Cited by 589Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

At the interface of sensory and motor dysfunctions and Alzheimer’s disease.

Open access
Albers, Mark W., Gilmore, Grover C., Kaye, Jeffrey, Murphy, Claire, Wingfield, Arthur, Bennett, David A., Boxer, Adam L., Buchman, Aron S. +20 more·2015·Alzheimer's & Dementia

Abstract

Recent evidence indicates that sensory and motor changes may precede the cognitive symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of developing AD. Traditionally, sensory and motor dysfunctions in aging and AD have been studied separately. To ascertain the evidence supporting the relationship between age-related changes in sensory and motor systems and the development of AD and to facilitate communication between several disciplines, the National Institute on Aging held an exploratory workshop titled "Sensory and Motor Dysfunctions in Aging and AD." The scientific sessions of the workshop focused on age-related and neuropathologic changes in the olfactory, visual, auditory, and motor systems, followed by extensive discussion and hypothesis generation related to the possible links among sensory, cognitive, and motor domains in aging and AD. Based on the data presented and discussed at this workshop, it is clear that sensory and motor regions of the central nervous system are affected by AD pathology and that interventions targeting amelioration of sensory-motor deficits in AD may enhance patient function as AD progresses.

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Registry

Crossref · 10.1016/j.jalz.2014.04.514

Cites

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  • Eleven ROIs have nominally significant correlations with both behaviors, including key sensory regions (VCP, VCS, and MGD) linked to early symptoms of AD in humans.

    “Eleven ROIs have nominally significant correlations with both behaviors (Supplementary Table 10), including key sensory regions (VCP, VCS, and MGD) linked to early symptoms of AD in humans71-74.”

    From Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice (2026) · cites this paper as [74]

    The Visual System neuropathology section reports that visual cortical areas can be affected early in AD, supporting the visual-region portion. The Auditory System neuropathology section reports pathology in the medial geniculate nucleus but says its presence in presymptomatic patients with hearing loss has not been investigated, so it does not establish that region’s link to early human symptoms. The eleven-ROI correlations are the citing paper’s own result, not a finding attributed to this source. (LLM, conf=0.88)

    Experimental — accuracy not yet measured
  • Neuropsychiatric symptoms, alongside behavioral disorders, deficits in locomotor activity, and changes in reflex and sensory function, precede cognitive deficits in AD.

    “Moreover, neuropsychiatric symptoms, alongside behavioral disorders, deficits in locomotor activity, and changes in reflex and sensory function, precede cognitive deficits in AD (Albers et al., 2015; Buchman and Bennett, 2011; Cortes et al., 2018).”

    From Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model (2024) · cites this paper as Albers et al., 2015

    The Introduction says that changes in smell, hearing, and walking speed may precede cognitive impairment by 5–15 years. The Discussion likewise says some sensory and motor deficits may precede cognitive symptoms, but cautions that others appear concurrently and not all patients show such early changes. These passages do not establish that neuropsychiatric symptoms, behavioral disorders, or reflex changes precede cognitive deficits. (LLM, conf=0.88)

    Experimental — accuracy not yet measured
  • Epidemiological research has provided evidence of a significant association between hearing loss and incident dementia.

    “From a population health perspective, epidemiological research has provided evidence of a significant association between hearing loss and incident dementia (Albers et al. 2015) and prompted questions regarding the potential advantages of adopting a more integrated approach to research on hearing health and cognitive health (Dupuis et al. 2015; Pichora-Fuller et al. 2015).”

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Cites

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Research works printed but not linked: 4

  1. [113]Wijk H Berg S Sivik L Steen B Colour discrimination, colour naming and colour preferences among individuals with Alzheimer’s disease Int J Geriatr Psychiatry 1999 14 12 1000 5 10607966
  2. [140]Prakasam A Muthuswamy A Ablonczy Z Greig NH Fauq A Rao KJ Differential accumulation of secreted AbetaPP metabolites in ocular fluids J Alzheimers Dis 2010 20 4 1243 53 20413851 PMC3397687
  3. [151]Mardin CY Structural diagnostics of course observation for glaucoma Ophthalmologe 2013 110 11 1036 44 24231910
  4. [152]Renard JP Fenolland JR El Chehab H Francoz M Marill AM Messaoudi R Analysis of macular ganglion cell complex (GCC) with spectral-domain optical coherence tomography (SD-OCT) in glaucoma J Fr Ophtalmol 2013 36 4 299 309 23541535

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Authors
Albers, M. W., Gilmore, G. C., Kaye, J., Murphy, C., Wingfield, A., Bennett, D. A., Boxer, A. L., Buchman, A. S., Cruickshanks, K. J., Devanand, D. P., Duffy, C. J., Gall, C. M., Gates, G. A., Granholm, A., Hensch, T., Holtzer, R., Hyman, B. T., Lin, F. R., McKee, A. C., Morris, J. C., Petersen, R. C., Silbert, L. C., Struble, R. G., Trojanowski, J. Q., Verghese, J., Wilson, D. A., Xu, S., & Zhang, L. I.
Affiliations
  • Harvard University (US)
  • Case Western Reserve University (US)
  • Oregon Health & Science University (US)
  • San Diego State University (US)
  • Brandeis University (US)
  • Rush University Medical Center (US)
  • University of California, San Francisco (US)
  • University of Wisconsin–Madison (US)
  • Columbia University (US)
  • University of Rochester Medicine (US)
  • University of California, Irvine (US)
  • University of Washington (US)
  • Medical University of South Carolina (US)
  • Albert Einstein College of Medicine (US)
  • Johns Hopkins University (US)
  • Boston University (US)
  • Washington University in St. Louis (US)
  • Mayo Clinic (US)
  • SIU Medicine (US)
  • University of Pennsylvania (US)
  • Nathan Kline Institute for Psychiatric Research (US)
  • University of Southern California (US)
Corresponding author
Albers, Mark W.
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2014-07-08
Volume
11
Issue
1
Pages
70-98
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
OpenAlex
W2148230634
Cited by
589
References
361
Citations by year
2026: 34 · 2025: 65 · 2024: 66 · 2023: 61 · 2022: 63 · 2021: 63 · 2020: 53 · 2019: 55 · 2018: 40 · 2017: 40 · 2016: 32 · 2015: 14 · 2014: 2 · 2013: 1
FWCI
4.06
Type
journal article
Language
en
Open access
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institutes of Health (1dp2od006662-01)
  • National Institute on Aging (R01AG017917, R01AG041795, R01AG037693, R01AG004085, P30AG010124, R01AG044920, R01AG015819, P30AG008017, R01AG019714, R01AG031278, P50AG005146, P50AG005134, RF1AG015819, R01AG038791, P30AG062421)
  • National Institute on Deafness and Other Communication Disorders (K23DC011279, R01DC008983)
  • National Institute of Neurological Disorders and Stroke (R21NS085711)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
Keywords
Alzheimer's disease, sensory dysfunction
MeSH terms
Aging, Alzheimer Disease, Humans, Movement Disorders, Sensation Disorders, United States, Disease Progression, Early Diagnosis, National Institute on Aging (U.S.)

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