Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours
Abstract
Impulsive-compulsive behaviours are a significant source of morbidity for patients with Parkinson's disease receiving dopaminergic therapy. The development of these behaviours may reflect sensitization of the neural response to non-drug rewards, similar to that proposed for sensitization to drug rewards in addiction. Here, by using (11)C-raclopride positron emission tomography imaging, we investigated the effects of reward-related cues and L-dopa challenge in patients with Parkinson's disease with and without impulsive-compulsive behaviours on striatal levels of synaptic dopamine. Eighteen patients (11 with and seven without impulsive-compulsive behaviours) underwent three (11)C-raclopride positron emission tomography scans. The impulsive-compulsive behaviours included hypersexuality, binge eating, punding, compulsive use of dopamine replacement therapy, compulsive buying and pathological gambling, with eight patients exhibiting more than one impulsive-compulsive behaviour. There were no significant differences in baseline dopamine D2 receptor availability between the Parkinson's disease groups. No differences were found when comparing the percentage change of raclopride binding potential between the two Parkinson's disease groups following L-dopa challenge with neutral cues. The group with Parkinson's disease with impulsive-compulsive behaviours had a greater reduction of ventral striatum (11)C-raclopride binding potential following reward-related cue exposure, relative to neutral cue exposure, following L-dopa challenge (16.3% compared with 5.8% in Parkinson's disease controls, P = 0.016). The heightened response of striatal reward circuitry to heterogeneous reward-related visual cues among a group of patients with different impulsive-compulsive behaviours is consistent with a global sensitization to appetitive behaviours with dopaminergic therapy in vulnerable individuals. Our findings are relevant for the broader debate on the relation between impulsive-compulsive behaviours and addictions and may have important implications with regards to advertisement legislation in an effort to prevent the onset of behavioural addictions.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Parkinson's patients with hypersexuality also reveal sensitization of the system.
“They also reveal sensitization of the system (O 'Sullivan, et al., 2011).”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as O 'Sullivan, et al., 2011
Cites
Hughes, A. J., Daniel, S. E., Kilford, L., & Lees, A. J. (1992) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.3.181 · Cited by 10,378 · see citing works
Self-citationThe neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
(2005) · CTIT technical reports series · Cited by 5,307 · see citing works
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785 · see citing works
The debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347 · see citing works
Simplified Reference Tissue Model for PET Receptor Studies
Lammertsma, A. A., & Hume, S. P. (1996) · NeuroImage · doi:10.1006/nimg.1996.0066 · Cited by 2,025 · see citing works
Dissecting components of reward: ‘liking’, ‘wanting’, and learning
Berridge, K. C., Robinson, T. E., & Aldridge, J. W. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.014 · Cited by 1,942 · see citing works
The incentive sensitization theory of addiction: some current issues
Robinson, T. E., & Berridge, K. C. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0093 · Cited by 1,717 · see citing works
Meta‐analysis of cue‐reactivity in addiction research
Carter, B. L., & Tiffany, S. T. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.9433273.x · Cited by 1,638 · see citing works
Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
Johnson, P. M., & Kenny, P. J. (2010) · Nature Neuroscience · doi:10.1038/nn.2519 · Cited by 1,495 · see citing works
Impulse Control Disorders in Parkinson Disease
Weintraub, D. A., Koester, J., Potenza, M. N., Siderowf, A. D., Stacy, M. A., Voon, V., Whetteckey, J., Wunderlich, G. R., & Lang, A. E. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.65 · Cited by 1,493 · see citing works
Evidence for striatal dopamine release during a video game
Koepp, M. J., Gunn, R. N., Lawrence, A. D., Cunningham, V. J., Dagher, A., Jones, T., Brooks, D. J., Bench, C. J., & Grasby, P. M. (1998) · Nature · doi:10.1038/30498 · Cited by 1,279 · see citing works
Self-citationPetry, N. M., Stinson, F. S., & Grant, B. F. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0504 · Cited by 1,245 · see citing works
Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Logan, J., Childress, A.-R., Jayne, M., Ma, Y., & Wong, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1544-06.2006 · Cited by 1,164 · see citing works
Parametric Imaging of Ligand-Receptor Binding in PET Using a Simplified Reference Region Model
