchsinger, J. A. (2006) · Annals of Neurology · doi:10.1002/ana.20854 · Cited by 1,103
Self-citationAgeing and neuronal vulnerability
Mattson, M. P., & Magnus, T. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1886 · Cited by 957
BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders
Mattson, M. P., Maudsley, S., & Martin, B. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.001 · Cited by 942
Physical Activity, Diet, and Risk of Alzheimer Disease
Scarmeas, N. (2009) · JAMA · doi:10.1001/jama.2009.1144 · Cited by 916
Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms
Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, V. A., & Fang, E. F. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.01.002 · Cited by 870
Metadata
- Authors
- Luchsinger, J. A., Tang, M.-X., Shea, S., & Mayeux, R.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 2002-08-01
- Volume
- 59
- Issue
- 8
- Pages
- 1258
- ISSN
- 0003-9942 (ISSN-L)
- OpenAlex
- W1987925748
- Cited by
- 472
- References
- 10
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- closed
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