Dietary Restriction Benefits Learning and Motor Performance of Aged Mice

Brain foods: The effects of nutrients on brain function.

Gómez-Pinilla, F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2421 · Cited by 1,372 · see citing works

Neural mechanisms of ageing and cognitive decline

Bishop, N. A., Lu, T., & Yankner, B. A. (2010) · Nature · doi:10.1038/nature08983 · Cited by 1,323 · see citing works

Gene-expression profile of the ageing brain in mice

Lee, C.-K., Weindruch, R., & Prolla, T. A. (2000) · Nature Genetics · doi:10.1038/77046 · Cited by 1,055 · see citing works

Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice

Lee, J., Duan, W., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01085.x · Cited by 975 · see citing works

Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting

Anton, S. D., Moehl, K., Donahoo, W. T., Marosi, K., Lee, S. A., Mainous, A. G., Leeuwenburgh, C., & Mattson, M. P. (2017) · Obesity · doi:10.1002/oby.22065 · Cited by 782 · see citing works

Free radicals and aging

Barja, G. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.07.005 · Cited by 653 · see citing works

Genetic analysis of ageing: role of oxidative damage and environmental stresses

Martin, G. M., Austad, S. N., & Johnson, T. E. (1996) · Nature Genetics · doi:10.1038/ng0596-25 · Cited by 641 · see citing works

Intermittent metabolic switching, neuroplasticity and brain health

Mattson, M. P., Moehl, K., Ghena, N., Schmaedick, M., & Cheng, A. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.156 · Cited by 624 · see citing works

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

Kapogiannis, D., & Mattson, M. P. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70277-5 · Cited by 594 · see citing works

Caloric restriction improves memory in elderly humans

Witte, A. V., Fobker, M., Gellner, R., Knecht, S., & Flöel, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808587106 · Cited by 574 · see citing works

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies

Maalouf, M., Rho, J. M., & Mattson, M. P. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.09.002 · Cited by 575 · see citing works

Caloric Intake and the Risk of Alzheimer Disease

Luchsinger, J. A., Tang, M., Shea, S. A., & Mayeux, R. P. (2002) · Archives of Neurology · doi:10.1001/archneur.59.8.1258 · Cited by 470 · see citing works

Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems

Mattson, M. P., & Wan, R. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.12.007 · Cited by 464 · see citing works

Sirtuins as potential targets for metabolic syndrome

Guarente, L. (2006) · Nature · doi:10.1038/nature05486 · Cited by 468 · see citing works

Neuronal and glial calcium signaling in Alzheimer’s disease

Mattson, M. P., & Chan, S. L. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00128-3 · Cited by 454 · see citing works

Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice

Lee, J., Seroogy, K. B., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00747.x · Cited by 455 · see citing works

How does calorie restriction work?Preprint

Koubova, J., & Guarente, L. (2003) · Genes & Development · doi:10.1101/gad.1052903 · Cited by 455 · see citing works

Modification of Brain Aging and Neurodegenerative Disorders by Genes, Diet, and Behavior

Mattson, M. P., Chan, S. L., & Duan, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00004.2002 · Cited by 438 · see citing works

Mitochondria and Neuroplasticity

Cheng, A., Hou, Y., & Mattson, M. P. (2010) · ASN NEURO · doi:10.1042/an20100019 · Cited by 433 · see citing works

Dietary Restriction Increases the Number of Newly Generated Neural Cells, and Induces BDNF Expression, in the Dentate Gyrus of Rats

Lee, J., Duan, W., Long, J. M., Ingram, D. K., & Mattson, M. P. (2000) · Journal of Molecular Neuroscience · doi:10.1385/jmn:15:2:99 · Cited by 407 · see citing works

Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span

Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R., Morale, M. C., Lucero, J., Brownell, S., Fabre, V., Huitron-Resendiz, S., Henriksen, S., Zorrilla, E. P., et al. (2006) · Science · doi:10.1126/science.1132191 · Cited by 392 · see citing works

Sirtuins in Aging and DiseasePreprint

Guarente, L. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.024 · Cited by 371 · see citing works

Revenge of the “Sit”: How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity

Vaynman, S., & Gomez‐Pinilla, F. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20979 · Cited by 299 · see citing works

Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms

Mattson, M. P., Duan, W., & Guo, Z. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01586.x · Cited by 285 · see citing works

Effects of intermittent feeding upon body weight and lifespan in inbred mice: interaction of genotype and age