Gunn, R. N., Lammertsma, A. A., Hume, S. P., & Cunningham, V. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0303 · Cited by 1,085 · see citing works
Imaging dopamine's role in drug abuse and addiction
Volkow, N. D., Fowler, J. S., Wang, G. J., Baler, R., & Telang, F. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.022 · Cited by 988 · see citing works
DSM-IV pathological gambling in the National Comorbidity Survey Replication
Kessler, R. C., Hwang, I., LaBrie, R., Petukhova, M., Sampson, N. A., Winters, K. C., & Shaffer, H. J. (2008) · Psychological Medicine · doi:10.1017/s0033291708002900 · Cited by 928 · cited 4× · see citing works
“Third, there is evidence that cue reactivity is not necessarily focused on a single reward but can ‘spill-over’ to other rewards (Sodano and Wulfert, 2010), and several patients showed more than one impulsive-compulsive behaviour, consistent with the known comorbidity between impulsive-compulsive behaviours (Petry et…”
InfluentialGiovannoni, G. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.4.423 · Cited by 587 · see citing works
Brief measures of sensation seeking for screening and large-scale surveys
Stephenson, M. T., Hoyle, R. H., Palmgreen, P., & Slater, M. D. (2003) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2003.08.003 · Cited by 557 · see citing works
Steeves, T. D. L., Miyasaki, J., Zurowski, M., Lang, A. E., Pellecchia, G., Van Eimeren, T., Rusjan, P., Houle, S., & Strafella, A. P. (2009) · Brain · doi:10.1093/brain/awp054 · Cited by 502 · see citing works
Schott, B. H., Minuzzi, L., Krebs, R. M., Elmenhorst, D., Lang, M., Winz, O. H., Seidenbecher, C. I., Coenen, H. H., Heinze, H.-J., Zilles, K., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2058-08.2008 · Cited by 496 · see citing works
Personality and substance use disorders: A prospective study.
Sher, K. J., Bartholow, B. D., & Wood, M. D. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.68.5.818 · Cited by 483 · cited 4× · see citing works
“, 1998), and prospectively predicts development of impulsive-compulsive behaviours and addiction (Sher et al., 2000; Cyders and Smith, 2008).”
InfluentialPunding in Parkinson's disease: Its relation to the dopamine dysregulation syndrome
Evans, A. H., Katzenschlager, R., Paviour, D. C., O’Sullivan, J. D., Appel, S., Lawrence, A. D., & Lees, A. J. (2004) · Movement Disorders · doi:10.1002/mds.20045 · Cited by 474 · see citing works
Self-citationCompulsive drug use linked to sensitized ventral striatal dopamine transmission.
Evans, A. H., Pavese, N., Lawrence, A. D., Tai, Y. F., Appel, S., Doder, M., Brooks, D. J., Lees, A. J., & Piccini, P. (2006) · Annals of Neurology · doi:10.1002/ana.20822 · Cited by 473 · see citing works
Self-citationImpulse Buying: Its Relation to Personality Traits and Cues
Youn, S., & Faber, R. J. (2000) · ACR North American Advances · Cited by 449 · see citing works
Wyvell, C. L., & Berridge, K. C. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07831.2001 · Cited by 436 · see citing works
Drug Addiction Endophenotypes: Impulsive Versus Sensation-Seeking Personality Traits
Ersche, K. D., Turton, A. J., Pradhan, S., Bullmore, E. T., & Robbins, T. W. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.015 · Cited by 422 · see citing works
Punding in Parkinson's disease: Its relation to the dopamine dysregulation syndrome
Evans, A., Katzenschlager, R., Paviour, D. C., Appel‐Cresswell, S., Lawrence, A., & Lees, A. J. (2004) · UCL Discovery (University College London) · Cited by 401 · see citing works
Self-citationMedication-Related Impulse Control and Repetitive Behaviors in Parkinson Disease
Voon, V., & Fox, S. H. (2007) · Archives of Neurology · doi:10.1001/archneur.64.8.1089 · Cited by 397 · see citing works
The Architecture of Reward Value Coding in the Human Orbitofrontal Cortex
Sescousse, G., Redouté, J., & Dreher, J.-C. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3501-10.2010 · Cited by 353 · see citing works
A Single Scatter Simulation Technique for Scatter Correction in 3D PET
Watson, C. C., Newport, D. F., & Casey, M. (1996) · Computational imaging and vision · doi:10.1007/978-94-015-8749-5_18 · Cited by 333 · see citing works
Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving
Wong, D. F., Kuwabara, H., Schretlen, D. J., Bonson, K. R., Zhou, Y., Nandi, A., Brašić, J. R., Kimes, A. S., Maris, M. A., Kumar, A., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301194 · Cited by 311 · see citing works
The Mind of an Addicted Brain: Neural Sensitization of Wanting Versus Liking
Berridge, K. C., & Robinson, T. E. (1995) · Current Directions in Psychological Science · doi:10.1111/1467-8721.ep10772316 · Cited by 290 · see citing works
Mechanisms underlying dopamine-mediated reward bias in compulsive behaviors
Voon, V., Pessiglione, M., Brezing, C., Gallea, C., Fernandez, H. H., Dolan, R. J., & Hallett, M. (2010) · Neuron · doi:10.1016/j.neuron.2009.12.027 · Cited by 280 · see citing works
Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry?
