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Cited by 358Traumatic Brain Injury ResearchNeurobiology of Language and BilingualismNeuroscience and Music Perception

Auditory Processing in Severely Brain Injured Patients: Differences Between the Minimally Conscious State and the Persistent Vegetative State

Boly, Mélanie, Faymonville, Marie-Elisabeth, Peigneux, Philippe, Lambermont, Bernard, Damas, Pierre, Del Fiore, Guy, Degueldre, Christian, Franck, Georges +5 more·2004·Archives of Neurology
DOI 10.1001/archneur.61.2.233
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Abstract

BACKGROUND: The minimally conscious state (MCS) is a recently defined clinical condition; it differs from the persistent vegetative state (PVS) by the presence of inconsistent, but clearly discernible, behavioral evidence of consciousness. OBJECTIVE: To study auditory processing among patients who are in an MCS, patients who are in a PVS, and healthy control subjects. METHODS: By means of (15)O-radiolabeled water-positron emission tomography, we measured changes in regional cerebral blood flow induced by auditory click stimuli in 5 patients in an MCS, 15 patients in a PVS, and 18 healthy controls. RESULTS: In both patients in an MCS and the healthy controls, auditory stimulation activated bilateral superior temporal gyri (Brodmann areas 41, 42, and 22). In patients in a PVS, the activation was restricted to Brodmann areas 41 and 42 bilaterally. We also showed that, compared with patients in a PVS, patients in an MCS demonstrated a stronger functional connectivity between the secondary auditory cortex and temporal and prefrontal association cortices. CONCLUSIONS: Although assumptions about the level of consciousness in severely brain injured patients are difficult to make, our findings suggest that the cerebral activity observed in patients in an MCS is more likely to lead to higher-order integrative processes, thought to be necessary for the gain of conscious auditory perception.

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  • Tactile or auditory stimulations during vegetative state can still activate primary somatosensory cortex (S1) or primary auditory cortex (A1), respectively, in the absence of perception and without the involvement of higher-order associative areas.

    “For example, tactile (Laureys et al., 2002) or auditory (Boly et al., 2004; Laureys et al., 2000) stimulations during vegetative state can still activate primary somatosensory cortex (S1) or primary auditory cortex (A1), respectively, in the absence of perception and without the involvement of higher-order associative areas.”

    From Perception is associated with the brain’s metabolic response to sensory stimulation (2022) · cites this paper as Boly et al., 2004

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Authors
Boly, M., Faymonville, M.-E., Peigneux, P., Lambermont, B., Damas, P., Del Fiore, G., Degueldre, C., Franck, G., Luxen, A., Lamy, M., Moonen, G., Maquet, P., & Laureys, S.
Affiliations
  • University of Liège (BE)
  • Centre Hospitalier Universitaire de Liège (BE)
ORCID
Venue
Archives of Neurology
Publisher
American Medical Association (AMA)
Published
2004-02-01
Volume
61
Issue
2
Pages
233
ISSN
0003-9942 (ISSN-L)
DOI
10.1001/archneur.61.2.233
OpenAlex
W1967836750
Cited by
358
References
25
Citations by year
2026: 2 · 2025: 10 · 2024: 8 · 2023: 13 · 2022: 7 · 2021: 5 · 2020: 15 · 2019: 8 · 2018: 8 · 2017: 17 · 2016: 9 · 2015: 24 · 2014: 15 · 2013: 33 · 2012: 30
FWCI
13.95
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
  • ORBi (University of Liège) (submittedVersion)
Funders
Newcastle University
Topics
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
Keywords
auditory processing, minimally conscious state, persistent vegetative state, severe brain injury, cerebral blood flow, superior temporal gyrus, functional connectivity, auditory cortex, consciousness, positron emission tomography
MeSH terms
Acoustic Stimulation, Adult, Aged, Auditory Perception, Brain Injuries, Cerebrovascular Circulation, Consciousness, Electroencephalography, Female, Humans, Male, Middle Aged, Oxygen Radioisotopes, Psychophysiology, Tomography, Emission-Computed, Persistent Vegetative State

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