The DOI matches its Crossref record.
Optic Nerve Damage in Human Glaucoma: III. Quantitative Correlation of Nerve Fiber Loss and Visual Field Defect in Glaucoma, Ischemic Neuropathy, Papilledema, and Toxic Neuropathy
Abstract
The number and distribution of human optic nerve axons were compared with clinical measurements available the same eyes, including visual acuity, disc appearance, and visual field studies. Definite loss of axons occurs prior to reproducible visual field defects in some patients suspected of having glaucoma. In glaucoma, the superior and inferior poles of the nerve lose nerve fibers at a selectively greater rate, leading to an hourglass-shaped atrophy. Cavernous degeneration of the retrobulbar optic nerve is rarely observed in chronic glaucoma. The pattern of atrophy in examples of toxic amblyopia, ischemic optic neuropathy and chronic papilledema differ from that of glaucoma, suggesting different mechanisms of damage in these conditions.
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Cited by
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Albers, M. W., Gilmore, G. C., Kaye, J., Murphy, C., Wingfield, A., Bennett, D. A., Boxer, A. L., Buchman, A. S., Cruickshanks, K. J., Devanand, D. P., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.04.514 · Cited by 589
Williams, R. W., & Herrup, K. (1988) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.11.030188.002231 · Cited by 585
Chronic human glaucoma causing selectively greater loss of large optic nerve fibers
Quigley, H. A., Dunkelberger, G. R., & Green, W. R. (1988) · Ophthalmology · doi:10.1016/s0161-6420(88)33176-3 · Cited by 563
Self-citationGupta, N. (2006) · British Journal of Ophthalmology · doi:10.1136/bjo.2005.086769 · Cited by 434
Yücel, Y. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(03)00026-0 · Cited by 384
Chang, S., & Bowden, A. K. (2019) · Journal of Biomedical Optics · doi:10.1117/1.jbo.24.9.090901 · Cited by 99
Retinal nerve fiber layer abnormalities in Alzheimer's disease
Hedges, T. R., Galves, R. P., Speigelman, D., Barbas, N. R., Peli, E., & Yardley, C. J. (1996) · Acta Ophthalmologica Scandinavica · doi:10.1111/j.1600-0420.1996.tb00090.x · Cited by 92
Does Retinal Ganglion Cell Loss Precede Visual Field Loss in Glaucoma?
Hood, D. C. (2019) · Journal of Glaucoma · doi:10.1097/ijg.0000000000001380 · Cited by 29
Metadata
- Authors
- Quigley, H. A.
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 1982-01-01
- Volume
- 100
- Issue
- 1
- Pages
- 135
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W2116153835
- Cited by
- 1,177
- References
- 0
- FWCI
- 38.93
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