Lawrence, A. D., Evans, A. H., & Lees, A. J. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00529-5 · Cited by 280 · see citing works
Self-citationBikinis Instigate Generalized Impatience in Intertemporal Choice
Van den Bergh, B., Dewitte, S., & Warlop, L. (2008) · Journal of Consumer Research · doi:10.1086/525505 · Cited by 269 · see citing works
Dopamine Dysregulation Syndrome: An Overview of its Epidemiology, Mechanisms and Management
OʼSullivan, S. S., Evans, A. H., & Lees, A. J. (2009) · CNS Drugs · doi:10.2165/00023210-200923020-00005 · Cited by 265 · see citing works
Self-citationDopamine Transmission in the Human Striatum during Monetary Reward Tasks
Zald, D. H., Boileau, I., El-Dearedy, W., Gunn, R., McGlone, F., Dichter, G. S., & Dagher, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4643-03.2004 · Cited by 238 · see citing works
Impulsive and compulsive behaviors in Parkinson's disease
Evans, A. H., Strafella, A. P., Weintraub, D. A., & Stacy, M. A. (2009) · Movement Disorders · doi:10.1002/mds.22505 · Cited by 233 · see citing works
Self-citationInternet Gambling: An Online Empirical Study Among Student Gamblers
Griffiths, M. D., & Barnes, A. (2007) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-007-9083-7 · Cited by 231 · see citing works
Gallagher, D. A., O’Sullivan, S. S., Evans, A. H., Lees, A. J., & Schrag, A. E. (2007) · Movement Disorders · doi:10.1002/mds.21611 · Cited by 224 · see citing works
Self-citationBoileau, I., Dagher, A., Leyton, M., Welfeld, K., Booij, L., Diksic, M., & Benkelfat, C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4370-06.2007 · Cited by 222 · see citing works
Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD
van Eimeren, T., Pellecchia, G., Cilia, R., Ballanger, B., Steeves, T. D. L., Houle, S., Miyasaki, J. M., Zurowski, M., Lang, A. E., & Strafella, A. P. (2010) · Neurology · doi:10.1212/wnl.0b013e3181fc27fa · Cited by 199 · see citing works
Clarifying the role of personality dispositions in risk for increased gambling behavior
Cyders, M., & Smith, G. T. (2008) · Personality and Individual Differences · doi:10.1016/j.paid.2008.06.002 · Cited by 194 · see citing works
A review of the effects of perceived drug use opportunity on self-reported urge.
Wertz, J. M., & Sayette, M. A. (2001) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.9.1.3 · Cited by 192 · see citing works
Cue-elicited craving for food: a fresh approach to the study of binge eating
Sobik, L. E., Hutchison, K. E., & Craighead, L. W. (2005) · Appetite · doi:10.1016/j.appet.2004.12.001 · Cited by 186 · see citing works
Housden, C. R., O’Sullivan, S. S., Joyce, E. M., Lees, A. J., & Roiser, J. P. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.84 · Cited by 176 · see citing works
Self-citationComorbidity of impulse control disorders in pathological gamblers
Grant, J. E., & Kim, S. W. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2003.00162.x · Cited by 172 · see citing works
Effects of a low dose of alcohol on cognitive biases and craving in heavy drinkers
Schoenmakers, T. M., Wiers, R. W. H. J., & Field, M. (2007) · Psychopharmacology · doi:10.1007/s00213-007-1023-5 · Cited by 170 · see citing works
Fiorino, D. F., & Phillips, A. G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00456.1999 · Cited by 170 · see citing works
Imaging in Parkinson's disease: the role of monoamines in behavior.
