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PRELIMINARY ANALYSIS OF FUNCTIONS OF THE TEMPORAL LOBES IN MONKEYS
Abstract
In previous communications1we pointed out that the chief symptoms following bilateral temporal lobectomy in the rhesus monkey consist in "psychic blindness" (Seelenblindheit) or visual agnosia, strong "oral" tendencies and profound emotional changes. Our results were primarily based on an analysis of the behavioral symptoms of a female rhesus monkey which had been studied for a period of four months following the operations. The type of disturbance analyzed in that case seemed to be similar to the "associative mind blindness" of Lissauer.2It is true that the diagnosis "agnosia" can be only of practical importance and merely serves to raise a number of questions. A review of the clinical literature indicates that the more carefully a case is studied the more difficult it may be to decide whether there is really an "agnostic" or merely a "visual" defect, that is, whether the variety of "agnostic" symptoms can be
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“This goes back to the original findings of hypersexuality in individuals with frontal lobe damage or Kluver-Bucy syndrome.94”
From Assessment and treatment of compulsive sexual behavior disorder: a sexual medicine perspective (2024) · cites this paper as [94]
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“Conversely, lesioning of the amygdala results in hypersexuality (Kluver and Bucy 1997), increased circulating LH (Lawton and Sawyer 1970), and prevents the stress-induced suppression of LH pulses (Lin et al. 2011).”
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“…a more complex network has been implicated including some highly sexually dimorphic brain regions of interest, such as amygdala (Zola-Morgan et al., 1991; Kluver and Bucy, 1997), hippocampus, cingulate cortex (Mac, 1949; Papez, 1995), medial PFC, and periacqueductal gray (Price and Drevets, 2010).”
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“The syndrome was first described in monkeys with bilateral temporal lobectomy including the amygdala (Klüver & Bucy, 1939) and in humans it includes bizarre eating, drinking, chewing and biting, altered emotional behaviour and abnormal sexual drive.”
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“Authored by Pierre Gloor,(2) this chapter critically summarized a now largely forgotten body of stimulation, recording, and lesion studies, including the well-known Kluver–Bucy syndrome.(3) With respect to the latter, Gloor commented that while changes in emotional behaviors are consistently observed after amygdala le…”
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“Their bilateral removal of temporal lobes in monkeys evoked typical changes in social cognition— visual agnosia, decreased fear, tameness, hypersexuality, hyperorality, and social withdrawal [109].”
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“The amygdala itself has long been considered to be involved in emotional responses (Klüver and Bucy 1939; Weiskrantz 1956).”
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“The source of the excessive visual interest in objects that follows bilateral temporal lobectomy (Klüver & Bucy, 1939) as well as selective amygdala lesions (Meunier et al., 1999; present study) is unknown.”
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“As initially proposed by Klüver and Bucy (1939), in monkeys the amygdala appears to be essential to process fearful signals.”
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“The amygdala is intimately involved in emotional behavior (Kluver and Bucy 1939; LeDoux 2000), and its role in the generation of anxiety and conditioned fear is well known (Davis 1992; LeDoux 1995).”
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“94 In addition to hyperresponsiveness of mesolimbic dopamine, there is a general finding that the regions in the left hemisphere that mediate excitation are hyperresponsive, whereas regions in the right hemisphere that mediate inhibition are hyporesponsive.”
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Metadata
- Authors
- KLÜVER, H.
- Corresponding author
- KLÜVER, HEINRICH
- Venue
- Archives of Neurology And Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1939-12-01
- Volume
- 42
- Issue
- 6
- Pages
- 979
- ISSN
- 0096-6754 (ISSN-L)
- OpenAlex
- W2169771257
- Cited by
- 1,696
- References
- 0
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 22 · 2023: 9 · 2022: 11 · 2021: 27 · 2020: 21 · 2019: 16 · 2018: 25 · 2017: 27 · 2016: 26 · 2015: 34 · 2014: 32 · 2013: 43 · 2012: 39
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Neurology And Psychiatry (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Neurology › Neurology and Historical Studies
- Keywords
- temporal lobe, rhesus monkeys, visual agnosia, emotional change, behavioral symptoms
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