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Cited by 155Sleep and Wakefulness ResearchTreatment of Major DepressionSleep and related disorders

The DOI matches its Crossref record.

Total Prolonged Drug-Induced REM Sleep Suppression in Anxious-Depressed Patients

Wyatt, Richard J.·1971·Archives of General Psychiatry
DOI 10.1001/archpsyc.1971.01750080049007
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Abstract

Monoamine oxidase inhibitors (MAOI) are a class of drugs which are capable of totally suppressing REM sleep. The MAOI phenelzine was given to six anxious-depressed patients while daily behavioral and EEG sleep records were made. REM sleep was completely suppressed for from 14 to 40 nights. Upon discontinuation of MAOI REM sleep increased as much as 250% above normal levels. The bipolar EEG changes were paralleled by similar changes in depression and anxiety. The behavior of all six patients markedly improved at times when REM sleep was completely absent. Two of the four patients studied after MAOI discontinuation became profoundly anxious with REM compensation. The morning recall of dreams also closely paralleled the presence or absence of REM sleep. Evidence from this study and others indicate that suppression of REM sleep might help to alleviate depression.

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Crossref · 10.1001/archpsyc.1971.01750080049007

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  • PSG studies have confirmed a tendency for prolonged sleep latency and impaired sleep continuity associated with increased awakenings and increased WASO in patients treated with MAOIs.

    “PSG studies have confirmed a tendency for prolonged sleep latency and impaired sleep continuity associated with increased awakenings and increased WASO in patients being treated with these compounds [Wyatt et al., 1971;Kupfer and Bowers, 1972].”

    From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Wyatt et al., 1971

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Metadata

Authors
Wyatt, R. J.
Affiliations
National Institute of Mental Health (US)
Corresponding author
Wyatt, Richard J.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1971-02-01
Volume
24
Issue
2
Pages
145
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1971.01750080049007
OpenAlex
W2112531765
Cited by
155
References
0
Citations by year
2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 1 · 2012: 3
FWCI
8.51
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
REM sleep suppression, monoamine oxidase inhibitors, phenelzine, depression, anxiety, REM sleep deprivation, dream recall, antidepressant effects
MeSH terms
Adult, Anxiety, Depression, Dreams, Electroencephalography, Electromyography, Electrooculography, Female, Humans, Male, Middle Aged, Monoamine Oxidase Inhibitors, Phenelzine, Sleep Deprivation, Sleep, REM

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