Goodrick, C. L., Ingram, D. K., Reynolds, M. A., Freeman, J. R., & Cider, N. (1990) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(90)90107-q · Cited by 279 · see citing works

Influences of Dietary Restriction and Age on Liver Enzyme Activities and Lipid Peroxidation in Mice

Koizumi, A., Weindruch, R. H., & Walford, R. L. (1987) · Journal of Nutrition · doi:10.1093/jn/117.2.361 · Cited by 279 · see citing works

ENERGY INTAKE, MEAL FREQUENCY, AND HEALTH: A Neurobiological Perspective

Mattson, M. P. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.050304.092526 · Cited by 258 · see citing works

Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria

Lass, A., Sohal, B. H., Weindruch, R. H., Forster, M. J., & Sohal, R. S. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00144-0 · Cited by 251 · see citing works

Dietary Restriction and Aging

Masoro, E. J. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb06767.x · Cited by 242 · see citing works

Neuroprotective signaling and the aging brain: take away my food and let me run11Published on the World Wide Web on 24 August 2000.

Mattson, M. P. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02790-6 · Cited by 238 · see citing works

Disruption of Neurogenesis in the Subventricular Zone of Adult Mice,and in Human Cortical Neuronal Precursor Cells in Culture, by Amyloid β-Peptideby Amyloid β-Peptide

Haughey, N. J., Liu, D., Nath, A., Borchard, A. C., & Mattson, M. P. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:1:2:125 · Cited by 236 · see citing works

SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus

Satoh, A., Brace, C. S., Ben-Josef, G., West, T., Wozniak, D. F., Holtzman, D. M., Herzog, E. D., & Imai, S.-I. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1385-10.2010 · Cited by 237 · see citing works

The roles of TNF in brain dysfunction and disease

Clark, I. A., Alleva, L. M., & Vissel, B. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.08.007 · Cited by 232 · see citing works

Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice

Hao, S., Avraham, Y., Mechoulam, R., & Berry, E. M. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00059-5 · Cited by 229 · see citing works

Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications

Pataky, M. W., Young, W. F., & Nair, K. S. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.07.033 · Cited by 207 · see citing works

Neuronal and Cognitive Plasticity: A Neurocognitive Framework for Ameliorating Cognitive Aging

Greenwood, P. M., & Parasuraman, R. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00150 · Cited by 202 · see citing works

The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction

Morgan, T. E., Xie, Z., Goldsmith, S., Yoshida, T., Lanzrein, A.-S., Stone, D., Rozovsky, I., Perry, G., Smith, M. A., & Finch, C. E. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00334-0 · Cited by 195 · see citing works

Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor

Fontán-Lozano, Á., Sáez-Cassanelli, J. L., Inda, M. C., de los Santos-Arteaga, M., Sierra-Domínguez, S. A., López-Lluch, G., Delgado-García, J. M., & Carrión, Á. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2757-07.2007 · Cited by 195 · see citing works

Reversal of Behavioral and Metabolic Abnormalities, and Insulin Resistance Syndrome, by Dietary Restriction in Mice Deficient in Brain-Derived Neurotrophic Factor

Duan, W., Guo, Z., Jiang, H., Ware, M., & Mattson, M. P. (2003) · Endocrinology · doi:10.1210/en.2002-0113 · Cited by 194 · see citing works

Preconditioning provides neuroprotection in models of CNS disease: Paradigms and clinical significance

Stetler, R. A., Leak, R. K., Gan, Y., Li, P., Zhang, F., Hu, X., Zheng, J., Chen, J., Zigmond, M. J., & Gao, Y. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.005 · Cited by 189 · see citing works

Brain‐derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice

Duan, W., Guo, Z., & Mattson, M. P. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00071.x · Cited by 187 · see citing works

Dietary Restriction Stimulates BDNF Production in the Brain and Thereby Protects Neurons Against Excitotoxic Injury

Duan, W., Lee, J., Guo, Z., & Mattson, M. P. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:1:1 · Cited by 183 · see citing works

Impact of diet on adult hippocampal neurogenesis

Stangl, D., & Thuret, S. (2009) · Genes & Nutrition · doi:10.1007/s12263-009-0134-5 · Cited by 182 · see citing works

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

Liu, Y., Cheng, A., Li, Y.-J., Yang, Y., Kishimoto, Y., Zhang, S., Wang, Y., Wan, R., Raefsky, S. M., Lu, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09897-1 · Cited by 176 · see citing works

Dysregulation of Cellular Calcium Homeostasis in Alzheimer's Disease: Bad Genes and Bad Habits

