Auditory processing in the vegetative state
Abstract
H(2)(15)O-PET was used to investigate changes in regional cerebral blood flow in response to auditory stimulation in patients in the vegetative state. Five patients in a vegetative state of hypoxic origin were compared with 18 age-matched controls. In addition, the cerebral metabolism of these patients and 53 age-matched controls was studied using [(18)F]fluorodeoxyglucose. In control subjects, auditory click stimuli activated bilateral auditory cortices [Brodmann areas (BA) 41 and 42] and the contralateral auditory association cortices (BA 22). In the patients, although resting metabolism was decreased to 61% of normal values, bilateral auditory areas 41 and 42 showed activation as seen in the controls, but the temporoparietal junction cortex (BA 22) failed to be activated. Moreover, the auditory association cortex was functionally disconnected from the posterior parietal association area (BA 40), the anterior cingulate cortex (BA 24) and the hippocampus, as revealed by psychophysiological interaction analysis. Thus, despite altered resting metabolism, the auditory primary cortices were still activated during external stimulation, whereas hierarchically higher-order multi- modal association areas were not. Such a cascade of functional disconnections along the auditory cortical pathways, from the primary auditory areas to multimodal and limbic areas, suggests that the residual cortical processing observed in the vegetative state cannot lead to the integrative processes that are thought to be necessary for the attainment of the normal level of awareness.
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Tactile or auditory stimulations during vegetative state can still activate primary somatosensory cortex (S1) or primary auditory cortex (A1), respectively, in the absence of perception and without the involvement of higher-order associative areas.
“For example, tactile (Laureys et al., 2002) or auditory (Boly et al., 2004; Laureys et al., 2000) stimulations during vegetative state can still activate primary somatosensory cortex (S1) or primary auditory cortex (A1), respectively, in the absence of perception and without the involvement of higher-order associative areas.”
From Perception is associated with the brain’s metabolic response to sensory stimulation (2022) · cites this paper as Laureys et al., 2000
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Laureys, S., Faymonville, M.-É., Goldman, S., Degueldre, C., Phillips, C. L. M., Lambermont, B. C., Aerts, J. J., Lamy, M., Luxen, A., Franck, G., et al. (2001) · Elsevier eBooks · doi:10.1016/b978-012285751-5/50050-8 · Cited by 13 · see citing works
Self-citationFractured brain function in unconscious humans II: Functional brain imaging using MEG.
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Engelien, A. (1999) · Neurocase · doi:10.1093/neucas/5.5.385 · Cited by 12 · see citing works
Cerebral Function in Vegetative State studied by Positron Emission Tomography
Laureys, S., Faymonville, M. E., & Lamy, M. (2000) · Yearbook of intensive care and emergency medicine · doi:10.1007/978-3-662-13455-9_49 · Cited by 11 · see citing works
Self-citationFaymonville, M. E., Mambourg, P.-H., Albert, A., et al. (1996) · British Journal of Anaesthesia · doi:10.1016/s0007-0912(18)30876-6 · Cited by 8 · see citing works
MATHEW, R. (1991) · Psychiatry Research · doi:10.1016/0165-1781(91)90152-f · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Hackett TA, Stepniewska I, Kaas JH. Subdivisions of auditory cortex and ipsilateral cortical connections of the parabelt auditory cortex in macaque monkeys. J Comp Neurol 1998; 394: 475-95.
- Heilman KM, Pandya DN, Karol EA, Geschwind N. Auditory inattention. Arch Neurol 1971; 24: 323-5.
