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Cited by 92Sleep and Work-Related FatigueSleep and Wakefulness ResearchSchizophrenia research and treatment

Studies of sleep deprivation-relationship to schizophrenia

BLISS, EUGENE L.·1959·Archives of Neurology And Psychiatry
DOI 10.1001/archneurpsyc.1959.02340150080009
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Abstract

Introduction There were several reasons for investigating the effects of sleep deprivation in man. One was simply a curiosity about the unusual consequences of prolonged insomnia described by earlier investigators. Kleitman1and Tyler2cited in detail the hallucinations and "psychotic-like" symptoms that occur under these circumstances and also described subjects who developed short-lived "schizophrenic" psychoses. Psychological alterations, such as inattention, apathy, illusions, and hallucinations, which commonly appear after 36 to 50 hours of wakefulness, have been noted to coincide with an increase in high-frequency, low-amplitude waves on the electroencephalogogram.3-5In contrast to such spontaneous psychological disturbances, sleep-deprived subjects have been able to perform normally on specific tests designed to measure work capacity, psychomotor performance, intellectual acumen, and personality structure.1,8Measurements of the basal metabolic rate, blood sugar, alkaline reserve, blood and urinary adrenal steroids, etc., have not been found to change significantly with sleep deprivation.1,5

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Crossref · 10.1001/archneurpsyc.1959.02340150080009

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  • Sleep deprivation in otherwise healthy individuals leads to emergence of psychotic-like experiences, such as hallucinations, with the frequency and severity of these experiences increasing with time spent awake.

    “Small studies carried out in the 1950s and 1960s reported that sleep deprivation in otherwise healthy individuals leads to emergence of psychotic-like experiences, such as hallucinations, with the frequency and severity of these experiences increasing with time spent awake”

    From The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review (2015) · cites this paper as Bliss et al., 1959

  • The beneficial mood-elevating effect of sleep deprivation is paralleled by reports of emotional lability in healthy adults under conditions of sleep loss, commonly describing episodes of inappropriate euphoria and giddiness, and oscillating periods of lopsided positive emotional reactivity.

    “Interestingly, this beneficial mood-elevating effect is paralleled by reports of emotional lability in healthy adults under conditions of sleep loss, commonly describing episodes of inappropriate euphoria and giddiness, and oscillating periods of lopsided positive emotional reactivity (Bliss et al., 1959; Horne, 1993; Dahl, 1996).”

    From Sleep deprivation amplifies reactivity of brain reward networks, biasing the appraisal of positive emotional experiences (2011) · cites this paper as Bliss et al., 1959

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Authors
BLISS, E. L.
Corresponding author
BLISS, EUGENE L.
Venue
Archives of Neurology And Psychiatry
Publisher
American Medical Association (AMA)
Published
1959-03-01
Volume
81
Issue
3
Pages
348
ISSN
0096-6754 (ISSN-L)
DOI
10.1001/archneurpsyc.1959.02340150080009
OpenAlex
W2166918019
Cited by
92
References
9
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 3 · 2013: 2 · 2012: 2
FWCI
15.52
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Neurology And Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
sleep deprivation, schizophrenia, hallucinations, psychotic-like symptoms, psychomotor performance, work capacity, basal metabolic rate, adrenal steroids
MeSH terms
Humans, Schizophrenia, Sleep, Sleep Deprivation

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