Brooks, D., & Piccini, P. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.017 · Cited by 158 · see citing works
Self-citationDecreased ventral striatal activity with impulse control disorders in Parkinson's disease
Rao, H., Mamikonyan, E., Detre, J. A., Siderowf, A. D., Stern, M. B., Potenza, M. N., & Weintraub, D. A. (2010) · Movement Disorders · doi:10.1002/mds.23147 · Cited by 148 · see citing works
Dopamine release in ventral striatum of pathological gamblers losing money
Linnet, J., Peterson, E., Doudet, D. J., Gjedde, A., & Møller, A. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01591.x · Cited by 127 · see citing works
Three-Dimensional Image Reconstruction in Radiology and Nuclear Medicine
Grangeat, P., & Amans, J. (1996) · Computational imaging and vision · doi:10.1007/978-94-015-8749-5 · Cited by 108 · see citing works
Nocjar, C., & Panksepp, J. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00321-7 · Cited by 106 · see citing works
West, R., & USSHER, M. H. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1742-x · Cited by 93 · see citing works
Risk and learning in impulsive and nonimpulsive patients with Parkinson's disease
Djamshidian, A., Jha, A., O’Sullivan, S. S., Silveira‐Moriyama, L., Jacobson, C., Brown, P., Lees, A. J., & Averbeck, B. B. (2010) · Movement Disorders · doi:10.1002/mds.23247 · Cited by 90 · see citing works
Self-citationImpulse-control disorders in alcoholics are related to sensation seeking and not to impulsivity
Lejoyeux, M., Feuché, N., Loi, S., et al. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00103-6 · Cited by 67 · see citing works
Parkinson's Disease and pathological gambling: Results from a functional MRI study
Frosini, D., Pesaresi, I., Cosottini, M., Belmonte, G., Rossi, C. A., Dell’Osso, L., Murri, L., Bonuccelli, U., & Ceravolo, R. (2010) · Movement Disorders · doi:10.1002/mds.23369 · Cited by 65 · see citing works
Cue Reactivity in Active Pathological, Abstinent Pathological, and Regular Gamblers
Sodano, R., & Wulfert, E. (2009) · Journal of Gambling Studies · doi:10.1007/s10899-009-9146-8 · Cited by 64 · see citing works
Yip, S. W., White, M. A., Grilo, C. M., & Potenza, M. N. (2010) · Journal of Gambling Studies · doi:10.1007/s10899-010-9207-z · Cited by 32 · see citing works
Ranaldi, R., Egan, J., Kest, K., Fein, M., & Delamater, A. R. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.08.006 · Cited by 28 · see citing works
Drugs, Environment, Brain, and Behavior
Crombag, H. S., & Robinson, T. E. (2004) · Current Directions in Psychological Science · doi:10.1111/j.0963-7214.2004.00285.x · Cited by 13 · see citing works
Grant, J. E., & Odlaug, B. L. (2014) · Springer eBooks · doi:10.1007/978-3-642-27772-6_368-4 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Liking, wanting, and the incentive-sensitization theory of addiction
Berridge, K. C., & Robinson, T. E. (2016) · American Psychologist · doi:10.1037/amp0000059 · Cited by 1,440 · see citing works
From prediction error to incentive salience: mesolimbic computation of reward motivation.
Berridge, K. C. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.07990.x · Cited by 700 · see citing works
Leeman, R. F., & Potenza, M. N. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2550-7 · Cited by 448 · see citing works
Evolving Concepts of Emotion and Motivation
Berridge, K. C. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.01647 · Cited by 273 · see citing works
Smartphone addiction and associated consequences: Role of loneliness and self-regulation
Mahapatra, S. (2019) · Behaviour & Information Technology · doi:10.1080/0144929x.2018.1560499 · Cited by 261 · see citing works
Lawrence, N. S., Hinton, E. C., Parkinson, J. A., & Lawrence, A. D. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.06.070 · Cited by 242 · see citing works
Self-citationBlum, K., Gardner, E., Oscar-Berman, M., & Gold, M. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212798919110 · Cited by 218 · see citing works
Striatal Dopamine and the Interface between Motivation and Cognition
Aarts, E., van Holstein, M., & Cools, R. (2011) · Frontiers in Psychology · doi:10.3389/fpsyg.2011.00163 · Cited by 211 · see citing works
Boileau, I., Payer, D., Chugani, B., Lobo, D. S. S., Houle, S., Wilson, A. A., Warsh, J., Kish, S. J., & Zack, M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.163 · Cited by 198 · see citing works
Clark, L., Stokes, P. R., Wu, K., Michalczuk, R., Benecke, A., Watson, B. J., Egerton, A., Piccini, P., Nutt, D. J., Bowden-Jones, H., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.06.067 · Cited by 193 · see citing works
Self-citationPolitis, M., Loane, C., Wu, K., O’Sullivan, S. S., Woodhead, Z., Kiferle, L., Lawrence, A. D., Lees, A. J., & Piccini, P. (2013) · Brain · doi:10.1093/brain/aws326 · Cited by 191 · see citing works
Self-citationBoileau, I., Payer, D., Chugani, B., Lobo, D., Behzadi, A., Rusjan, P. M., Houle, S., Wilson, A. A., Warsh, J., Kish, S. J., et al. (2013) · Addiction · doi:10.1111/add.12066 · Cited by 190 · see citing works
Striatal ups and downs: Their roles in vulnerability to addictions in humans
Leyton, M., & Vezina, P. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.018 · Cited by 165 · see citing works
Sensation-seeking: dopaminergic modulation and risk for psychopathology
Norbury, A., & Husain, M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.015 · Cited by 142 · see citing works
A systematic review of impulse control disorders in Parkinson’s disease.