Cited by
Sorted by citations
Brain function in coma, vegetative state, and related disorders
Laureys, S., Owen, A. M., & Schiff, N. D. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00852-x · Cited by 1,033 · see citing works
Self-citationGlobal workspace theory of consciousness: toward a cognitive neuroscience of human experience
Baars, B. J. (2005) · Progress in Brain Research · doi:10.1016/s0079-6123(05)50004-9 · Cited by 888 · see citing works
The neural correlate of (un)awareness: lessons from the vegetative state
Laureys, S. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.10.010 · Cited by 813 · see citing works
Self-citation<i>The Neural Correlates of Consciousness</i>: <i>An Update</i>
Tononi, G., & Koch, C. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.004 · Cited by 627 · see citing works
Cytology and functionally correlated circuits of human posterior cingulate areas
Vogt, B. A., Vogt, L., & Laureys, S. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.048 · Cited by 484 · see citing works
Self-citationCortical processing of noxious somatosensory stimuli in the persistent vegetative state
Laureys, S., Faymonville, M. E., Peigneux, P., Damas, P., Lambermont, B., Del Fiore, G., Degueldre, C., Aerts, J., Luxen, A., Franck, G., et al. (2002) · NeuroImage · doi:10.1006/nimg.2002.1236 · Cited by 432 · see citing works
Self-citationThe neurobehavioral nature of fishes and the question of awareness and pain.
Rose, J. D. (2002) · Reviews in Fisheries Science · doi:10.1080/20026491051668 · Cited by 413 · see citing works
Brain, conscious experience and the observing self
Baars, B. J., Ramsøy, T. Z., & Laureys, S. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.015 · Cited by 404 · see citing works
Self-citationComa and consciousness: paradigms (re)framed by neuroimaging
Laureys, S., & Schiff, N. D. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.041 · Cited by 397 · see citing works
Self-citationAuditory Processing across the Sleep-Wake Cycle
Portas, C. M., Krakow, K., Allen, P., Josephs, O., Armony, J. L., & Frith, C. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00169-0 · Cited by 392 · see citing works
Boly, M., Faymonville, M.-E., Peigneux, P., Lambermont, B., Damas, P., Del Fiore, G., Degueldre, C., Franck, G., Luxen, A., Lamy, M., et al. (2004) · Archives of Neurology · doi:10.1001/archneur.61.2.233 · Cited by 358 · see citing works
Self-citationConsciousness in humans and non-human animals: recent advances and future directions
Boly, M., Seth, A. K., Wilke, M., Ingmundson, P., Baars, B., Laureys, S., Edelman, D. B., & Tsuchiya, N. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00625 · Cited by 291 · see citing works
Self-citationConsciousness supporting networks
Demertzi, A., Soddu, A., & Laureys, S. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.12.003 · Cited by 196 · see citing works
Self-citationImas, O. A., Ropella, K. M., Ward, B. D., Wood, J. D., & Hudetz, A. G. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.06.018 · Cited by 189 · see citing works
Fridman, E. A., Beattie, B. J., Broft, A., Laureys, S., & Schiff, N. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320969111 · Cited by 147 · see citing works
Self-citationBruno, M. A., Fernández-Espejo, D., Lehembre, R., Tshibanda, L., Vanhaudenhuyse, A., Gosseries, O., Lommers, E., Napolitani, M., Noirhomme, Q., Boly, M., et al. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00021-1 · Cited by 59 · see citing works
Self-citationChangeux, J.-P. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1832 · Cited by 31 · see citing works
Perception is associated with the brain’s metabolic response to sensory stimulation
DiNuzzo, M., Mangia, S., Moraschi, M., Mascali, D., Hagberg, G. E., & Giove, F. (2022) · eLife · doi:10.7554/elife.71016 · Cited by 25 · see citing works
- Authors
- Laureys, S.
- Affiliations
- University of Liège (BE)
- Corresponding author
- Laureys, S.
- ORCID
- Laureys, S.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-08-01
- Volume
- 123
- Issue
- 8
- Pages
- 1589-1601
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2102082234
- Cited by
- 311
- References
- 110
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 7 · 2023: 10 · 2022: 5 · 2021: 2 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 10 · 2016: 7 · 2015: 19 · 2014: 21 · 2013: 22 · 2012: 18
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- Fonds De La Recherche Scientifique - FNRS
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- vegetative state, auditory processing, regional cerebral blood flow, brain glucose metabolism, auditory cortex activation, auditory association cortex, temporoparietal junction, functional connectivity, psychophysiological interaction, hypoxic brain injury, awareness, anterior cingulate cortex, hippocampus
- MeSH terms
- Acoustic Stimulation, Adult, Auditory Cortex, Auditory Perception, Cerebrovascular Circulation, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Tomography, Emission-Computed, Persistent Vegetative State
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