Mattson, M. P., & Chan, S. L. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:205 · Cited by 178 · see citing works

Controlling caloric consumption: protocols for rodents and rhesus monkeys☆

Pugh, T. D., Klopp, R. G., & Weindruch, R. H. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00043-3 · Cited by 174 · see citing works

Stress and adolescent hippocampal neurogenesis: diet and exercise as cognitive modulators

Hueston, C. M., Cryan, J. F., & Nolan, Y. M. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.48 · Cited by 171 · see citing works

Influence of differential housing on emotional behaviour and neurotrophin levels in mice

Zhu, S., Yee, B. K., Nyffeler, M., Winblad, B. G., Feldon, J., & Mohammed, A. H. S. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.11.024 · Cited by 174 · see citing works

Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms

Mattson, M. P. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00226-3 · Cited by 171 · see citing works

Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability

Adams, M. M., Shi, L., Linville, M. C., Forbes, M. E., Long, A. B., Bennett, C., Newton, I. G., Carter, C. S., Sonntag, W. E., Riddle, D. R., et al. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.01.016 · Cited by 170 · see citing works

Caloric restriction: From soup to nuts

Spindler, S. R. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.10.003 · Cited by 168 · see citing works

Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation

Zhu, H., Guo, Q., & Mattson, M. P. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01827-2 · Cited by 166 · see citing works

Dietary restriction at old age lowers mitochondrial oxygen radical production and leak at complex I and oxidative DNA damage in rat brain

Sanz, A., Caro, P., Ibañez, J., Gómez, J., Gredilla, R., & Barja, G. (2005) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-005-4131-0 · Cited by 165 · see citing works

Molecular mechanisms of brain aging and neurodegenerative disorders: Lessons from dietary restriction

Prolla, T. A., & Mattson, M. P. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01957-3 · Cited by 159 · see citing works

Antioxidant Therapy in Alzheimers Disease: Theory and Practice

Aliev, G., Obrenovich, M. E., Reddy, V. P., Shenk, J. C., Moreira, P. I., Nunomura, A., Zhu, X., Smith, M. A., & Perry, G. L. (2008) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955708786369582 · Cited by 158 · see citing works

Blood-to-brain communication in aging and rejuvenation

Bieri, G., Schroer, A. B., & Villeda, S. A. (2023) · Nature Neuroscience · doi:10.1038/s41593-022-01238-8 · Cited by 156 · see citing works

Revisiting the Role of Fat Mass in the Life Extension Induced by Caloric Restriction

Barzilai, N., & Gupta, G. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.3.b89 · Cited by 152 · see citing works

The influences of diet and exercise on mental health through hormesis

Gómez‐Pinilla, F. (2007) · Ageing Research Reviews · doi:10.1016/j.arr.2007.04.003 · Cited by 149 · see citing works

Drosophila as a model for age-related impairment in locomotor and other behaviors

Jones, M. A., & Grotewiel, M. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.012 · Cited by 149 · see citing works

Chronic Intermittent Fasting Improves Cognitive Functions and Brain Structures in Mice

Li, L., Wang, Z., & Zuo, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066069 · Cited by 147 · see citing works

The Life History of Whole-Organism Performance

Lailvaux, S. P., & Husak, J. F. (2014) · The Quarterly Review of Biology · doi:10.1086/678567 · Cited by 147 · see citing works

AMP‐activated Protein Kinase and FoxO Transcription Factors in Dietary Restriction–induced Longevity

Greer, E. L., Banko, M. R., & Brunet, A. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04019.x · Cited by 146 · see citing works

Adult-Onset Growth Hormone and Insulin-Like Growth Factor I Deficiency Reduces Neoplastic Disease, Modifies Age-Related Pathology, and Increases Life Span

Sonntag, W. E., Carter, C. S., Ikeno, Y., Ekenstedt, K. J., Carlson, C. S., Loeser, R. F., Chakrabarty, S., Lee, S., Bennett, C., Ingram, R. L., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0058 · Cited by 144 · see citing works

Brain synaptosomal aging: Free radicals and membrane fluidity

Choi, J.-H., & Yu, B. P. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00106-t · Cited by 146 · see citing works

Complex maze learning in rodents as a model of age-related memory impairment

Ingram, D. K. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80101-5 · Cited by 138 · see citing works

Gene–Diet Interactions in Brain Aging and Neurodegenerative Disorders

Mattson, M. P. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-5_part_2-200309021-00012 · Cited by 137 · see citing works