Callesen, M. B., Scheel-Krüger, J., Kringelbach, M. L., & Møller, A. (2013) · Journal of Parkinson s Disease · doi:10.3233/jpd-120165 · Cited by 130 · see citing works
Depression and impulse control disorders in Parkinson׳s disease: two sides of the same coin?
Vriend, C., Pattij, T., van der Werf, Y. D., Voorn, P., Booij, J., Rutten, S., Berendse, H. W., & van den Heuvel, O. A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.001 · Cited by 106 · see citing works
Dopamine Agonists and the Suppression of Impulsive Motor Actions in Parkinson Disease
Wylie, S. A., Claassen, D. O., Huizenga, H. M., Schewel, K. D., Ridderinkhof, K. R., Bashore, T. R., & van den Wildenberg, W. P. M. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00241 · Cited by 76 · see citing works
Explanatory pluralism: An unrewarding prediction error for free energy theorists
Colombo, M., & Wright, C. (2017) · Brain and Cognition · doi:10.1016/j.bandc.2016.02.003 · Cited by 67 · see citing works
Neurobiological basis of hypersexuality
Kühn, S., & Gallinat, J. (2016) · International Review of Neurobiology · doi:10.1016/bs.irn.2016.04.002 · Cited by 55 · see citing works
On Cue: Striatal Ups and Downs in Addictions
Leyton, M., & Vezina, P. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.036 · Cited by 53 · see citing works
Stievenard, A., Méquinion, M., Andrews, Z. B., Destée, A., Chartier-Harlin, M.-C., Viltart, O., & Vanbesien-Mailliot, C. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.021 · Cited by 39 · see citing works
A motivation model of sex addiction – Relevance to the controversy over the concept
Toates, F. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104872 · Cited by 25 · see citing works
Kassim, F. M. (2023) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.2856 · Cited by 11 · see citing works
“Studies have also indicated that dopamine‐related disorders such as ADHD (Nigg et al., 2002) and parkinsonism (Menza et al., 1993; O'Sullivan et al., 2011; Terracciano et al., 2021) have associations with novelty seeking and neuroticism personality traits.”
Background
- Authors
- O'Sullivan, S. S., Wu, K., Politis, M., Lawrence, A. D., Evans, A. H., Bose, S. K., Djamshidian, A., Lees, A. J., & Piccini, P.
- Affiliations
- Hammersmith Hospital (GB)
- Cardiff University (GB)
- The Royal Melbourne Hospital (AU)
- University College London (GB)
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-02-24
- Volume
- 134
- Issue
- 4
- Pages
- 969-978
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2120927079
- Cited by
- 297
- References
- 64
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 14 · 2021: 15 · 2020: 56 · 2019: 20 · 2018: 19 · 2017: 25 · 2016: 15 · 2015: 28 · 2014: 21 · 2013: 27 · 2012: 21
- FWCI
- 16.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Parkinson's UK (J-0704)
- University of Illinois at Chicago
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, dopamine release, striatum, ventral striatum, dopaminergic therapy, hypersexuality, binge eating, punding, gambling addiction, compulsive buying, behavioral addiction
- MeSH terms
- Aged, Brain Mapping, Compulsive Behavior, Corpus Striatum, Cues, Dopamine, Female, Humans, Impulsive Behavior, Male, Middle Aged, Parkinson Disease, Radionuclide Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
