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Cited by 177Dietary Effects on HealthGenetics, Aging, and Longevity in Model OrganismsMemory and Neural Mechanisms

The effects of life-long food restriction on spatial memory in young and aged Fischer 344 rats measured in the eight-arm radial and the Morris water mazes

STEWART, J, MITCHELL, J, KALANT, N·1989·Neurobiology of Aging
DOI 10.1016/0197-4580(89)90003-1
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Abstract

The effect of life-long 60% ad lib food restriction on performance in two tasks involving spatial memory, the eight-arm radial maze and the Morris water maze, was studied in young and aged Fischer 344 rats. Restricted (R) and ad lib (AL) feeding groups were compared at 8, 16, and 24 months of age on both tasks. A 30-month-old R group was also tested in the Morris water maze. In the eight-arm maze, although 24-month-old animals performed more poorly than 8- and 16-month-old animals during the first week of testing, overall accuracy of performance did not vary significantly as a function of age. Twenty-four-month-old animals took longer to make 10 choices than did younger animals, and there was a significant interaction between feeding regimen and age, reflecting the fact that at the two younger ages, R groups performed more quickly than the AL groups. In the Morris water maze, both distance swum and time to find the platform increased with age. Life-long food restriction led to small but significant improvements in performance in the water maze in aged rats. R groups showed evidence for better retention over 24-hour intervals than did AL groups. By 30 months of age, however, R animals showed impaired performance relative to younger R groups. These differential findings on the two tasks, as they were used here, suggest that there was greater impairment with age on the spatial memory task requiring retention of information over long intervals than there was on the task primarily involving working memory within a trial.(ABSTRACT TRUNCATED AT 250 WORDS)

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  • Caloric restriction prevents many age-dependent gene expression changes in the mouse brain, reduces age-related brain atrophy in rhesus macaques, and has significant beneficial effects on the age-dependent impairment of learning and memory in rodents and humans.

    “It prevents many age-dependent gene expression changes in the mouse brain (8,43), reduces age-related brain atrophy in rhesus macaques (75) and has significant beneficial effects on the age-dependent impairment of learning and memory in rodents (76,77) and humans (78).”

    From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [77]

  • Caloric restriction has beneficial effects on the function of the brain and its vulnerability to age-dependent pathology.

    “Caloric restriction has also been widely documented to have beneficial effects on the function of the brain and its vulnerability to age-dependent pathology.”

    From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [77]

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Authors
STEWART, J., MITCHELL, J., & KALANT, N.
Affiliations
  • Concordia University (CA)
  • Jewish General Hospital (CA)
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
1989-11
Volume
10
Issue
6
Pages
669-675
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/0197-4580(89)90003-1
OpenAlex
W2120690437
Cited by
177
References
31
Citations by year
2026: 2 · 2024: 3 · 2023: 2 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 2 · 2013: 5 · 2012: 4
FWCI
2.84
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
dietary restriction, spatial memory, aging, eight-arm radial maze, Morris water maze, working memory, long-term retention, age-related cognitive decline, F344 rats, ad libitum feeding
MeSH terms
Aging, Animals, Food Deprivation, Male, Memory, Rats, Inbred F344, Spatial Behavior, Task Performance and Analysis, Time Factors, Rats

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