Caloric Restriction in Older Adults—Differential Effects of Weight Loss and Reduced Weight on Brain Structure and Function

Prehn, K., von Schwartzenberg, R. J., Mai, K., Zeitz, U., Witte, A. V., Hampel, D. J., Szela, A.-M., Fabian, S., Grittner, U., Spranger, J., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw008 · Cited by 133 · see citing works

Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice

Wahl, D., Solon‐Biet, S. M., Wang, Q., Wali, J. A., Pulpitel, T., Clark, X., Raubenheimer, D., Senior, A. M., Sinclair, D. A., Cooney, G. J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.070 · Cited by 135 · see citing works

Mid-life onset of dietary restriction extends life and prolongs cognitive functioning

Means, L. W., Higgins, J. L., & Fernandez, T. J. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90243-9 · Cited by 132 · see citing works

Prophylactic activation of neuroprotective stress response pathways by dietary and behavioral manipulations

Mattson, M. P., Duan, W., Wan, R., & Guo, Z. (2004) · NeuroRx · doi:10.1602/neurorx.1.1.111 · Cited by 130 · see citing works

Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: Mitochondrial dysfunction, glutamate dysregulation and impaired protein synthesis

Poon, H. F., Shepherd, H. M., Reed, T. T., Calabrese, V., Stella, A. G., Pennisi, G., Cai, J., Pierce, W. M. J., Klein, J. B., & Butterfield, D. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.014 · Cited by 127 · see citing works

Cognitive Performances Are Selectively Enhanced during Chronic Caloric Restriction or Resveratrol Supplementation in a Primate

Dal‐Pan, A., Pifferi, F., Marchal, J., Picq, J., & Aujard, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016581 · Cited by 123 · see citing works

Calorie restriction in rodents: Caveats to consider

Ingram, D. K., & de Cabo, R. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.008 · Cited by 122 · see citing works

Caloric restriction: Beneficial effects on brain aging and Alzheimer’s disease

Van Cauwenberghe, C., Vandendriessche, C., Libert, C., & Vandenbroucke, R. E. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9647-6 · Cited by 121 · see citing works

The Impact of External Factors on the Epigenome:In Uteroand over Lifetime

Toraño, E. G., García, M. G., Fernández-Morera, J. L., García, P. N., & Fernández, A. F. (2016) · BioMed Research International · doi:10.1155/2016/2568635 · Cited by 125 · see citing works

Short-term fasting and prolonged semistarvation have opposite effects on 2-AG levels in mouse brain

Hanus, L. O., Avraham, Y., Ben‐Shushan, D., Zolotarev, O., Berry, E. M., & Mechoulam, R. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03046-4 · Cited by 120 · see citing works

Unravelling the health effects of fasting: a long road from obesity treatment to healthy life span increase and improved cognition

de Toledo, F. W., Grundler, F., Sirtori, C. R., & Ruscica, M. (2020) · Annals of Medicine · doi:10.1080/07853890.2020.1770849 · Cited by 119 · see citing works

Emerging neuroprotective strategies for Alzheimer's disease: dietary restriction, telomerase activation, and stem cell therapy

Mattson, M. P. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00115-7 · Cited by 117 · see citing works

The glucocorticoid paradox of caloric restriction in slowing brain aging

PATEL, N., & Finch, C. E. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00017-9 · Cited by 115 · see citing works

Activity Measures in Rhesus Monkeys on Long-Term Calorie Restriction

Weed, J. L., Lane, M. A., Roth, G. S., Speer, D. L., & Ingram, D. K. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00147-9 · Cited by 116 · see citing works

Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice

Wu, P., Shen, Q., Dong, S., Xu, Z., Tsien, J. Z., & Hu, Y. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.03.028 · Cited by 116 · see citing works

Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho

Dias, G. P., Murphy, T., Stangl, D., Ahmet, S., Morisse, B., Nix, A., Aimone, L. J., Aimone, J. B., Kuro‐o, M., Gage, F. H., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01102-4 · Cited by 115 · see citing works

Exploring the Role of Genetic Variability and Lifestyle in Oxidative Stress Response for Healthy Aging and Longevity

Dato, S., Crocco, P., D’Aquila, P., Rango, F. D., Bellizzi, D., Rose, G., & Passarino, G. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140816443 · Cited by 109 · see citing works

Will caloric restriction and folate protect against AD and PD?

