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Optic Nerve Damage in Human Glaucoma: III. Quantitative Correlation of Nerve Fiber Loss and Visual Field Defect in Glaucoma, Ischemic Neuropathy, Papilledema, and Toxic Neuropathy
Abstract
The number and distribution of human optic nerve axons were compared with clinical measurements available the same eyes, including visual acuity, disc appearance, and visual field studies. Definite loss of axons occurs prior to reproducible visual field defects in some patients suspected of having glaucoma. In glaucoma, the superior and inferior poles of the nerve lose nerve fibers at a selectively greater rate, leading to an hourglass-shaped atrophy. Cavernous degeneration of the retrobulbar optic nerve is rarely observed in chronic glaucoma. The pattern of atrophy in examples of toxic amblyopia, ischemic optic neuropathy and chronic papilledema differ from that of glaucoma, suggesting different mechanisms of damage in these conditions.
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Citations
Cited by
Morphologic Changes in the Lamina Cribrosa Correlated with Neural Loss in Open-Angle Glaucoma
Quigley, H. A., Hohman, R. M., Addicks, E. M., Massof, R. W., & Green, W. R. (1983) · American Journal of Ophthalmology · doi:10.1016/0002-9394(83)90389-6 · Cited by 680
Self-citationAt the interface of sensory and motor dysfunctions and Alzheimer’s disease.
Albers, M. W., Gilmore, G. C., Kaye, J., Murphy, C., Wingfield, A., Bennett, D. A., Boxer, A. L., Buchman, A. S., Cruickshanks, K. J., Devanand, D. P., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.04.514 · Cited by 589
Williams, R. W., & Herrup, K. (1988) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.11.030188.002231 · Cited by 585
Chronic human glaucoma causing selectively greater loss of large optic nerve fibers
Quigley, H. A., Dunkelberger, G. R., & Green, W. R. (1988) · Ophthalmology · doi:10.1016/s0161-6420(88)33176-3 · Cited by 563
Self-citationGupta, N. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2005.086769 · Cited by 434
Metadata
- Authors
- Quigley, H. A.
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 1982-01-01
- Volume
- 100
- Issue
- 1
- Pages
- 135
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W2116153835
- Cited by
- 1,177
- References
- 0
- FWCI
- 38.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Optic Nerve Damage in Human Glaucoma: III. Quantitative Correlation of Nerve Fiber Loss and Visual Field Defect in Glaucoma, Ischemic Neuropathy, Papilledema, and Toxic Neuropathy. https://app.cochat.ai/papers/10.1001/archopht.1982.01030030137016
- The paper
- Quigley, H. A. (1982). Optic Nerve Damage in Human Glaucoma: III. Quantitative Correlation of Nerve Fiber Loss and Visual Field Defect in Glaucoma, Ischemic Neuropathy, Papilledema, and Toxic Neuropathy. Archives of Ophthalmology. https://doi.org/10.1001/archopht.1982.01030030137016
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