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PRELIMINARY ANALYSIS OF FUNCTIONS OF THE TEMPORAL LOBES IN MONKEYS
Abstract
In previous communications1we pointed out that the chief symptoms following bilateral temporal lobectomy in the rhesus monkey consist in "psychic blindness" (Seelenblindheit) or visual agnosia, strong "oral" tendencies and profound emotional changes. Our results were primarily based on an analysis of the behavioral symptoms of a female rhesus monkey which had been studied for a period of four months following the operations. The type of disturbance analyzed in that case seemed to be similar to the "associative mind blindness" of Lissauer.2It is true that the diagnosis "agnosia" can be only of practical importance and merely serves to raise a number of questions. A review of the clinical literature indicates that the more carefully a case is studied the more difficult it may be to decide whether there is really an "agnostic" or merely a "visual" defect, that is, whether the variety of "agnostic" symptoms can be
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“This goes back to the original findings of hypersexuality in individuals with frontal lobe damage or Kluver-Bucy syndrome.94”
From Assessment and treatment of compulsive sexual behavior disorder: a sexual medicine perspective (2024) · cites this paper as [94]
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“Kluver and Bucy first demonstrated hypersexuality in rhesus monkeys following bilateral temporal lobectomy [11].”
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“…when damaged or diseased, temporal-limbic structures have also been linked to hypersexuality (Baird, Wilson, Bladin, Saling, & Reutens, 2002; Kluver & Bucy, 1939; Ozmen, Erdogan, Duvenci, Ozyurt, & Ozkara, 2004), a finding that may at first blush appear to be most relevant for this…”
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“One of the earliest demonstrations that V1 could not be the entire story in terms of visual recognition and that there must be extrastriate visual function was the study of Kluver-Bucy syndrome (49).”
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“Laboratory animal studies have shown impaired fear expression and avoidance behavior after amygdala lesions in monkeys (Kluver & Bucy, 1939; Weiskrantz, 1956; Aggleton & Passingham, 1981; Kalin, Shelton, Davidson, & Kelley, 2001) and rodents (Blair, Sotres-Bayon, Moita, & Ledoux, 2005; Blanchard &…”
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“Considering the experiments achieved by Klüver and Bucy [51], monkeys’ behavior were studied in relation with fear.”
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“Kluver and Bucy will show, in 1939, that changes in behavior in monkeys may be associated with temporal lobe lessions (Kluver & Bucy, 1997), whereas in 1941 Jasper and Kershmann will prove that the temporal lobe is the site of origin of psychomotor seizures (Jasper & Kershmann, 1941).”
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“The impairment is in some respects similar to the Kluver-Bucy Syndrome (Kluver & Bucy, 1939), a disorder characterised by the loss of knowledge about the emotional significance of objects in primates and humans.”
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“The Klüver–Bucy syndrome (KBS) was first described in rhesus monkeys after bilateral temporal lobectomy (1) and is characterized by hypersexuality, excessive oral tendencies, dietary changes, loss of normal fear, lack of aggression, psychic blindness, and excessive attentiveness to visual stimuli.”
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Klüver-Bucy Syndrome in Juvenile Neuronal Ceroid Lipofuscinosis
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“(e.g., Brown & Schafer, 1888; Emery et al., 2001; Kling, 1968; Kling, 1974; Kling & Cornell, 1971; Kling, Lancaster, & Benitone, 1970; Klüver & Bucy, 1939; Machado, Emery, et al., 2008; Mirsky, 1960; Schreiner & Kling, 1956).”
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“…states and hysteria, the r81e of the temporal lobes in memory function and in the experience and registration of emotional change, the work of Kliiver and Bucy (1939), of Papez (1937) and of MacLean (1949), the effect on the adrenal cortex of activity in the amygdaloid nucleus and other…”
BackgroundOxytocin and elderly MRI-based hippocampus and amygdala volume: a 7-year follow-up study
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“The hippocampus has memory functions (Scoville and Milner, 1957), and the amygdala has emotional functions (Klu¨ver and Bucy, 1997).”