Mattson, M. P. (2003) · Neurology · doi:10.1212/01.wnl.0000042785.02850.11 · Cited by 111 · see citing works

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

Rendeiro, C., Guerreiro, J. D. T., Williams, C. M., & Spencer, J. P. E. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000146 · Cited by 112 · see citing works

Dietary Restriction and Aging: Historical Phases, Mechanisms and Current Directions

Walford, R. L., Harris, S. B., & Weindruch, R. H. (1987) · Journal of Nutrition · doi:10.1093/jn/117.10.1650 · Cited by 110 · see citing works

Beneficial Effects of Dietary Restriction on Cerebral Cortical Synaptic Terminals

Guo, Z., Ersöz, A., Butterfield, D. A., & Mattson, M. P. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750314.x · Cited by 110 · see citing works

Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit

Sainsbury, A., & Zhang, L. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.09.025 · Cited by 108 · see citing works

Age Sensitivity of Behavioral Tests and Brain Substrates of Normal Aging in Mice

Kennard, J. A., & Woodruff-Pak, D. (2011) · Front. Ag. Neurosci. · doi:10.3389/fnagi.2011.00009 · Cited by 116 · see citing works

Neuroprotective and neurorestorative signal transduction mechanisms in brain aging: modification by genes, diet and behavior

Mattson, M. P., Duan, W., Chan, S. L., Cheng, A., Haughey, N. J., Gary, D. S., GUO, Z., Lee, J., & Furukawa, K. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00025-8 · Cited by 107 · see citing works

Lessons learned from gene expression profile studies of aging and caloric restriction

Park, S.-K., & Prolla, T. A. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2004.09.003 · Cited by 106 · see citing works

Environmental influences on cognitive decline in aged rats

Winocur, G. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00107-9 · Cited by 106 · see citing works

No benefit of dietary restriction on disease onset or progression in amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase mutant mice

Pedersen, W. A., & Mattson, M. P. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01471-7 · Cited by 104 · see citing works

Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer’s disease1,2 1Guest Editors: Mark A. Smith and George Perry 2This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

Doré, S. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00805-5 · Cited by 102 · see citing works

Molecular Bases of Caloric Restriction Regulation of Neuronal Synaptic Plasticity

Fontán‐Lozano, Á., López‐Lluch, G., Delgado-Garcia, J. M., Navas, P., & Carrión, Á. M. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8040-1 · Cited by 98 · see citing works

Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria

Miwa, S., Czapiewski, R., Wan, T., Bell, A., Hill, K. N., von Zglinicki, T., & Saretzki, G. C. (2016) · Aging · doi:10.18632/aging.101089 · Cited by 98 · see citing works

Influence of genetic background on daily running-wheel activity differs with aging

Turner, M. J., Kleeberger, S. R., & Lightfoot, J. T. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00243.2004 · Cited by 93 · see citing works

Anti-Inflammatory Mechanisms of Dietary Restriction in Slowing Aging Processes

Morgan, T. E., Wong, A., & Finch, C. E. (2006) · KARGER eBooks · doi:10.1159/000096557 · Cited by 92 · see citing works

The biosure study: Influence of composition of diet and food consumption on longevity, degenerative diseases and neoplasia in wistar rats studied for up to 30 months post weaning

Roe, F. J. C., Lee, P. N., Conybeare, G., Kelly, D., Matter, B. E., Prentice, D. E., & Tobin, G. (1995) · Food and Chemical Toxicology · doi:10.1016/0278-6915(95)80200-2 · Cited by 92 · see citing works

Mid-life onset of dietary restriction extends life and prolongs cognitive functioning

Means, L. W., Higgins, J. L., & Fernandez, T. J. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90243-9 · Cited by 132 · see citing works

Changes in behaviors of male C57BL/6J mice across adult life span and effects of dietary restriction

Fahlström, A., Zeberg, H., & Ulfhake, B. (2011) · AGE · doi:10.1007/s11357-011-9320-7 · Cited by 72 · see citing works

Effects of Dietary Restriction on Physical Performance in Mice

Ishihara, H., Fan, W., Kouda, K., Nakamura, H., Kohno, H., Nishio, N., & Sonoda, Y. (2005) · Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science · doi:10.2114/jpa.24.209 · Cited by 10 · see citing works

Effects of chronic adult dietary restriction on spatial learning in the aged F344×BN hybrid F1 rat

Fitting, S., Booze, R. M., Gilbert, C. A., & Mactutus, C. F. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.10.017 · Cited by 13 · see citing works

Life-long diet restriction failed to retard cognitive aging in Fischer-344 rats☆

Markowska, A. L. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00031-7 · Cited by 76 · see citing works