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“, breaking the resilience of the system) and that after unilateral stimulation or resection, there are compensatory upregulations of activation in contralateral regions, peridamage areas and increased positive transcallosal functional connectivity (Binney and Lambon Ralph 2015; Jung and Lambon Ralph 2016; Rice et al.…”
BackgroundResultThe Neural Correlates of Shoulder Apprehension: A Functional MRI Study
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“The amygdala is also important for detecting environmental threats [16, 17] and for coordinating responses to threat and danger [18, 19].”
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“Klüver and Bucy (1939) showed that complete removal of the amygdala and surrounding brain areas resulted in fearless monkeys that would examine every object in a strange room, whereas a monkey with an intact amygdala would not do this.”
BackgroundTransient Kluver-Bucy syndrome following complex partial status epilepticus.
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“After the surgery the patient developed the features of a syndrome that had been described by Kluver and Bucy in 1939 following bilateral temporal resection in monkeys [2].”
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“The amygdala is critical for detecting potential danger through sensory inputs (Klüver and Bucy 1939; LeDoux 2000).”
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“…2004a; Bliss-Moreau et al., 2013; Brown & Schafer, 1888; Emery et al., 2001; Kling, 1968; Kling et al., 1970; Kling & Cornell, 1971; Kling, 1974; Klüver & Bucy, 1939; Machado, Emery, et al., 2008; Mirsky, 1960; Moadab et al., 2015; Schreiner & Kling, 1956), the social effects of early damage to…”
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“For example, monkeys with Klüver–Bucy syndrome, resulting from bilateral lesions to the anterior temporal lobes, exhibit lack of facial expression and absence of emotional reactions [Klüver & Bucy, 1939].”
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“Kluver and Bucy (1939)* and Kaada (1951). Papez described the major structures and interconnecting pathways of the limbic system, and he proposed that this system might provide the neural substrate for emotion.”
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Reading the Freudian theory of sexual drives from a functional neuroimaging perspective
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“This model is consistent with the hypersexual syndromes observed in patients whose lateral temporal regions are injured, either by pathological processes such as tumors (Burns and Swerdlow, 2003) or after experimental or therapeutic surgery [Klüver-Bucy syndrome in monkeys (Klüver and Bucy, 1939); and its counterpart…”
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“Generally similar behavioral changes were also observed in primates after amygdaloid lesions (Kluver and Bucy, 1939; Weiskrantz, 1956).”
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“…tracts between the superior olive and inferior colliculus, commenting that these behavioural changes were reminiscent of autistic children when comparing their findings with those of Kluver and Bucy (1997) who obtained similar behavioural deficits after removing the temporal lobes of monkeys.”
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“Kluver and Bucey ( 1939) found that removal of the amygdala in monkeys produced tranquility.”
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“due to bilateral temporal lobe lesions, which resulted in bizarre hypersexuality in non-human primates (Kluver and Bucy, 1939).”
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Afferent projections to the hypothalamic area controlling emotional responses (HACER).
Devito, J. L., & Smith, O. (1982) · Brain Research · doi:10.1016/0006-8993(82)90389-4 · Cited by 20
Metadata
- Authors
- KLÜVER, H.
- Corresponding author
- KLÜVER, HEINRICH
- Venue
- Archives of Neurology And Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1939-12-01
- Volume
- 42
- Issue
- 6
- Pages
- 979
- ISSN
- 0096-6754 (ISSN-L)
- OpenAlex
- W2169771257
- Cited by
- 1,696
- References
- 0
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 22 · 2023: 9 · 2022: 11 · 2021: 27 · 2020: 21 · 2019: 16 · 2018: 25 · 2017: 27 · 2016: 26 · 2015: 34 · 2014: 32 · 2013: 43 · 2012: 39
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology And Psychiatry (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Neurology › Neurology and Historical Studies
- Keywords
- temporal lobe, rhesus monkeys, visual agnosia, emotional change, behavioral symptoms
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